The network for 'nodal signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

nodal signaling pathway

A series of molecular signals initiated by the binding of a nodal protein to an activin receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.

NameDescriptionProbabilityFunc Analog Organism
SMAD7SMAD family member 70.971
SMAD2SMAD family member 20.907
SMAD3SMAD family member 30.895
SMAD1SMAD family member 10.679
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.503
SMURF2SMAD specific E3 ubiquitin protein ligase 20.443
FKBP1AFK506 binding protein 1A, 12kDa0.289
ENGendoglin0.096
SMAD5SMAD family member 50.093
BMP2bone morphogenetic protein 20.093
TGFBR1transforming growth factor, beta receptor 10.086
CXXC5CXXC finger protein 50.045
SMAD4SMAD family member 40.033
CTBP2C-terminal binding protein 20.032
ACVR1activin A receptor, type I0.031
PRKG1protein kinase, cGMP-dependent, type I0.018
TGFB1transforming growth factor, beta 10.017
FSTL1follistatin-like 10.017
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.014
BMPR1Abone morphogenetic protein receptor, type IA0.013
SKIv-ski sarcoma viral oncogene homolog (avian)0.012
GDF5growth differentiation factor 50.011
TGFB3transforming growth factor, beta 30.011
SMAD6SMAD family member 60.010
SMURF1SMAD specific E3 ubiquitin protein ligase 10.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.155
flhfloating head0.152
lft1lefty10.134
gro1groucho 10.111
dact2dapper homolog 2, antagonist of beta-catenin (xenopus)0.047
bonbonnie and clyde0.045
klf4Kruppel-like factor 40.043
nog1noggin 10.041
aplnrbapelin receptor b0.039
drldraculin0.038
fzd8bfrizzled homolog 8b0.032
lft2lefty20.027
ntlano tail a0.024
nkx2.5NK2 transcription factor related 50.019
nkd1naked cuticle homolog 1 (Drosophila)0.016
rarabretinoic acid receptor, alpha b0.014
ippkinositol 1,3,4,5,6-pentakisphosphate 2-kinase0.012
nipblbnovel protein similar to vertebrate Nipped-B homolog and nipped-b homolog b (Drosophila)0.011
wnt11wingless-type MMTV integration site family, member 110.011
mespamesoderm posterior a0.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Nodalnodal1.000
Pbx1pre B-cell leukemia transcription factor 10.980
Foxh1forkhead box H10.890
Smad4MAD homolog 4 (Drosophila)0.802
Wnt5awingless-related MMTV integration site 5A0.706
Hoxa9homeobox A90.513
Bmp4bone morphogenetic protein 40.379
Hoxa13homeobox A130.313
Lefty2left-right determination factor 20.302
Gata4GATA binding protein 40.264
Fgfr1fibroblast growth factor receptor 10.215
Gdf1growth differentiation factor 10.213
Smad3MAD homolog 3 (Drosophila)0.181
Gdf6growth differentiation factor 60.181
Axin1axin 10.178
Pitx2paired-like homeodomain transcription factor 20.149
Gdf5growth differentiation factor 50.142
Bptfbromodomain PHD finger transcription factor0.130
Ror2receptor tyrosine kinase-like orphan receptor 20.129
Bmpr1abone morphogenetic protein receptor, type 1A0.110
Gli3GLI-Kruppel family member GLI30.100
Acvr1activin A receptor, type 10.090
Gas1growth arrest specific 10.089
Lefty1left right determination factor 10.086
Bmp7bone morphogenetic protein 70.081
Pbx3pre B-cell leukemia transcription factor 30.078
Meis1Meis homeobox 10.078
Dact3dapper homolog 3, antagonist of beta-catenin (xenopus)0.074
Nognoggin0.068
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.064
Msx2homeobox, msh-like 20.064
Gdf3growth differentiation factor 30.056
Dnahc5dynein, axonemal, heavy chain 50.055
Hand1heart and neural crest derivatives expressed transcript 10.055
Pbx2pre B-cell leukemia transcription factor 20.052
Tdgf1teratocarcinoma-derived growth factor 10.052
Acvr1bactivin A receptor, type 1B0.051
Apcadenomatosis polyposis coli0.048
Prrx1paired related homeobox 10.047
Tcf7l1transcription factor 7-like 1 (T-cell specific, HMG box)0.046
Hand2heart and neural crest derivatives expressed transcript 20.045
Zic3zinc finger protein of the cerebellum 30.042
Ctnnb1catenin (cadherin associated protein), beta 10.042
Smosmoothened homolog (Drosophila)0.041
Efna4ephrin A40.038
Shhsonic hedgehog0.038
Hoxb6homeobox B60.038
Wt1Wilms tumor 1 homolog0.035
Prrx2paired related homeobox 20.035
Acvr2bactivin receptor IIB0.034
Dnahc11dynein, axonemal, heavy chain 110.033
Tbx15T-box 150.032
Msx1homeobox, msh-like 10.030
Cdoncell adhesion molecule-related/down-regulated by oncogenes0.029
Wnt3wingless-related MMTV integration site 30.027
Fgfr2fibroblast growth factor receptor 20.025
Rnf111ring finger 1110.025
Mapk7mitogen-activated protein kinase 70.024
Hoxa6homeobox A60.023
Otx2orthodenticle homolog 2 (Drosophila)0.023
Tead2TEA domain family member 20.022
Dusp9dual specificity phosphatase 90.022
Dkk1dickkopf homolog 1 (Xenopus laevis)0.022
Ptk2PTK2 protein tyrosine kinase 20.021
Cilp2cartilage intermediate layer protein 20.021
Zfp503zinc finger protein 5030.021
Alx1ALX homeobox 10.019
Ptk7PTK7 protein tyrosine kinase 70.019
Appamyloid beta (A4) precursor protein0.018
Hoxa11homeobox A110.018
Hoxc4homeobox C40.018
Megf8multiple EGF-like-domains 80.017
Sfrp2secreted frizzled-related protein 20.017
Lef1lymphoid enhancer binding factor 10.017
Qrich1glutamine-rich 10.016
Meis2Meis homeobox 20.016
Fgf8fibroblast growth factor 80.016
Ascl2achaete-scute complex homolog 2 (Drosophila)0.016
Pbx4pre-B-cell leukemia homeobox 40.016
Slc22a6solute carrier family 22 (organic anion transporter), member 60.016
Hoxb3homeobox B30.016
Zfp36l1zinc finger protein 36, C3H type-like 10.016
Pou5f1POU domain, class 5, transcription factor 10.015
Slc23a3solute carrier family 23 (nucleobase transporters), member 30.015
Ptgdrprostaglandin D receptor0.015
Efsembryonal Fyn-associated substrate0.015
Tcf21transcription factor 210.015
Pnliprp2pancreatic lipase-related protein 20.014
Scn7asodium channel, voltage-gated, type VII, alpha0.014
Fgfr3fibroblast growth factor receptor 30.014
Acvr2aactivin receptor IIA0.014
H1fxH1 histone family, member X0.014
Tcf7transcription factor 7, T-cell specific0.013
Gdf7growth differentiation factor 70.013
Reckreversion-inducing-cysteine-rich protein with kazal motifs0.013
Nr2f2nuclear receptor subfamily 2, group F, member 20.013
Crlf1cytokine receptor-like factor 10.012
Bcl10B-cell leukemia/lymphoma 100.012
Foxc1forkhead box C10.012
Ovol2ovo-like 2 (Drosophila)0.012
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism