The network for 'cyclic nucleotide mediated signaling' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cyclic nucleotide mediated signaling

Any intracellular signal transduction in which the signal is passed on within the cell via a cyclic nucleotide. Includes production or release of the cyclic nucleotide, and downstream effectors that further transmit the signal within the cell.

NameDescriptionProbabilityFunc Analog Organism
IL8interleukin 80.995
CXCL2chemokine (C-X-C motif) ligand 20.979
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.968
CXCL3chemokine (C-X-C motif) ligand 30.965
CCL5chemokine (C-C motif) ligand 50.961
CCR5chemokine (C-C motif) receptor 50.926
PTPN13protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)0.911
ARRB1arrestin, beta 10.851
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.816
GNB1guanine nucleotide binding protein (G protein), beta polypeptide 10.782
CCL20chemokine (C-C motif) ligand 200.734
MPDZmultiple PDZ domain protein0.711
CXCL10chemokine (C-X-C motif) ligand 100.672
IL1Binterleukin 1, beta0.635
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.566
IFNGinterferon, gamma0.527
CXCL11chemokine (C-X-C motif) ligand 110.490
IL2RBinterleukin 2 receptor, beta0.486
CXCL5chemokine (C-X-C motif) ligand 50.455
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.447
CCL4chemokine (C-C motif) ligand 40.438
DPP4dipeptidyl-peptidase 40.422
CRHcorticotropin releasing hormone0.404
CXCL9chemokine (C-X-C motif) ligand 90.376
TBXA2Rthromboxane A2 receptor0.340
POU3F2POU class 3 homeobox 20.327
PAX3paired box 30.309
CXCR5chemokine (C-X-C motif) receptor 50.304
CCL22chemokine (C-C motif) ligand 220.282
CXCL6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.255
TBC1D10ATBC1 domain family, member 10A0.230
CCL2chemokine (C-C motif) ligand 20.228
PTGIRprostaglandin I2 (prostacyclin) receptor (IP)0.223
IL6interleukin 6 (interferon, beta 2)0.212
CCL8chemokine (C-C motif) ligand 80.210
INF2inverted formin, FH2 and WH2 domain containing0.201
SSTR3somatostatin receptor 30.200
A2Malpha-2-macroglobulin0.197
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.157
SOD2superoxide dismutase 2, mitochondrial0.154
CCL11chemokine (C-C motif) ligand 110.151
CXCR3chemokine (C-X-C motif) receptor 30.140
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.126
IL10interleukin 100.115
PHYHIPLphytanoyl-CoA 2-hydroxylase interacting protein-like0.111
CCR2chemokine (C-C motif) receptor 20.110
TNFtumor necrosis factor0.109
UBA1ubiquitin-like modifier activating enzyme 10.093
UBR3ubiquitin protein ligase E3 component n-recognin 3 (putative)0.092
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.090
CCL7chemokine (C-C motif) ligand 70.085
PTENphosphatase and tensin homolog0.085
CD40LGCD40 ligand0.084
ITGA2Bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)0.082
FBXW5F-box and WD repeat domain containing 50.075
APOC1apolipoprotein C-I0.074
HPhaptoglobin0.074
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.072
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)0.072
NEDD4neural precursor cell expressed, developmentally down-regulated 40.070
CXCL13chemokine (C-X-C motif) ligand 130.068
MEOX2mesenchyme homeobox 20.068
CCL19chemokine (C-C motif) ligand 190.067
TNFAIP6tumor necrosis factor, alpha-induced protein 60.067
FASFas (TNF receptor superfamily, member 6)0.066
RAMP3receptor (G protein-coupled) activity modifying protein 30.061
IRF4interferon regulatory factor 40.061
YAP1Yes-associated protein 10.060
CCR4chemokine (C-C motif) receptor 40.059
SELEselectin E0.057
CCR7chemokine (C-C motif) receptor 70.055
TNFRSF10Ctumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain0.054
CALCAcalcitonin-related polypeptide alpha0.053
GHRHRgrowth hormone releasing hormone receptor0.053
RGS1regulator of G-protein signaling 10.052
SSTR2somatostatin receptor 20.050
CACYBPcalcyclin binding protein0.050
SMAD7SMAD family member 70.049
INHBAinhibin, beta A0.049
PLEKpleckstrin0.047
DRD2dopamine receptor D20.047
SOCS3suppressor of cytokine signaling 30.046
TNFRSF9tumor necrosis factor receptor superfamily, member 90.045
CXCR2chemokine (C-X-C motif) receptor 20.042
HTR2C5-hydroxytryptamine (serotonin) receptor 2C0.041
SLAMF7SLAM family member 70.041
GNAO1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O0.041
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.040
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.040
PTGER3prostaglandin E receptor 3 (subtype EP3)0.040
CCL3chemokine (C-C motif) ligand 30.039
CLEC7AC-type lectin domain family 7, member A0.039
SLC9A3R2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 20.039
BTRCbeta-transducin repeat containing0.038
VPS29vacuolar protein sorting 29 homolog (S. cerevisiae)0.038
SKP1S-phase kinase-associated protein 10.037
MATKmegakaryocyte-associated tyrosine kinase0.037
TAL1T-cell acute lymphocytic leukemia 10.035
ACTR3ARP3 actin-related protein 3 homolog (yeast)0.034
OR2AG1olfactory receptor, family 2, subfamily AG, member 10.033
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Slc34a1solute carrier family 34 (sodium phosphate), member 10.953
Leprleptin receptor0.854
Esr1estrogen receptor 1 (alpha)0.672
Klklotho0.581
Cckbrcholecystokinin B receptor0.488
Drd2dopamine receptor D20.430
Adrb1adrenergic receptor, beta 10.400
Pnpla2patatin-like phospholipase domain containing 20.363
Ppargperoxisome proliferator activated receptor gamma0.351
Cyp19a1cytochrome P450, family 19, subfamily a, polypeptide 10.347
Rims2regulating synaptic membrane exocytosis 20.270
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.256
Cav1caveolin 1, caveolae protein0.251
Retret proto-oncogene0.223
Smad4MAD homolog 4 (Drosophila)0.204
Lepleptin0.201
Shc3src homology 2 domain-containing transforming protein C30.184
Nos1nitric oxide synthase 1, neuronal0.168
Ghrgrowth hormone receptor0.157
Esr2estrogen receptor 2 (beta)0.116
Ptenphosphatase and tensin homolog0.109
Ccl2chemokine (C-C motif) ligand 20.100
Crhr1corticotropin releasing hormone receptor 10.095
Nr3c1nuclear receptor subfamily 3, group C, member 10.088
Slc17a1solute carrier family 17 (sodium phosphate), member 10.079
Nos3nitric oxide synthase 3, endothelial cell0.078
Fgf10fibroblast growth factor 100.076
Thrbthyroid hormone receptor beta0.075
Rims1regulating synaptic membrane exocytosis 10.073
Pax8paired box gene 80.070
Nfatc2nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 20.066
Npy2rneuropeptide Y receptor Y20.062
Prkacaprotein kinase, cAMP dependent, catalytic, alpha0.051
Kitlkit ligand0.050
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.048
Mrvi1MRV integration site 10.048
Prkg1protein kinase, cGMP-dependent, type I0.047
RorbRAR-related orphan receptor beta0.047
Galr1galanin receptor 10.043
Sncbsynuclein, beta0.043
Cftrcystic fibrosis transmembrane conductance regulator homolog0.042
Oprm1opioid receptor, mu 10.041
Itgb1integrin beta 1 (fibronectin receptor beta)0.040
Fbxl20F-box and leucine-rich repeat protein 200.040
Lmx1bLIM homeobox transcription factor 1 beta0.039
Ptgs2prostaglandin-endoperoxide synthase 20.039
Ptpn11protein tyrosine phosphatase, non-receptor type 110.039
Rgs9regulator of G-protein signaling 90.038
Arnt2aryl hydrocarbon receptor nuclear translocator 20.038
Apcadenomatosis polyposis coli0.038
Plcg1phospholipase C, gamma 10.037
Hcn1hyperpolarization-activated, cyclic nucleotide-gated K+ 10.036
Smad1MAD homolog 1 (Drosophila)0.036
Npy1rneuropeptide Y receptor Y10.034
Kcnd1potassium voltage-gated channel, Shal-related family, member 10.033
Asap1ArfGAP with SH# domain, ankyrin repeat and PH domain10.032
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.031
Syt7synaptotagmin VII0.031
Fabp4fatty acid binding protein 4, adipocyte0.031
Adipoqadiponectin, C1Q and collagen domain containing0.030
Mitfmicrophthalmia-associated transcription factor0.030
Rgs4regulator of G-protein signaling 40.029
Plcb1phospholipase C, beta 10.029
Acanaggrecan0.029
Has2hyaluronan synthase 20.029
Ccbp2chemokine binding protein 20.029
Pdx1pancreatic and duodenal homeobox 10.028
Sntb1syntrophin, basic 10.028
Slc12a1solute carrier family 12, member 10.028
Drd4dopamine receptor D40.027
Drd3dopamine receptor D30.027
Selpselectin, platelet0.026
Neurog3neurogenin 30.026
Htr1d5-hydroxytryptamine (serotonin) receptor 1D0.026
Siglec1sialic acid binding Ig-like lectin 1, sialoadhesin0.026
Kcna2potassium voltage-gated channel, shaker-related subfamily, member 20.026
Tac2tachykinin 20.026
Arandrogen receptor0.025
Il10rainterleukin 10 receptor, alpha0.025
Sstr2somatostatin receptor 20.025
Nppbnatriuretic peptide type B0.025
Htra3HtrA serine peptidase 30.025
Mc5rmelanocortin 5 receptor0.025
Sstr4somatostatin receptor 40.024
Edil3EGF-like repeats and discoidin I-like domains 30.024
Bcar1breast cancer anti-estrogen resistance 10.024
Ptgfrprostaglandin F receptor0.024
Nrgnneurogranin0.024
Kcna1potassium voltage-gated channel, shaker-related subfamily, member 10.024
Cdkn2acyclin-dependent kinase inhibitor 2A0.024
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.023
Ncam2neural cell adhesion molecule 20.023
Edn2endothelin 20.023
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.023
Gria1glutamate receptor, ionotropic, AMPA1 (alpha 1)0.023
Vdrvitamin D receptor0.023
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.023
Fut1fucosyltransferase 10.023
Epha6Eph receptor A60.022
Sertad2SERTA domain containing 20.022
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
SSB2Ssb2p0.035
UBI4Ubi4p0.021
NOP1Nop1p0.020
RPL13ARpl13ap0.018
HAS1Has1p0.015
NOP58Nop58p0.014
RPL17BRpl17bp0.014
URA7Ura7p0.014
RPL7ARpl7ap0.013
YVH1Yvh1p0.013
PWP1Pwp1p0.013
RIX1Rix1p0.013
DBP9Dbp9p0.013
SUP45Sup45p0.012
BRX1Brx1p0.011
ASC1Asc1p0.011
RPS16BRps16bp0.011
RPS0ARps0ap0.011
RPC40Rpc40p0.011
RPL16BRpl16bp0.010
KAP123Kap123p0.010
RPS24ARps24ap0.010
RPS22ARps22ap0.010
TIF3Tif3p0.010
RPC53Rpc53p0.010