The network for 'elastic fiber assembly' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

elastic fiber assembly

Assembly of the extracellular matrix fibers that enables the matrix to recoil after transient stretching.

NameDescriptionProbabilityFunc Analog Organism
TEKTEK tyrosine kinase, endothelial1.000
FBN1fibrillin 10.996
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.963
FN1fibronectin 10.871
FLNAfilamin A, alpha0.855
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.852
CTGFconnective tissue growth factor0.797
FGAfibrinogen alpha chain0.757
LOXL1lysyl oxidase-like 10.744
FBLN1fibulin 10.628
PDZD11PDZ domain containing 110.622
MYL9myosin, light chain 9, regulatory0.616
LTBP2latent transforming growth factor beta binding protein 20.373
COL1A2collagen, type I, alpha 20.281
EFEMP2EGF containing fibulin-like extracellular matrix protein 20.273
FLNBfilamin B, beta0.253
MFAP4microfibrillar-associated protein 40.238
FGGfibrinogen gamma chain0.209
GFI1Bgrowth factor independent 1B transcription repressor0.175
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.164
HSPG2heparan sulfate proteoglycan 20.153
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.153
LOXlysyl oxidase0.125
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.111
VCAM1vascular cell adhesion molecule 10.099
TLN1talin 10.085
GRB7growth factor receptor-bound protein 70.083
TRPM7transient receptor potential cation channel, subfamily M, member 70.082
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.081
ANGPT2angiopoietin 20.076
PDLIM5PDZ and LIM domain 50.072
CAP1CAP, adenylate cyclase-associated protein 1 (yeast)0.069
ACTA2actin, alpha 2, smooth muscle, aorta0.069
IGFBP3insulin-like growth factor binding protein 30.064
PRELPproline/arginine-rich end leucine-rich repeat protein0.064
SHC1SHC (Src homology 2 domain containing) transforming protein 10.062
FBLN2fibulin 20.062
ACTN1actinin, alpha 10.062
TRPM6transient receptor potential cation channel, subfamily M, member 60.061
LAMA2laminin, alpha 20.060
IQGAP1IQ motif containing GTPase activating protein 10.060
CALD1caldesmon 10.056
ILKintegrin-linked kinase0.055
ANGPT1angiopoietin 10.054
CXCL12chemokine (C-X-C motif) ligand 120.051
C3complement component 30.050
FBLN5fibulin 50.048
COL3A1collagen, type III, alpha 10.047
SDC2syndecan 20.046
AHNAKAHNAK nucleoprotein0.045
THBS1thrombospondin 10.045
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.044
ASCC2activating signal cointegrator 1 complex subunit 20.044
ZNF512Bzinc finger protein 512B0.044
ITGAVintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)0.043
IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon0.043
CNN2calponin 20.040
COL1A1collagen, type I, alpha 10.039
MYL6myosin, light chain 6, alkali, smooth muscle and non-muscle0.036
COL5A2collagen, type V, alpha 20.036
MYH10myosin, heavy chain 10, non-muscle0.035
CORO1Ccoronin, actin binding protein, 1C0.033
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.033
SPTBN1spectrin, beta, non-erythrocytic 10.032
MXRA8matrix-remodelling associated 80.027
CD34CD34 molecule0.027
ACTN4actinin, alpha 40.027
TPM4tropomyosin 40.026
IGFBP4insulin-like growth factor binding protein 40.026
CLDN5claudin 50.026
CLEC3BC-type lectin domain family 3, member B0.026
LASP1LIM and SH3 protein 10.025
TIE1tyrosine kinase with immunoglobulin-like and EGF-like domains 10.025
MYH11myosin, heavy chain 11, smooth muscle0.025
COL14A1collagen, type XIV, alpha 10.024
CD44CD44 molecule (Indian blood group)0.024
RBFOX2RNA binding protein, fox-1 homolog (C. elegans) 20.023
ACTC1actin, alpha, cardiac muscle 10.023
DDR2discoidin domain receptor tyrosine kinase 20.023
TUBB6tubulin, beta 60.023
ADH1Balcohol dehydrogenase 1B (class I), beta polypeptide0.022
TNCtenascin C0.022
APOA1apolipoprotein A-I0.022
TGFBItransforming growth factor, beta-induced, 68kDa0.022
CNN1calponin 1, basic, smooth muscle0.022
FYNFYN oncogene related to SRC, FGR, YES0.022
LRRC32leucine rich repeat containing 320.022
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Tgfbr2transforming growth factor, beta receptor II0.999
Fbn1fibrillin 10.995
Loxlysyl oxidase0.960
Igfbp6insulin-like growth factor binding protein 60.647
Mmp2matrix metallopeptidase 20.611
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.582
Agtr1aangiotensin II receptor, type 1a0.476
Ltbp2latent transforming growth factor beta binding protein 20.470
Tenc1tensin like C1 domain-containing phosphatase0.452
Tgfb1i1transforming growth factor beta 1 induced transcript 10.410
Sod3superoxide dismutase 3, extracellular0.405
Ldlrlow density lipoprotein receptor0.315
Fbln5fibulin 50.302
Cnn1calponin 10.242
Efemp2epidermal growth factor-containing fibulin-like extracellular matrix protein 20.238
Col6a1collagen, type VI, alpha 10.225
Loxl1lysyl oxidase-like 10.213
Aoc3amine oxidase, copper containing 30.211
Nbl1neuroblastoma, suppression of tumorigenicity 10.208
Figfc-fos induced growth factor0.207
Thbs2thrombospondin 20.203
Mrc2mannose receptor, C type 20.199
Sorbs3sorbin and SH3 domain containing 30.199
Col1a2collagen, type I, alpha 20.194
Aebp1AE binding protein 10.190
Col16a1collagen, type XVI, alpha 10.186
Slc39a4solute carrier family 39 (zinc transporter), member 40.182
Prelpproline arginine-rich end leucine-rich repeat0.165
Slc9a3r2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 20.149
Steap3STEAP family member 30.144
Lama2laminin, alpha 20.143
Col6a2collagen, type VI, alpha 20.137
Lamb2laminin, beta 20.134
Nid1nidogen 10.133
Svep1sushi, von Willebrand factor type A, EGF and pentraxin domain containing 10.130
Apoeapolipoprotein E0.129
Egfl7EGF-like domain 70.125
Acta2actin, alpha 2, smooth muscle, aorta0.113
Thbs3thrombospondin 30.098
Iduaiduronidase, alpha-L-0.087
Fbln2fibulin 20.082
Pcolceprocollagen C-endopeptidase enhancer protein0.080
Mcammelanoma cell adhesion molecule0.075
Mfap5microfibrillar associated protein 50.074
Sox13SRY-box containing gene 130.070
Acvrl1activin A receptor, type II-like 10.070
Slit3slit homolog 3 (Drosophila)0.068
Mrvi1MRV integration site 10.066
Col6a3collagen, type VI, alpha 30.064
Timp3tissue inhibitor of metalloproteinase 30.064
Dpep1dipeptidase 1 (renal)0.060
Ptrfpolymerase I and transcript release factor0.060
Ltbp4latent transforming growth factor beta binding protein 40.057
Notch3Notch gene homolog 3 (Drosophila)0.057
Chrm2cholinergic receptor, muscarinic 2, cardiac0.056
Nos3nitric oxide synthase 3, endothelial cell0.054
Htra3HtrA serine peptidase 30.054
Serpine1serine (or cysteine) peptidase inhibitor, clade E, member 10.049
Tgfbr1transforming growth factor, beta receptor I0.048
Cyr61cysteine rich protein 610.047
Ctgfconnective tissue growth factor0.046
Agtr2angiotensin II receptor, type 20.046
Cfdcomplement factor D (adipsin)0.043
Itgbl1integrin, beta-like 10.043
Cd248CD248 antigen, endosialin0.043
Pdlim3PDZ and LIM domain 30.043
Hspg2perlecan (heparan sulfate proteoglycan 2)0.042
Adamts2a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20.041
Mylkmyosin, light polypeptide kinase0.041
Sema3fsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F0.040
Ptgisprostaglandin I2 (prostacyclin) synthase0.040
Lamc2laminin, gamma 20.040
Ddr2discoidin domain receptor family, member 20.039
Col4a5collagen, type IV, alpha 50.039
Lama5laminin, alpha 50.039
Gas1growth arrest specific 10.037
Itgb4integrin beta 40.036
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.034
Atp7aATPase, Cu++ transporting, alpha polypeptide0.034
Smoc2SPARC related modular calcium binding 20.033
Upk3buroplakin 3B0.033
Mfap4microfibrillar-associated protein 40.033
Tnxbtenascin XB0.032
Trim47tripartite motif-containing 470.032
Myh11myosin, heavy polypeptide 11, smooth muscle0.031
Slc2a10solute carrier family 2 (facilitated glucose transporter), member 100.030
Srpx2sushi-repeat-containing protein, X-linked 20.030
Six5sine oculis-related homeobox 5 homolog (Drosophila)0.030
Lamb1laminin B10.028
Chpfchondroitin polymerizing factor0.028
Cav1caveolin 1, caveolae protein0.027
Col4a2collagen, type IV, alpha 20.027
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Actg2actin, gamma 2, smooth muscle, enteric0.317
Col5a2collagen, type V, alpha 20.298
Col1a2collagen, type I, alpha 20.174
Tpm2tropomyosin 2, beta0.158
Fbn1fibrillin 10.111
Postnperiostin, osteoblast specific factor0.058
Col3a1collagen, type III, alpha 10.058
Rcn3reticulocalbin 3, EF-hand calcium binding domain0.056
Acta2smooth muscle alpha-actin0.055
Rhojras homolog gene family, member J0.050
Col5a1collagen, type V, alpha 10.049
Fn1fibronectin 10.045
Flnafilamin A, alpha0.034
Plod2procollagen lysine, 2-oxoglutarate 5-dioxygenase 20.025
Cnn1calponin 1, basic, smooth muscle0.024
Aebp1AE binding protein 10.023
Efemp2EGF-containing fibulin-like extracellular matrix protein 20.022
Myl9myosin, light chain 9, regulatory0.021
Fkbp10FK506 binding protein 100.016
Pcolceprocollagen C-endopeptidase enhancer0.016
Ptgisprostaglandin I2 (prostacyclin) synthase0.016
Lamc1laminin, gamma 10.013
Col1a1collagen, type I, alpha 10.012
Ctskcathepsin K0.012
Bocbiregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein0.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism