The network for 'regulation of metanephros development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of metanephros development

Any process that modulates the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine.

NameDescriptionProbabilityFunc Analog Organism
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.903
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.882
VEGFAvascular endothelial growth factor A0.355
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.160
TIMP3TIMP metallopeptidase inhibitor 30.112
NRP1neuropilin 10.101
NKX2-1NK2 homeobox 10.091
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.067
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.062
CEBPBCCAAT/enhancer binding protein (C/EBP), beta0.056
FOSFBJ murine osteosarcoma viral oncogene homolog0.055
DVL3dishevelled, dsh homolog 3 (Drosophila)0.051
PDGFAplatelet-derived growth factor alpha polypeptide0.050
IER2immediate early response 20.040
EGR3early growth response 30.036
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.034
TJP2tight junction protein 2 (zona occludens 2)0.033
AMOTL1angiomotin like 10.030
PLCG1phospholipase C, gamma 10.029
COL6A1collagen, type VI, alpha 10.026
SNAI1snail homolog 1 (Drosophila)0.026
FOSBFBJ murine osteosarcoma viral oncogene homolog B0.024
EGFRepidermal growth factor receptor0.024
EGR2early growth response 20.023
JUNBjun B proto-oncogene0.021
AMOTL2angiomotin like 20.020
SKP1S-phase kinase-associated protein 10.020
STC1stanniocalcin 10.017
COL2A1collagen, type II, alpha 10.017
PTPN14protein tyrosine phosphatase, non-receptor type 140.017
COL5A1collagen, type V, alpha 10.016
TEAD1TEA domain family member 1 (SV40 transcriptional enhancer factor)0.016
MPDZmultiple PDZ domain protein0.016
CYR61cysteine-rich, angiogenic inducer, 610.016
COL4A1collagen, type IV, alpha 10.015
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.015
FOSL1FOS-like antigen 10.014
RUNX1runt-related transcription factor 10.014
HNF1AHNF1 homeobox A0.014
TP53BP2tumor protein p53 binding protein, 20.014
TEAD4TEA domain family member 40.014
TRIB1tribbles homolog 1 (Drosophila)0.014
AESamino-terminal enhancer of split0.014
SLC9A3R2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 20.013
NOGnoggin0.012
TGFB2transforming growth factor, beta 20.012
GLIS2GLIS family zinc finger 20.012
BBS1Bardet-Biedl syndrome 10.011
AMOTangiomotin0.011
BMPR1Bbone morphogenetic protein receptor, type IB0.011
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.011
KLF5Kruppel-like factor 5 (intestinal)0.011
SPRY4sprouty homolog 4 (Drosophila)0.011
FZD4frizzled homolog 4 (Drosophila)0.011
CDKN2Bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)0.011
JUNjun proto-oncogene0.011
OSMRoncostatin M receptor0.011
CAV1caveolin 1, caveolae protein, 22kDa0.011
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.010
IGF1Rinsulin-like growth factor 1 receptor0.010
SIM2single-minded homolog 2 (Drosophila)0.010
TAOK1TAO kinase 10.010
DDIT4DNA-damage-inducible transcript 40.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Retret proto-oncogene0.992
Vegfavascular endothelial growth factor A0.985
Nos3nitric oxide synthase 3, endothelial cell0.980
Pax2paired box gene 20.965
Lhx1LIM homeobox protein 10.916
C1qacomplement component 1, q subcomponent, alpha polypeptide0.866
Ren1renin 1 structural0.864
Nr5a1nuclear receptor subfamily 5, group A, member 10.767
Gdnfglial cell line derived neurotrophic factor0.720
Fgf8fibroblast growth factor 80.633
Bcl2B-cell leukemia/lymphoma 20.572
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.570
Wnt4wingless-related MMTV integration site 40.517
Emx2empty spiracles homolog 2 (Drosophila)0.465
Sall4sal-like 4 (Drosophila)0.464
Pax8paired box gene 80.437
Ptgs2prostaglandin-endoperoxide synthase 20.407
Lama5laminin, alpha 50.398
C1qccomplement component 1, q subcomponent, C chain0.390
C1qbcomplement component 1, q subcomponent, beta polypeptide0.376
Foxc2forkhead box C20.344
Tbrachyury0.337
Bdkrb2bradykinin receptor, beta 20.325
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.316
Fgfr2fibroblast growth factor receptor 20.311
Lmx1aLIM homeobox transcription factor 1 alpha0.307
Shhsonic hedgehog0.291
Sall1sal-like 1 (Drosophila)0.246
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.242
Dkk1dickkopf homolog 1 (Xenopus laevis)0.241
Hoxd11homeobox D110.240
Kdrkinase insert domain protein receptor0.229
Leprleptin receptor0.202
Rararetinoic acid receptor, alpha0.197
Fgfr1fibroblast growth factor receptor 10.196
Tbx1T-box 10.195
FosFBJ osteosarcoma oncogene0.192
Rarbretinoic acid receptor, beta0.184
TyrobpTYRO protein tyrosine kinase binding protein0.180
Gli3GLI-Kruppel family member GLI30.169
Wnt9bwingless-type MMTV integration site 9B0.165
Rargretinoic acid receptor, gamma0.162
Yap1yes-associated protein 10.159
Ptprbprotein tyrosine phosphatase, receptor type, B0.159
Trp53transformation related protein 530.157
Gli2GLI-Kruppel family member GLI20.151
Agtr1aangiotensin II receptor, type 1a0.148
Gfra1glial cell line derived neurotrophic factor family receptor alpha 10.144
Wt1Wilms tumor 1 homolog0.143
Ednrbendothelin receptor type B0.140
Fgf3fibroblast growth factor 30.134
Msx1homeobox, msh-like 10.125
Vax1ventral anterior homeobox containing gene 10.124
Hoxa11homeobox A110.121
Nognoggin0.116
Wnt6wingless-related MMTV integration site 60.113
Gfra2glial cell line derived neurotrophic factor family receptor alpha 20.111
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.108
Hoxa1homeobox A10.106
Wwtr1WW domain containing transcription regulator 10.104
JunJun oncogene0.099
Sox10SRY-box containing gene 100.093
Foxd2forkhead box D20.089
Foxc1forkhead box C10.083
Alx3aristaless-like homeobox 30.081
Otx1orthodenticle homolog 1 (Drosophila)0.079
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.077
Pitx3paired-like homeodomain transcription factor 30.074
Flt4FMS-like tyrosine kinase 40.073
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.072
Tbx2T-box 20.070
Phox2bpaired-like homeobox 2b0.068
Pou5f1POU domain, class 5, transcription factor 10.065
Gbx2gastrulation brain homeobox 20.063
Sox7SRY-box containing gene 70.062
Pax3paired box gene 30.060
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.060
Csf1rcolony stimulating factor 1 receptor0.059
Gfra3glial cell line derived neurotrophic factor family receptor alpha 30.057
Ldlrlow density lipoprotein receptor0.056
Sall3sal-like 3 (Drosophila)0.056
Osr1odd-skipped related 1 (Drosophila)0.055
Nos2nitric oxide synthase 2, inducible0.055
Trp73transformation related protein 730.054
Wnt10bwingless related MMTV integration site 10b0.054
Hoxa3homeobox A30.053
Ror2receptor tyrosine kinase-like orphan receptor 20.053
Nos1nitric oxide synthase 1, neuronal0.053
Nr0b1nuclear receptor subfamily 0, group B, member 10.052
Nkx1-2NK1 transcription factor related, locus 2 (Drosophila)0.050
Bmp4bone morphogenetic protein 40.050
Hmx3H6 homeobox 30.049
Tead3TEA domain family member 30.048
Ctnnb1catenin (cadherin associated protein), beta 10.046
Csf1colony stimulating factor 1 (macrophage)0.046
Bmp7bone morphogenetic protein 70.046
Tnfrsf8tumor necrosis factor receptor superfamily, member 80.045
Foxf1aforkhead box F1a0.045
Npas1neuronal PAS domain protein 10.043
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.043
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Junbjun B proto-oncogene0.752
Egr1early growth response 10.489
Ier2immediate early response 20.402
FosFBJ osteosarcoma oncogene0.368
Parp14poly (ADP-ribose) polymerase family, member 140.349
LOC100362108poly (ADP-ribose) polymerase family, member 100.326
LOC100365106rCG32755-like0.287
Egr2early growth response 20.213
Nr4a1nuclear receptor subfamily 4, group A, member 10.187
Dusp6dual specificity phosphatase 60.164
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.134
Efnb1ephrin B10.102
Klf6Kruppel-like factor 60.099
Rnf213ring finger protein 2130.097
Irf7interferon regulatory factor 70.096
Rararetinoic acid receptor, alpha0.095
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.093
Zfp36zinc finger protein 360.092
Il6stinterleukin 6 signal transducer0.083
Ltbp3latent transforming growth factor beta binding protein 30.083
Pim1pim-1 oncogene0.070
JunJun oncogene0.061
Rxraretinoid X receptor alpha0.061
Flt1FMS-related tyrosine kinase 10.060
Smad1SMAD family member 10.058
Myo1bmyosin Ib0.057
Mx2myxovirus (influenza virus) resistance 20.056
Tgfbr3transforming growth factor, beta receptor III0.056
Btg2BTG family, member 20.055
Bmp6bone morphogenetic protein 60.055
Hoxc4homeo box C40.054
Gpr176G protein-coupled receptor 1760.047
Dusp1dual specificity phosphatase 10.047
Sp110SP110 nuclear body protein0.046
Unc5bunc-5 homolog B (C. elegans)0.045
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.045
Synposynaptopodin0.044
Hoxb8homeo box B80.044
Mafbv-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)0.042
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.041
Nr4a3nuclear receptor subfamily 4, group A, member 30.039
Dlc1deleted in liver cancer 10.038
Insrrinsulin receptor-related receptor0.038
Syde1synapse defective 1, Rho GTPase, homolog 1 (C. elegans)0.037
Gata3GATA binding protein 30.037
Ppp1r15aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.037
Nek9NIMA (never in mitosis gene a)- related kinase 90.037
Slit3slit homolog 3 (Drosophila)0.037
MrgprfMAS-related GPR, member F0.036
RT1-S3RT1 class Ib, locus S30.036
Nos3nitric oxide synthase 3, endothelial cell0.035
Snai1snail homolog 1 (Drosophila)0.035
Lgals3bplectin, galactoside-binding, soluble, 3 binding protein0.034
Ankrd1ankyrin repeat domain 1 (cardiac muscle)0.034
Eif2ak2eukaryotic translation initiation factor 2-alpha kinase 20.034
Ptpn14protein tyrosine phosphatase, non-receptor type 140.032
Ptpn1protein tyrosine phosphatase, non-receptor type 10.032
Errfi1ERBB receptor feedback inhibitor 10.032
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.031
Irs1insulin receptor substrate 10.030
Dtx3ldeltex 3-like (Drosophila)0.030
Ube2l6ubiquitin-conjugating enzyme E2L 60.030
Lama5laminin, alpha 50.030
Ddr1discoidin domain receptor tyrosine kinase 10.029
Atf3activating transcription factor 30.028
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.028
Irf9interferon regulatory factor 90.028
Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)0.028
Myd88myeloid differentiation primary response gene 880.028
Ddx58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.027
PVRpoliovirus receptor0.027
Tfebtranscription factor EB0.027
Igtpinterferon gamma induced GTPase0.027
Hoxa1homeo box A10.027
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.027
Prrx1paired related homeobox 10.027
Nptxrneuronal pentraxin receptor0.027
Trim5tripartite motif-containing 50.027
Inhbainhibin beta-A0.026
Ptger3prostaglandin E receptor 3 (subtype EP3)0.026
Igfbp3insulin-like growth factor binding protein 30.026
Cx3cl1chemokine (C-X3-C motif) ligand 10.025
Foxq1forkhead box Q10.025
Has2hyaluronan synthase 20.025
Sirpasignal-regulatory protein alpha0.025
MaxMYC associated factor X0.025
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.025
Kcns1potassium voltage-gated channel, delayed-rectifier, subfamily S, member 10.024
Grin2aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.024
Rrbp1ribosome binding protein 10.024
Bhlhe40basic helix-loop-helix family, member e400.024
Zfp36l1zinc finger protein 36, C3H type-like 10.023
Ube2hubiquitin-conjugating enzyme E2H0.023
Egfl7EGF-like-domain, multiple 70.023
C1rcomplement component 1, r subcomponent0.023
Mmp23matrix metallopeptidase 230.023
Slc39a14solute carrier family 39 (zinc transporter), member 140.023
NrarpNotch-regulated ankyrin repeat protein0.022
Nraddneurotrophin receptor associated death domain0.022
Adra2badrenergic, alpha-2B-, receptor0.022
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism