The network for 'negative regulation of i kappab kinase nf kappab signaling' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of i kappab kinase nf kappab signaling

Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.

NameDescriptionProbabilityFunc Analog Organism
RIPK2receptor-interacting serine-threonine kinase 20.867
BIRC3baculoviral IAP repeat containing 30.722
CASP3caspase 3, apoptosis-related cysteine peptidase0.628
CASP8caspase 8, apoptosis-related cysteine peptidase0.628
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.613
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.607
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.589
BIRC2baculoviral IAP repeat containing 20.556
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.545
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.489
C1QAcomplement component 1, q subcomponent, A chain0.449
XIAPX-linked inhibitor of apoptosis0.446
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.440
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.394
CASP9caspase 9, apoptosis-related cysteine peptidase0.242
CFLARCASP8 and FADD-like apoptosis regulator0.239
TNFRSF6Btumor necrosis factor receptor superfamily, member 6b, decoy0.213
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.195
CASP10caspase 10, apoptosis-related cysteine peptidase0.178
TNIP2TNFAIP3 interacting protein 20.160
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.156
NLRC4NLR family, CARD domain containing 40.154
TRAF1TNF receptor-associated factor 10.149
NFKBIBnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta0.141
IL4Rinterleukin 4 receptor0.127
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.114
PSMD2proteasome (prosome, macropain) 26S subunit, non-ATPase, 20.114
MAP3K8mitogen-activated protein kinase kinase kinase 80.103
HIPK3homeodomain interacting protein kinase 30.102
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.096
FASFas (TNF receptor superfamily, member 6)0.090
IFNAR1interferon (alpha, beta and omega) receptor 10.089
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.079
NR0B1nuclear receptor subfamily 0, group B, member 10.079
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.064
GFM1G elongation factor, mitochondrial 10.058
C1QCcomplement component 1, q subcomponent, C chain0.055
CUL1cullin 10.050
PTPN1protein tyrosine phosphatase, non-receptor type 10.050
TNIP1TNFAIP3 interacting protein 10.049
APAF1apoptotic peptidase activating factor 10.047
CASP7caspase 7, apoptosis-related cysteine peptidase0.047
TRAF6TNF receptor-associated factor 60.046
EP300E1A binding protein p3000.044
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.044
TRAF3TNF receptor-associated factor 30.042
NFKBIEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.041
BBS10Bardet-Biedl syndrome 100.041
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.039
CRADDCASP2 and RIPK1 domain containing adaptor with death domain0.036
IRF1interferon regulatory factor 10.034
PSMD7proteasome (prosome, macropain) 26S subunit, non-ATPase, 70.034
JAK1Janus kinase 10.034
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.034
IRF9interferon regulatory factor 90.029
MAP3K14mitogen-activated protein kinase kinase kinase 140.029
IL2RBinterleukin 2 receptor, beta0.028
MYH9myosin, heavy chain 9, non-muscle0.027
MAP3K3mitogen-activated protein kinase kinase kinase 30.027
ZNF84zinc finger protein 840.024
IFNAR2interferon (alpha, beta and omega) receptor 20.023
RANBP3RAN binding protein 30.023
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.023
C1QBcomplement component 1, q subcomponent, B chain0.023
BCAR1breast cancer anti-estrogen resistance 10.023
ZNF260zinc finger protein 2600.022
OPTNoptineurin0.022
TNFAIP3tumor necrosis factor, alpha-induced protein 30.022
TRAF5TNF receptor-associated factor 50.021
CSNK1Ecasein kinase 1, epsilon0.021
IL12RB2interleukin 12 receptor, beta 20.020
ZNF585Azinc finger protein 585A0.020
NMIN-myc (and STAT) interactor0.020
SNAI1snail homolog 1 (Drosophila)0.019
NFKBIZnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta0.019
ZNF432zinc finger protein 4320.018
DIABLOdiablo, IAP-binding mitochondrial protein0.018
PSMD6proteasome (prosome, macropain) 26S subunit, non-ATPase, 60.018
RAPGEF1Rap guanine nucleotide exchange factor (GEF) 10.017
ACTN1actinin, alpha 10.017
KAT2BK(lysine) acetyltransferase 2B0.017
GIT2G protein-coupled receptor kinase interacting ArfGAP 20.017
TRIM63tripartite motif containing 630.017
FLNAfilamin A, alpha0.016
CCDC90Bcoiled-coil domain containing 90B0.016
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.016
PFN1profilin 10.016
HOXA9homeobox A90.016
PYDC2pyrin domain containing 20.016
USP15ubiquitin specific peptidase 150.016
FLNBfilamin B, beta0.015
RIPK3receptor-interacting serine-threonine kinase 30.015
STAT5Asignal transducer and activator of transcription 5A0.015
MEFVMediterranean fever0.015
PXNpaxillin0.014
RIPK4receptor-interacting serine-threonine kinase 40.014
ZNF189zinc finger protein 1890.014
ZNF180zinc finger protein 1800.014
ARL4DADP-ribosylation factor-like 4D0.013
ZNF569zinc finger protein 5690.013
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
nfkbiaanuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a0.160
arhgdigRho GDP dissociation inhibitor (GDI) gamma0.142
gadd45bagrowth arrest and DNA-damage-inducible, beta a0.105
caspacaspase a0.097
capns1acalpain, small subunit 1 a0.091
s100v2S100 calcium binding protein V20.067
pdcd6ipprogrammed cell death 6 interacting protein0.064
mcl1amyeloid cell leukemia sequence 1a0.056
cd63Cd63 antigen0.054
LOC100006361galanin-like0.052
phlda2pleckstrin homology-like domain, family A, member 20.050
cav1caveolin 10.050
gabarapaGABA(A) receptor-associated protein a0.049
ip6k2inositol hexaphosphate kinase 20.042
cnot6CCR4-NOT transcription complex, subunit 60.040
nccrp1nonspecific cytotoxic cell receptor protein 10.040
fuca2fucosidase, alpha-L- 2, plasma0.037
agr2anterior gradient homolog 2 (Xenopus laevis)0.037
zgc:110340zgc:1103400.036
grid2glutamate receptor, ionotropic, delta 20.035
relv-rel reticuloendotheliosis viral oncogene homolog0.034
klf2aKruppel-like factor 2a0.034
nfkbiabnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b0.033
mibmind bomb0.033
nod1nucleotide-binding oligomerization domain containing 10.033
si:ch73-60e21.1si:ch73-60e21.10.032
itm2bbintegral membrane protein 2Bb0.031
serpinb1serpin peptidase inhibitor, clade B (ovalbumin), member 10.030
mpzl2myelin protein zero-like 20.029
march6membrane-associated ring finger (C3HC4) 60.027
anxa5bannexin A5b0.027
s100a10bS100 calcium binding protein A10b0.027
fxyd6lFXYD domain containing ion transport regulator 6 like0.026
stxbp2syntaxin binding protein 20.025
hnrnpkheterogeneous nuclear ribonucleoprotein K0.025
capns1bcalpain, small subunit 1 b0.025
ghsragrowth hormone secretagogue receptor a0.025
dlatdihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)0.025
LOC100000332e3 ubiquitin-protein ligase RNF182-like0.025
icnictacalcin0.024
junbjun B proto-oncogene0.024
anxa2aannexin A2a0.024
socs3asuppressor of cytokine signaling 3a0.023
fkbp5FK506 binding protein 50.023
junjun proto-oncogene0.023
acot11aacyl-CoA thioesterase 11a0.023
hcrthypocretin (orexin) neuropeptide precursor0.023
stap2bsignal transducing adaptor family member 2b0.022
card9caspase recruitment domain family, member 90.022
wu:fj37c10wu:fj37c100.022
zgc:110717zgc:1107170.022
mcl1bmyeloid cell leukemia sequence 1b0.022
atp6v1e1bATPase, H+ transporting, lysosomal, V1 subunit E isoform 1b0.022
ahnakAHNAK nucleoprotein0.022
brd3abromodomain containing 3a0.021
wnt9bwingless-type MMTV integration site family, member 9B0.021
sc:d0144sc:d01440.021
maxmyc-associated factor X0.020
sb:cb252sb:cb2520.020
mtnr1bbmelatonin receptor 1B b and melatonin receptor 1B0.020
atp6v0caATPase, H+ transporting, lysosomal, V0 subunit c, a0.020
terttelomerase reverse transcriptase0.019
chmp5chromatin modifying protein 50.019
ift88intraflagellar transport 88 homolog0.019
tph2tryptophan hydroxylase 2 (tryptophan 5-monooxygenase)0.019
mmp15bmatrix metallopeptidase 15b0.019
si:ch211-9d9.3si:ch211-9d9.30.019
cry2acryptochrome 2a0.018
ube2i2ubiquitin-conjugating enzyme E2I20.018
gins2GINS complex subunit 20.018
usp7ubiquitin specific peptidase 7 (herpes virus-associated)0.018
zgc:64114zgc:641140.018
fosv-fos FBJ murine osteosarcoma viral oncogene homolog0.018
akirin2akirin 20.018
aldocaaldolase C, fructose-bisphosphate, a0.018
zgc:92380zgc:923800.018
si:dkey-236e20.2si:dkey-236e20.20.018
phb2prohibitin 20.017
brd2bbromodomain containing 2b0.017
irf2bp2ainterferon regulatory factor 2 binding protein 2a0.017
unc45aunc-45 homolog A (C. elegans)0.017
zgc:73328zgc:733280.017
csnk1dacasein kinase 1, delta a0.017
zgc:113210zgc:1132100.017
ogt.1O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) 10.017
grm5aglutamate receptor, metabotropic 5a0.017
LOC557072caspase recruitment domain-containing protein 11-like0.017
papolbpoly(A) polymerase beta (testis specific)0.017
stc1lstanniocalcin 1, like0.016
pias4aprotein inhibitor of activated STAT, 4a0.016
chn1chimerin (chimaerin) 10.016
smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.016
supt6hsuppressor of Ty 6 homolog0.016
ftsjd1FtsJ methyltransferase domain containing 10.016
nfe2l2nuclear factor (erythroid-derived 2)-like 20.016
hnrprheterogeneous nuclear ribonucleoprotein R0.016
smek1SMEK homolog 1, suppressor of mek1 (Dictyostelium)0.016
polr2apolymerase (RNA) II (DNA directed) polypeptide A0.016
itpk1inositol 1,3,4-triphosphate 5/6 kinase0.016
pkzprotein kinase containing Z-DNA binding domains0.016
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
slprslipper0.024
Myd88CG2078 gene product from transcript CG2078-RA0.011
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism