The network for 'biomineral tissue development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

biomineral tissue development

Formation of hard tissues that consist mainly of inorganic compounds, and also contain a small amounts of organic matrices that are believed to play important roles in their formation.

NameDescriptionProbabilityFunc Analog Organism
CCR5chemokine (C-C motif) receptor 50.999
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.985
COL1A1collagen, type I, alpha 10.968
TGFB1transforming growth factor, beta 10.947
COL6A1collagen, type VI, alpha 10.850
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.820
FSTL1follistatin-like 10.799
IL8interleukin 80.779
DCNdecorin0.739
COL3A1collagen, type III, alpha 10.713
CCL5chemokine (C-C motif) ligand 50.676
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.610
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.602
SMAD7SMAD family member 70.599
ENGendoglin0.592
TGFB3transforming growth factor, beta 30.583
CCL4chemokine (C-C motif) ligand 40.557
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.524
FGF1fibroblast growth factor 1 (acidic)0.515
FKBP1AFK506 binding protein 1A, 12kDa0.475
TJP1tight junction protein 1 (zona occludens 1)0.475
BMPR1Abone morphogenetic protein receptor, type IA0.470
IL6interleukin 6 (interferon, beta 2)0.413
CCL22chemokine (C-C motif) ligand 220.406
CXCL9chemokine (C-X-C motif) ligand 90.394
BMPR1Bbone morphogenetic protein receptor, type IB0.383
COL5A2collagen, type V, alpha 20.366
COL1A2collagen, type I, alpha 20.358
BMP2bone morphogenetic protein 20.334
LOXlysyl oxidase0.291
ELNelastin0.291
CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.278
CCR7chemokine (C-C motif) receptor 70.274
CXCL12chemokine (C-X-C motif) ligand 120.253
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.243
GDF5growth differentiation factor 50.235
HDAC4histone deacetylase 40.233
IFNGinterferon, gamma0.231
DPTdermatopontin0.222
SPARCsecreted protein, acidic, cysteine-rich (osteonectin)0.209
PVRL4poliovirus receptor-related 40.207
POSTNperiostin, osteoblast specific factor0.202
FGF10fibroblast growth factor 100.200
COL18A1collagen, type XVIII, alpha 10.177
COL6A2collagen, type VI, alpha 20.175
KDM2Blysine (K)-specific demethylase 2B0.173
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.172
COL5A1collagen, type V, alpha 10.165
CCL11chemokine (C-C motif) ligand 110.155
CCR4chemokine (C-C motif) receptor 40.155
NCOR2nuclear receptor corepressor 20.154
CCL13chemokine (C-C motif) ligand 130.147
PCGF1polycomb group ring finger 10.134
ARRDC3arrestin domain containing 30.134
CXCL13chemokine (C-X-C motif) ligand 130.134
MXRA5matrix-remodelling associated 50.134
IRF4interferon regulatory factor 40.129
CCL7chemokine (C-C motif) ligand 70.122
FGF21fibroblast growth factor 210.122
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.118
CCL20chemokine (C-C motif) ligand 200.118
WISP1WNT1 inducible signaling pathway protein 10.118
COL6A3collagen, type VI, alpha 30.115
PLXDC1plexin domain containing 10.115
GATA1GATA binding protein 1 (globin transcription factor 1)0.111
GATA2GATA binding protein 20.106
PRKAR1Aprotein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)0.106
VCANversican0.105
CCL3chemokine (C-C motif) ligand 30.103
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.100
COL2A1collagen, type II, alpha 10.099
PCOLCEprocollagen C-endopeptidase enhancer0.098
COL14A1collagen, type XIV, alpha 10.098
THBS2thrombospondin 20.097
SETD8SET domain containing (lysine methyltransferase) 80.089
ISLRimmunoglobulin superfamily containing leucine-rich repeat0.089
CCL19chemokine (C-C motif) ligand 190.088
IL10interleukin 100.088
EIF2C2eukaryotic translation initiation factor 2C, 20.087
MATKmegakaryocyte-associated tyrosine kinase0.086
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.085
TAL1T-cell acute lymphocytic leukemia 10.085
WFIKKN1WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 10.085
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.085
TM4SF1transmembrane 4 L six family member 10.084
CCL2chemokine (C-C motif) ligand 20.083
TGFBR1transforming growth factor, beta receptor 10.082
CCL18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)0.082
WNT2wingless-type MMTV integration site family member 20.082
ADAM12ADAM metallopeptidase domain 120.081
FOXF2forkhead box F20.080
PTGISprostaglandin I2 (prostacyclin) synthase0.079
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)0.079
OLFML3olfactomedin-like 30.079
LUMlumican0.078
MMP11matrix metallopeptidase 11 (stromelysin 3)0.076
DPP4dipeptidyl-peptidase 40.075
ADAMTS2ADAM metallopeptidase with thrombospondin type 1 motif, 20.074
FGF7fibroblast growth factor 70.074
IL2RBinterleukin 2 receptor, beta0.070
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
bmp2bbone morphogenetic protein 2b0.738
bmp4bone morphogenetic protein 40.469
col10a1collagen, type X, alpha 10.399
col5a1procollagen, type V, alpha 10.353
acvr2bactivin receptor IIb0.254
mmp15bmatrix metallopeptidase 15b0.209
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.142
spry4sprouty (Drosophila) homolog 40.112
prdm5PR domain containing 50.112
irf6interferon regulatory factor 60.105
col1a2collagen, type I, alpha 20.104
bmpr2abone morphogenetic protein receptor, type II a (serine/threonine kinase)0.092
trim71tripartite motif-containing 710.091
fn1fibronectin 10.080
rargbretinoic acid receptor, gamma b0.073
mecomMDS1 and EVI1 complex locus0.073
col5a2lcollagen, type V, alpha 2-like0.070
acvr2aactivin receptor IIa0.066
runx1runt-related transcription factor 10.065
bmp2abone morphogenetic protein 2a0.061
slc12a2solute carrier family 12 (potassium/chloride transporters), member 20.060
axin1axin 10.060
rxraaretinoid X receptor, alpha a0.055
robo3roundabout homolog 30.051
LOC100536439parathyroid hormone-related protein-like0.050
zgc:111821zgc:1118210.049
tjp1tight junction protein 1 (zona occludens 1)0.049
dlx4adistal-less homeobox gene 4a0.048
LOC100002342carboxypeptidase A6-like0.047
foxe1forkhead box E1 (thyroid transcription factor 2)0.046
unc5cunc-5 homolog C (C. elegans)0.043
cmybtranscription factor cmyb0.043
wnt5bwingless-type MMTV integration site family, member 5b0.037
bonbonnie and clyde0.037
sec31asec31 homolog A (S. cerevisiae)0.037
smoc2secreted modular calcium binding protein 20.037
wnt10awingless-type MMTV integration site family, member 10a0.037
ntlano tail a0.036
pkd2polycystic kidney disease 20.036
dicer1Dicer1, Dcr-1 homolog (Drosophila)0.036
gpr126G protein-coupled receptor 1260.035
tbx5aT-box 5a0.035
egr2bearly growth response 2b0.034
trpv6transient receptor potential cation channel, subfamily V, member 60.034
dlx5adistal-less homeobox gene 5a0.033
cdh2cadherin 2, neuronal0.033
mmp9matrix metalloproteinase 90.033
tnnt2atroponin T2a, cardiac0.032
mgpmatrix Gla protein0.032
mtpmicrosomal triglyceride transfer protein0.032
dusp6dual specificity phosphatase 60.032
chpfchondroitin polymerizing factor0.032
hoxa13bhomeo box A13b0.031
lratblecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)0.030
LOC556849ectonucleoside triphosphate diphosphohydrolase 5-like0.030
ptpraprotein tyrosine phosphatase, receptor type, A0.030
prmt1protein arginine methyltransferase 10.030
fgfr3fibroblast growth factor receptor 30.030
enpp1ectonucleotide pyrophosphatase/phosphodiesterase 10.029
disp1dispatched homolog 1 (Drosophila)0.029
zgc:77051zgc:770510.029
twist2twist20.029
col11a2collagen type XI alpha-20.028
tbx1T-box 10.028
msxdmuscle segment homeobox D0.027
hhexhematopoietically expressed homeobox0.027
surf4lsurfeit gene 4, like0.027
vcanbversican b0.027
tp63tumor protein p630.026
cxcl12achemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)0.026
smad7MAD, mothers against decapentaplegic homolog 7 (Drosophila)0.025
myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.025
xylt1xylosyltransferase 10.025
acvr1lactivin A receptor, type I like0.024
tuba8l3tubulin, alpha 8 like 30.024
fzd7afrizzled homolog 7a0.024
sox11bSRY-box containing gene 11b0.023
spns2spinster homolog 2 (Drosophila)0.023
foxi1forkhead box I10.023
raraaretinoic acid receptor, alpha a0.023
smurf2SMAD specific E3 ubiquitin protein ligase 20.023
ptprsaprotein tyrosine phosphatase, receptor type, s, a0.023
vmhcventricular myosin heavy chain0.022
jag1bjagged 1b0.022
nog3noggin 30.022
itga3bintegrin, alpha 3b0.022
mapk6mitogen-activated protein kinase 60.021
ntn2netrin 20.021
wnt11rwingless-type MMTV integration site family, member 11, related0.021
plod1aprocollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1a0.021
plod2procollagen-lysine, 2-oxoglutarate 5-dioxygenase 20.021
lats1LATS, large tumor suppressor, homolog 1 (Drosophila)0.021
smad9MAD homolog 9 (Drosophila)0.021
appbamyloid beta (A4) precursor protein b0.020
aqp1a.1aquaporin 1a, tandem duplicate 10.020
bcl2B-cell leukemia/lymphoma 20.019
tmem2transmembrane protein 20.019
fgf20afibroblast growth factor 20a0.019
gata5GATA-binding protein 50.019
ambplalpha-1-microglobulin/bikunin precursor, like0.018
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Fgf8fibroblast growth factor 80.965
Tbx3T-box 30.875
Bmp4bone morphogenetic protein 40.853
Tgfbr2transforming growth factor, beta receptor II0.850
Dlx5distal-less homeobox 50.845
Nodalnodal0.840
Col1a1collagen, type I, alpha 10.829
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.823
Prrx2paired related homeobox 20.815
Pax8paired box gene 80.788
Pthlhparathyroid hormone-like peptide0.779
Bcl2B-cell leukemia/lymphoma 20.758
Gdf3growth differentiation factor 30.735
Smosmoothened homolog (Drosophila)0.725
Runx2runt related transcription factor 20.724
Scn5asodium channel, voltage-gated, type V, alpha0.720
Ror2receptor tyrosine kinase-like orphan receptor 20.700
Wt1Wilms tumor 1 homolog0.690
Nos3nitric oxide synthase 3, endothelial cell0.649
Pax2paired box gene 20.648
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.631
Hic1hypermethylated in cancer 10.620
Prrx1paired related homeobox 10.590
Amelxamelogenin X chromosome0.585
Fgfr2fibroblast growth factor receptor 20.581
Fgf10fibroblast growth factor 100.581
Hand1heart and neural crest derivatives expressed transcript 10.571
Gata6GATA binding protein 60.564
Gli2GLI-Kruppel family member GLI20.563
Fgf4fibroblast growth factor 40.545
Lhx6LIM homeobox protein 60.544
Nf1neurofibromatosis 10.532
Lumlumican0.529
Alx4aristaless-like homeobox 40.500
Smad6MAD homolog 6 (Drosophila)0.476
Leprleptin receptor0.450
Smad3MAD homolog 3 (Drosophila)0.449
Alx3aristaless-like homeobox 30.416
Gata4GATA binding protein 40.408
Hcn4hyperpolarization-activated, cyclic nucleotide-gated K+ 40.399
Fgfr1fibroblast growth factor receptor 10.385
Bgnbiglycan0.379
Retret proto-oncogene0.368
Gli1GLI-Kruppel family member GLI10.338
Mmp2matrix metallopeptidase 20.331
Wnt6wingless-related MMTV integration site 60.328
Apcadenomatosis polyposis coli0.323
Shhsonic hedgehog0.322
Tgfb2transforming growth factor, beta 20.320
Sox9SRY-box containing gene 90.319
Elnelastin0.313
Bmp5bone morphogenetic protein 50.305
Kcnq1potassium voltage-gated channel, subfamily Q, member 10.302
Fgfr3fibroblast growth factor receptor 30.298
Loxl1lysyl oxidase-like 10.290
Tgfb3transforming growth factor, beta 30.290
Lhx1LIM homeobox protein 10.288
Ltbp2latent transforming growth factor beta binding protein 20.268
Hoxa1homeobox A10.267
Fut1fucosyltransferase 10.256
Sall1sal-like 1 (Drosophila)0.252
Bdkrb2bradykinin receptor, beta 20.250
Smad7MAD homolog 7 (Drosophila)0.247
Hoxb1homeobox B10.245
Hoxd13homeobox D130.239
Sall4sal-like 4 (Drosophila)0.237
Lmx1aLIM homeobox transcription factor 1 alpha0.231
Tgfb1i1transforming growth factor beta 1 induced transcript 10.228
Tpothyroid peroxidase0.225
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.214
Aebp1AE binding protein 10.214
Bmp2bone morphogenetic protein 20.213
Il6stinterleukin 6 signal transducer0.211
Islrimmunoglobulin superfamily containing leucine-rich repeat0.207
Dkk1dickkopf homolog 1 (Xenopus laevis)0.206
Col1a2collagen, type I, alpha 20.202
Gpc3glypican 30.201
Pitx3paired-like homeodomain transcription factor 30.198
Esr1estrogen receptor 1 (alpha)0.197
Ddx60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.196
Fgf3fibroblast growth factor 30.195
Inhbainhibin beta-A0.194
Pou3f1POU domain, class 3, transcription factor 10.192
Foxf1aforkhead box F1a0.191
Hba-xhemoglobin X, alpha-like embryonic chain in Hba complex0.190
Tbx5T-box 50.188
Pax9paired box gene 90.187
NanogNanog homeobox0.187
Zic3zinc finger protein of the cerebellum 30.186
Foxh1forkhead box H10.185
Lepleptin0.185
Drd2dopamine receptor D20.184
Smad4MAD homolog 4 (Drosophila)0.184
Smad1MAD homolog 1 (Drosophila)0.182
Hand2heart and neural crest derivatives expressed transcript 20.181
Tbx2T-box 20.179
Ptenphosphatase and tensin homolog0.178
Thrbthyroid hormone receptor beta0.177
Msx1homeobox, msh-like 10.177
Fmodfibromodulin0.176
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Col5a1collagen, type V, alpha 10.075
LOC100364212heterogeneous nuclear ribonucleoprotein K-like0.026
Soat1sterol O-acyltransferase 10.022
Vcanversican0.022
Smad7SMAD family member 70.019
Alas2aminolevulinate, delta-, synthase 20.018
Fgfr1Fibroblast growth factor receptor 10.017
Pla2g4aphospholipase A2, group IVA (cytosolic, calcium-dependent)0.015
Fbn1fibrillin 10.015
Jak1Janus kinase 10.015
Loxlysyl oxidase0.014
Pspnpersephin0.013
Cd44Cd44 molecule0.013
Col3a1collagen, type III, alpha 10.013
Gna15guanine nucleotide binding protein, alpha 150.013
Aspnasporin0.012
Slc13a3solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 30.012
Serpine2serine (or cysteine) peptidase inhibitor, clade E, member 20.011
Jak2Janus kinase 20.011
Lig3ligase III, DNA, ATP-dependent0.011
Ptpn14protein tyrosine phosphatase, non-receptor type 140.011
Dlg3discs, large homolog 3 (Drosophila)0.010
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.010
Cyp1b1cytochrome P450, family 1, subfamily b, polypeptide 10.010
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism