The network for 'negative regulation of icosanoid secretion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of icosanoid secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of an icosanoid from a cell.

NameDescriptionProbabilityFunc Analog Organism
CYP4F2cytochrome P450, family 4, subfamily F, polypeptide 20.999
SPG20spastic paraplegia 20 (Troyer syndrome)0.998
CYP3A43cytochrome P450, family 3, subfamily A, polypeptide 430.976
CYP4F12cytochrome P450, family 4, subfamily F, polypeptide 120.949
CYP4F3cytochrome P450, family 4, subfamily F, polypeptide 30.947
CYP2C9cytochrome P450, family 2, subfamily C, polypeptide 90.897
CYP2B6cytochrome P450, family 2, subfamily B, polypeptide 60.761
DSEdermatan sulfate epimerase0.652
CYP4F11cytochrome P450, family 4, subfamily F, polypeptide 110.567
CYP3A4cytochrome P450, family 3, subfamily A, polypeptide 40.474
ADH6alcohol dehydrogenase 6 (class V)0.405
CYP2C19cytochrome P450, family 2, subfamily C, polypeptide 190.373
CYP3A5cytochrome P450, family 3, subfamily A, polypeptide 50.364
IDH1isocitrate dehydrogenase 1 (NADP+), soluble0.350
RDH16retinol dehydrogenase 16 (all-trans)0.293
CYP3A7cytochrome P450, family 3, subfamily A, polypeptide 70.251
KNG1kininogen 10.242
AZGP1alpha-2-glycoprotein 1, zinc-binding0.222
SULT1B1sulfotransferase family, cytosolic, 1B, member 10.218
HRGhistidine-rich glycoprotein0.189
HAO1hydroxyacid oxidase (glycolate oxidase) 10.183
HNF4Ahepatocyte nuclear factor 4, alpha0.153
AKR1C4aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)0.151
G6PCglucose-6-phosphatase, catalytic subunit0.146
FABP1fatty acid binding protein 1, liver0.143
SULT2A1sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 10.139
MAT1Amethionine adenosyltransferase I, alpha0.130
SLC10A1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.127
DAOD-amino-acid oxidase0.125
HMGCS23-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)0.124
HALhistidine ammonia-lyase0.116
YIPF6Yip1 domain family, member 60.110
AADACarylacetamide deacetylase (esterase)0.092
F9coagulation factor IX0.090
C8Acomplement component 8, alpha polypeptide0.089
DIO1deiodinase, iodothyronine, type I0.088
STK39serine threonine kinase 390.079
CYP2C18cytochrome P450, family 2, subfamily C, polypeptide 180.078
OTCornithine carbamoyltransferase0.077
SLC2A2solute carrier family 2 (facilitated glucose transporter), member 20.075
UGT1A3UDP glucuronosyltransferase 1 family, polypeptide A30.072
ACSL4acyl-CoA synthetase long-chain family member 40.069
TMEM41Btransmembrane protein 41B0.068
CEACAM8carcinoembryonic antigen-related cell adhesion molecule 80.065
GSTA3glutathione S-transferase alpha 30.064
BHMTbetaine--homocysteine S-methyltransferase0.064
ABCC2ATP-binding cassette, sub-family C (CFTR/MRP), member 20.063
ARG1arginase, liver0.058
SERPINA6serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 60.058
PAHphenylalanine hydroxylase0.057
KLHL2kelch-like 2, Mayven (Drosophila)0.053
TMPRSS4transmembrane protease, serine 40.050
C8Bcomplement component 8, beta polypeptide0.050
FETUBfetuin B0.049
CYP2E1cytochrome P450, family 2, subfamily E, polypeptide 10.049
MASP2mannan-binding lectin serine peptidase 20.048
F13Bcoagulation factor XIII, B polypeptide0.046
PCK1phosphoenolpyruvate carboxykinase 1 (soluble)0.044
CYP2C8cytochrome P450, family 2, subfamily C, polypeptide 80.042
HSD17B2hydroxysteroid (17-beta) dehydrogenase 20.042
CYP4B1cytochrome P450, family 4, subfamily B, polypeptide 10.041
APOFapolipoprotein F0.041
FUT6fucosyltransferase 6 (alpha (1,3) fucosyltransferase)0.041
SLC22A1solute carrier family 22 (organic cation transporter), member 10.041
CYP4F8cytochrome P450, family 4, subfamily F, polypeptide 80.040
STARD4StAR-related lipid transfer (START) domain containing 40.040
SERPINC1serpin peptidase inhibitor, clade C (antithrombin), member 10.040
PIPprolactin-induced protein0.039
CEACAM6carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)0.039
ALDOBaldolase B, fructose-bisphosphate0.038
SULT2B1sulfotransferase family, cytosolic, 2B, member 10.038
HGDhomogentisate 1,2-dioxygenase0.038
PRLRprolactin receptor0.035
EPHX2epoxide hydrolase 2, cytoplasmic0.035
HPD4-hydroxyphenylpyruvate dioxygenase0.033
DEFB1defensin, beta 10.032
ADH1Calcohol dehydrogenase 1C (class I), gamma polypeptide0.032
CYP4A11cytochrome P450, family 4, subfamily A, polypeptide 110.031
SCNN1Asodium channel, nonvoltage-gated 1 alpha0.031
AKR1D1aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)0.030
NAT8N-acetyltransferase 8 (GCN5-related, putative)0.029
NR1H4nuclear receptor subfamily 1, group H, member 40.029
AKR1B10aldo-keto reductase family 1, member B10 (aldose reductase)0.029
SLC38A3solute carrier family 38, member 30.029
BAATbile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)0.028
CYP2J2cytochrome P450, family 2, subfamily J, polypeptide 20.028
C9complement component 90.028
SEC14L2SEC14-like 2 (S. cerevisiae)0.028
APOC3apolipoprotein C-III0.028
ADH1Aalcohol dehydrogenase 1A (class I), alpha polypeptide0.028
PKLRpyruvate kinase, liver and RBC0.027
ABCB11ATP-binding cassette, sub-family B (MDR/TAP), member 110.027
KRT13keratin 130.027
XDHxanthine dehydrogenase0.027
SLC22A7solute carrier family 22 (organic anion transporter), member 70.026
CFHR4complement factor H-related 40.026
SLC28A1solute carrier family 28 (sodium-coupled nucleoside transporter), member 10.026
SULT1E1sulfotransferase family 1E, estrogen-preferring, member 10.025
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
TankTRAF family member-associated Nf-kappa B activator0.013
D15Ertd621eDNA segment, Chr 15, ERATO Doi 621, expressed0.012
Col3a1collagen, type III, alpha 10.011
BtkBruton agammaglobulinemia tyrosine kinase0.011
Col12a1collagen, type XII, alpha 10.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism