The network for 'negative regulation of cell growth' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of cell growth

Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.

NameDescriptionProbabilityFunc Analog Organism
TP53tumor protein p530.996
SMAD2SMAD family member 20.977
SMURF2SMAD specific E3 ubiquitin protein ligase 20.955
CREBBPCREB binding protein0.934
SMAD4SMAD family member 40.921
SIN3ASIN3 homolog A, transcription regulator (yeast)0.911
SMAD3SMAD family member 30.864
CDK6cyclin-dependent kinase 60.858
SMAD7SMAD family member 70.776
CCND1cyclin D10.775
SMAD1SMAD family member 10.663
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.641
CDK4cyclin-dependent kinase 40.636
TSC2tuberous sclerosis 20.591
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.589
FGF1fibroblast growth factor 1 (acidic)0.553
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.529
ARandrogen receptor0.524
RARAretinoic acid receptor, alpha0.518
CCND3cyclin D30.514
SMAD5SMAD family member 50.485
HDAC2histone deacetylase 20.483
TGFBR1transforming growth factor, beta receptor 10.454
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.431
DAXXdeath-domain associated protein0.424
SMAD9SMAD family member 90.419
SKILSKI-like oncogene0.410
FKBP1AFK506 binding protein 1A, 12kDa0.387
SKIv-ski sarcoma viral oncogene homolog (avian)0.385
VEGFAvascular endothelial growth factor A0.378
HSPA1Bheat shock 70kDa protein 1B0.367
HSPA8heat shock 70kDa protein 80.356
TGFB3transforming growth factor, beta 30.354
NR2E3nuclear receptor subfamily 2, group E, member 30.350
ABI2abl-interactor 20.341
HSPA1Aheat shock 70kDa protein 1A0.327
TGFB1transforming growth factor, beta 10.322
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.296
BAG3BCL2-associated athanogene 30.286
BMP2bone morphogenetic protein 20.280
PPP1CAprotein phosphatase 1, catalytic subunit, alpha isozyme0.279
GRB10growth factor receptor-bound protein 100.253
PAX3paired box 30.233
NCOR2nuclear receptor corepressor 20.232
KHDRBS1KH domain containing, RNA binding, signal transduction associated 10.224
UHRF2ubiquitin-like with PHD and ring finger domains 20.220
RUNX1runt-related transcription factor 10.211
SCHIP1schwannomin interacting protein 10.204
MAP3K5mitogen-activated protein kinase kinase kinase 50.203
GRB7growth factor receptor-bound protein 70.199
APPamyloid beta (A4) precursor protein0.197
SMURF1SMAD specific E3 ubiquitin protein ligase 10.193
MAST2microtubule associated serine/threonine kinase 20.188
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.188
GDF5growth differentiation factor 50.181
CDK5cyclin-dependent kinase 50.181
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.176
SNX33sorting nexin 330.174
NCOA1nuclear receptor coactivator 10.172
HSPB1heat shock 27kDa protein 10.171
NRP1neuropilin 10.171
DLG1discs, large homolog 1 (Drosophila)0.170
CXXC5CXXC finger protein 50.165
PTMAprothymosin, alpha0.165
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.161
RNF11ring finger protein 110.159
NR0B2nuclear receptor subfamily 0, group B, member 20.149
GHRgrowth hormone receptor0.141
BMPR1Bbone morphogenetic protein receptor, type IB0.140
ATG13ATG13 autophagy related 13 homolog (S. cerevisiae)0.139
TFRCtransferrin receptor (p90, CD71)0.139
EGR2early growth response 20.137
YAP1Yes-associated protein 10.131
RBBP4retinoblastoma binding protein 40.123
SFRP1secreted frizzled-related protein 10.122
RXRAretinoid X receptor, alpha0.120
ENGendoglin0.119
RB1CC1RB1-inducible coiled-coil 10.117
SMAD6SMAD family member 60.117
NCOA6nuclear receptor coactivator 60.116
SREBF2sterol regulatory element binding transcription factor 20.114
ZFYVE9zinc finger, FYVE domain containing 90.113
CDC37cell division cycle 37 homolog (S. cerevisiae)0.112
RB1retinoblastoma 10.110
SP1Sp1 transcription factor0.109
SH3D19SH3 domain containing 190.109
HDAC1histone deacetylase 10.109
KAT2BK(lysine) acetyltransferase 2B0.109
BCL2L1BCL2-like 10.107
IRAK2interleukin-1 receptor-associated kinase 20.105
FOXO3forkhead box O30.105
SQSTM1sequestosome 10.104
CABLES1Cdk5 and Abl enzyme substrate 10.104
TFAP2Atranscription factor AP-2 alpha (activating enhancer binding protein 2 alpha)0.104
ACVR1activin A receptor, type I0.102
BMP7bone morphogenetic protein 70.102
PAPPApregnancy-associated plasma protein A, pappalysin 10.101
HSPB2heat shock 27kDa protein 20.101
HES1hairy and enhancer of split 1, (Drosophila)0.101
PGK1phosphoglycerate kinase 10.100
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
slit3slit (Drosophila) homolog 30.448
inhbaainhibin, beta Aa0.381
has2hyaluronan synthase 20.282
nav3neuron navigator 30.237
metmet proto-oncogene (hepatocyte growth factor receptor)0.212
angptl2angiopoietin-like 20.183
slit1aslit homolog 1a (Drosophila)0.151
nrp2bneuropilin 2b0.147
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.143
evx1even-skipped homeobox 10.139
fgfr3fibroblast growth factor receptor 30.134
bocbrother of CDO0.118
ptpraprotein tyrosine phosphatase, receptor type, A0.102
igfbp3insulin-like growth factor binding protein 30.102
hgfahepatocyte growth factor a0.100
ntn1anetrin 1a0.099
hif1abhypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b0.098
sulf1sulfatase 10.092
ebf3early B-cell factor 30.091
lhx2bLIM homeobox 2b0.091
wif1wnt inhibitory factor 10.086
zbtb4zinc finger and BTB domain containing 40.083
fabp11afatty acid binding protein 11a0.082
sema3dsemaphorin 3d0.070
crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.068
pax6bpaired box gene 6b0.065
efnb3bephrin B3b0.064
phox2apaired-like homeobox 2a0.063
sfrp1asecreted frizzled-related protein 1a0.063
slc6a8solute carrier family 6 (neurotransmitter transporter, creatine), member 80.063
osr1odd-skipped related 1 (Drosophila)0.062
foxa1forkhead box A10.061
bmp2abone morphogenetic protein 2a0.060
pax7bpaired box gene 7b0.057
rargaretinoic acid receptor gamma a0.053
mecomMDS1 and EVI1 complex locus0.053
hgfbhepatocyte growth factor b0.052
fzd7afrizzled homolog 7a0.049
sema3aasemaphorin 3aa0.047
coe2coe20.046
foxa3forkhead box A30.045
dip2cDIP2 disco-interacting protein 2 homolog C (Drosophila)0.045
pvrl1bpoliovirus receptor-related 1b0.044
dmbx1adiencephalon/mesencephalon homeobox 1a0.042
nr2f5nuclear receptor subfamily 2, group F, member 50.042
pkm2apyruvate kinase, muscle, a0.041
snai1asnail homolog 1a (Drosophila)0.039
efnb2aephrin B2a0.035
rbpms2RNA binding protein with multiple splicing 20.035
ntn1bnetrin 1b0.034
epha4aeph receptor A4a0.033
msnamoesin a0.032
ptgs1prostaglandin-endoperoxide synthase 10.032
tfectranscription factor EC0.032
traf4atnf receptor-associated factor 4a0.031
irx2airoquois homeobox protein 2, a0.031
fgfr2fibroblast growth factor receptor 20.031
olfm2olfactomedin 20.030
slit2slit (Drosophila) homolog 20.029
foxp1bforkhead box P1b0.029
zdhhc8bzinc finger, DHHC-type containing 8b0.028
apobapolipoprotein B0.028
nrp1aneuropilin 1a0.027
acta1aactin, alpha 1a, skeletal muscle0.027
LOC567452G protein-coupled receptor kinase 5-like0.027
pbx1apre-B-cell leukemia transcription factor 1a0.026
inhainhibin, alpha0.026
neo1neogenin 10.026
atp2a1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.024
igf2ainsulin-like growth factor 2a0.024
stmn4stathmin-like 40.024
zgc:63947zgc:639470.023
tnfsf10ltumor necrosis factor (ligand) superfamily, member 10 like0.022
wnt8awingless-type MMTV integration site family, member 8a0.022
robo2roundabout homolog 20.022
hsp90a.1heat shock protein 90-alpha 10.021
col2a1acollagen type II, alpha-1a0.020
nog1noggin 10.020
fgfrl1afibroblast growth factor receptor-like 1a0.020
grhl2bgrainyhead-like 2b (Drosophila)0.020
igf1rbinsulin-like growth factor 1b receptor0.020
gsnagelsolin a0.020
wnt4awingless-type MMTV integration site family, member 4a0.019
tcf7transcription factor 7 (T-cell specific, HMG-box)0.019
kif5bbkinesin family member 5B, b0.019
pou3f3aPOU class 3 homeobox 3a0.019
bmpr1bbbone morphogenetic protein receptor, type 1bb0.019
znf703zinc finger protein 7030.019
kal1aKallmann syndrome 1a sequence0.019
LOC797832similar to signal peptide, CUB domain, EGF-like 10.019
rasgef1bbRasGEF domain family, member 1Bb0.018
pygmbphosphorylase, glycogen (muscle) b0.018
nrp2aneuropilin 2a0.018
paqr8progestin and adipoQ receptor family member VIII0.018
dab1adisabled homolog 1a (Drosophila)0.017
limk1LIM domain kinase 10.017
loxlysyl oxidase0.017
col4a5collagen, type IV, alpha 5 (Alport syndrome)0.017
alcamaactivated leukocyte cell adhesion molecule a0.017
aldh1a3aldehyde dehydrogenase 1 family, member A30.017
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
dockdreadlocks0.058
slislit0.021
roboroundabout0.018
Wnt5Wnt oncogene analog 50.018
kibrakibra ortholog0.017
CG14061CG14061 gene product from transcript CG14061-RA0.017
Gyc76CGuanylyl cyclase at 76C0.017
hkbhuckebein0.015
Ptp69DProtein tyrosine phosphatase 69D0.014
Pi3K92ECG4141 gene product from transcript CG4141-RB0.014
prosprospero0.013
myoglianinCG1838 gene product from transcript CG1838-RD0.012
nkdnaked cuticle0.012
Atg1Autophagy-specific gene 10.011
NetBNetrin-B0.011
stumpsCG31317 gene product from transcript CG31317-RC0.010
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ptenphosphatase and tensin homolog0.997
Trp53transformation related protein 530.985
Apcadenomatosis polyposis coli0.981
Robo1roundabout homolog 1 (Drosophila)0.936
Esr1estrogen receptor 1 (alpha)0.903
Smad3MAD homolog 3 (Drosophila)0.880
AxlAXL receptor tyrosine kinase0.859
Arandrogen receptor0.830
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.810
Bcl2B-cell leukemia/lymphoma 20.802
Gli3GLI-Kruppel family member GLI30.801
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.712
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.704
Gli2GLI-Kruppel family member GLI20.692
Rb1retinoblastoma 10.656
Leprleptin receptor0.651
Slit3slit homolog 3 (Drosophila)0.649
Cdkn1bcyclin-dependent kinase inhibitor 1B0.635
Amhr2anti-Mullerian hormone type 2 receptor0.612
Tsc2tuberous sclerosis 20.605
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.593
Sfrp1secreted frizzled-related protein 10.571
Ctnnb1catenin (cadherin associated protein), beta 10.571
Arhgef11Rho guanine nucleotide exchange factor (GEF) 110.569
Nodalnodal0.548
Mdm2transformed mouse 3T3 cell double minute 20.519
Inhainhibin alpha0.504
BrafBraf transforming gene0.497
Nos3nitric oxide synthase 3, endothelial cell0.483
Cdkn2ccyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)0.464
Pax2paired box gene 20.439
Rararetinoic acid receptor, alpha0.415
Lhx1LIM homeobox protein 10.375
Fgfr1fibroblast growth factor receptor 10.370
Bmp4bone morphogenetic protein 40.358
Vhlvon Hippel-Lindau tumor suppressor0.333
Robo2roundabout homolog 2 (Drosophila)0.333
Slit2slit homolog 2 (Drosophila)0.323
Rargretinoic acid receptor, gamma0.308
Fshrfollicle stimulating hormone receptor0.305
Sfrp2secreted frizzled-related protein 20.304
Kitkit oncogene0.291
Dlx5distal-less homeobox 50.291
Fzd1frizzled homolog 1 (Drosophila)0.290
Sema6dsema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D0.283
Wnt5awingless-related MMTV integration site 5A0.282
Thbs1thrombospondin 10.281
Shhsonic hedgehog0.281
Fgf18fibroblast growth factor 180.270
Epha4Eph receptor A40.262
Foxa2forkhead box A20.262
Pgrprogesterone receptor0.261
Nf1neurofibromatosis 10.257
Fzd8frizzled homolog 8 (Drosophila)0.255
Ephb3Eph receptor B30.251
Csf1colony stimulating factor 1 (macrophage)0.248
SkilSKI-like0.240
Onecut1one cut domain, family member 10.223
Nr5a1nuclear receptor subfamily 5, group A, member 10.219
Lepleptin0.217
BaxBCL2-associated X protein0.215
Tsc1tuberous sclerosis 10.210
Gab1growth factor receptor bound protein 2-associated protein 10.208
Dkk1dickkopf homolog 1 (Xenopus laevis)0.207
Tcf21transcription factor 210.207
Ndnnecdin0.204
Dhhdesert hedgehog0.201
Meox2mesenchyme homeobox 20.201
Ror1receptor tyrosine kinase-like orphan receptor 10.200
Matn4matrilin 40.192
Emx2empty spiracles homolog 2 (Drosophila)0.190
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.188
Nognoggin0.187
Grb10growth factor receptor bound protein 100.185
Igf1insulin-like growth factor 10.184
Gli1GLI-Kruppel family member GLI10.184
Prrx1paired related homeobox 10.182
Gdf11growth differentiation factor 110.178
Arid1bAT rich interactive domain 1B (SWI-like)0.177
Cdk5r1cyclin-dependent kinase 5, regulatory subunit 1 (p35)0.174
Plxna1plexin A10.173
Pthlhparathyroid hormone-like peptide0.170
Nf2neurofibromatosis 20.166
Hif1ahypoxia inducible factor 1, alpha subunit0.166
Tyro3TYRO3 protein tyrosine kinase 30.164
Fstfollistatin0.159
Insrinsulin receptor0.159
SrcRous sarcoma oncogene0.158
Ptgs2prostaglandin-endoperoxide synthase 20.157
Fgf10fibroblast growth factor 100.155
Gdnfglial cell line derived neurotrophic factor0.154
Ifi203interferon activated gene 2030.153
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.149
Trp63transformation related protein 630.147
Mertkc-mer proto-oncogene tyrosine kinase0.147
Efsembryonal Fyn-associated substrate0.147
Cdkn2acyclin-dependent kinase inhibitor 2A0.146
Msh2mutS homolog 2 (E. coli)0.146
Ptpruprotein tyrosine phosphatase, receptor type, U0.145
Spnb2spectrin beta 20.145
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cav1caveolin 1, caveolae protein0.046
Nos3nitric oxide synthase 3, endothelial cell0.040
Gja1gap junction protein, alpha 10.038
Ahsgalpha-2-HS-glycoprotein0.025
LOC100362824caveolin 2-like0.023
Prl6a1prolactin family 6, subfamily a, member 10.021
Apoa5apolipoprotein A-V0.019
Tpothyroid peroxidase0.018
Robo1roundabout homolog 1 (Drosophila)0.018
LOC299282Serine protease inhibitor0.017
Grm5glutamate receptor, metabotropic 50.017
Serpina6serine (or cysteine) peptidase inhibitor, clade A, member 60.017
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.016
Tgfbr2transforming growth factor, beta receptor II0.016
Pxdnperoxidasin homolog (Drosophila)0.016
Mcammelanoma cell adhesion molecule0.016
Slc22a7solute carrier family 22 (organic anion transporter), member 70.015
BokBCL2-related ovarian killer0.015
Cckarcholecystokinin A receptor0.015
Trib1tribbles homolog 1 (Drosophila)0.015
LOC100360403ATP-binding cassette, sub-family C, member 9-like0.014
Itgamintegrin, alpha M0.014
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.014
Flt1FMS-related tyrosine kinase 10.014
Nfibnuclear factor I/B0.014
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.013
Nedd4neural precursor cell expressed, developmentally down-regulated 40.013
Cyp11b3cytochrome P450, family 11, subfamily b, polypeptide 30.013
Pkm2pyruvate kinase, muscle0.013
Ednrbendothelin receptor type B0.013
Cox6a2cytochrome c oxidase, subunit VIa, polypeptide 20.013
Twist2twist homolog 2 (Drosophila)0.013
Novnephroblastoma overexpressed gene0.012
Acsm2acyl-CoA synthetase medium-chain family member 20.012
Sisucrase-isomaltase (alpha-glucosidase)0.012
Cav2caveolin 20.012
Cd9CD9 molecule0.012
Cyb5r3cytochrome b5 reductase 30.012
Hspb1heat shock protein 10.012
Fermt2fermitin family homolog 2 (Drosophila)0.011
RGD1564163similar to RIKEN cDNA 1700025K230.011
Trim47tripartite motif-containing 470.011
Selpselectin P0.011
Cyp2d2cytochrome P450, family 2, subfamily d, polypeptide 20.011
Nexnnexilin (F actin binding protein)0.011
Rup2urinary protein 20.011
Cdk5r2cyclin-dependent kinase 5, regulatory subunit 2 (p39)0.011
Tgfb3transforming growth factor, beta 30.011
Adrb2adrenergic, beta-2-, receptor, surface0.011
Hspb2heat shock protein beta 20.011
LOC100361571keratin associated protein 1-3-like0.011
Pon1paraoxonase 10.011
Serpinb7serpin peptidase inhibitor, clade B (ovalbumin), member 70.011
Agxtalanine-glyoxylate aminotransferase0.010
Fgf18fibroblast growth factor 180.010
Ctsdcathepsin D0.010
Sostsclerosteosis0.010
Insl3insulin-like 30.010
Cd37CD37 molecule0.010
Actn2actinin alpha 20.010
Foxc2forkhead box C20.010
KitlgKIT ligand0.010
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
IME4Ime4p0.791
IZH4Izh4p0.361
DIG1Dig1p0.251
STI1Sti1p0.179
TEC1Tec1p0.133
SSA4Ssa4p0.111
SSA3Ssa3p0.108
PSP2Psp2p0.093
SWI1Swi1p0.083
KSS1Kss1p0.051
RSC6Rsc6p0.045
BTN2Btn2p0.045
SCH9Sch9p0.041
ORC4Orc4p0.040
SLZ1Slz1p0.039
DOT6Dot6p0.033
CAC2Cac2p0.032
MER1Mer1p0.029
RAX1Rax1p0.029
CPR6Cpr6p0.029
MPT5Mpt5p0.028
TBF1Tbf1p0.027
NOP10Nop10p0.019
HEF3Hef3p0.019
FIR1Fir1p0.019
YLR455Whypothetical protein0.018
SFL1Sfl1p0.018
KIC1Kic1p0.017
SFG1Sfg1p0.017
MEP1Mep1p0.017
TYE7Tye7p0.017
RAP1Rap1p0.016
YLR264C-Ahypothetical protein0.015
SAN1San1p0.015
SWM2Swm2p0.015
GAL11Gal11p0.015
PCL2Pcl2p0.015
FLO8Flo8p0.014
ADH7Adh7p0.014
PMA2Pma2p0.013
SRD1Srd1p0.013
ARP10Arp10p0.013
OPI1Opi1p0.013
CRT10Crt10p0.012
GYL1Gyl1p0.012
ECM27Ecm27p0.012
SPS4Sps4p0.012
ESP1Esp1p0.011
CUP1-1Cup1-1p0.011
RSC30Rsc30p0.011
SSA2Ssa2p0.011
YLR162Whypothetical protein0.011
URA3Ura3p0.011
MEP3Mep3p0.010
TAF5Taf5p0.010
HIF1Hif1p0.010
YOL038C-Ahypothetical protein0.010
CHA1Cha1p0.010
PSR1Psr1p0.010
HEM13Hem13p0.010
HOHop0.010
LEU2Leu2p0.010