The network for 'neural tube formation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

neural tube formation

The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.

NameDescriptionProbabilityFunc Analog Organism
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide1.000
SMAD3SMAD family member 30.999
APCadenomatous polyposis coli0.999
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.999
TSC2tuberous sclerosis 20.994
TAB2TGF-beta activated kinase 1/MAP3K7 binding protein 20.991
LRRK2leucine-rich repeat kinase 20.988
DVL3dishevelled, dsh homolog 3 (Drosophila)0.986
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.981
SQSTM1sequestosome 10.971
STRN3striatin, calmodulin binding protein 30.970
STK3serine/threonine kinase 30.966
CASP9caspase 9, apoptosis-related cysteine peptidase0.955
MEOX2mesenchyme homeobox 20.953
XIAPX-linked inhibitor of apoptosis0.952
PRKCZprotein kinase C, zeta0.948
TRAF6TNF receptor-associated factor 60.948
TRRAPtransformation/transcription domain-associated protein0.947
CREBBPCREB binding protein0.942
ESR1estrogen receptor 10.932
SMAD2SMAD family member 20.920
ACTBactin, beta0.899
ZRANB1zinc finger, RAN-binding domain containing 10.886
GSK3Bglycogen synthase kinase 3 beta0.876
CASP10caspase 10, apoptosis-related cysteine peptidase0.876
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.862
EP300E1A binding protein p3000.859
STK4serine/threonine kinase 40.849
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.846
ACTG1actin, gamma 10.840
USP9Xubiquitin specific peptidase 9, X-linked0.831
AXIN1axin 10.828
SMAD4SMAD family member 40.798
CASP3caspase 3, apoptosis-related cysteine peptidase0.777
RXRAretinoid X receptor, alpha0.772
SOX10SRY (sex determining region Y)-box 100.772
CSNK1Ecasein kinase 1, epsilon0.767
BAIAP2BAI1-associated protein 20.751
DDX3XDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked0.744
SLMAPsarcolemma associated protein0.736
SETD8SET domain containing (lysine methyltransferase) 80.735
SEC23ASec23 homolog A (S. cerevisiae)0.713
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.711
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.707
BCORBCL6 corepressor0.694
BBS1Bardet-Biedl syndrome 10.683
PPP1R16Aprotein phosphatase 1, regulatory (inhibitor) subunit 16A0.682
KIF5Bkinesin family member 5B0.667
PAK2p21 protein (Cdc42/Rac)-activated kinase 20.648
ZFYVE9zinc finger, FYVE domain containing 90.639
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.632
INADLInaD-like (Drosophila)0.631
PCM1pericentriolar material 10.608
TAB3TGF-beta activated kinase 1/MAP3K7 binding protein 30.606
DVL1dishevelled, dsh homolog 1 (Drosophila)0.604
CTBP2C-terminal binding protein 20.598
AKT1v-akt murine thymoma viral oncogene homolog 10.595
SAV1salvador homolog 1 (Drosophila)0.581
SMARCC2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 20.570
ZFXzinc finger protein, X-linked0.551
RPL18Aribosomal protein L18a0.539
BBS2Bardet-Biedl syndrome 20.519
ERBB2IPerbb2 interacting protein0.504
MAP3K7mitogen-activated protein kinase kinase kinase 70.503
SEC24DSEC24 family, member D (S. cerevisiae)0.489
LMAN1lectin, mannose-binding, 10.477
SASS6spindle assembly 6 homolog (C. elegans)0.468
MTA1metastasis associated 10.467
ATXN1ataxin 10.466
SMURF2SMAD specific E3 ubiquitin protein ligase 20.465
EXOC7exocyst complex component 70.464
SKIv-ski sarcoma viral oncogene homolog (avian)0.454
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.451
PSEN1presenilin 10.450
MED25mediator complex subunit 250.449
NCOR1nuclear receptor corepressor 10.425
PARD3par-3 partitioning defective 3 homolog (C. elegans)0.424
STRNstriatin, calmodulin binding protein0.412
RASA1RAS p21 protein activator (GTPase activating protein) 10.405
PARD6Bpar-6 partitioning defective 6 homolog beta (C. elegans)0.396
DLG5discs, large homolog 5 (Drosophila)0.378
PRKCIprotein kinase C, iota0.373
SP1Sp1 transcription factor0.365
CTBP1C-terminal binding protein 10.357
ANKRD28ankyrin repeat domain 280.355
YAP1Yes-associated protein 10.353
BBS10Bardet-Biedl syndrome 100.350
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.341
NCOA6nuclear receptor coactivator 60.337
PUM1pumilio homolog 1 (Drosophila)0.334
EPAS1endothelial PAS domain protein 10.326
CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.322
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.320
NCOA1nuclear receptor coactivator 10.318
SORBS3sorbin and SH3 domain containing 30.317
PIN1peptidylprolyl cis/trans isomerase, NIMA-interacting 10.317
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.316
ARID1BAT rich interactive domain 1B (SWI1-like)0.315
IQGAP1IQ motif containing GTPase activating protein 10.314
CALM1calmodulin 1 (phosphorylase kinase, delta)0.312
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
nkd1naked cuticle homolog 1 (Drosophila)0.953
foxd3forkhead box D30.750
hoxb1bhomeo box B1b0.735
epb41l5erythrocyte membrane protein band 4.1 like 50.721
sox9aSRY-box containing gene 9a0.605
ift88intraflagellar transport 88 homolog0.549
crb2acrumbs homolog 2a0.549
rargaretinoic acid receptor gamma a0.457
egr2bearly growth response 2b0.443
dladeltaA0.419
id2ainhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a0.383
kif17kinesin family member 170.373
scribscribbled homolog (Drosophila)0.348
zeb2azinc finger E-box binding homeobox 2a0.338
zic2bzic family member 2 (odd-paired homolog, Drosophila) b0.324
gbx2gastrulation brain homeo box 20.311
raraaretinoic acid receptor, alpha a0.303
hoxb1ahomeo box B1a0.279
meis2.2myeloid ecotropic viral integration site 2.20.267
eng2bengrailed 2b0.257
hoxb3ahomeo box B3a0.256
six3asine oculis homeobox homolog 3a0.246
msxcmuscle segment homeobox C0.237
zic4zic family member 40.234
zic5zic family member 5 (odd-paired homolog, Drosophila)0.212
otx2orthodenticle homolog 20.187
shhasonic hedgehog a0.167
meis3myeloid ecotropic viral integration site 30.162
spry2sprouty homolog 20.162
fzd7afrizzled homolog 7a0.161
lratblecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)0.153
bocbrother of CDO0.152
foxg1aforkhead box G1a0.140
irx7iroquois homeobox protein 70.134
mpp5amembrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a)0.133
wnt5bwingless-type MMTV integration site family, member 5b0.121
alcambactivated leukocyte cell adhesion molecule b0.118
pou3f3bPOU class 3 homeobox 3b0.118
sulf2sulfatase 20.117
oc90otoconin 900.112
crabp2acellular retinoic acid binding protein 2, a0.109
irx3airoquois homeobox protein 3a0.107
dctn1adynactin 1a0.106
robo1roundabout homolog 10.104
cdiptCDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)0.102
gdf6agrowth differentiation factor 6a0.102
gpr98G protein-coupled receptor 980.099
cdoncell adhesion molecule-related/down-regulated by oncogenes0.098
col2a1acollagen type II, alpha-1a0.097
fgfr2fibroblast growth factor receptor 20.096
skianuclear oncoprotein skia0.096
spry1sprouty homolog 1 (Drosophila)0.096
plekhg4pleckstrin homology domain containing, family G (with RhoGef domain) member 40.095
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.095
fgf3fibroblast growth factor 30.094
odz4odd Oz/ten-m homolog 40.094
sox19aSRY-box containing gene 19a0.093
hmx3homeo box (H6 family) 30.089
hoxb2ahomeo box B2a0.087
lfnglunatic fringe homolog0.087
hoxb5ahomeo box B5a0.087
gyltl1bglycosyltransferase-like 1b0.086
etv5bets variant 5b0.084
pax6apaired box gene 6a0.083
guca1cguanylate cyclase activator 1C0.082
tfap2atranscription factor AP-2 alpha0.082
sox3SRY-box containing gene 30.081
nkx6.1NK6 transcription factor related, locus 1 (Drosophila)0.081
meis2.1myeloid ecotropic viral integration site 2.10.081
mab21l2mab-21-like 20.077
mibmind bomb0.076
irx1airoquois homeobox protein 1, a0.073
lmx1b.2LIM homeobox transcription factor 1, beta 20.072
axin2axin 2 (conductin, axil)0.070
mdkbmidkine-related growth factor b0.069
lhx5LIM homeobox 50.068
prkciprotein kinase C, iota0.067
zic1zic family member 1 (odd-paired homolog, Drosophila)0.066
wnt11wingless-type MMTV integration site family, member 110.066
dlx3bdistal-less homeobox gene 3b0.064
dync1h1dynein, cytoplasmic 1, heavy chain 10.063
zic2azic family member 2 (odd-paired homolog, Drosophila), a0.058
dpysl5adihydropyrimidinase-like 5a0.057
fgfr1bfibroblast growth factor receptor 1b0.054
twist1atwist1a0.052
olig3oligodendrocyte transcription factor 30.052
hoxa3ahomeo box A3a0.051
zic3zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)0.050
bmp2bbone morphogenetic protein 2b0.050
tcf7l1atranscription factor 7-like 1a (T-cell specific, HMG-box)0.049
sox1aSRY-box containing gene 1a0.048
tbx2bT-box 2b0.048
pcdh19protocadherin 190.046
neurodneurogenic differentiation0.046
eng2aengrailed 2a0.046
pcdh18aprotocadherin 18a0.045
gbx1gastrulation brain homeobox 10.045
eng1aengrailed 1a0.043
lrrtm1leucine rich repeat transmembrane neuronal 10.043
vangl2vang-like 2 (van gogh, Drosophila)0.043
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog1.000
Gli3GLI-Kruppel family member GLI31.000
Fgfr2fibroblast growth factor receptor 21.000
Pax3paired box gene 31.000
Otx2orthodenticle homolog 2 (Drosophila)1.000
Pax2paired box gene 21.000
Vangl2vang-like 2 (van gogh, Drosophila)1.000
Pbx1pre B-cell leukemia transcription factor 11.000
Tcfap2atranscription factor AP-2, alpha1.000
Pitx2paired-like homeodomain transcription factor 20.999
Bmp4bone morphogenetic protein 40.999
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.999
Eya1eyes absent 1 homolog (Drosophila)0.999
Fgf8fibroblast growth factor 80.998
Smosmoothened homolog (Drosophila)0.997
Hoxa1homeobox A10.997
Gli2GLI-Kruppel family member GLI20.997
Hand1heart and neural crest derivatives expressed transcript 10.997
Sox2SRY-box containing gene 20.997
Msx1homeobox, msh-like 10.997
Prrx1paired related homeobox 10.997
Bmp7bone morphogenetic protein 70.996
Sall4sal-like 4 (Drosophila)0.995
Fgfr1fibroblast growth factor receptor 10.995
Pax6paired box gene 60.994
Rargretinoic acid receptor, gamma0.993
Tbx1T-box 10.990
Zic3zinc finger protein of the cerebellum 30.988
Lhx1LIM homeobox protein 10.986
Foxc1forkhead box C10.985
Vegfavascular endothelial growth factor A0.984
Chrdchordin0.983
Ctnnb1catenin (cadherin associated protein), beta 10.982
Gbx2gastrulation brain homeobox 20.978
Nodalnodal0.975
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.972
Nognoggin0.967
Pax9paired box gene 90.967
Wnt5awingless-related MMTV integration site 5A0.966
Dvl2dishevelled 2, dsh homolog (Drosophila)0.957
Foxc2forkhead box C20.954
Fgf10fibroblast growth factor 100.953
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.953
Apcadenomatosis polyposis coli0.949
Sfrp2secreted frizzled-related protein 20.948
Dlx5distal-less homeobox 50.941
Dvl3dishevelled 3, dsh homolog (Drosophila)0.940
Emx2empty spiracles homolog 2 (Drosophila)0.940
Rarbretinoic acid receptor, beta0.939
Msx2homeobox, msh-like 20.936
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.926
Wnt3awingless-related MMTV integration site 3A0.924
Hes1hairy and enhancer of split 1 (Drosophila)0.921
En1engrailed 10.916
Chd7chromodomain helicase DNA binding protein 70.913
Foxg1forkhead box G10.909
Hoxd13homeobox D130.905
Prrx2paired related homeobox 20.901
Emx1empty spiracles homolog 1 (Drosophila)0.888
Mks1Meckel syndrome, type 10.886
Ascl1achaete-scute complex homolog 1 (Drosophila)0.886
Hoxa2homeobox A20.883
Acvr1activin A receptor, type 10.882
Hand2heart and neural crest derivatives expressed transcript 20.881
Pax8paired box gene 80.879
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.878
Rararetinoic acid receptor, alpha0.876
Pitx1paired-like homeodomain transcription factor 10.876
Wt1Wilms tumor 1 homolog0.869
Hoxa13homeobox A130.859
Ednraendothelin receptor type A0.853
Fzd1frizzled homolog 1 (Drosophila)0.838
Meox2mesenchyme homeobox 20.834
Smad6MAD homolog 6 (Drosophila)0.831
Alx4aristaless-like homeobox 40.830
Ptch1patched homolog 10.818
Lrp2low density lipoprotein receptor-related protein 20.815
Mn1meningioma 10.814
Foxh1forkhead box H10.798
Dvl1dishevelled, dsh homolog 1 (Drosophila)0.796
Jag1jagged 10.796
Efna2ephrin A20.795
Tbx2T-box 20.793
Smad3MAD homolog 3 (Drosophila)0.768
Tbx15T-box 150.767
Arid1aAT rich interactive domain 1A (SWI-like)0.767
Isl1ISL1 transcription factor, LIM/homeodomain0.760
Retret proto-oncogene0.759
Lrp6low density lipoprotein receptor-related protein 60.756
Tbx3T-box 30.747
Yap1yes-associated protein 10.744
Hoxa5homeobox A50.743
Otx1orthodenticle homolog 1 (Drosophila)0.736
Smad1MAD homolog 1 (Drosophila)0.729
Ift88intraflagellar transport 88 homolog (Chlamydomonas)0.728
Pou5f1POU domain, class 5, transcription factor 10.716
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.712
Gas1growth arrest specific 10.708
Tcfap2ctranscription factor AP-2, gamma0.704
Axin1axin 10.703
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Actbactin, beta0.066
Ptov1prostate tumor overexpressed 10.036
Atf2activating transcription factor 20.029
Pfn1profilin 10.025
Ireb2iron responsive element binding protein 20.023
Ptmsparathymosin0.023
Scaf1SR-related CTD-associated factor 10.020
Csnk1g3casein kinase 1, gamma 30.019
Pgm2phosphoglucomutase 20.019
Uba1ubiquitin-like modifier activating enzyme 10.019
ArhgdiaRho GDP dissociation inhibitor (GDI) alpha0.018
Dcakddephospho-CoA kinase domain containing0.018
Mapk9mitogen-activated protein kinase 90.017
Atp6v0a1ATPase, H+ transporting, lysosomal V0 subunit A10.016
Tuba1ctubulin, alpha 1C0.016
Cyfip1cytoplasmic FMR1 interacting protein 10.016
Ect2epithelial cell transforming sequence 2 oncogene0.015
Fat1FAT tumor suppressor homolog 1 (Drosophila)0.015
Actg1actin, gamma 10.015
G3bp2GTPase activating protein (SH3 domain) binding protein 20.015
Ncdnneurochondrin0.015
Fkbp1aFK506 binding protein 1a0.015
Loxl1lysyl oxidase-like 10.014
Calrcalreticulin0.014
Tmem168transmembrane protein 1680.013
Tubb5tubulin, beta 50.013
Kitv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog0.013
Skiv2l2superkiller viralicidic activity 2-like 2 (S. cerevisiae)0.013
Pfklphosphofructokinase, liver0.013
Cxxc4CXXC finger 40.013
Cap1CAP, adenylate cyclase-associated protein 1 (yeast)0.012
Fmr1fragile X mental retardation 10.012
Smc2structural maintenance of chromosomes 20.012
Tgoln1trans-golgi network protein0.012
Dmddystrophin0.012
RGD1309414similar to KIAA0913 protein0.012
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.012
Clptm1cleft lip and palate associated transmembrane protein 10.012
Ptpn12protein tyrosine phosphatase, non-receptor type 120.012
Smek2SMEK homolog 2, suppressor of mek1 (Dictyostelium)0.012
Pcbp4poly(rC) binding protein 40.012
Dact1dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)0.011
Zfp260zinc finger protein 2600.011
Gosr1golgi SNAP receptor complex member 10.011
Vegfavascular endothelial growth factor A0.011
Dctn1dynactin 10.011
Nnatneuronatin0.011
Mlf2myeloid leukemia factor 20.011
Ppp3r1protein phosphatase 3, regulatory subunit B, alpha isoform0.011
Bocbiregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein0.011
Foxs1forkhead box S10.011
Sc65synaptonemal complex protein SC650.010
Cenpfcentromere protein F0.010
Acvr1activin A receptor, type I0.010
Arpc4actin related protein 2/3 complex, subunit 40.010
Neurl4neuralized homolog 4 (Drosophila)0.010
Casp3caspase 30.010
Fzd2frizzled homolog 2 (Drosophila)0.010
Best2bestrophin 20.010
Man2c1mannosidase, alpha, class 2C, member 10.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism