The network for 'positive regulation of metanephros development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of metanephros development

Any process that increases the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine.

NameDescriptionProbabilityFunc Analog Organism
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide1.000
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)1.000
VEGFAvascular endothelial growth factor A0.987
PLCG1phospholipase C, gamma 10.938
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.907
NRP1neuropilin 10.835
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.818
PDGFAplatelet-derived growth factor alpha polypeptide0.649
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.474
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.465
FOSFBJ murine osteosarcoma viral oncogene homolog0.457
PGFplacental growth factor0.329
SNAI1snail homolog 1 (Drosophila)0.227
EGR3early growth response 30.179
NKX2-1NK2 homeobox 10.149
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.134
CEBPBCCAAT/enhancer binding protein (C/EBP), beta0.122
COL4A1collagen, type IV, alpha 10.116
EGR2early growth response 20.106
TIMP3TIMP metallopeptidase inhibitor 30.103
PDGFCplatelet derived growth factor C0.084
PTPRBprotein tyrosine phosphatase, receptor type, B0.072
MDFIMyoD family inhibitor0.060
NR4A1nuclear receptor subfamily 4, group A, member 10.053
STC1stanniocalcin 10.053
IER2immediate early response 20.052
FOSBFBJ murine osteosarcoma viral oncogene homolog B0.050
COL5A1collagen, type V, alpha 10.049
COL2A1collagen, type II, alpha 10.044
COL1A1collagen, type I, alpha 10.041
COL6A1collagen, type VI, alpha 10.038
DVL3dishevelled, dsh homolog 3 (Drosophila)0.033
TAOK1TAO kinase 10.032
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.032
NR4A3nuclear receptor subfamily 4, group A, member 30.027
AESamino-terminal enhancer of split0.026
FLT4fms-related tyrosine kinase 40.026
BHLHE40basic helix-loop-helix family, member e400.024
PTPRJprotein tyrosine phosphatase, receptor type, J0.022
NR4A2nuclear receptor subfamily 4, group A, member 20.020
METmet proto-oncogene (hepatocyte growth factor receptor)0.020
VAT1vesicle amine transport protein 1 homolog (T. californica)0.019
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.019
PTENphosphatase and tensin homolog0.018
NAB2NGFI-A binding protein 2 (EGR1 binding protein 2)0.018
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.018
INSRinsulin receptor0.016
CAV1caveolin 1, caveolae protein, 22kDa0.016
FGFR1fibroblast growth factor receptor 10.015
DDIT4DNA-damage-inducible transcript 40.014
CD248CD248 molecule, endosialin0.014
GFRA1GDNF family receptor alpha 10.014
ZNF205zinc finger protein 2050.013
WT1Wilms tumor 10.013
PHLDA1pleckstrin homology-like domain, family A, member 10.013
DVL1dishevelled, dsh homolog 1 (Drosophila)0.012
FGF18fibroblast growth factor 180.012
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.012
ROBO4roundabout homolog 4, magic roundabout (Drosophila)0.011
DDIT3DNA-damage-inducible transcript 30.011
ADAMTS5ADAM metallopeptidase with thrombospondin type 1 motif, 50.011
TRIB1tribbles homolog 1 (Drosophila)0.010
RGS16regulator of G-protein signaling 160.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Pax2paired box gene 20.998
Retret proto-oncogene0.949
Vegfavascular endothelial growth factor A0.791
Fbn1fibrillin 10.577
C1qbcomplement component 1, q subcomponent, beta polypeptide0.573
Nos3nitric oxide synthase 3, endothelial cell0.508
Bcl2B-cell leukemia/lymphoma 20.448
Wt1Wilms tumor 1 homolog0.434
C1qccomplement component 1, q subcomponent, C chain0.409
C1qacomplement component 1, q subcomponent, alpha polypeptide0.408
Lhx1LIM homeobox protein 10.358
Tgfbr2transforming growth factor, beta receptor II0.323
Foxc2forkhead box C20.277
Msx1homeobox, msh-like 10.264
Apoeapolipoprotein E0.261
Ptgs2prostaglandin-endoperoxide synthase 20.210
Fgfr2fibroblast growth factor receptor 20.207
Emx2empty spiracles homolog 2 (Drosophila)0.198
Rararetinoic acid receptor, alpha0.191
Pax3paired box gene 30.190
Shhsonic hedgehog0.188
Ldlrlow density lipoprotein receptor0.162
Jag1jagged 10.155
Nab2Ngfi-A binding protein 20.143
Hoxa1homeobox A10.142
TyrobpTYRO protein tyrosine kinase binding protein0.126
Phox2bpaired-like homeobox 2b0.113
Tbx1T-box 10.110
Gfra1glial cell line derived neurotrophic factor family receptor alpha 10.090
Rargretinoic acid receptor, gamma0.088
Fgf10fibroblast growth factor 100.086
Gbx2gastrulation brain homeobox 20.082
Gdnfglial cell line derived neurotrophic factor0.078
Csf1colony stimulating factor 1 (macrophage)0.078
Lmx1aLIM homeobox transcription factor 1 alpha0.073
Trp53transformation related protein 530.066
Sox10SRY-box containing gene 100.063
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.062
Eya1eyes absent 1 homolog (Drosophila)0.054
Gucy2eguanylate cyclase 2e0.053
Wnt9bwingless-type MMTV integration site 9B0.051
Rarbretinoic acid receptor, beta0.050
Ren1renin 1 structural0.050
Lama5laminin, alpha 50.046
Foxc1forkhead box C10.041
Agtr1aangiotensin II receptor, type 1a0.039
Egr2early growth response 20.039
Tgfb1transforming growth factor, beta 10.038
Otx1orthodenticle homolog 1 (Drosophila)0.035
Gfra2glial cell line derived neurotrophic factor family receptor alpha 20.032
Ctsscathepsin S0.032
Ly86lymphocyte antigen 860.031
Wnt4wingless-related MMTV integration site 40.031
Notch2Notch gene homolog 2 (Drosophila)0.030
Hoxa3homeobox A30.030
Hoxa11homeobox A110.028
Rxraretinoid X receptor alpha0.028
Lhx9LIM homeobox protein 90.027
Bdkrb2bradykinin receptor, beta 20.026
Lef1lymphoid enhancer binding factor 10.026
Gfra3glial cell line derived neurotrophic factor family receptor alpha 30.026
Leprleptin receptor0.023
H2-Ab1histocompatibility 2, class II antigen A, beta 10.023
Isl1ISL1 transcription factor, LIM/homeodomain0.022
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.022
SrcRous sarcoma oncogene0.022
Fgf8fibroblast growth factor 80.021
Fgf3fibroblast growth factor 30.021
Hoxb3homeobox B30.021
Fgfr1fibroblast growth factor receptor 10.020
Tie1tyrosine kinase with immunoglobulin-like and EGF-like domains 10.020
Bmp4bone morphogenetic protein 40.020
Meox2mesenchyme homeobox 20.019
Egr1early growth response 10.019
Pdgfbplatelet derived growth factor, B polypeptide0.018
Hoxd11homeobox D110.018
Osr1odd-skipped related 1 (Drosophila)0.018
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.017
Sox18SRY-box containing gene 180.017
Ror2receptor tyrosine kinase-like orphan receptor 20.017
Hic1hypermethylated in cancer 10.017
Foxd2forkhead box D20.017
Msx2homeobox, msh-like 20.017
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.016
Hand1heart and neural crest derivatives expressed transcript 10.016
Hmx3H6 homeobox 30.016
Kdrkinase insert domain protein receptor0.016
Gata3GATA binding protein 30.016
Gli3GLI-Kruppel family member GLI30.016
Pou4f2POU domain, class 4, transcription factor 20.015
FosFBJ osteosarcoma oncogene0.015
Ptprbprotein tyrosine phosphatase, receptor type, B0.015
Ascl1achaete-scute complex homolog 1 (Drosophila)0.015
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.015
Agtrapangiotensin II, type I receptor-associated protein0.015
Nr5a1nuclear receptor subfamily 5, group A, member 10.014
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.014
Bmp2bone morphogenetic protein 20.013
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.013
Zeb1zinc finger E-box binding homeobox 10.013
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Nr4a1nuclear receptor subfamily 4, group A, member 10.657
Egr2early growth response 20.642
Egr1early growth response 10.601
FosFBJ osteosarcoma oncogene0.368
Junbjun B proto-oncogene0.233
Nr4a2nuclear receptor subfamily 4, group A, member 20.058
Dusp6dual specificity phosphatase 60.052
Flt1FMS-related tyrosine kinase 10.049
PVRpoliovirus receptor0.040
Cyr61cysteine-rich, angiogenic inducer, 610.039
Rln1relaxin 10.038
Snai1snail homolog 1 (Drosophila)0.036
Bmp6bone morphogenetic protein 60.032
Pacs1phosphofurin acidic cluster sorting protein 10.029
Btg2BTG family, member 20.028
Nr4a3nuclear receptor subfamily 4, group A, member 30.028
Col5a1collagen, type V, alpha 10.026
Gata6GATA binding protein 60.026
JunJun oncogene0.024
Unc5bunc-5 homolog B (C. elegans)0.023
Olr1356olfactory receptor 13560.022
Inhbainhibin beta-A0.022
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.022
Ccl2chemokine (C-C motif) ligand 20.021
Efnb1ephrin B10.020
Ier2immediate early response 20.020
Amelxamelogenin X chromosome0.020
LOC691153hypothetical protein LOC6911530.020
Fgfr2fibroblast growth factor receptor 20.020
Ccnl1cyclin L10.019
Htra3HtrA serine peptidase 30.018
Atf3activating transcription factor 30.018
Cnga4cyclic nucleotide gated channel alpha 40.018
Nxph3neurexophilin 30.017
Cx3cl1chemokine (C-X3-C motif) ligand 10.017
Nos3nitric oxide synthase 3, endothelial cell0.017
CebpdCCAAT/enhancer binding protein (C/EBP), delta0.016
Olr1413olfactory receptor 14130.016
Ptprvprotein tyrosine phosphatase, receptor type, V0.016
Gpr182G protein-coupled receptor 1820.016
Irs1insulin receptor substrate 10.015
Rrp9ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)0.015
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.014
Csf1colony stimulating factor 1 (macrophage)0.014
Ghrhgrowth hormone releasing hormone0.014
Slit3slit homolog 3 (Drosophila)0.014
Has2hyaluronan synthase 20.014
Arandrogen receptor0.013
Kcng1potassium voltage-gated channel, subfamily G, member 10.013
Itpr3inositol 1,4,5-triphosphate receptor, type 30.013
Lama5laminin, alpha 50.013
Hoxa1homeo box A10.013
Gucy2dguanylate cyclase 2d0.013
Cyp11b3cytochrome P450, family 11, subfamily b, polypeptide 30.013
Col12a1collagen, type XII, alpha 10.013
Lamc1laminin, gamma 10.012
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.012
Kcnc3potassium voltage gated channel, Shaw-related subfamily, member 30.012
Gpr176G protein-coupled receptor 1760.012
Ptpn14protein tyrosine phosphatase, non-receptor type 140.012
Arcactivity-regulated cytoskeleton-associated protein0.012
Olr825olfactory receptor 8250.012
Efna5ephrin A50.011
NrarpNotch-regulated ankyrin repeat protein0.011
Grin2aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.011
Scn5asodium channel, voltage-gated, type V, alpha subunit0.011
Megf6multiple EGF-like-domains 60.011
Slc13a1solute carrier family 13 (sodium/sulfate symporters), member 10.011
LOC100360403ATP-binding cassette, sub-family C, member 9-like0.011
Mmp23matrix metallopeptidase 230.011
Dlc1deleted in liver cancer 10.011
Gabrdgamma-aminobutyric acid (GABA) A receptor, delta0.011
Plxnd1plexin D10.011
C1qtnf6C1q and tumor necrosis factor related protein 60.011
Kcnj4potassium inwardly-rectifying channel, subfamily J, member 40.010
Ltbp3latent transforming growth factor beta binding protein 30.010
Creb3l1cAMP responsive element binding protein 3-like 10.010
Agtr1aangiotensin II receptor, type 1a0.010
Madcam1mucosal vascular addressin cell adhesion molecule 10.010
Dlgap3discs, large (Drosophila) homolog-associated protein 30.010
Ghrgrowth hormone receptor0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism