The network for 'cell junction assembly' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cell junction assembly

A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction.

NameDescriptionProbabilityFunc Analog Organism
CDC42cell division cycle 42 (GTP binding protein, 25kDa)1.000
EGFRepidermal growth factor receptor0.998
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.998
FYNFYN oncogene related to SRC, FGR, YES0.996
TJP1tight junction protein 1 (zona occludens 1)0.992
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.991
FLNAfilamin A, alpha0.989
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.989
SMURF2SMAD specific E3 ubiquitin protein ligase 20.977
SMAD2SMAD family member 20.975
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.953
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.947
ITGB4integrin, beta 40.943
PTPN13protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)0.939
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.893
VEGFAvascular endothelial growth factor A0.881
BCAR1breast cancer anti-estrogen resistance 10.855
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.854
PLCG1phospholipase C, gamma 10.837
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.802
APCadenomatous polyposis coli0.802
SORBS3sorbin and SH3 domain containing 30.793
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.782
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.776
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.717
CTNND1catenin (cadherin-associated protein), delta 10.712
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.708
SHC1SHC (Src homology 2 domain containing) transforming protein 10.698
SMAD1SMAD family member 10.694
FN1fibronectin 10.690
NRP1neuropilin 10.689
MDM2Mdm2 p53 binding protein homolog (mouse)0.667
HNRNPDheterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)0.653
SMAD7SMAD family member 70.648
ITGA3integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)0.642
RHOAras homolog gene family, member A0.619
NCF1neutrophil cytosolic factor 10.616
PAK2p21 protein (Cdc42/Rac)-activated kinase 20.592
FHL2four and a half LIM domains 20.586
CASKcalcium/calmodulin-dependent serine protein kinase (MAGUK family)0.581
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.578
CD63CD63 molecule0.564
S100A8S100 calcium binding protein A80.549
JUPjunction plakoglobin0.535
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.534
TJP2tight junction protein 2 (zona occludens 2)0.501
PTK2PTK2 protein tyrosine kinase 20.501
S100A6S100 calcium binding protein A60.483
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.473
PDIA3protein disulfide isomerase family A, member 30.446
CDH5cadherin 5, type 2 (vascular endothelium)0.444
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.438
S100A9S100 calcium binding protein A90.401
HNRNPH3heterogeneous nuclear ribonucleoprotein H3 (2H9)0.396
EPHA2EPH receptor A20.392
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.387
KRT8keratin 80.377
ADAM17ADAM metallopeptidase domain 170.371
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.363
STRN3striatin, calmodulin binding protein 30.351
HNRNPKheterogeneous nuclear ribonucleoprotein K0.350
EPS8epidermal growth factor receptor pathway substrate 80.337
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.333
SMAD3SMAD family member 30.332
PSEN1presenilin 10.312
FLNBfilamin B, beta0.312
QKIquaking homolog, KH domain RNA binding (mouse)0.293
PKP4plakophilin 40.291
NCK1NCK adaptor protein 10.287
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.282
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.282
F11RF11 receptor0.278
S100A4S100 calcium binding protein A40.271
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.262
GNAI2guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 20.255
NCF2neutrophil cytosolic factor 20.246
GDAguanine deaminase0.241
ANGPT2angiopoietin 20.230
ERBB2IPerbb2 interacting protein0.225
PKP3plakophilin 30.223
DSG2desmoglein 20.217
ATXN1ataxin 10.214
YAP1Yes-associated protein 10.207
TRIM29tripartite motif containing 290.205
TRIP6thyroid hormone receptor interactor 60.202
BMP2bone morphogenetic protein 20.201
KRT14keratin 140.198
S100A2S100 calcium binding protein A20.196
LAD1ladinin 10.194
HNRNPH1heterogeneous nuclear ribonucleoprotein H1 (H)0.190
DDX5DEAD (Asp-Glu-Ala-Asp) box polypeptide 50.190
ITGA6integrin, alpha 60.178
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
kdrlkinase insert domain receptor like0.512
cdh1cadherin 1, epithelial0.135
jupjunction plakoglobin0.052
f11rF11 receptor0.049
llgl2lethal giant larvae homolog 2 (Drosophila)0.040
elavl1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.031
pard6gbpar-6 partitioning defective 6 homolog gamma B (C. elegans)0.024
osr1odd-skipped related 1 (Drosophila)0.021
lsrlipolysis stimulated lipoprotein receptor0.017
myf6myogenic factor 60.017
cldn7bclaudin 7b0.016
arrdc1aarrestin domain containing 1a0.016
vegfaavascular endothelial growth factor Aa0.015
cntn1acontactin 1a0.014
spint1aserine peptidase inhibitor, Kunitz type 1 a0.013
pak2ap21 (CDKN1A)-activated kinase 2a0.012
ptpraprotein tyrosine phosphatase, receptor type, A0.011
wlswntless homolog (Drosophila)0.011
itgb1aintegrin, beta 1a0.011
arhgef7bRho guanine nucleotide exchange factor (GEF) 7b0.011
cx43.4connexin 43.40.010
gna12guanine nucleotide binding protein (G protein) alpha 120.010
pdia3protein disulfide isomerase family A, member 30.010
prkciprotein kinase C, iota0.010
wt1bwilms tumor 1b0.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
McrMacroglobulin complement-related0.998
Nrx-IVNeurexin IV0.990
Rab11Rab-protein 110.900
Tsf2Transferrin 20.885
fz2frizzled 20.876
CG1298CG1298 gene product from transcript CG1298-RA0.792
nrv2nervana 20.755
frcfringe connection0.661
CG2813CG2813 gene product from transcript CG2813-RA0.550
Myo31DFMyosin 31DF0.535
CycECyclin E0.518
CG8121CG8121 gene product from transcript CG8121-RA0.424
Syx1ASyntaxin 1A0.378
AtpalphaNa pump alpha subunit0.376
rheaCG6831 gene product from transcript CG6831-RA0.372
X11LCG5675 gene product from transcript CG5675-RB0.328
CG17218CG17218 gene product from transcript CG17218-RA0.319
Rac1CG2248 gene product from transcript CG2248-RA0.304
Vap-33-1CG5014 gene product from transcript CG5014-RB0.286
fogfolded gastrulation0.276
Cdc42CG12530 gene product from transcript CG12530-RA0.264
LanB2Laminin B20.261
par-1CG8201 gene product from transcript CG8201-RA0.252
Traf4TNF-receptor-associated factor 40.238
RalaRas-related protein0.236
jebjelly belly0.220
elavembryonic lethal abnormal vision0.212
howheld out wings0.212
norpAno receptor potential A0.211
ogreoptic ganglion reduced0.206
SnooSno oncogene0.205
AceAcetylcholine esterase0.203
wbwing blister0.188
LanALaminin A0.185
AdarAdenosine deaminase acting on RNA0.184
Mes2CG11100 gene product from transcript CG11100-RB0.168
HopHsp70/Hsp90 organizing protein homolog0.161
ewgerect wing0.154
l(2)gllethal (2) giant larvae0.150
pdm2POU domain protein 20.143
Galpha49BG protein alpha49B0.133
Rho1CG8416 gene product from transcript CG8416-RB0.133
snostrawberry notch0.131
Gp93Glycoprotein 930.125
CycACyclin A0.123
aPKCatypical protein kinase C0.120
Atg1Autophagy-specific gene 10.118
sqhspaghetti squash0.116
SmoxSmad on X0.115
lunaCG33473 gene product from transcript CG33473-RB0.115
Ggamma1G protein gamma 10.114
Sema-1aCG18405 gene product from transcript CG18405-RD0.112
PatjCG12021 gene product from transcript CG12021-RC0.111
PvrPDGF- and VEGF-receptor related0.110
cindrCIN85 and CD2AP orthologue0.104
rawCG12437 gene product from transcript CG12437-RB0.102
TrhTryptophan hydroxylase0.102
CG4168CG4168 gene product from transcript CG4168-RA0.101
Src42ASrc oncogene at 42A0.101
14-3-3zetaCG17870 gene product from transcript CG17870-RB0.100
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ctnnb1catenin (cadherin associated protein), beta 10.992
Smad6MAD homolog 6 (Drosophila)0.982
Rac1RAS-related C3 botulinum substrate 10.944
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.943
Ptk2PTK2 protein tyrosine kinase 20.915
Dlg4discs, large homolog 4 (Drosophila)0.860
Col4a2collagen, type IV, alpha 20.787
Cdh5cadherin 50.758
Lamc1laminin, gamma 10.750
Tjp1tight junction protein 10.748
Cd151CD151 antigen0.732
Wwtr1WW domain containing transcription regulator 10.705
Appamyloid beta (A4) precursor protein0.589
Lhx1LIM homeobox protein 10.567
Itgb1integrin beta 1 (fibronectin receptor beta)0.535
Col4a1collagen, type IV, alpha 10.492
Fgfr1fibroblast growth factor receptor 10.475
Bcl2B-cell leukemia/lymphoma 20.442
Myadmmyeloid-associated differentiation marker0.434
Bcar1breast cancer anti-estrogen resistance 10.430
Nid1nidogen 10.410
Lama5laminin, alpha 50.401
Mef2dmyocyte enhancer factor 2D0.393
Cdc42cell division cycle 42 homolog (S. cerevisiae)0.383
Axin1axin 10.361
Tenc1tensin like C1 domain-containing phosphatase0.358
Tspan9tetraspanin 90.356
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.352
Fermt2fermitin family homolog 2 (Drosophila)0.313
Ncor2nuclear receptor co-repressor 20.304
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.300
Wnt3awingless-related MMTV integration site 3A0.295
Ephb4Eph receptor B40.282
Ctnnd1catenin (cadherin associated protein), delta 10.267
Hspg2perlecan (heparan sulfate proteoglycan 2)0.259
Fzd4frizzled homolog 4 (Drosophila)0.258
Pdgfbplatelet derived growth factor, B polypeptide0.257
Emp2epithelial membrane protein 20.255
Rock2Rho-associated coiled-coil containing protein kinase 20.248
Krt19keratin 190.245
Amotl2angiomotin-like 20.233
Pvrl2poliovirus receptor-related 20.231
Wnt4wingless-related MMTV integration site 40.229
Spnb2spectrin beta 20.228
Epas1endothelial PAS domain protein 10.224
Trp53transformation related protein 530.221
Cdh1cadherin 10.217
Cdc42ep1CDC42 effector protein (Rho GTPase binding) 10.217
Sstr4somatostatin receptor 40.211
Mta1metastasis associated 10.209
Jupjunction plakoglobin0.201
Nf2neurofibromatosis 20.197
Tnks1bp1tankyrase 1 binding protein 10.192
Dlg2discs, large homolog 2 (Drosophila)0.191
Gab1growth factor receptor bound protein 2-associated protein 10.186
Gsk3bglycogen synthase kinase 3 beta0.183
Tinagl1tubulointerstitial nephritis antigen-like 10.182
Itga5integrin alpha 5 (fibronectin receptor alpha)0.179
Kdrkinase insert domain protein receptor0.176
Apcadenomatosis polyposis coli0.173
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.172
Slc12a4solute carrier family 12, member 40.170
Fgfr4fibroblast growth factor receptor 40.167
Spna2spectrin alpha 20.165
Flt4FMS-like tyrosine kinase 40.160
Dlg1discs, large homolog 1 (Drosophila)0.158
Grb7growth factor receptor bound protein 70.158
BaxBCL2-associated X protein0.157
Itga6integrin alpha 60.155
Tjp2tight junction protein 20.154
Cnp2',3'-cyclic nucleotide 3' phosphodiesterase0.154
Efsembryonal Fyn-associated substrate0.151
Ptprbprotein tyrosine phosphatase, receptor type, B0.151
Tcf7l1transcription factor 7-like 1 (T-cell specific, HMG box)0.149
Dab1disabled homolog 1 (Drosophila)0.146
Rhbdf1rhomboid family 1 (Drosophila)0.145
Flnafilamin, alpha0.142
Metmet proto-oncogene0.142
Wwc2WW, C2 and coiled-coil domain containing 20.141
Cldn16claudin 160.140
Ctnna1catenin (cadherin associated protein), alpha 10.139
Irf6interferon regulatory factor 60.138
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.137
Dsg2desmoglein 20.136
Cltcclathrin, heavy polypeptide (Hc)0.130
Plxna1plexin A10.127
Notch3Notch gene homolog 3 (Drosophila)0.125
Ldb3LIM domain binding 30.122
Oca2oculocutaneous albinism II0.121
Cd2apCD2-associated protein0.120
Fam129bfamily with sequence similarity 129, member B0.120
Smad4MAD homolog 4 (Drosophila)0.119
Dag1dystroglycan 10.118
Tpm4tropomyosin 40.118
Sema3bsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B0.118
Wasf2WAS protein family, member 20.117
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.117
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Lamc1laminin, gamma 10.284
Acvr1activin A receptor, type I0.140
Myh9myosin, heavy chain 9, non-muscle0.090
Taok1TAO kinase 10.066
Anxa4annexin A40.064
Dchs1dachsous 1 (Drosophila)0.061
Anxa2annexin A20.054
Calcrlcalcitonin receptor-like0.051
Dag1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.045
Tpm3tropomyosin 3, gamma0.039
Sirpasignal-regulatory protein alpha0.037
Ptafrplatelet-activating factor receptor0.037
Il2rbinterleukin 2 receptor, beta0.034
Inpp5dinositol polyphosphate-5-phosphatase D0.032
Dock8dedicator of cytokinesis 80.032
S100a6S100 calcium binding protein A60.032
S100a4S100 calcium-binding protein A40.031
Kcna5potassium voltage-gated channel, shaker-related subfamily, member 50.028
Itgb1integrin, beta 10.028
Capn2calpain 20.028
Tgfbr3transforming growth factor, beta receptor III0.027
Galnt1UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)0.026
Lrrc33leucine rich repeat containing 330.026
Prkcaprotein kinase C, alpha0.025
Anxa5annexin A50.024
S100a11S100 calcium binding protein A11 (calizzarin)0.024
Pdlim5PDZ and LIM domain 50.024
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.024
Ube2g1ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)0.023
Fgfr1Fibroblast growth factor receptor 10.023
Magi2membrane associated guanylate kinase, WW and PDZ domain containing 20.023
Jak1Janus kinase 10.022
Scn3asodium channel, voltage-gated, type III, alpha0.022
Arih1ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1 (Drosophila)0.022
Emp1epithelial membrane protein 10.022
Smc4structural maintenance of chromosomes 40.022
Olr1271olfactory receptor 12710.022
Adam10ADAM metallopeptidase domain 100.022
Lgr4leucine-rich repeat-containing G protein-coupled receptor 40.021
FcgrtFc fragment of IgG, receptor, transporter, alpha0.021
Dgkidiacylglycerol kinase, iota0.021
Ccl5chemokine (C-C motif) ligand 50.021
Flnbfilamin, beta0.021
Myo1emyosin IE0.020
Cd8aCD8a molecule0.020
Cald1caldesmon 10.020
Csf1colony stimulating factor 1 (macrophage)0.020
Jak2Janus kinase 20.019
F11rF11 receptor0.019
Npm1nucleophosmin (nucleolar phosphoprotein B23, numatrin)0.018
Prkcdprotein kinase C, delta0.018
C5ar1complement component 5a receptor 10.018
Tgfbr2transforming growth factor, beta receptor II0.017
Ehd4EH-domain containing 40.017
Ctsl1cathepsin L10.017
Ptmaprothymosin alpha0.017
Cstbcystatin B (stefin B)0.017
C3complement component 30.016
Ptk2bPTK2B protein tyrosine kinase 2 beta0.016
Cnn3calponin 3, acidic0.016
UgcgUDP-glucose ceramide glucosyltransferase0.016
Ceacam1carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)0.016
Kcnj8potassium inwardly-rectifying channel, subfamily J, member 80.016
Myo1bmyosin Ib0.015
Bcar1breast cancer anti-estrogen resistance 10.015
Prkcbprotein kinase C, beta0.015
Dhx9DEAH (Asp-Glu-Ala-His) box polypeptide 90.015
Tmbim1transmembrane BAX inhibitor motif containing 10.015
Bmpr1abone morphogenetic protein receptor, type IA0.015
Fgfr2fibroblast growth factor receptor 20.015
Pde4bphosphodiesterase 4B, cAMP specific0.015
Gnai3guanine nucleotide binding protein (G protein), alpha inhibiting 30.015
Tmod3tropomodulin 30.015
Baiap2BAI1-associated protein 20.015
Hnrnpkheterogeneous nuclear ribonucleoprotein K0.014
Prf1perforin 1 (pore forming protein)0.014
Cd151CD151 molecule (Raph blood group)0.014
Itpr3inositol 1,4,5-triphosphate receptor, type 30.014
Il13ra1interleukin 13 receptor, alpha 10.014
Syt8synaptotagmin VIII0.014
Bin2abeta-galactosidase-like protein0.014
Mapk1mitogen activated protein kinase 10.013
Appamyloid beta (A4) precursor protein0.013
LOC683626similar to limb-bud and heart0.013
Robo2roundabout homolog 2 (Drosophila)0.013
Scn2bsodium channel, voltage-gated, type II, beta0.013
Caskcalcium/calmodulin-dependent serine protein kinase (MAGUK family)0.013
Shank1SH3 and multiple ankyrin repeat domains 10.013
Csnk1g3casein kinase 1, gamma 30.013
Ireb2iron responsive element binding protein 20.013
Vamp3vesicle-associated membrane protein 30.013
Myo1gmyosin IG0.013
Hmgb1high mobility group box 10.013
Arf6ADP-ribosylation factor 60.013
Smad4SMAD family member 40.013
Grin1glutamate receptor, ionotropic, N-methyl D-aspartate 10.013
Arhgef7Rho guanine nucleotide exchange factor (GEF7)0.012
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism