The network for 'protein activation cascade' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

protein activation cascade

A response to a stimulus that consists of a sequential series of modifications to a set of proteins where the product of one reaction acts catalytically in the following reaction. The magnitude of the response is typically amplified at each successive step in the cascade. Modifications typically include proteolysis or covalent modification, and may also include binding events.

NameDescriptionProbabilityFunc Analog Organism
C1Rcomplement component 1, r subcomponent1.000
C1Scomplement component 1, s subcomponent1.000
C3complement component 30.979
FGBfibrinogen beta chain0.978
KRT15keratin 150.968
C1QAcomplement component 1, q subcomponent, A chain0.956
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.879
TP63tumor protein p630.863
SERPING1serpin peptidase inhibitor, clade G (C1 inhibitor), member 10.838
FGAfibrinogen alpha chain0.817
C1QBcomplement component 1, q subcomponent, B chain0.815
KRT19keratin 190.745
KRT17keratin 170.668
C1QCcomplement component 1, q subcomponent, C chain0.579
TEKTEK tyrosine kinase, endothelial0.537
ALBalbumin0.488
PPLperiplakin0.446
KRT14keratin 140.440
CFHcomplement factor H0.439
PLGplasminogen0.392
KRT18keratin 180.387
FGGfibrinogen gamma chain0.362
APOEapolipoprotein E0.319
CFIcomplement factor I0.313
A2Malpha-2-macroglobulin0.312
MASP1mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)0.300
DCNdecorin0.212
HRGhistidine-rich glycoprotein0.203
SERPINC1serpin peptidase inhibitor, clade C (antithrombin), member 10.181
DMBT1deleted in malignant brain tumors 10.177
F2coagulation factor II (thrombin)0.172
APCSamyloid P component, serum0.163
METmet proto-oncogene (hepatocyte growth factor receptor)0.160
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.157
MASP2mannan-binding lectin serine peptidase 20.155
LPAlipoprotein, Lp(a)0.151
KRT6Bkeratin 6B0.139
APOHapolipoprotein H (beta-2-glycoprotein I)0.127
C4Bcomplement component 4B (Chido blood group)0.124
C19orf50chromosome 19 open reading frame 500.114
RPS6KA6ribosomal protein S6 kinase, 90kDa, polypeptide 60.107
CFHR1complement factor H-related 10.103
ALOX12arachidonate 12-lipoxygenase0.103
PLATplasminogen activator, tissue0.102
KNG1kininogen 10.100
CYP2A6cytochrome P450, family 2, subfamily A, polypeptide 60.091
CYP1A2cytochrome P450, family 1, subfamily A, polypeptide 20.086
FCN2ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)0.077
ANGPT2angiopoietin 20.071
HPhaptoglobin0.070
C8Acomplement component 8, alpha polypeptide0.061
KRT6Akeratin 6A0.057
LECT2leukocyte cell-derived chemotaxin 20.057
ADH1Balcohol dehydrogenase 1B (class I), beta polypeptide0.056
LBPlipopolysaccharide binding protein0.054
C7complement component 70.054
C8Bcomplement component 8, beta polypeptide0.053
CFBcomplement factor B0.053
DPTdermatopontin0.052
RARRES2retinoic acid receptor responder (tazarotene induced) 20.050
CPceruloplasmin (ferroxidase)0.047
CYTBcytochrome b0.047
KRT6Ckeratin 6C0.043
SPP2secreted phosphoprotein 2, 24kDa0.040
C2complement component 20.038
APOA1apolipoprotein A-I0.037
TATtyrosine aminotransferase0.036
SAA4serum amyloid A4, constitutive0.036
NNMTnicotinamide N-methyltransferase0.036
LRP1low density lipoprotein receptor-related protein 10.035
CFHR2complement factor H-related 20.035
HPXhemopexin0.035
KRT2keratin 20.034
C6complement component 60.034
CTSBcathepsin B0.033
HABP2hyaluronan binding protein 20.033
CXCL12chemokine (C-X-C motif) ligand 120.032
KRT9keratin 90.032
C10orf10chromosome 10 open reading frame 100.031
CYP4A11cytochrome P450, family 4, subfamily A, polypeptide 110.030
PPP2R2Bprotein phosphatase 2, regulatory subunit B, beta0.030
CPN1carboxypeptidase N, polypeptide 10.030
C4BPBcomplement component 4 binding protein, beta0.028
PTGDSprostaglandin D2 synthase 21kDa (brain)0.028
MBL2mannose-binding lectin (protein C) 2, soluble0.027
SERPINF2serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 20.027
FETUBfetuin B0.027
VTNvitronectin0.026
CD164CD164 molecule, sialomucin0.026
GLYATglycine-N-acyltransferase0.026
EMILIN1elastin microfibril interfacer 10.026
IGF1insulin-like growth factor 1 (somatomedin C)0.025
CLUclusterin0.024
TRIM29tripartite motif containing 290.023
ITIH1inter-alpha (globulin) inhibitor H10.023
RDH16retinol dehydrogenase 16 (all-trans)0.023
EMP1epithelial membrane protein 10.023
PHYHphytanoyl-CoA 2-hydroxylase0.022
KRT4keratin 40.022
CCL16chemokine (C-C motif) ligand 160.021
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
zgc:103710zgc:1037100.769
c3bcomplement component c3b0.757
cfbcomplement factor B0.507
si:dkey-76b14.4si:dkey-76b14.40.490
cfhl4complement factor H like 40.329
foxi3aforkhead box I3a0.221
ucp1uncoupling protein 10.179
apomapolipoprotein M0.153
LOC100149056pannexin-3-like0.147
fgbfibrinogen, B beta polypeptide0.126
calcrcalcitonin receptor0.126
bhmtbetaine-homocysteine methyltransferase0.121
cps1carbamoyl-phosphate synthase 1, mitochondrial0.113
LOC566708FL cytokine receptor-like0.110
nr1h5nuclear receptor subfamily 1, group H, member 50.107
c1qccomplement component 1, q subcomponent, C chain0.102
f5coagulation factor V0.101
cpceruloplasmin0.091
vtnbvitronectin b0.079
plgplasminogen0.072
slc4a4bsolute carrier family 4, sodium bicarbonate cotransporter, member 4b0.071
apoeaapolipoprotein Ea0.065
ambplalpha-1-microglobulin/bikunin precursor, like0.065
ca15acarbonic anhydrase XV a0.064
rbp4retinol binding protein 4, plasma0.061
rhcgl1Rhesus blood group, C glycoprotein, like 10.057
grn1granulin 10.056
fn1bfibronectin 1b0.052
tagln2transgelin 20.049
sat1aspermidine/spermine N1-acetyltransferase 1a0.049
LOC100330224fatty acid binding protein 1b-like0.049
s1pr3sphingosine-1-phosphate receptor 30.046
f7coagulation factor VII0.046
vdrbvitamin D receptor b0.043
pcsk9proprotein convertase subtilisin/kexin type 90.043
itih2inter-alpha (globulin) inhibitor H20.042
zgc:112992zgc:1129920.040
itgb1aintegrin, beta 1a0.039
c1qbcomplement component 1, q subcomponent, B chain0.038
zgc:194131zgc:1941310.038
c1qacomplement component 1, q subcomponent, A chain0.037
pcsk5bproprotein convertase subtilisin/kexin type 5b0.036
ahsgalpha-2-HS-glycoprotein0.036
sfrp1bsecreted frizzled-related protein 1b0.036
mep1a.1meprin A, alpha.10.035
apobapolipoprotein B0.035
psmb9aproteasome (prosome, macropain) subunit, beta type, 9a0.034
LOC560602novel protein similar to vertebrate solute carrier family 2 (facilitated glucose transporter), member 6 (SLC2A6)0.034
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.034
sepp1bselenoprotein P, plasma, 1b0.033
grnagranulin a0.033
ghrbgrowth hormone receptor b0.033
adipor2adiponectin receptor 20.032
frem1aFras1 related extracellular matrix 1a0.032
ghragrowth hormone receptor a0.032
cldniclaudin i0.031
cd209CD209 molecule0.030
cd40CD40 antigen0.030
si:ch211-140f21.1si:ch211-140f21.10.030
pth1aparathyroid hormone 1a0.029
LOC794635complement C4-like0.029
pplperiplakin0.028
rhcgbRhesus blood group, C glycoprotein b0.027
hoxa1ahomeo box A1a0.027
insrbinsulin receptor b0.027
crfb7cytokine receptor family member b70.026
krt8keratin 80.025
angptl3angiopoietin-like 30.024
plod1aprocollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1a0.024
pcsk2proprotein convertase subtilisin/kexin type 20.024
zgc:92061zgc:920610.024
wnt10awingless-type MMTV integration site family, member 10a0.023
dysfdysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)0.023
slc2a13solute carrier family 2 (facilitated glucose transporter), member 130.022
rhagRhesus blood group-associated glycoprotein0.021
gcm2glial cells missing homolog 2 (Drosophila)0.021
c9complement component 90.020
slc12a10.1solute carrier family 12 (sodium/potassium/chloride transporters), member 10.10.020
mxamyxovirus (influenza) resistance A0.020
nkd1naked cuticle homolog 1 (Drosophila)0.020
sdprbserum deprivation response b0.019
si:dkey-21e7.2si:dkey-21e7.20.019
fgafibrinogen alpha chain0.019
LOC567384interferon-induced protein with tetratricopeptide repeats 5-like0.019
wu:fi14a03wu:fi14a030.019
tlr21toll-like receptor 210.018
fasFas (TNF receptor superfamily, member 6)0.018
asphaspartate beta-hydroxylase0.018
cecr1bcat eye syndrome chromosome region, candidate 1b0.018
crfb13cytokine receptor family member b130.017
LOC100149559complement C1q-like protein 4-like0.017
si:ch211-215l11.5si:ch211-215l11.50.017
slc12a10.2solute carrier family 12 (sodium/potassium/chloride transporters), member 10.20.017
calcrlacalcitonin receptor-like a0.017
LOC100005283Gig2-like protein DreE0.017
zgc:174888zgc:1748880.016
slc4a11solute carrier family 4, sodium borate transporter, member 110.016
chsy1chondroitin sulfate synthase 10.015
krt18keratin 180.015
mst1macrophage stimulating 1 (hepatocyte growth factor-like)0.015
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
C1qccomplement component 1, q subcomponent, C chain0.998
Klk1b5kallikrein 1-related peptidase b50.996
C1racomplement component 1, r subcomponent A0.991
Klk1b26kallikrein 1-related petidase b260.981
C1qacomplement component 1, q subcomponent, alpha polypeptide0.979
Klk1b8kallikrein 1-related peptidase b80.977
Klk1b1kallikrein 1-related peptidase b10.973
Klk1kallikrein 10.964
Folr2folate receptor 2 (fetal)0.930
Klk1b11kallikrein 1-related peptidase b110.923
Fgafibrinogen alpha chain0.907
Itih4inter alpha-trypsin inhibitor, heavy chain 40.895
Klk1b21kallikrein 1-related peptidase b210.890
Klk1b4kallikrein 1-related pepidase b40.871
C3complement component 30.860
C4bcomplement component 4B (Childo blood group)0.828
Cd59aCD59a antigen0.817
C1qbcomplement component 1, q subcomponent, beta polypeptide0.810
Cfhcomplement component factor h0.803
Kng1kininogen 10.793
Aif1allograft inflammatory factor 10.786
Klk1b27kallikrein 1-related peptidase b270.762
Klk1b3kallikrein 1-related peptidase b30.754
Klk1b9kallikrein 1-related peptidase b90.736
Apoeapolipoprotein E0.727
C2complement component 2 (within H-2S)0.717
Fggfibrinogen gamma chain0.713
Cd59bCD59b antigen0.676
C1rbcomplement component 1, r subcomponent B0.673
C1scomplement component 1, s subcomponent0.608
Klk1b16kallikrein 1-related peptidase b160.607
Klk1b24kallikrein 1-related peptidase b240.585
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.545
Serping1serine (or cysteine) peptidase inhibitor, clade G, member 10.479
F9coagulation factor IX0.477
Hrghistidine-rich glycoprotein0.431
Tmem176atransmembrane protein 176A0.402
Rarres2retinoic acid receptor responder (tazarotene induced) 20.397
Cpceruloplasmin0.377
Mrc1mannose receptor, C type 10.371
Serpina10serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 100.361
Egfbp2epidermal growth factor binding protein type B0.341
Saa4serum amyloid A 40.327
Cd19CD19 antigen0.325
Ifitm3interferon induced transmembrane protein 30.311
TyrobpTYRO protein tyrosine kinase binding protein0.301
1300017J02RikRIKEN cDNA 1300017J02 gene0.286
H2-Aahistocompatibility 2, class II antigen A, alpha0.281
Mug1murinoglobulin 10.279
Tmem176btransmembrane protein 176B0.276
Mup3major urinary protein 30.275
Ighimmunoglobulin heavy chain complex0.254
Cd5lCD5 antigen-like0.253
Pzppregnancy zone protein0.244
Hgdhomogentisate 1, 2-dioxygenase0.243
Cyp2c70cytochrome P450, family 2, subfamily c, polypeptide 700.238
Cyp2d10cytochrome P450, family 2, subfamily d, polypeptide 100.216
Agxtalanine-glyoxylate aminotransferase0.212
Emr1EGF-like module containing, mucin-like, hormone receptor-like sequence 10.210
Apcsserum amyloid P-component0.204
Serpina12serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 120.195
Otcornithine transcarbamylase0.195
Hchemolytic complement0.174
Hsd3b7hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 70.165
Nnmtnicotinamide N-methyltransferase0.148
F13bcoagulation factor XIII, beta subunit0.132
Ahsgalpha-2-HS-glycoprotein0.129
Col14a1collagen, type XIV, alpha 10.126
Cd74CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)0.126
Akr1c6aldo-keto reductase family 1, member C60.121
Adh4alcohol dehydrogenase 4 (class II), pi polypeptide0.121
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.120
Ces1ccarboxylesterase 1C0.119
Smr3asubmaxillary gland androgen regulated protein 3A0.112
Timd2T-cell immunoglobulin and mucin domain containing 20.112
Apoc4apolipoprotein C-IV0.108
Orm2orosomucoid 20.106
Elnelastin0.102
Ccl6chemokine (C-C motif) ligand 60.099
Ambpalpha 1 microglobulin/bikunin0.099
C9complement component 90.092
Grngranulin0.090
Cyp8b1cytochrome P450, family 8, subfamily b, polypeptide 10.090
Dptdermatopontin0.090
Fcgr2bFc receptor, IgG, low affinity IIb0.089
Ctsqcathepsin Q0.089
Ctshcathepsin H0.088
Procprotein C0.083
Halhistidine ammonia lyase0.083
F7coagulation factor VII0.079
Mug2murinoglobulin 20.078
Ivlinvolucrin0.076
F12coagulation factor XII (Hageman factor)0.076
Cpn1carboxypeptidase N, polypeptide 10.075
Fcnaficolin A0.074
Ly86lymphocyte antigen 860.071
Mbl2mannose-binding lectin (protein C) 20.071
Cfbcomplement factor B0.069
Lipclipase, hepatic0.068
H2-Eb1histocompatibility 2, class II antigen E beta0.067
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cfbcomplement factor B0.822
C1scomplement component 1, s subcomponent0.770
Cpceruloplasmin0.490
Serping1serine (or cysteine) peptidase inhibitor, clade G, member 10.334
C1rcomplement component 1, r subcomponent0.235
C3complement component 30.184
Fggfibrinogen gamma chain0.184
Tftransferrin0.155
C1qacomplement component 1, q subcomponent, A chain0.087
C4bcomplement component 4B (Chido blood group)0.084
Lbplipopolysaccharide binding protein0.068
Serpina10serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 100.066
C4bpbcomplement component 4 binding protein, beta0.059
C2complement component 20.049
Cficomplement factor I0.047
A2malpha-2-macroglobulin0.034
Emr1EGF-like module containing, mucin-like, hormone receptor-like 10.031
Pzppregnancy-zone protein0.031
Rnase4ribonuclease, RNase A family 40.031
Fabp1fatty acid binding protein 1, liver0.031
Cd302CD302 molecule0.028
Tmem176btransmembrane protein 176B0.026
Cd48Cd48 molecule0.023
Icam1intercellular adhesion molecule 10.023
F13a1coagulation factor XIII, A1 polypeptide0.021
Testintestin gene0.021
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.020
LOC100363106LRRG00130-like0.016
Apohapolipoprotein H (beta-2-glycoprotein I)0.016
C8bcomplement component 8, beta polypeptide0.016
Efemp1EGF-containing fibulin-like extracellular matrix protein 10.016
Cpb2carboxypeptidase B2 (plasma)0.015
Serpinf2serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 20.015
Ctsl1cathepsin L10.015
Foxi2forkhead box I20.014
Abcb11ATP-binding cassette, subfamily B (MDR/TAP), member 110.014
C9complement component 90.014
LOC100360501ribonuclease inhibitor-like0.014
Kng1kininogen 10.014
Itih4inter alpha-trypsin inhibitor, heavy chain 40.014
Tcf21transcription factor 210.014
Inhbcinhibin beta C0.014
Mbl1mannose-binding lectin (protein A) 10.014
F10coagulation factor X0.013
Serpina1serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10.013
Ctsccathepsin C0.013
Fam115cfamily with sequence similarity 115, member C0.013
Alox5aparachidonate 5-lipoxygenase activating protein0.013
Ccl6chemokine (C-C motif) ligand 60.013
Lgals3bplectin, galactoside-binding, soluble, 3 binding protein0.012
Sec62SEC62 homolog (S. cerevisiae)0.012
Pgcpplasma glutamate carboxypeptidase0.012
Klk1lkallikrein 1-like peptidase0.012
F2coagulation factor II (thrombin)0.012
Kng2kininogen 20.011
Itih1inter-alpha trypsin inhibitor, heavy chain 10.011
Serpina11serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 110.011
Azgp1alpha-2-glycoprotein 1, zinc-binding0.011
Cfhcomplement factor H0.011
C6complement component 60.011
Mrc1mannose receptor, C type 10.010
Cd163CD163 molecule0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism