The network for 'regulation of cytokine secretion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of cytokine secretion

Any process that modulates the frequency, rate or extent of the regulated release of cytokines from a cell.

NameDescriptionProbabilityFunc Analog Organism
TAL1T-cell acute lymphocytic leukemia 10.920
BTN3A3butyrophilin, subfamily 3, member A30.787
TRAF1TNF receptor-associated factor 10.784
NLRC4NLR family, CARD domain containing 40.781
APOEapolipoprotein E0.741
BTN3A1butyrophilin, subfamily 3, member A10.717
CD80CD80 molecule0.710
BTN3A2butyrophilin, subfamily 3, member A20.708
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.643
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.642
PILRApaired immunoglobin-like type 2 receptor alpha0.538
IL10RAinterleukin 10 receptor, alpha0.487
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.462
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.447
FGAfibrinogen alpha chain0.424
CRPC-reactive protein, pentraxin-related0.419
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.409
LILRB3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 30.393
CCR1chemokine (C-C motif) receptor 10.391
HLA-Gmajor histocompatibility complex, class I, G0.383
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.360
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.349
CTLA4cytotoxic T-lymphocyte-associated protein 40.348
AXLAXL receptor tyrosine kinase0.318
FCN2ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)0.271
IL1Binterleukin 1, beta0.270
CCL4chemokine (C-C motif) ligand 40.264
LATlinker for activation of T cells0.258
HCKhemopoietic cell kinase0.255
S100A10S100 calcium binding protein A100.247
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.239
PTPN6protein tyrosine phosphatase, non-receptor type 60.232
CDH5cadherin 5, type 2 (vascular endothelium)0.232
IL1R1interleukin 1 receptor, type I0.230
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.218
CAV1caveolin 1, caveolae protein, 22kDa0.218
CD86CD86 molecule0.208
ANXA1annexin A10.202
NLRP3NLR family, pyrin domain containing 30.192
TRIM39tripartite motif containing 390.186
STAT6signal transducer and activator of transcription 6, interleukin-4 induced0.182
SIGLEC7sialic acid binding Ig-like lectin 70.179
LILRA2leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 20.178
HLA-DQA1major histocompatibility complex, class II, DQ alpha 10.173
SP100SP100 nuclear antigen0.173
KLRD1killer cell lectin-like receptor subfamily D, member 10.172
PTPRBprotein tyrosine phosphatase, receptor type, B0.169
ITGB5integrin, beta 50.166
RUNX1runt-related transcription factor 10.155
SHC2SHC (Src homology 2 domain containing) transforming protein 20.155
LCATlecithin-cholesterol acyltransferase0.152
SLC11A1solute carrier family 11 (proton-coupled divalent metal ion transporters), member 10.152
ANXA4annexin A40.151
IRF8interferon regulatory factor 80.149
IL10interleukin 100.148
PECAM1platelet/endothelial cell adhesion molecule0.145
SETD8SET domain containing (lysine methyltransferase) 80.143
FCN1ficolin (collagen/fibrinogen domain containing) 10.142
TLR2toll-like receptor 20.140
ZNF263zinc finger protein 2630.134
SHC1SHC (Src homology 2 domain containing) transforming protein 10.133
FCARFc fragment of IgA, receptor for0.129
TREM1triggering receptor expressed on myeloid cells 10.128
SMN1survival of motor neuron 1, telomeric0.127
GZMBgranzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)0.126
IL1R2interleukin 1 receptor, type II0.126
MS4A6Amembrane-spanning 4-domains, subfamily A, member 6A0.125
BTN2A2butyrophilin, subfamily 2, member A20.125
S100A12S100 calcium binding protein A120.125
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.123
CD48CD48 molecule0.122
KLRK1killer cell lectin-like receptor subfamily K, member 10.121
ANGPT2angiopoietin 20.120
CYBBcytochrome b-245, beta polypeptide0.119
MEFVMediterranean fever0.118
TRIM22tripartite motif containing 220.115
S100A9S100 calcium binding protein A90.114
S100A8S100 calcium binding protein A80.112
CD163CD163 molecule0.112
CCR2chemokine (C-C motif) receptor 20.111
IL22RA1interleukin 22 receptor, alpha 10.109
FZD1frizzled homolog 1 (Drosophila)0.108
COTL1coactosin-like 1 (Dictyostelium)0.105
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.103
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.103
HLA-DRB4major histocompatibility complex, class II, DR beta 40.103
CUL2cullin 20.101
IL18RAPinterleukin 18 receptor accessory protein0.099
FPR1formyl peptide receptor 10.099
CSF2RBcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.097
PSTPIP1proline-serine-threonine phosphatase interacting protein 10.096
C19orf50chromosome 19 open reading frame 500.096
CFIcomplement factor I0.095
IFNGinterferon, gamma0.091
PYDC2pyrin domain containing 20.091
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.090
TRAF5TNF receptor-associated factor 50.088
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Pax8paired box gene 80.989
Tnftumor necrosis factor0.939
Casp4caspase 4, apoptosis-related cysteine peptidase0.896
Gpr33G protein-coupled receptor 330.895
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.892
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.813
Leprleptin receptor0.778
Il1binterleukin 1 beta0.776
Ltalymphotoxin A0.748
Csf2rb2colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)0.701
Aireautoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)0.691
Cd40CD40 antigen0.688
Tlr4toll-like receptor 40.688
Il10rainterleukin 10 receptor, alpha0.672
Agtr1aangiotensin II receptor, type 1a0.669
Ccr6chemokine (C-C motif) receptor 60.663
Ccl2chemokine (C-C motif) ligand 20.641
Klrb1bkiller cell lectin-like receptor subfamily B member 1B0.641
Pdcd1programmed cell death 10.633
Ren1renin 1 structural0.627
Cd160CD160 antigen0.607
Pax2paired box gene 20.581
Il1rninterleukin 1 receptor antagonist0.580
Clec4dC-type lectin domain family 4, member d0.568
Csf2colony stimulating factor 2 (granulocyte-macrophage)0.552
Cd44CD44 antigen0.540
Cd80CD80 antigen0.534
Icosinducible T-cell co-stimulator0.526
Ncr1natural cytotoxicity triggering receptor 10.511
Il2rbinterleukin 2 receptor, beta chain0.492
Nos2nitric oxide synthase 2, inducible0.491
Ccl8chemokine (C-C motif) ligand 80.489
Sh2d2aSH2 domain protein 2A0.478
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.455
BlkB lymphoid kinase0.442
Grap2GRB2-related adaptor protein 20.440
Ctswcathepsin W0.435
Csf1colony stimulating factor 1 (macrophage)0.416
Tnfsf11tumor necrosis factor (ligand) superfamily, member 110.408
Sfrp4secreted frizzled-related protein 40.407
Klrg1killer cell lectin-like receptor subfamily G, member 10.407
Siglec1sialic acid binding Ig-like lectin 1, sialoadhesin0.392
Map3k14mitogen-activated protein kinase kinase kinase 140.391
Selpselectin, platelet0.387
Itgaxintegrin alpha X0.387
Batf3basic leucine zipper transcription factor, ATF-like 30.377
Irf1interferon regulatory factor 10.376
Clec4eC-type lectin domain family 4, member e0.375
Cd209bCD209b antigen0.374
FaslFas ligand (TNF superfamily, member 6)0.373
Il18rapinterleukin 18 receptor accessory protein0.372
Socs1suppressor of cytokine signaling 10.362
Il1r1interleukin 1 receptor, type I0.361
Slc11a1solute carrier family 11 (proton-coupled divalent metal ion transporters), member 10.357
Dkk1dickkopf homolog 1 (Xenopus laevis)0.351
Adrb1adrenergic receptor, beta 10.350
Cxcr5chemokine (C-X-C motif) receptor 50.343
Tgfbr2transforming growth factor, beta receptor II0.336
Cxcl2chemokine (C-X-C motif) ligand 20.334
MefvMediterranean fever0.331
Pdcd1lg2programmed cell death 1 ligand 20.314
Xcl1chemokine (C motif) ligand 10.304
Cd8aCD8 antigen, alpha chain0.299
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.298
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.298
Cd86CD86 antigen0.297
Gpr132G protein-coupled receptor 1320.296
Ggt5gamma-glutamyltransferase 50.292
Ghrhrgrowth hormone releasing hormone receptor0.287
Ccl22chemokine (C-C motif) ligand 220.272
Cd4CD4 antigen0.271
Cybbcytochrome b-245, beta polypeptide0.269
Tnfsf14tumor necrosis factor (ligand) superfamily, member 140.267
Ccl6chemokine (C-C motif) ligand 60.267
Casp1caspase 10.265
Ptgirprostaglandin I receptor (IP)0.264
ItkIL2-inducible T-cell kinase0.259
Gzmbgranzyme B0.256
Tbx21T-box 210.254
Tnfsf8tumor necrosis factor (ligand) superfamily, member 80.253
ND6NADH dehydrogenase subunit 60.250
Drd2dopamine receptor D20.248
Clec7aC-type lectin domain family 7, member a0.245
Dok1docking protein 10.241
Apoeapolipoprotein E0.239
Batfbasic leucine zipper transcription factor, ATF-like0.233
Ccl3chemokine (C-C motif) ligand 30.233
Mmp12matrix metallopeptidase 120.231
Il27rainterleukin 27 receptor, alpha0.223
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.222
Pcdh12protocadherin 120.221
Gab2growth factor receptor bound protein 2-associated protein 20.217
Slpisecretory leukocyte peptidase inhibitor0.205
Ubdubiquitin D0.204
Ltblymphotoxin B0.203
Birc3baculoviral IAP repeat-containing 30.202
Cd28CD28 antigen0.201
Atp4bATPase, H+/K+ exchanging, beta polypeptide0.201
Il1rl1interleukin 1 receptor-like 10.198
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Il1binterleukin 1 beta0.135
Ceacam10carcinoembryonic antigen-related cell adhesion molecule 100.110
Tlr4toll-like receptor 40.093
Cybbcytochrome b-245, beta polypeptide0.083
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.073
Sirpasignal-regulatory protein alpha0.065
Cd80Cd80 molecule0.063
Arl11ADP-ribosylation factor-like 110.061
Mca32mast cell antigen 320.060
Il6interleukin 60.057
Pla2g4aphospholipase A2, group IVA (cytosolic, calcium-dependent)0.054
Il1ainterleukin 1 alpha0.046
Ctsccathepsin C0.046
Bdkrb2bradykinin receptor B20.044
Il2rbinterleukin 2 receptor, beta0.039
Mmp12matrix metallopeptidase 120.036
Plauplasminogen activator, urokinase0.035
Ptprcprotein tyrosine phosphatase, receptor type, C0.034
Itpr2inositol 1,4,5-triphosphate receptor, type 20.032
Jak2Janus kinase 20.029
Nat1N-acetyltransferase 10.027
Casp1caspase 10.025
Ptpn18protein tyrosine phosphatase, non-receptor type 180.025
Ptger2prostaglandin E receptor 2 (subtype EP2)0.024
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.024
Ltbp2latent transforming growth factor beta binding protein 20.022
Cd44Cd44 molecule0.022
Ccl3chemokine (C-C motif) ligand 30.020
Ednraendothelin receptor type A0.019
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.019
Lilrb3lleukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3-like0.019
Cxcr3chemokine (C-X-C motif) receptor 30.019
Gja4gap junction protein, alpha 40.018
Fosl1fos-like antigen 10.018
Prl8a9prolactin family 8, subfamily a, member 90.018
Selpselectin P0.018
Cpa3carboxypeptidase A3, mast cell0.017
Cskc-src tyrosine kinase0.016
Tnftumor necrosis factor (TNF superfamily, member 2)0.016
Ccl22chemokine (C-C motif) ligand 220.016
S1pr2sphingosine-1-phosphate receptor 20.016
Mcpt1mast cell protease 10.016
Ccr2chemokine (C-C motif) receptor 20.016
Fcnbficolin B0.015
Pax8paired box 80.015
LOC100364854similar to RIKEN cDNA A430107P09 gene-like0.015
Lst1leukocyte specific transcript 10.015
Akr1c14aldo-keto reductase family 1, member C140.015
Nraddneurotrophin receptor associated death domain0.015
Mov10Moloney leukemia virus 100.014
B4galt1UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 10.014
Hcls1hematopoietic cell specific Lyn substrate 10.014
Crotcarnitine O-octanoyltransferase0.014
Slc34a1solute carrier family 34 (sodium phosphate), member 10.014
Cd14CD14 molecule0.014
Klrc2killer cell lectin-like receptor subfamily C, member 20.014
Socs3suppressor of cytokine signaling 30.014
Mmp8matrix metallopeptidase 80.013
Cd8aCD8a molecule0.013
Serpini2serine (or cysteine) peptidase inhibitor, clade I, member 20.013
Inpp5dinositol polyphosphate-5-phosphatase D0.013
Oprk1opioid receptor, kappa 10.013
Ctsqcathepsin Q0.013
Il8rbinterleukin 8 receptor, beta0.013
Ifnginterferon gamma0.013
Il2rginterleukin 2 receptor, gamma0.012
Enpp3ectonucleotide pyrophosphatase/phosphodiesterase 30.012
Cxcl2chemokine (C-X-C motif) ligand 20.012
C1qtnf6C1q and tumor necrosis factor related protein 60.012
Cd86CD86 molecule0.012
C5ar1complement component 5a receptor 10.012
Ptger4prostaglandin E receptor 4 (subtype EP4)0.012
Lpllipoprotein lipase0.012
Anpepalanyl (membrane) aminopeptidase0.012
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.012
Havcr1hepatitis A virus cellular receptor 10.012
Tbxas1thromboxane A synthase 1, platelet0.011
Cd79bCd79b molecule, immunoglobulin-associated beta0.011
Cd38CD38 molecule0.011
Ccl5chemokine (C-C motif) ligand 50.011
Accn5amiloride-sensitive cation channel 5, intestinal0.011
Rag1recombination activating gene 10.011
Adam17ADAM metallopeptidase domain 170.011
Col15a1collagen, type XV, alpha 10.011
Olfml2bolfactomedin-like 2B0.011
Cma1chymase 1, mast cell0.011
Pik3cdphosphoinositide-3-kinase, catalytic, delta polypeptide0.011
Olr1500olfactory receptor 15000.011
Map3k8mitogen-activated protein kinase kinase kinase 80.010
Ugt1a6UDP glucuronosyltransferase 1 family, polypeptide A60.010
Dsppdentin sialophosphoprotein0.010
Psgb1pregnancy-specific beta 1-glycoprotein0.010
Gja5gap junction protein, alpha 50.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism