The network for 'cellular response to toxic substance' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cellular response to toxic substance

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.

NameDescriptionProbabilityFunc Analog Organism
CASP9caspase 9, apoptosis-related cysteine peptidase0.670
APAF1apoptotic peptidase activating factor 10.352
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.337
IL1R1interleukin 1 receptor, type I0.279
XIAPX-linked inhibitor of apoptosis0.269
MGEA5meningioma expressed antigen 5 (hyaluronidase)0.265
ZNF746zinc finger protein 7460.206
FBXO7F-box protein 70.200
CASP7caspase 7, apoptosis-related cysteine peptidase0.199
HDAC4histone deacetylase 40.191
CDK2cyclin-dependent kinase 20.186
PRDX1peroxiredoxin 10.170
EGLN3egl nine homolog 3 (C. elegans)0.162
CRELD2cysteine-rich with EGF-like domains 20.121
MPDZmultiple PDZ domain protein0.120
EGR2early growth response 20.112
IL8interleukin 80.101
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.101
FOSBFBJ murine osteosarcoma viral oncogene homolog B0.093
HERPUD1homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 10.090
HDAC9histone deacetylase 90.090
EPAS1endothelial PAS domain protein 10.086
SNAI1snail homolog 1 (Drosophila)0.083
EP300E1A binding protein p3000.078
EGLN1egl nine homolog 1 (C. elegans)0.072
SKP1S-phase kinase-associated protein 10.071
IER2immediate early response 20.067
FOSFBJ murine osteosarcoma viral oncogene homolog0.058
CCND3cyclin D30.055
MEF2Amyocyte enhancer factor 2A0.052
CCNDBP1cyclin D-type binding-protein 10.051
EGR3early growth response 30.051
VHLvon Hippel-Lindau tumor suppressor0.049
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.049
KAT2BK(lysine) acetyltransferase 2B0.048
UHRF2ubiquitin-like with PHD and ring finger domains 20.047
CCND1cyclin D10.046
TSC2tuberous sclerosis 20.045
MAP1LC3Bmicrotubule-associated protein 1 light chain 3 beta0.041
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.039
IL1RAPinterleukin 1 receptor accessory protein0.039
ESR1estrogen receptor 10.036
EIF4A2eukaryotic translation initiation factor 4A20.035
SIAH1seven in absentia homolog 1 (Drosophila)0.035
CCNE1cyclin E10.034
HCFC1host cell factor C1 (VP16-accessory protein)0.034
CCND2cyclin D20.033
SP1Sp1 transcription factor0.033
DDX5DEAD (Asp-Glu-Ala-Asp) box polypeptide 50.033
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.031
JUNBjun B proto-oncogene0.031
SSX4synovial sarcoma, X breakpoint 40.031
DYNLT1dynein, light chain, Tctex-type 10.030
GFERgrowth factor, augmenter of liver regeneration0.030
ZFC3H1zinc finger, C3H1-type containing0.029
YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.029
WEE1WEE1 homolog (S. pombe)0.028
MYOD1myogenic differentiation 10.028
RIPK2receptor-interacting serine-threonine kinase 20.028
BARX1BARX homeobox 10.028
CEBPBCCAAT/enhancer binding protein (C/EBP), beta0.027
SHANK1SH3 and multiple ankyrin repeat domains 10.026
CHP2calcineurin B homologous protein 20.025
MAP3K5mitogen-activated protein kinase kinase kinase 50.025
PCYT2phosphate cytidylyltransferase 2, ethanolamine0.024
DDAH2dimethylarginine dimethylaminohydrolase 20.024
CDK6cyclin-dependent kinase 60.024
CAMK2Acalcium/calmodulin-dependent protein kinase II alpha0.024
BTRCbeta-transducin repeat containing0.024
STX16syntaxin 160.023
KCNF1potassium voltage-gated channel, subfamily F, member 10.023
AKT3v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)0.023
RHOT1ras homolog gene family, member T10.023
BIRC2baculoviral IAP repeat containing 20.023
PACRGPARK2 co-regulated0.023
DUSP1dual specificity phosphatase 10.023
SPTBN1spectrin, beta, non-erythrocytic 10.022
FSCN2fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)0.022
UBASH3Bubiquitin associated and SH3 domain containing B0.021
CHRNA4cholinergic receptor, nicotinic, alpha 40.021
DNAJB9DnaJ (Hsp40) homolog, subfamily B, member 90.020
NR4A1nuclear receptor subfamily 4, group A, member 10.020
ATP1B1ATPase, Na+/K+ transporting, beta 1 polypeptide0.020
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.020
MKRN1makorin ring finger protein 10.020
FBXW7F-box and WD repeat domain containing 70.020
PRKCZprotein kinase C, zeta0.020
MANFmesencephalic astrocyte-derived neurotrophic factor0.019
IL1RNinterleukin 1 receptor antagonist0.019
MYLK2myosin light chain kinase 20.019
TCF4transcription factor 40.019
IFNAR1interferon (alpha, beta and omega) receptor 10.019
KLF10Kruppel-like factor 100.019
TRAF1TNF receptor-associated factor 10.019
S100A6S100 calcium binding protein A60.019
OPRD1opioid receptor, delta 10.019
DUSP6dual specificity phosphatase 60.019
ARGLU1arginine and glutamate rich 10.019
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
hsp90b1heat shock protein 90, beta (grp94), member 10.565
hsd3b1hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 10.490
hspd1heat shock 60kD protein 1 (chaperonin)0.177
oprm1opioid receptor, mu 10.155
cyp19a1bcytochrome P450, family 19, subfamily A, polypeptide 1b0.137
mef2camyocyte enhancer factor 2ca0.136
thtyrosine hydroxylase0.107
mapk8bmitogen-activated protein kinase 8b0.088
oprk1opioid receptor, kappa 10.085
sox9bSRY-box containing gene 9b0.073
slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.070
igfbp1ainsulin-like growth factor binding protein 1a0.056
igf3insulin-like growth factor 30.055
foxh1forkhead box H10.054
lgi1bleucine-rich, glioma inactivated 1b0.053
hint2histidine triad nucleotide binding protein 20.052
srfserum response factor0.049
manfmesencephalic astrocyte-derived neurotrophic factor0.048
smyd1bSET and MYND domain containing 1b0.046
mef2cbmyocyte enhancer factor 2cb0.044
plcb3phospholipase C, beta 3 (phosphatidylinositol-specific)0.043
fshrfollicle stimulating hormone receptor0.042
tac1tachykinin 10.041
ikzf5IKAROS family zinc finger 50.040
trpc1transient receptor potential cation channel, subfamily C, member 10.039
tbx20T-box 200.035
rag1recombination activating gene 10.034
furinafurin (paired basic amino acid cleaving enzyme) a0.034
starsteroidogenic acute regulatory protein0.034
bmp15bone morphogenetic protein 150.032
prox1prospero-related homeobox gene 10.031
plxnb2aplexin b2a0.031
cyp19a1acytochrome P450, family 19, subfamily A, polypeptide 1a0.031
chrna1cholinergic receptor, nicotinic, alpha polypeptide 10.029
ef1aelongation factor 1-alpha0.029
s1pr2sphingosine-1-phosphate receptor 20.028
mpp5amembrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a)0.028
mstnamyostatin a0.028
spi1spleen focus forming virus (SFFV) proviral integration oncogene spi10.025
cnr1cannabinoid receptor 10.025
paqr7bprogestin and adipoQ receptor family member VII, b0.025
mychmyelocytomatosis oncogene homolog0.024
mapk14amitogen-activated protein kinase 14a0.024
cdh5cadherin 50.024
adam17aa disintegrin and metalloproteinase domain 17a0.024
ddcdopa decarboxylase0.023
mpzmyelin protein zero0.023
nr4a2bnuclear receptor subfamily 4, group A, member 2b0.023
pgrprogesterone receptor0.021
ncam1bneural cell adhesion molecule 1b0.020
trpv6transient receptor potential cation channel, subfamily V, member 60.020
inhainhibin, alpha0.020
ccng1cyclin G10.019
cyp17a1cytochrome P450, family 17, subfamily A, polypeptide 10.019
cadm2bcell adhesion molecule 2b0.019
hey2hairy/enhancer-of-split related with YRPW motif 20.019
htr1aa5-hydroxytryptamine (serotonin) receptor 1A a0.019
vtg4vitellogenin 40.018
ptgeslprostaglandin E synthase 2-like0.018
c1qccomplement component 1, q subcomponent, C chain0.018
unc45bunc-45 homolog B (C. elegans)0.018
tlr21toll-like receptor 210.017
foxp2forkhead box P20.017
cdkrap3CDK5 regulatory subunit associated protein 30.017
ucn3lurocortin 3, like0.017
xirp1xin actin-binding repeat containing 10.017
cbr1lcarbonyl reductase 1-like0.017
pafah1b1bplatelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b0.017
dnajc3DnaJ (Hsp40) homolog, subfamily C, member 30.017
crhcorticotropin releasing hormone0.017
hsd17b1hydroxysteroid (17-beta) dehydrogenase 10.016
nanos3nanos homolog 30.016
mvpmajor vault protein0.016
paqr8progestin and adipoQ receptor family member VIII0.016
ryr1bryanodine receptor 1b (skeletal)0.015
npy8brneuropeptide Y receptor Y8b0.015
cldnaclaudin a0.015
chatcholine acetyltransferase0.015
oprd1bopioid receptor, delta 1b0.015
limk2LIM domain kinase 20.015
slc25a25asolute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25a0.015
lhcgrluteinizing hormone/choriogonadotropin receptor0.015
arf1ADP-ribosylation factor 10.014
cdiptCDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)0.014
ihhaIndian hedgehog homolog a0.014
uts1urotensin 10.014
gria1aglutamate receptor, ionotropic, AMPA 1a0.014
tpm4tropomyosin 40.014
nppanatriuretic peptide precursor A0.014
galcbgalactosylceramidase b0.013
gria3aglutamate receptor, ionotropic, AMPA 3a0.013
elmo1engulfment and cell motility 1 (ced-12 homolog, C. elegans)0.013
ywhaqatyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a0.013
cacnb1calcium channel, voltage-dependent, beta 1 subunit0.013
or111-10odorant receptor, family D, subfamily 111, member 100.013
ripk2receptor-interacting serine-threonine kinase 20.013
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Rb1retinoblastoma 10.793
Mdm2transformed mouse 3T3 cell double minute 20.381
FosFBJ osteosarcoma oncogene0.296
Manfmesencephalic astrocyte-derived neurotrophic factor0.238
Nr3c1nuclear receptor subfamily 3, group C, member 10.185
Hdac4histone deacetylase 40.170
Apcadenomatosis polyposis coli0.134
Itgb1integrin beta 1 (fibronectin receptor beta)0.133
Nfe2l2nuclear factor, erythroid derived 2, like 20.129
Hsp90b1heat shock protein 90, beta (Grp94), member 10.095
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.090
Ptgs2prostaglandin-endoperoxide synthase 20.082
Ptenphosphatase and tensin homolog0.081
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.081
Trp53transformation related protein 530.079
Creld2cysteine-rich with EGF-like domains 20.073
Ctnnb1catenin (cadherin associated protein), beta 10.069
Ahraryl-hydrocarbon receptor0.058
Arandrogen receptor0.057
Hdac5histone deacetylase 50.054
Mef2cmyocyte enhancer factor 2C0.053
Notch1Notch gene homolog 1 (Drosophila)0.050
Cdkn2ccyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)0.049
Dnajb11DnaJ (Hsp40) homolog, subfamily B, member 110.043
Ptpn11protein tyrosine phosphatase, non-receptor type 110.039
Cdkn2dcyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)0.035
Apoeapolipoprotein E0.034
Sdf2l1stromal cell-derived factor 2-like 10.031
Mef2dmyocyte enhancer factor 2D0.029
Lhcgrluteinizing hormone/choriogonadotropin receptor0.028
Stat3signal transducer and activator of transcription 30.027
Prdx1peroxiredoxin 10.027
Kiss1KiSS-1 metastasis-suppressor0.025
S100a6S100 calcium binding protein A6 (calcyclin)0.024
Nr4a1nuclear receptor subfamily 4, group A, member 10.024
Cav1caveolin 1, caveolae protein0.023
Psen1presenilin 10.023
Pdia6protein disulfide isomerase associated 60.022
Ppargperoxisome proliferator activated receptor gamma0.022
Ccnd1cyclin D10.021
Jak2Janus kinase 20.021
Hprthypoxanthine guanine phosphoribosyl transferase0.020
Rbl2retinoblastoma-like 20.018
Nf1neurofibromatosis 10.018
Ttc14tetratricopeptide repeat domain 140.018
Dusp1dual specificity phosphatase 10.017
JunbJun-B oncogene0.016
Vhlvon Hippel-Lindau tumor suppressor0.016
Hif1ahypoxia inducible factor 1, alpha subunit0.016
Hspa5heat shock protein 50.016
Notch2Notch gene homolog 2 (Drosophila)0.015
Pdia3protein disulfide isomerase associated 30.015
Xbp1X-box binding protein 10.014
JunJun oncogene0.014
Kitkit oncogene0.014
Chd7chromodomain helicase DNA binding protein 70.014
Akr1c21aldo-keto reductase family 1, member C210.014
Irs2insulin receptor substrate 20.013
Anxa2annexin A20.013
Hao2hydroxyacid oxidase 20.013
Dlg1discs, large homolog 1 (Drosophila)0.013
Drd2dopamine receptor D20.013
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.012
Esr2estrogen receptor 2 (beta)0.012
Starsteroidogenic acute regulatory protein0.012
Thrathyroid hormone receptor alpha0.012
Hsd3b6hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 60.012
Aqp8aquaporin 80.012
Esr1estrogen receptor 1 (alpha)0.011
Hoxa10homeobox A100.011
WwoxWW domain-containing oxidoreductase0.011
Rpn1ribophorin I0.011
Socs3suppressor of cytokine signaling 30.011
Ncoa3nuclear receptor coactivator 30.011
Gadd45agrowth arrest and DNA-damage-inducible 45 alpha0.010
Klf5Kruppel-like factor 50.010
Klhl24kelch-like 24 (Drosophila)0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism