IMP
Process View
The network for 'negative regulation of i kappab kinase nf kappab signaling' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
negative regulation of i kappab kinase nf kappab signaling
Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| RIPK2 | receptor-interacting serine-threonine kinase 2 | 0.867 | |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.722 | |
| CASP3 | caspase 3, apoptosis-related cysteine peptidase | 0.628 | |
| CASP8 | caspase 8, apoptosis-related cysteine peptidase | 0.628 | |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.613 | |
| RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.607 | |
| IKBKB | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 0.589 | |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.556 | |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.545 | |
| RELA | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 0.489 | |
| C1QA | complement component 1, q subcomponent, A chain | 0.449 | |
| XIAP | X-linked inhibitor of apoptosis | 0.446 | |
| NFKB2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 0.440 | |
| IKBKG | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | 0.394 | |
| CASP9 | caspase 9, apoptosis-related cysteine peptidase | 0.242 | |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.239 | |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | 0.213 | |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.195 | |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | 0.178 | |
| TNIP2 | TNFAIP3 interacting protein 2 | 0.160 | |
| REL | v-rel reticuloendotheliosis viral oncogene homolog (avian) | 0.156 | |
| NLRC4 | NLR family, CARD domain containing 4 | 0.154 | |
| TRAF1 | TNF receptor-associated factor 1 | 0.149 | |
| NFKBIB | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta | 0.141 | |
| IL4R | interleukin 4 receptor | 0.127 | |
| RELB | v-rel reticuloendotheliosis viral oncogene homolog B | 0.114 | |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.114 | |
| MAP3K8 | mitogen-activated protein kinase kinase kinase 8 | 0.103 | |
| HIPK3 | homeodomain interacting protein kinase 3 | 0.102 | |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.096 | |
| FAS | Fas (TNF receptor superfamily, member 6) | 0.090 | |
| IFNAR1 | interferon (alpha, beta and omega) receptor 1 | 0.089 | |
| CASP1 | caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) | 0.079 | |
| NR0B1 | nuclear receptor subfamily 0, group B, member 1 | 0.079 | |
| PPARGC1A | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | 0.064 | |
| GFM1 | G elongation factor, mitochondrial 1 | 0.058 | |
| C1QC | complement component 1, q subcomponent, C chain | 0.055 | |
| CUL1 | cullin 1 | 0.050 | |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.050 | |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.049 | |
| APAF1 | apoptotic peptidase activating factor 1 | 0.047 | |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | 0.047 | |
| TRAF6 | TNF receptor-associated factor 6 | 0.046 | |
| EP300 | E1A binding protein p300 | 0.044 | |
| RAC1 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 0.044 | |
| TRAF3 | TNF receptor-associated factor 3 | 0.042 | |
| NFKBIE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | 0.041 | |
| BBS10 | Bardet-Biedl syndrome 10 | 0.041 | |
| LATS2 | LATS, large tumor suppressor, homolog 2 (Drosophila) | 0.039 | |
| CRADD | CASP2 and RIPK1 domain containing adaptor with death domain | 0.036 | |
| IRF1 | interferon regulatory factor 1 | 0.034 | |
| PSMD7 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 | 0.034 | |
| JAK1 | Janus kinase 1 | 0.034 | |
| CRKL | v-crk sarcoma virus CT10 oncogene homolog (avian)-like | 0.034 | |
| IRF9 | interferon regulatory factor 9 | 0.029 | |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | 0.029 | |
| IL2RB | interleukin 2 receptor, beta | 0.028 | |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.027 | |
| MAP3K3 | mitogen-activated protein kinase kinase kinase 3 | 0.027 | |
| ZNF84 | zinc finger protein 84 | 0.024 | |
| IFNAR2 | interferon (alpha, beta and omega) receptor 2 | 0.023 | |
| RANBP3 | RAN binding protein 3 | 0.023 | |
| TNFRSF10A | tumor necrosis factor receptor superfamily, member 10a | 0.023 | |
| C1QB | complement component 1, q subcomponent, B chain | 0.023 | |
| BCAR1 | breast cancer anti-estrogen resistance 1 | 0.023 | |
| ZNF260 | zinc finger protein 260 | 0.022 | |
| OPTN | optineurin | 0.022 | |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.022 | |
| TRAF5 | TNF receptor-associated factor 5 | 0.021 | |
| CSNK1E | casein kinase 1, epsilon | 0.021 | |
| IL12RB2 | interleukin 12 receptor, beta 2 | 0.020 | |
| ZNF585A | zinc finger protein 585A | 0.020 | |
| NMI | N-myc (and STAT) interactor | 0.020 | |
| SNAI1 | snail homolog 1 (Drosophila) | 0.019 | |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.019 | |
| ZNF432 | zinc finger protein 432 | 0.018 | |
| DIABLO | diablo, IAP-binding mitochondrial protein | 0.018 | |
| PSMD6 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 | 0.018 | |
| RAPGEF1 | Rap guanine nucleotide exchange factor (GEF) 1 | 0.017 | |
| ACTN1 | actinin, alpha 1 | 0.017 | |
| KAT2B | K(lysine) acetyltransferase 2B | 0.017 | |
| GIT2 | G protein-coupled receptor kinase interacting ArfGAP 2 | 0.017 | |
| TRIM63 | tripartite motif containing 63 | 0.017 | |
| FLNA | filamin A, alpha | 0.016 | |
| CCDC90B | coiled-coil domain containing 90B | 0.016 | |
| SRC | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | 0.016 | |
| PFN1 | profilin 1 | 0.016 | |
| HOXA9 | homeobox A9 | 0.016 | |
| PYDC2 | pyrin domain containing 2 | 0.016 | |
| USP15 | ubiquitin specific peptidase 15 | 0.016 | |
| FLNB | filamin B, beta | 0.015 | |
| RIPK3 | receptor-interacting serine-threonine kinase 3 | 0.015 | |
| STAT5A | signal transducer and activator of transcription 5A | 0.015 | |
| MEFV | Mediterranean fever | 0.015 | |
| PXN | paxillin | 0.014 | |
| RIPK4 | receptor-interacting serine-threonine kinase 4 | 0.014 | |
| ZNF189 | zinc finger protein 189 | 0.014 | |
| ZNF180 | zinc finger protein 180 | 0.014 | |
| ARL4D | ADP-ribosylation factor-like 4D | 0.013 | |
| ZNF569 | zinc finger protein 569 | 0.013 |
Loading network...
Danio rerio| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| nfkbiaa | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a | 0.160 | |
| arhgdig | Rho GDP dissociation inhibitor (GDI) gamma | 0.142 | |
| gadd45ba | growth arrest and DNA-damage-inducible, beta a | 0.105 | |
| caspa | caspase a | 0.097 | |
| capns1a | calpain, small subunit 1 a | 0.091 | |
| s100v2 | S100 calcium binding protein V2 | 0.067 | |
| pdcd6ip | programmed cell death 6 interacting protein | 0.064 | |
| mcl1a | myeloid cell leukemia sequence 1a | 0.056 | |
| cd63 | Cd63 antigen | 0.054 | |
| LOC100006361 | galanin-like | 0.052 | |
| phlda2 | pleckstrin homology-like domain, family A, member 2 | 0.050 | |
| cav1 | caveolin 1 | 0.050 | |
| gabarapa | GABA(A) receptor-associated protein a | 0.049 | |
| ip6k2 | inositol hexaphosphate kinase 2 | 0.042 | |
| cnot6 | CCR4-NOT transcription complex, subunit 6 | 0.040 | |
| nccrp1 | nonspecific cytotoxic cell receptor protein 1 | 0.040 | |
| fuca2 | fucosidase, alpha-L- 2, plasma | 0.037 | |
| agr2 | anterior gradient homolog 2 (Xenopus laevis) | 0.037 | |
| zgc:110340 | zgc:110340 | 0.036 | |
| grid2 | glutamate receptor, ionotropic, delta 2 | 0.035 | |
| rel | v-rel reticuloendotheliosis viral oncogene homolog | 0.034 | |
| klf2a | Kruppel-like factor 2a | 0.034 | |
| nfkbiab | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b | 0.033 | |
| mib | mind bomb | 0.033 | |
| nod1 | nucleotide-binding oligomerization domain containing 1 | 0.033 | |
| si:ch73-60e21.1 | si:ch73-60e21.1 | 0.032 | |
| itm2bb | integral membrane protein 2Bb | 0.031 | |
| serpinb1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.030 | |
| mpzl2 | myelin protein zero-like 2 | 0.029 | |
| march6 | membrane-associated ring finger (C3HC4) 6 | 0.027 | |
| anxa5b | annexin A5b | 0.027 | |
| s100a10b | S100 calcium binding protein A10b | 0.027 | |
| fxyd6l | FXYD domain containing ion transport regulator 6 like | 0.026 | |
| stxbp2 | syntaxin binding protein 2 | 0.025 | |
| hnrnpk | heterogeneous nuclear ribonucleoprotein K | 0.025 | |
| capns1b | calpain, small subunit 1 b | 0.025 | |
| ghsra | growth hormone secretagogue receptor a | 0.025 | |
| dlat | dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) | 0.025 | |
| LOC100000332 | e3 ubiquitin-protein ligase RNF182-like | 0.025 | |
| icn | ictacalcin | 0.024 | |
| junb | jun B proto-oncogene | 0.024 | |
| anxa2a | annexin A2a | 0.024 | |
| socs3a | suppressor of cytokine signaling 3a | 0.023 | |
| fkbp5 | FK506 binding protein 5 | 0.023 | |
| jun | jun proto-oncogene | 0.023 | |
| acot11a | acyl-CoA thioesterase 11a | 0.023 | |
| hcrt | hypocretin (orexin) neuropeptide precursor | 0.023 | |
| stap2b | signal transducing adaptor family member 2b | 0.022 | |
| card9 | caspase recruitment domain family, member 9 | 0.022 | |
| wu:fj37c10 | wu:fj37c10 | 0.022 | |
| zgc:110717 | zgc:110717 | 0.022 | |
| mcl1b | myeloid cell leukemia sequence 1b | 0.022 | |
| atp6v1e1b | ATPase, H+ transporting, lysosomal, V1 subunit E isoform 1b | 0.022 | |
| ahnak | AHNAK nucleoprotein | 0.022 | |
| brd3a | bromodomain containing 3a | 0.021 | |
| wnt9b | wingless-type MMTV integration site family, member 9B | 0.021 | |
| sc:d0144 | sc:d0144 | 0.021 | |
| max | myc-associated factor X | 0.020 | |
| sb:cb252 | sb:cb252 | 0.020 | |
| mtnr1bb | melatonin receptor 1B b and melatonin receptor 1B | 0.020 | |
| atp6v0ca | ATPase, H+ transporting, lysosomal, V0 subunit c, a | 0.020 | |
| tert | telomerase reverse transcriptase | 0.019 | |
| chmp5 | chromatin modifying protein 5 | 0.019 | |
| ift88 | intraflagellar transport 88 homolog | 0.019 | |
| tph2 | tryptophan hydroxylase 2 (tryptophan 5-monooxygenase) | 0.019 | |
| mmp15b | matrix metallopeptidase 15b | 0.019 | |
| si:ch211-9d9.3 | si:ch211-9d9.3 | 0.019 | |
| cry2a | cryptochrome 2a | 0.018 | |
| ube2i2 | ubiquitin-conjugating enzyme E2I2 | 0.018 | |
| gins2 | GINS complex subunit 2 | 0.018 | |
| usp7 | ubiquitin specific peptidase 7 (herpes virus-associated) | 0.018 | |
| zgc:64114 | zgc:64114 | 0.018 | |
| fos | v-fos FBJ murine osteosarcoma viral oncogene homolog | 0.018 | |
| akirin2 | akirin 2 | 0.018 | |
| aldoca | aldolase C, fructose-bisphosphate, a | 0.018 | |
| zgc:92380 | zgc:92380 | 0.018 | |
| si:dkey-236e20.2 | si:dkey-236e20.2 | 0.018 | |
| phb2 | prohibitin 2 | 0.017 | |
| brd2b | bromodomain containing 2b | 0.017 | |
| irf2bp2a | interferon regulatory factor 2 binding protein 2a | 0.017 | |
| unc45a | unc-45 homolog A (C. elegans) | 0.017 | |
| zgc:73328 | zgc:73328 | 0.017 | |
| csnk1da | casein kinase 1, delta a | 0.017 | |
| zgc:113210 | zgc:113210 | 0.017 | |
| ogt.1 | O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) 1 | 0.017 | |
| grm5a | glutamate receptor, metabotropic 5a | 0.017 | |
| LOC557072 | caspase recruitment domain-containing protein 11-like | 0.017 | |
| papolb | poly(A) polymerase beta (testis specific) | 0.017 | |
| stc1l | stanniocalcin 1, like | 0.016 | |
| pias4a | protein inhibitor of activated STAT, 4a | 0.016 | |
| chn1 | chimerin (chimaerin) 1 | 0.016 | |
| smarca4 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 | 0.016 | |
| supt6h | suppressor of Ty 6 homolog | 0.016 | |
| ftsjd1 | FtsJ methyltransferase domain containing 1 | 0.016 | |
| nfe2l2 | nuclear factor (erythroid-derived 2)-like 2 | 0.016 | |
| hnrpr | heterogeneous nuclear ribonucleoprotein R | 0.016 | |
| smek1 | SMEK homolog 1, suppressor of mek1 (Dictyostelium) | 0.016 | |
| polr2a | polymerase (RNA) II (DNA directed) polypeptide A | 0.016 | |
| itpk1 | inositol 1,3,4-triphosphate 5/6 kinase | 0.016 | |
| pkz | protein kinase containing Z-DNA binding domains | 0.016 |