The network for 'negative regulation of proteasomal protein catabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of proteasomal protein catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of proteasomal protein catabolic process.

NameDescriptionProbabilityFunc Analog Organism
CDC27cell division cycle 27 homolog (S. cerevisiae)0.842
BUB1Bbudding uninhibited by benzimidazoles 1 homolog beta (yeast)0.834
BUB3budding uninhibited by benzimidazoles 3 homolog (yeast)0.631
ANAPC7anaphase promoting complex subunit 70.548
CCT4chaperonin containing TCP1, subunit 4 (delta)0.317
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.309
COPS5COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)0.307
RB1retinoblastoma 10.266
BUB1budding uninhibited by benzimidazoles 1 homolog (yeast)0.261
MAP1LC3Bmicrotubule-associated protein 1 light chain 3 beta0.204
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.191
CCT8chaperonin containing TCP1, subunit 8 (theta)0.181
PPP1CAprotein phosphatase 1, catalytic subunit, alpha isozyme0.181
DOT1LDOT1-like, histone H3 methyltransferase (S. cerevisiae)0.177
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.159
SQSTM1sequestosome 10.116
GFI1Bgrowth factor independent 1B transcription repressor0.105
CDK2cyclin-dependent kinase 20.104
TPBGtrophoblast glycoprotein0.103
NBR1neighbor of BRCA1 gene 10.092
PSMC6proteasome (prosome, macropain) 26S subunit, ATPase, 60.083
PSMD10proteasome (prosome, macropain) 26S subunit, non-ATPase, 100.080
CCNB1cyclin B10.080
CDC20cell division cycle 20 homolog (S. cerevisiae)0.078
SMAD2SMAD family member 20.077
COPS2COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)0.076
ASF1AASF1 anti-silencing function 1 homolog A (S. cerevisiae)0.072
GABARAPL1GABA(A) receptor-associated protein like 10.069
TRAF6TNF receptor-associated factor 60.067
SKA3spindle and kinetochore associated complex subunit 30.066
FANCD2Fanconi anemia, complementation group D20.065
C19orf39chromosome 19 open reading frame 390.063
COPS8COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)0.062
CASC5cancer susceptibility candidate 50.061
CBX5chromobox homolog 50.061
CREBBPCREB binding protein0.060
ANAPC4anaphase promoting complex subunit 40.060
CBX1chromobox homolog 10.058
EP300E1A binding protein p3000.058
PSMA3proteasome (prosome, macropain) subunit, alpha type, 30.057
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)0.057
ANAPC11anaphase promoting complex subunit 110.056
TP53BP1tumor protein p53 binding protein 10.055
SOD1superoxide dismutase 1, soluble0.055
SYVN1synovial apoptosis inhibitor 1, synoviolin0.054
DAXXdeath-domain associated protein0.053
TP53tumor protein p530.052
DLG1discs, large homolog 1 (Drosophila)0.049
PPP1CCprotein phosphatase 1, catalytic subunit, gamma isozyme0.049
HUWE1HECT, UBA and WWE domain containing 10.049
PSMD7proteasome (prosome, macropain) 26S subunit, non-ATPase, 70.048
ATG3ATG3 autophagy related 3 homolog (S. cerevisiae)0.046
PPP2CBprotein phosphatase 2, catalytic subunit, beta isozyme0.046
SMARCB1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 10.046
KPNA3karyopherin alpha 3 (importin alpha 4)0.043
CCNE1cyclin E10.043
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.041
CCND1cyclin D10.041
TERF2IPtelomeric repeat binding factor 2, interacting protein0.041
BAG2BCL2-associated athanogene 20.040
HDAC1histone deacetylase 10.040
MED1mediator complex subunit 10.040
MAP3K5mitogen-activated protein kinase kinase kinase 50.040
TERF1telomeric repeat binding factor (NIMA-interacting) 10.039
TINF2TERF1 (TRF1)-interacting nuclear factor 20.039
HIST2H2BEhistone cluster 2, H2be0.039
MAD2L1MAD2 mitotic arrest deficient-like 1 (yeast)0.039
PPP2R5Cprotein phosphatase 2, regulatory subunit B', gamma0.038
ZNF207zinc finger protein 2070.038
UHRF2ubiquitin-like with PHD and ring finger domains 20.038
CCNA2cyclin A20.038
CKS1BCDC28 protein kinase regulatory subunit 1B0.037
PRNPprion protein0.037
SKP1S-phase kinase-associated protein 10.036
PPP2R1Bprotein phosphatase 2, regulatory subunit A, beta0.035
PPP2R2Aprotein phosphatase 2, regulatory subunit B, alpha0.034
MAD1L1MAD1 mitotic arrest deficient-like 1 (yeast)0.034
GABARAPGABA(A) receptor-associated protein0.033
PSMC1proteasome (prosome, macropain) 26S subunit, ATPase, 10.033
SLBPstem-loop binding protein0.033
HDAC2histone deacetylase 20.033
PSMD11proteasome (prosome, macropain) 26S subunit, non-ATPase, 110.032
TOP3Atopoisomerase (DNA) III alpha0.032
CDC37cell division cycle 37 homolog (S. cerevisiae)0.032
MYST1MYST histone acetyltransferase 10.031
SNX9sorting nexin 90.031
PSMC2proteasome (prosome, macropain) 26S subunit, ATPase, 20.031
SLX4SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)0.031
LMNAlamin A/C0.031
CD2BP2CD2 (cytoplasmic tail) binding protein 20.030
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.030
NUF2NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)0.030
AKNAAT-hook transcription factor0.029
BRCA2breast cancer 2, early onset0.028
FXR2fragile X mental retardation, autosomal homolog 20.028
TLK2tousled-like kinase 20.028
EIF2Deukaryotic translation initiation factor 2D0.028
VCPvalosin containing protein0.027
MAD2L1BPMAD2L1 binding protein0.027
H2AFXH2A histone family, member X0.027
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
let-502Protein LET-5020.022
ani-1Protein ANI-10.021
gpr-2Protein GPR-20.019
T22C1.1Protein T22C1.10.018
his-45Protein HIS-450.018
ZK507.6Protein ZK507.60.017
pri-2Protein PRI-20.017
bli-1Protein BLI-10.017
CELE_ZK1025.3Protein ZK1025.30.017
imb-2Protein IMB-20.017
his-72Protein HIS-720.017
tba-2Protein TBA-20.016
C49H3.9Protein C49H3.90.016
his-6Protein HIS-60.015
CELE_E01G4.6Protein E01G4.60.015
sax-3Protein SAX-30.015
air-2Protein AIR-20.014
math-33Protein MATH-330.014
rnr-1Protein RNR-10.014
his-42Protein HIS-420.014
bah-1Protein BAH-10.014
F12F6.1Protein F12F6.10.014
lmn-1Protein LMN-10.014
bmk-1Protein BMK-10.014
cdh-7Protein CDH-70.013
goa-1Protein GOA-10.013
mex-3Protein MEX-30.013
htz-1Protein HTZ-10.013
F25B3.6Protein F25B3.60.013
hcp-1Protein HCP-10.013
mel-11Protein MEL-110.013
ntl-4Protein NTL-40.013
syx-17Protein SYX-170.013
sac-1Protein SAC-10.012
CELE_Y46G5A.29Protein Y46G5A.290.012
his-32Protein HIS-320.012
F44E2.8Protein F44E2.80.012
asd-1Protein ASD-10.012
col-38Protein COL-380.012
knl-3Protein KNL-30.012
W09D10.1Protein W09D10.10.012
col-110Protein COL-1100.012
ztf-7Protein ZTF-70.012
col-128Protein COL-1280.012
col-79Protein COL-790.012
CELE_C12D8.1Protein C12D8.10.012
K06B9.4Protein K06B9.40.012
hgrs-1Protein HGRS-10.012
CELE_T06G6.6Protein T06G6.60.012
hmp-1Protein HMP-10.012
R11A8.7Protein R11A8.70.011
exos-1Protein EXOS-10.011
ets-6Protein ETS-60.011
csc-1Protein CSC-10.011
daf-19Protein DAF-190.011
CELE_ZK1025.2Protein ZK1025.20.011
nmt-1Protein NMT-10.011
pcn-1Protein PCN-10.011
CELE_C24H12.5Protein C24H12.50.011
lin-23Protein LIN-230.011
knl-1Protein KNL-10.011
rpb-2Protein RPB-20.011
sqt-1Protein SQT-10.011
dcp-66Protein DCP-660.011
spdl-1Protein SPDL-10.011
csn-4Protein CSN-40.011
gck-1Protein GCK-10.010
cdl-1Protein CDL-10.010
cul-2Protein CUL-20.010
C41G7.3Protein C41G7.30.010
oac-30Protein OAC-300.010
cye-1Protein CYE-10.010
mcm-2Protein MCM-20.010
hsp-4Protein HSP-40.010
sop-3Protein SOP-30.010
col-111Protein COL-1110.010
his-59Protein HIS-590.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
fzyfizzy0.074
CSN4COP9 complex homolog subunit 40.069
ncdnon-claret disjunctional0.063
IswiImitation SWI0.055
CycBCyclin B0.050
Bap55Brahma associated protein 55kD0.048
ruxroughex0.039
Rpd3CG7471 gene product from transcript CG7471-RA0.039
Cap-GCG34438 gene product from transcript CG34438-RF0.037
hydhyperplastic discs0.037
bambag of marbles0.034
EgfrEpidermal growth factor receptor0.032
flflfalafel0.031
AlyCG1101 gene product from transcript CG1101-RA0.031
tefutelomere fusion0.030
CSN5COP9 complex homolog subunit 50.029
CG4030CG4030 gene product from transcript CG4030-RA0.027
CycB3Cyclin B30.027
cavcaravaggio0.026
Kap-alpha3karyopherin alpha30.025
CycACyclin A0.023
CSN3COP9 complex homolog subunit 30.022
ranCG1404 gene product from transcript CG1404-RB0.022
cnncentrosomin0.022
B52CG10851 gene product from transcript CG10851-RB0.020
KrnKeren0.020
sleslender lobes0.019
CG14213CG14213 gene product from transcript CG14213-RB0.019
Grip84gamma-tubulin ring protein 840.018
dre4CG1828 gene product from transcript CG1828-RB0.018
aslasterless0.018
BubR1Bub1-related kinase0.017
spn-Dspindle D0.017
Cdc37CG12019 gene product from transcript CG12019-RA0.017
Rpn11CG18174 gene product from transcript CG18174-RA0.016
CycTCyclin T0.016
CG1440CG1440 gene product from transcript CG1440-RA0.016
CG8223CG8223 gene product from transcript CG8223-RA0.016
Pros45CG1489 gene product from transcript CG1489-RA0.016
Nup153Nucleoporin 1530.016
nbsCG6754 gene product from transcript CG6754-RC0.015
IncenpInner centromere protein0.015
Cul-3Cullin-30.015
tldtolloid0.015
cdc2CG5363 gene product from transcript CG5363-RA0.015
Cks30ACyclin-dependent kinase subunit 30A0.014
Sep2Septin-20.014
KP78bCG17216 gene product from transcript CG17216-RB0.014
Spc105RSpc105-related0.014
edlETS-domain lacking0.014
SAKSak kinase0.013
Gef26CG9491 gene product from transcript CG9491-RB0.013
CG13625CG13625 gene product from transcript CG13625-RA0.013
gsbgooseberry0.013
endosendosulfine0.013
Fs(2)KetFemale sterile (2) Ketel0.013
Sld5CG14549 gene product from transcript CG14549-RA0.012
cdc16CG6759 gene product from transcript CG6759-RA0.012
zuczucchini0.012
CG6540CG6540 gene product from transcript CG6540-RA0.012
borrborealin-related0.012
oskoskar0.012
pr-set7CG3307 gene product from transcript CG3307-RC0.012
Top1Topoisomerase 10.012
Ras85DRas oncogene at 85D0.012
CG2926CG2926 gene product from transcript CG2926-RA0.012
Mi-2CG8103 gene product from transcript CG8103-RA0.012
mad2CG17498 gene product from transcript CG17498-RA0.012
Mcm5Minichromosome maintenance 50.012
mus312mutagen-sensitive 3120.011
kukkugelkern0.011
enokenoki mushroom0.011
prodproliferation disrupter0.011
RhoGEF4CG8606 gene product from transcript CG8606-RA0.011
PPP4R2rProtein phosphatase 4 regulatory subunit 2-related protein0.011
pluplutonium0.010
CSN6COP9 complex homolog subunit 60.010
TfIISRNA polymerase II elongation factor0.010
CG13089CG13089 gene product from transcript CG13089-RA0.010
HP1eCG8120 gene product from transcript CG8120-RA0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
PPH21Pph21p0.949
PPH22Pph22p0.917
MAD2Mad2p0.850
CDC55Cdc55p0.686
CDC20Cdc20p0.536
CTF13Ctf13p0.522
MAD3Mad3p0.377
RAD23Rad23p0.356
RTS1Rts1p0.331
HHF2Hhf2p0.307
CHL4Chl4p0.307
BUB3Bub3p0.254
YPI1Ypi1p0.230
CTF3Ctf3p0.229
HHT1Hht1p0.226
MAD1Mad1p0.218
CBF1Cbf1p0.194
KIP1Kip1p0.181
IML3Iml3p0.158
BUB1Bub1p0.133
TPD3Tpd3p0.119
TIP41Tip41p0.109
SDS22Sds22p0.104
RPT2Rpt2p0.095
GIP2Gip2p0.091
SLK19Slk19p0.085
PIG2Pig2p0.085
MTW1Mtw1p0.078
CAB3Cab3p0.071
CDC37Cdc37p0.069
SPT15Spt15p0.064
FMP48Fmp48p0.064
NSL1Nsl1p0.064
HTA1Hta1p0.062
PPZ1Ppz1p0.059
NBL1Nbl1p0.058
KIC1Kic1p0.055
RPT6Rpt6p0.053
ZDS1Zds1p0.052
UFD2Ufd2p0.051
DSK2Dsk2p0.048
PSY4Psy4p0.047
HHT2Hht2p0.042
SPO12Spo12p0.042
TGL2Tgl2p0.042
RPT1Rpt1p0.039
RFA1Rfa1p0.039
SLI15Sli15p0.038
BCK2Bck2p0.038
YIL151Chypothetical protein0.037
YML053Chypothetical protein0.037
GLG1Glg1p0.037
EAF1Eaf1p0.036
TOR2Tor2p0.035
CCT2Cct2p0.034
SPC105Spc105p0.031
TRA1Tra1p0.030
CUP1-1Cup1-1p0.030
SRD1Srd1p0.029
CSE4Cse4p0.029
YLR264C-Ahypothetical protein0.029
CHL1Chl1p0.029
CIN1Cin1p0.029
YLR162Whypothetical protein0.028
PRS2Prs2p0.028
STB2Stb2p0.028
STU1Stu1p0.027
YNR014Whypothetical protein0.027
LEU2Leu2p0.027
RAD61Rad61p0.027
BFA1Bfa1p0.027
YOL038C-Ahypothetical protein0.026
TID3Tid3p0.026
CDC48Cdc48p0.025
RPT3Rpt3p0.025
SMC4Smc4p0.025
CDC28Cdc28p0.025
STE4Ste4p0.025
GAC1Gac1p0.024
SKM1Skm1p0.024
HIT1Hit1p0.024
PDR15Pdr15p0.024
MER1Mer1p0.024
IRC15Irc15p0.024
SWR1Swr1p0.024
SKP1Skp1p0.024
FAU1Fau1p0.024
SAP155Sap155p0.023
NVJ1Nvj1p0.023
WSS1Wss1p0.023
TPI1Tpi1p0.023
ARG8Arg8p0.023
SPO14Spo14p0.023
BDF2Bdf2p0.022
RPT4Rpt4p0.022
ZPS1Zps1p0.022
YIR035Chypothetical protein0.022
YLR042Chypothetical protein0.022
IPL1Ipl1p0.022
NUF2Nuf2p0.022