The network for 'cyclin catabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cyclin catabolic process

The chemical reactions and pathways resulting in the breakdown of cyclins, proteins whose levels in a cell varies markedly during the cell cycle, and which play key roles in regulating cell cycle phase transitions.

NameDescriptionProbabilityFunc Analog Organism
CDC20cell division cycle 20 homolog (S. cerevisiae)1.000
CKS1BCDC28 protein kinase regulatory subunit 1B0.993
CUL1cullin 10.974
RBX1ring-box 1, E3 ubiquitin protein ligase0.968
CCNB1cyclin B10.963
CDK2cyclin-dependent kinase 20.875
CDC27cell division cycle 27 homolog (S. cerevisiae)0.824
MAD2L2MAD2 mitotic arrest deficient-like 2 (yeast)0.816
PTTG1pituitary tumor-transforming 10.756
COPS4COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)0.700
CCNA2cyclin A20.669
TCEB1transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)0.624
CCNB2cyclin B20.604
SKP2S-phase kinase-associated protein 2 (p45)0.433
CDT1chromatin licensing and DNA replication factor 10.358
ANAPC4anaphase promoting complex subunit 40.358
COPS5COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)0.333
COPS8COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)0.300
CDKN3cyclin-dependent kinase inhibitor 30.265
VHLvon Hippel-Lindau tumor suppressor0.248
CUL2cullin 20.239
PLK1polo-like kinase 10.238
CKS2CDC28 protein kinase regulatory subunit 20.168
FOXM1forkhead box M10.163
COPS2COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)0.145
ANAPC11anaphase promoting complex subunit 110.142
MAP3K5mitogen-activated protein kinase kinase kinase 50.125
UBE2Subiquitin-conjugating enzyme E2S0.124
SKP1S-phase kinase-associated protein 10.097
GFI1Bgrowth factor independent 1B transcription repressor0.092
COPS6COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)0.083
BUB1Bbudding uninhibited by benzimidazoles 1 homolog beta (yeast)0.065
BIRC5baculoviral IAP repeat containing 50.060
GFERgrowth factor, augmenter of liver regeneration0.057
SIRT2sirtuin 20.052
CDK1cyclin-dependent kinase 10.044
POLR2Kpolymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa0.043
CUL4Acullin 4A0.041
COPS3COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)0.038
FZR1fizzy/cell division cycle 20 related 1 (Drosophila)0.038
CLSPNclaspin0.035
MAKmale germ cell-associated kinase0.032
AURKBaurora kinase B0.032
COPS7ACOP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)0.030
CUL5cullin 50.028
ZYG11Bzyg-11 homolog B (C. elegans)0.025
LRR1leucine rich repeat protein 10.023
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)0.022
CUL4Bcullin 4B0.021
SNX9sorting nexin 90.021
PKMYT1protein kinase, membrane associated tyrosine/threonine 10.021
DCUN1D1DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)0.020
C8orf40chromosome 8 open reading frame 400.019
PIGPphosphatidylinositol glycan anchor biosynthesis, class P0.018
TCEB2transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)0.017
UBE2Cubiquitin-conjugating enzyme E2C0.016
SOCS1suppressor of cytokine signaling 10.016
MAD2L1MAD2 mitotic arrest deficient-like 1 (yeast)0.015
BUB1budding uninhibited by benzimidazoles 1 homolog (yeast)0.015
TXNthioredoxin0.014
ANAPC2anaphase promoting complex subunit 20.014
PSRC1proline/serine-rich coiled-coil 10.013
COMMD1copper metabolism (Murr1) domain containing 10.012
MAD1L1MAD1 mitotic arrest deficient-like 1 (yeast)0.011
JAG2jagged 20.011
MYBL2v-myb myeloblastosis viral oncogene homolog (avian)-like 20.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
dao-5Protein DAO-50.029
CELE_Y54G11A.11Protein Y54G11A.110.021
tag-296Protein TAG-2960.019
CELE_T05H4.11Protein T05H4.110.018
vps-33.2Protein VPS-33.20.015
air-1Protein AIR-10.014
acl-9Protein ACL-90.013
imb-2Protein IMB-20.013
cye-1Protein CYE-10.012
cin-4Protein CIN-40.011
hcp-2Protein HCP-20.011
K08E3.5Protein K08E3.50.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
ncdnon-claret disjunctional0.012
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Cdk1cyclin-dependent kinase 10.873
Ccnb2cyclin B20.758
Ccnb1cyclin B10.673
Birc5baculoviral IAP repeat-containing 50.622
Ccna2cyclin A20.356
Prc1protein regulator of cytokinesis 10.338
H2afxH2A histone family, member X0.251
Cdca8cell division cycle associated 80.229
Kif20akinesin family member 20A0.205
Rrm2ribonucleotide reductase M20.184
Cdc20cell division cycle 20 homolog (S. cerevisiae)0.137
Kif22kinesin family member 220.123
Mki67antigen identified by monoclonal antibody Ki 670.079
Ube2cubiquitin-conjugating enzyme E2C0.069
Plk1polo-like kinase 1 (Drosophila)0.065
Ckap2cytoskeleton associated protein 20.058
Asf1bASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.053
Bub1bbudding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)0.046
PbkPDZ binding kinase0.045
Ranbp9RAN binding protein 90.043
Racgap1Rac GTPase-activating protein 10.043
Cdca5cell division cycle associated 50.038
Uhrf1ubiquitin-like, containing PHD and RING finger domains, 10.037
Aurkbaurora kinase B0.036
Hist1h2aohistone cluster 1, H2ao0.030
Tk1thymidine kinase 10.030
Hmgb2high mobility group box 20.029
Kpna2karyopherin (importin) alpha 20.028
Cdkn3cyclin-dependent kinase inhibitor 30.027
Mad2l1MAD2 mitotic arrest deficient-like 1 (yeast)0.025
H2afzH2A histone family, member Z0.022
Mcm3minichromosome maintenance deficient 3 (S. cerevisiae)0.021
Mcm5minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)0.021
Tacc3transforming, acidic coiled-coil containing protein 30.021
Cenpacentromere protein A0.021
Ncaphnon-SMC condensin I complex, subunit H0.016
Ccnfcyclin F0.016
Cks2CDC28 protein kinase regulatory subunit 20.016
Kif11kinesin family member 110.015
Psme4proteasome (prosome, macropain) activator subunit 40.015
Cdc25ccell division cycle 25 homolog C (S. pombe)0.015
Snx14sorting nexin 140.015
Gm16517predicted gene, Gm165170.015
Top2atopoisomerase (DNA) II alpha0.014
D2Ertd750eDNA segment, Chr 2, ERATO Doi 750, expressed0.014
Spc24SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)0.014
Senp6SUMO/sentrin specific peptidase 60.014
Ect2ect2 oncogene0.013
Syncripsynaptotagmin binding, cytoplasmic RNA interacting protein0.013
Capn7calpain 70.012
Eif1axeukaryotic translation initiation factor 1A, X-linked0.012
Dab1disabled homolog 1 (Drosophila)0.012
Tmem205transmembrane protein 2050.012
Mef2amyocyte enhancer factor 2A0.012
Anlnanillin, actin binding protein0.012
Lzts2leucine zipper, putative tumor suppressor 20.012
Vkorc1vitamin K epoxide reductase complex, subunit 10.012
Aurkaaurora kinase A0.012
Kpna1karyopherin (importin) alpha 10.011
Mxd3Max dimerization protein 30.011
Ypel3yippee-like 3 (Drosophila)0.011
BC031181cDNA sequence BC0311810.010
Fuca1fucosidase, alpha-L- 1, tissue0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
CDC23Cdc23p0.042
CDC27Cdc27p0.025
APC2Apc2p0.019
CDC16Cdc16p0.018
APC4Apc4p0.015