The network for 'positive regulation of icosanoid secretion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of icosanoid secretion

Any process that activates or increases the frequency, rate or extent of the controlled release of an icosanoid from a cell.

NameDescriptionProbabilityFunc Analog Organism
MAP2K4mitogen-activated protein kinase kinase 40.994
IL1R1interleukin 1 receptor, type I0.766
MAPK14mitogen-activated protein kinase 140.458
IL1RAPinterleukin 1 receptor accessory protein0.237
XPO7exportin 70.213
IL1RNinterleukin 1 receptor antagonist0.203
LRRK2leucine-rich repeat kinase 20.198
C1orf93chromosome 1 open reading frame 930.179
BBS10Bardet-Biedl syndrome 100.111
IL8interleukin 80.105
CYP4F12cytochrome P450, family 4, subfamily F, polypeptide 120.089
XPNPEP1X-prolyl aminopeptidase (aminopeptidase P) 1, soluble0.063
CXCL3chemokine (C-X-C motif) ligand 30.056
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.056
ZBTB25zinc finger and BTB domain containing 250.052
CCL20chemokine (C-C motif) ligand 200.051
MAPK1mitogen-activated protein kinase 10.041
TRAF5TNF receptor-associated factor 50.040
CXCL2chemokine (C-X-C motif) ligand 20.040
MAP2K3mitogen-activated protein kinase kinase 30.040
ZFP36L1zinc finger protein 36, C3H type-like 10.037
LMO4LIM domain only 40.034
MAP3K4mitogen-activated protein kinase kinase kinase 40.034
CYP2B6cytochrome P450, family 2, subfamily B, polypeptide 60.028
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.027
CYP4F2cytochrome P450, family 4, subfamily F, polypeptide 20.027
CYP3A43cytochrome P450, family 3, subfamily A, polypeptide 430.026
ATF2activating transcription factor 20.026
ZC3HC1zinc finger, C3HC-type containing 10.025
CYP3A5cytochrome P450, family 3, subfamily A, polypeptide 50.025
RGS2regulator of G-protein signaling 2, 24kDa0.025
HPD4-hydroxyphenylpyruvate dioxygenase0.024
C6complement component 60.023
CYP2C9cytochrome P450, family 2, subfamily C, polypeptide 90.023
SBF1SET binding factor 10.022
C7orf36chromosome 7 open reading frame 360.021
MBTPS1membrane-bound transcription factor peptidase, site 10.021
IL6interleukin 6 (interferon, beta 2)0.020
AQP7aquaporin 70.020
PPP2R2Aprotein phosphatase 2, regulatory subunit B, alpha0.020
AQP9aquaporin 90.020
IL1R2interleukin 1 receptor, type II0.020
MKNK1MAP kinase interacting serine/threonine kinase 10.020
LGALS4lectin, galactoside-binding, soluble, 40.019
CYP2C19cytochrome P450, family 2, subfamily C, polypeptide 190.018
MAP3K1mitogen-activated protein kinase kinase kinase 10.018
SULT2A1sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 10.018
SERPINA6serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 60.018
CCL4chemokine (C-C motif) ligand 40.018
FUT6fucosyltransferase 6 (alpha (1,3) fucosyltransferase)0.018
TNFAIP6tumor necrosis factor, alpha-induced protein 60.017
SNRNP35small nuclear ribonucleoprotein 35kDa (U11/U12)0.017
RDH16retinol dehydrogenase 16 (all-trans)0.016
HMGCS23-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)0.016
TRMT2ATRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae)0.016
CYP3A4cytochrome P450, family 3, subfamily A, polypeptide 40.016
TNFRSF9tumor necrosis factor receptor superfamily, member 90.016
ABP1amiloride binding protein 1 (amine oxidase (copper-containing))0.015
SULT1B1sulfotransferase family, cytosolic, 1B, member 10.015
ADH6alcohol dehydrogenase 6 (class V)0.015
PCK1phosphoenolpyruvate carboxykinase 1 (soluble)0.015
FRZBfrizzled-related protein0.015
C8Acomplement component 8, alpha polypeptide0.015
MAP3K7mitogen-activated protein kinase kinase kinase 70.015
STAB2stabilin 20.015
CCL2chemokine (C-C motif) ligand 20.014
IRAK2interleukin-1 receptor-associated kinase 20.014
GH1growth hormone 10.014
NLRP3NLR family, pyrin domain containing 30.014
SULT2B1sulfotransferase family, cytosolic, 2B, member 10.014
AGXTalanine-glyoxylate aminotransferase0.014
C8Bcomplement component 8, beta polypeptide0.014
G6PCglucose-6-phosphatase, catalytic subunit0.014
TRAF1TNF receptor-associated factor 10.014
GP2glycoprotein 2 (zymogen granule membrane)0.014
SOD2superoxide dismutase 2, mitochondrial0.014
SLC10A1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.013
FABP1fatty acid binding protein 1, liver0.013
DDAH2dimethylarginine dimethylaminohydrolase 20.013
GPR84G protein-coupled receptor 840.013
PLAURplasminogen activator, urokinase receptor0.013
MAT1Amethionine adenosyltransferase I, alpha0.013
CXCL5chemokine (C-X-C motif) ligand 50.013
CYP2D6cytochrome P450, family 2, subfamily D, polypeptide 60.013
ABCC2ATP-binding cassette, sub-family C (CFTR/MRP), member 20.013
PLA2G2Aphospholipase A2, group IIA (platelets, synovial fluid)0.013
HALhistidine ammonia-lyase0.013
FOXN1forkhead box N10.013
GPX2glutathione peroxidase 2 (gastrointestinal)0.013
GPR109BG protein-coupled receptor 109B0.013
BCL2A1BCL2-related protein A10.013
IL7Rinterleukin 7 receptor0.013
CYP4F8cytochrome P450, family 4, subfamily F, polypeptide 80.013
TLR2toll-like receptor 20.012
GADD45Ggrowth arrest and DNA-damage-inducible, gamma0.012
KNG1kininogen 10.012
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ltalymphotoxin A0.994
Tnftumor necrosis factor0.981
Map3k14mitogen-activated protein kinase kinase kinase 140.930
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.708
Tnfsf11tumor necrosis factor (ligand) superfamily, member 110.516
Tnfsf14tumor necrosis factor (ligand) superfamily, member 140.399
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.335
Ltblymphotoxin B0.213
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.186
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.167
Il7interleukin 70.162
Ifnginterferon gamma0.158
Cxcl13chemokine (C-X-C motif) ligand 130.152
Ctskcathepsin K0.123
Casp4caspase 4, apoptosis-related cysteine peptidase0.099
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.091
Cxcr5chemokine (C-X-C motif) receptor 50.091
Cd40CD40 antigen0.072
Il1r1interleukin 1 receptor, type I0.060
Cd19CD19 antigen0.057
Il10interleukin 100.051
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.049
Toxthymocyte selection-associated high mobility group box0.046
Lyz2lysozyme 20.046
Il6interleukin 60.043
Ccl2chemokine (C-C motif) ligand 20.041
Nos2nitric oxide synthase 2, inducible0.031
Traf6TNF receptor-associated factor 60.026
Ikbkginhibitor of kappaB kinase gamma0.024
BtkBruton agammaglobulinemia tyrosine kinase0.023
Traf2TNF receptor-associated factor 20.022
Pou2af1POU domain, class 2, associating factor 10.021
Nlrp3NLR family, pyrin domain containing 30.019
S1pr2sphingosine-1-phosphate receptor 20.018
Ikzf1IKAROS family zinc finger 10.017
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.017
Irak4interleukin-1 receptor-associated kinase 40.015
Tcf3transcription factor 30.014
Irg1immunoresponsive gene 10.013
Il4interleukin 40.012
Pdcd1programmed cell death 10.011
Cd80CD80 antigen0.011
Il1rninterleukin 1 receptor antagonist0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Prkacbprotein kinase, cAMP dependent, catalytic, beta0.033
Vegfavascular endothelial growth factor A0.028
Syt4synaptotagmin IV0.027
Csnk1g1casein kinase 1, gamma 10.026
Arl5aADP-ribosylation factor-like 5A0.020
Rnf123ring finger protein 1230.019
Lgr4leucine-rich repeat-containing G protein-coupled receptor 40.018
Mll4myeloid/lymphoid or mixed-lineage leukemia 40.017
NsfN-ethylmaleimide-sensitive factor0.016
Tmem171transmembrane protein 1710.016
Kcnk1potassium channel, subfamily K, member 10.015
Map2k4mitogen activated protein kinase kinase 40.014
JunJun oncogene0.014
Stk40serine/threonine kinase 400.014
Ctbp1C-terminal binding protein 10.014
Tgm1transglutaminase 1, K polypeptide0.013
Lancl2LanC lantibiotic synthetase component C-like 2 (bacterial)0.013
Ppp3r1protein phosphatase 3, regulatory subunit B, alpha isoform0.013
SnrkSNF related kinase0.011
Mapk8mitogen-activated protein kinase 80.011
Tagln3transgelin 30.011
Ugt2a1UDP glucuronosyltransferase 2 family, polypeptide A10.011
Kcnt1potassium channel, subfamily T, member 10.011
Socs3suppressor of cytokine signaling 30.010
RGD621098similar to RIKEN cDNA D230025D16Rik0.010
Nenfneuron derived neurotrophic factor0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism