The network for 'androgen biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

androgen biosynthetic process

The chemical reactions and pathways resulting in the formation of androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics.

NameDescriptionProbabilityFunc Analog Organism
AKR1C2aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)1.000
AKR1C1aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)1.000
AKR1C3aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)1.000
CDK8cyclin-dependent kinase 80.969
ZHX1zinc fingers and homeoboxes 10.812
CDK19cyclin-dependent kinase 190.807
FGF18fibroblast growth factor 180.697
MED13mediator complex subunit 130.600
TADA2Atranscriptional adaptor 2A0.390
WNT1wingless-type MMTV integration site family, member 10.371
TGS1trimethylguanosine synthase 10.334
MED29mediator complex subunit 290.329
ESR2estrogen receptor 2 (ER beta)0.314
TNPO1transportin 10.267
THRAthyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)0.263
WIF1WNT inhibitory factor 10.214
IHHIndian hedgehog0.180
AADACarylacetamide deacetylase (esterase)0.174
CHEK2CHK2 checkpoint homolog (S. pombe)0.172
NQO1NAD(P)H dehydrogenase, quinone 10.150
AKR1B10aldo-keto reductase family 1, member B10 (aldose reductase)0.138
CYP26A1cytochrome P450, family 26, subfamily A, polypeptide 10.136
HIPK2homeodomain interacting protein kinase 20.123
PRRC2Cproline-rich coiled-coil 2C0.115
FGF8fibroblast growth factor 8 (androgen-induced)0.114
MED25mediator complex subunit 250.114
WNT3wingless-type MMTV integration site family, member 30.114
MED24mediator complex subunit 240.113
ACACAacetyl-CoA carboxylase alpha0.108
BHMTbetaine--homocysteine S-methyltransferase0.097
SFRP1secreted frizzled-related protein 10.092
ZNF148zinc finger protein 1480.092
MMP11matrix metallopeptidase 11 (stromelysin 3)0.091
PIRpirin (iron-binding nuclear protein)0.084
AKR1C4aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)0.080
CDK12cyclin-dependent kinase 120.080
FOXF2forkhead box F20.076
OTCornithine carbamoyltransferase0.073
NR0B2nuclear receptor subfamily 0, group B, member 20.073
RARAretinoic acid receptor, alpha0.066
WNT10Awingless-type MMTV integration site family, member 10A0.066
FOXC2forkhead box C2 (MFH-1, mesenchyme forkhead 1)0.065
RBBP5retinoblastoma binding protein 50.062
WNT4wingless-type MMTV integration site family, member 40.061
ENTPD2ectonucleoside triphosphate diphosphohydrolase 20.059
CYP11A1cytochrome P450, family 11, subfamily A, polypeptide 10.051
GNL3Lguanine nucleotide binding protein-like 3 (nucleolar)-like0.051
GSTM4glutathione S-transferase mu 40.051
HSD3B2hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 20.051
PRRX2paired related homeobox 20.050
LIPClipase, hepatic0.049
CDX1caudal type homeobox 10.049
HMX1H6 family homeobox 10.049
AQP5aquaporin 50.046
KCNJ5potassium inwardly-rectifying channel, subfamily J, member 50.046
SHHsonic hedgehog0.045
UGT1A3UDP glucuronosyltransferase 1 family, polypeptide A30.045
FGF3fibroblast growth factor 30.044
CXCL14chemokine (C-X-C motif) ligand 140.044
ANXA10annexin A100.044
FABP1fatty acid binding protein 1, liver0.043
GPX2glutathione peroxidase 2 (gastrointestinal)0.043
PKP1plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)0.042
CYP7B1cytochrome P450, family 7, subfamily B, polypeptide 10.042
ZNF33Bzinc finger protein 33B0.042
S100A2S100 calcium binding protein A20.041
HES2hairy and enhancer of split 2 (Drosophila)0.041
TGthyroglobulin0.041
TOP1topoisomerase (DNA) I0.040
APOFapolipoprotein F0.040
CLDN14claudin 140.040
USP42ubiquitin specific peptidase 420.040
LMX1ALIM homeobox transcription factor 1, alpha0.039
CDH6cadherin 6, type 2, K-cadherin (fetal kidney)0.038
GDNFglial cell derived neurotrophic factor0.038
MED13Lmediator complex subunit 13-like0.038
NKD1naked cuticle homolog 1 (Drosophila)0.038
BHLHE23basic helix-loop-helix family, member e230.038
HSD17B2hydroxysteroid (17-beta) dehydrogenase 20.037
NKD2naked cuticle homolog 2 (Drosophila)0.037
MED14mediator complex subunit 140.037
BNC1basonuclin 10.036
MYST1MYST histone acetyltransferase 10.036
HOXC8homeobox C80.036
TM4SF4transmembrane 4 L six family member 40.036
TRRAPtransformation/transcription domain-associated protein0.036
FOXE1forkhead box E1 (thyroid transcription factor 2)0.036
WNT7Awingless-type MMTV integration site family, member 7A0.036
PAHphenylalanine hydroxylase0.035
CACNA1Gcalcium channel, voltage-dependent, T type, alpha 1G subunit0.035
GYS2glycogen synthase 2 (liver)0.035
GDF10growth differentiation factor 100.035
KCNC3potassium voltage-gated channel, Shaw-related subfamily, member 30.035
CYP19A1cytochrome P450, family 19, subfamily A, polypeptide 10.035
IRX4iroquois homeobox 40.034
CYP4F12cytochrome P450, family 4, subfamily F, polypeptide 120.033
MAGEA11melanoma antigen family A, 110.033
NR1H4nuclear receptor subfamily 1, group H, member 40.033
ZNF281zinc finger protein 2810.033
LBX1ladybird homeobox 10.033
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
hsd17b12ahydroxysteroid (17-beta) dehydrogenase 12a0.361
inhainhibin, alpha0.235
si:ch211-284e13.2si:ch211-284e13.20.226
bactin2bactin20.193
igf3insulin-like growth factor 30.186
elovl5ELOVL family member 5, elongation of long chain fatty acids (yeast)0.130
hsd17b12bhydroxysteroid (17-beta) dehydrogenase 12b0.111
casrlcalcium-sensing receptor, like0.100
sfrp5secreted frizzled-related protein 50.093
lhcgrluteinizing hormone/choriogonadotropin receptor0.087
hsd17b3hydroxysteroid (17-beta) dehydrogenase 30.084
zgc:64114zgc:641140.083
slc2a2solute carrier family 2 (facilitated glucose transporter), member 20.081
cyp19a1bcytochrome P450, family 19, subfamily A, polypeptide 1b0.079
starsteroidogenic acute regulatory protein0.073
sox2SRY-box containing gene 20.066
cyp2p6cytochrome P450, family 2, subfamily P, polypeptide 60.065
mstnamyostatin a0.061
rspo1R-spondin homolog (Xenopus laevis)0.060
slc8a1bsolute carrier family 8 (sodium/calcium exchanger), member 1b0.060
inhbabinhibin, beta Ab0.057
pcsk7proprotein convertase subtilisin/kexin type 70.054
hprt1hypoxanthine phosphoribosyltransferase 10.053
ptgs1prostaglandin-endoperoxide synthase 10.053
cldn2claudin 20.049
cldndclaudin d0.043
fads2fatty acid desaturase 20.043
cldnaclaudin a0.042
sdhasuccinate dehydrogenase complex, subunit A, flavoprotein (Fp)0.042
cyp17a1cytochrome P450, family 17, subfamily A, polypeptide 10.042
trpv6transient receptor potential cation channel, subfamily V, member 60.039
cldn8claudin 80.037
vtg1vitellogenin 10.035
oclnboccludin b0.035
piwil1piwi-like 1 (Drosophila)0.035
cyp24a1cytochrome P450, family 24, subfamily A, polypeptide 10.030
abp1amiloride binding protein 1 (amine oxidase (copper-containing))0.030
polr2dpolymerase (RNA) II (DNA directed) polypeptide D0.028
rdh1retinol dehydrogenase 10.026
b2mbeta-2-microglobulin0.025
cd209CD209 molecule0.025
zgc:56630zgc:566300.024
pgrprogesterone receptor0.024
ptgeslprostaglandin E synthase 2-like0.024
osbpl7oxysterol binding protein-like 70.023
LOC100538108tissue-type plasminogen activator-like0.023
epas1bendothelial PAS domain protein 1b0.023
sod1superoxide dismutase 1, soluble0.023
defbl1defensin, beta-like 10.023
ela2lelastase 2 like0.022
efnb2aephrin B2a0.022
mt2metallothionein 20.022
gperG protein-coupled estrogen receptor 10.022
cdkl1cyclin-dependent kinase-like 1 (CDC2-related kinase)0.022
itln3intelectin 30.021
rln3arelaxin 3a0.021
cldn12claudin 120.021
hsd17b1hydroxysteroid (17-beta) dehydrogenase 10.020
lsm14bLSM14B, SCD6 homolog B (S. cerevisiae)0.019
paqr8progestin and adipoQ receptor family member VIII0.019
leprleptin receptor0.019
her5hairy-related 50.019
gdf9growth differentiation factor 90.019
cldniclaudin i0.018
ocrloculocerebrorenal syndrome of Lowe0.017
slc2a9l1solute carrier family 2 (facilitated glucose transporter), member 9-like 10.017
selpselectin P0.017
pthlhparathyroid hormone-like hormone0.017
adipor1badiponectin receptor 1b0.016
cyp51cytochrome P450, family 510.016
spg11spastic paraplegia 110.016
dio1deiodinase, iodothyronine, type I0.016
LOC100005232Gig2-like protein DreD0.016
oclnaoccludin a0.015
slc34a2asolute carrier family 34 (sodium phosphate), member 2a0.015
foxo3aforkhead box O3A0.015
cldnbclaudin b0.015
mxtx1mix-type homeobox gene 10.015
itga3bintegrin, alpha 3b0.014
elovl6lELOVL family member 6, elongation of long chain fatty acids like0.014
rp2retinitis pigmentosa 2 (X-linked recessive)0.013
mobkl1bMOB1, Mps One Binder kinase activator-like 1B (yeast)0.013
slc2a8solute carrier family 2 (facilitated glucose transporter), member 80.013
tm9sf3transmembrane 9 superfamily member 30.013
twist1atwist1a0.013
pcsk9proprotein convertase subtilisin/kexin type 90.013
dnajb11DnaJ (Hsp40) homolog, subfamily B, member 110.013
clptm1lcleft lip and palate associated transmembrane protein 1, like0.013
esr2bestrogen receptor 2b0.012
zgc:112282zgc:1122820.012
emx3empty spiracles homeobox 30.012
atp2b2ATPase, Ca++ transporting, plasma membrane 20.012
slc12a3solute carrier family 12 (sodium/chloride transporters), member 30.012
cldn11bclaudin 11b0.012
wnt4bwingless-type MMTV integration site family, member 4b0.012
defbl3defensin, beta-like 30.012
prmt8bprotein arginine methyltransferase 8b0.012
aqp12aquaporin 120.012
ptgs2aprostaglandin-endoperoxide synthase 2a0.012
adipor1aadiponectin receptor 1a0.012
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Pax8paired box gene 80.971
Pax2paired box gene 20.961
Wnt3awingless-related MMTV integration site 3A0.945
Amhr2anti-Mullerian hormone type 2 receptor0.910
Wnt4wingless-related MMTV integration site 40.875
Lhx1LIM homeobox protein 10.872
Tbrachyury0.834
Dkk1dickkopf homolog 1 (Xenopus laevis)0.774
Fgf8fibroblast growth factor 80.719
Wnt9awingless-type MMTV integration site 9A0.602
Hmx3H6 homeobox 30.574
Hsd11b2hydroxysteroid 11-beta dehydrogenase 20.554
Gdnfglial cell line derived neurotrophic factor0.554
Fgf18fibroblast growth factor 180.553
Pou3f3POU domain, class 3, transcription factor 30.551
Hoxd11homeobox D110.526
Wnt10bwingless related MMTV integration site 10b0.516
Slc12a1solute carrier family 12, member 10.505
Klklotho0.500
Emx2empty spiracles homolog 2 (Drosophila)0.493
Hoxa10homeobox A100.463
Cdx1caudal type homeobox 10.456
Otx1orthodenticle homolog 1 (Drosophila)0.440
Clic3chloride intracellular channel 30.321
Hpd4-hydroxyphenylpyruvic acid dioxygenase0.297
Cyp26a1cytochrome P450, family 26, subfamily a, polypeptide 10.277
IhhIndian hedgehog0.255
Adra1badrenergic receptor, alpha 1b0.247
Fzd8frizzled homolog 8 (Drosophila)0.234
Kcnh3potassium voltage-gated channel, subfamily H (eag-related), member 30.225
Muc5acmucin 5, subtypes A and C, tracheobronchial/gastric0.224
Bmp7bone morphogenetic protein 70.220
Barx1BarH-like homeobox 10.199
Efna4ephrin A40.197
Ncoa6nuclear receptor coactivator 60.197
Abcc6ATP-binding cassette, sub-family C (CFTR/MRP), member 60.195
Onecut1one cut domain, family member 10.194
Fgf3fibroblast growth factor 30.192
Cyp24a1cytochrome P450, family 24, subfamily a, polypeptide 10.189
Pou3f1POU domain, class 3, transcription factor 10.184
Emx1empty spiracles homolog 1 (Drosophila)0.179
Ror2receptor tyrosine kinase-like orphan receptor 20.176
Lmx1aLIM homeobox transcription factor 1 alpha0.175
BC021891cDNA sequence BC0218910.172
Wnt7awingless-related MMTV integration site 7A0.167
Hoxa13homeobox A130.165
3110079O15RikRIKEN cDNA 3110079O15 gene0.165
Krt15keratin 150.157
Dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.157
Hoxb5homeobox B50.147
Alx4aristaless-like homeobox 40.145
Col13a1collagen, type XIII, alpha 10.143
Prm3protamine 30.142
Pcsk5proprotein convertase subtilisin/kexin type 50.142
Hoxc9homeobox C90.141
Fgf10fibroblast growth factor 100.136
Arxaristaless related homeobox0.133
Zfp771zinc finger protein 7710.130
Wnt3wingless-related MMTV integration site 30.127
Vax1ventral anterior homeobox containing gene 10.126
Plac1placental specific protein 10.125
Ephb2Eph receptor B20.122
Lhcgrluteinizing hormone/choriogonadotropin receptor0.116
Nr5a1nuclear receptor subfamily 5, group A, member 10.115
Prl7a1prolactin family 7, subfamily a, member 10.115
Vstm2bV-set and transmembrane domain containing 2B0.113
Lyzl4lysozyme-like 40.112
Acanaggrecan0.110
Gli1GLI-Kruppel family member GLI10.110
Rarbretinoic acid receptor, beta0.108
BikBCL2-interacting killer0.107
Rspo1R-spondin homolog (Xenopus laevis)0.106
Rbpjlrecombination signal binding protein for immunoglobulin kappa J region-like0.106
NoboxNOBOX oogenesis homeobox0.104
Btbd17BTB (POZ) domain containing 170.103
Sp5trans-acting transcription factor 50.103
Grid1glutamate receptor, ionotropic, delta 10.102
Hoxd9homeobox D90.102
Prodh2proline dehydrogenase (oxidase) 20.102
Hsd3b6hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 60.100
Slc32a1solute carrier family 32 (GABA vesicular transporter), member 10.095
Slc34a2solute carrier family 34 (sodium phosphate), member 20.093
Keg1kidney expressed gene 10.090
Adra2badrenergic receptor, alpha 2b0.089
Arandrogen receptor0.089
Cyp11b2cytochrome P450, family 11, subfamily b, polypeptide 20.088
Tnp1transition protein 10.087
BC018465cDNA sequence BC0184650.087
Trp73transformation related protein 730.086
BC024139cDNA sequence BC0241390.085
Tgfatransforming growth factor alpha0.085
Twist2twist homolog 2 (Drosophila)0.084
Slc27a3solute carrier family 27 (fatty acid transporter), member 30.083
Tnfrsf8tumor necrosis factor receptor superfamily, member 80.083
Sim2single-minded homolog 2 (Drosophila)0.081
Foxf1aforkhead box F1a0.080
G6pc2glucose-6-phosphatase, catalytic, 20.080
Akr1c21aldo-keto reductase family 1, member C210.080
Gipc3GIPC PDZ domain containing family, member 30.079
Artnartemin0.078
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Akr1c18aldo-keto reductase family 1, member C180.458
Lhcgrluteinizing hormone/choriogonadotropin receptor0.447
Starsteroidogenic acute regulatory protein0.373
Hsd3b1hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 10.365
Nlrp6NLR family, pyrin domain containing 60.162
Slco1a1solute carrier organic anion transporter family, member 1a10.146
Aqp7aquaporin 70.139
Sult1c3sulfotransferase family, cytosolic, 1C, member 30.115
Prss3protease, serine, 30.090
Ugt2b5UDP glucuronosyltransferase 2 family, polypeptide B50.084
LOC293989cytochrome P450-like0.080
Lpllipoprotein lipase0.078
Acsl1acyl-CoA synthetase long-chain family member 10.066
Nr0b2nuclear receptor subfamily 0, group B, member 20.061
A1i3alpha-1-inhibitor III0.060
Ugt2bUDP glycosyltransferase 2 family, polypeptide B0.059
Cyp17a1cytochrome P450, family 17, subfamily a, polypeptide 10.057
Cyp2d2cytochrome P450, family 2, subfamily d, polypeptide 20.052
Gja3gap junction protein, alpha 30.045
Hpd4-hydroxyphenylpyruvate dioxygenase0.043
Hes2hairy and enhancer of split 2 (Drosophila)0.043
Otcornithine carbamoyltransferase0.043
RGD1564865similar to 20-alpha-hydroxysteroid dehydrogenase0.042
Sult1b1sulfotransferase family, cytosolic, 1B, member 10.041
Nr5a2nuclear receptor subfamily 5, group A, member 20.040
Mettl7bmethyltransferase like 7B0.038
Mgst2microsomal glutathione S-transferase 20.038
Serpina3mserine (or cysteine) proteinase inhibitor, clade A, member 3M0.037
Abcb11ATP-binding cassette, subfamily B (MDR/TAP), member 110.034
Defb4defensin beta 40.032
Adam18ADAM metallopeptidase domain 180.028
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.027
Nudt8nudix (nucleoside diphosphate linked moiety X)-type motif 80.027
Chrna3cholinergic receptor, nicotinic, alpha 30.027
Cyp2c12cytochrome P450, family 2, subfamily c, polypeptide 120.027
Scgb2a1secretoglobin, family 2A, member 10.027
Apoa2apolipoprotein A-II0.026
Hrh2histamine receptor H 20.026
Rbp7retinol binding protein 7, cellular0.025
Prlrprolactin receptor0.024
Hsd17b2hydroxysteroid (17-beta) dehydrogenase 20.024
Hao2hydroxyacid oxidase 2 (long chain)0.024
Hcrtr2hypocretin (orexin) receptor 20.023
Atp4bATPase, H+/K+ exchanging, beta polypeptide0.023
Nr1h4nuclear receptor subfamily 1, group H, member 40.022
Clca4chloride channel accessory 40.022
Il8rbinterleukin 8 receptor, beta0.021
Aqp8aquaporin 80.020
Epha3Eph receptor A30.019
Tipintimeless interacting protein0.019
Dnajc3DnaJ (Hsp40) homolog, subfamily C, member 30.019
Cyp4a10cytochrome P450, family 4, subfamily a, polypeptide 100.019
Cyp4f4cytochrome P450, family 4, subfamily f, polypeptide 40.019
Svs5seminal vesicle secretory protein 50.019
Slc10a1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.018
Dmrta1DMRT-like family A10.018
Hbg1hemoglobin, gamma A0.018
Cyp3a18cytochrome P450, family 3, subfamily a, polypeptide 180.017
Hsd17b6hydroxysteroid (17-beta) dehydrogenase 60.017
Sult1c2sulfotransferase family, cytosolic, 1C, member 20.016
F2rl2coagulation factor II (thrombin) receptor-like 20.016
Foxa2forkhead box A20.016
Dpp4dipeptidylpeptidase 40.016
Slc27a5solute carrier family 27 (fatty acid transporter), member 50.016
Sisucrase-isomaltase (alpha-glucosidase)0.016
LOC100365112carboxylesterase-like0.015
RGD1561551similar to Hypothetical protein MGC756640.014
Fabp4fatty acid binding protein 4, adipocyte0.014
RGD1304731similar to RIKEN cDNA 5330437I02 gene0.014
Fabp1fatty acid binding protein 1, liver0.014
Spt1salivary protein 10.014
Capn8calpain 80.014
Vtcn1V-set domain containing T cell activation inhibitor 10.014
Slc22a1solute carrier family 22 (organic cation transporter), member 10.014
Ephx1epoxide hydrolase 1, microsomal0.013
Dnase1deoxyribonuclease I0.013
Klkb1kallikrein B, plasma 10.013
Cd36CD36 molecule (thrombospondin receptor)0.013
Akp3alkaline phosphatase 3, intestine, not Mn requiring0.013
Dpep1dipeptidase 1 (renal)0.013
Zadh2zinc binding alcohol dehydrogenase, domain containing 20.013
Ugt2b36UDP glucuronosyltransferase 2 family, polypeptide B360.013
Stag3stromal antigen 30.012
Gpr150G protein-coupled receptor 1500.012
Naglt1Na+ dependent glucose transporter 10.012
Gipgastric inhibitory polypeptide0.012
Ghrgrowth hormone receptor0.012
Catcatalase0.012
Dhfrdihydrofolate reductase0.011
Clrn3clarin 30.011
Svs4seminal vesicle secretory protein 40.011
Pfkfb16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 10.011
C2cd4dC2 calcium-dependent domain containing 4D0.011
Slc40a1solute carrier family 39 (iron-regulated transporter), member 10.010
Fabp9fatty acid binding protein 9, testis0.010
Foxi2forkhead box I20.010
Cubncubilin (intrinsic factor-cobalamin receptor)0.010
Cyp2c22cytochrome P450, family 2, subfamily c, polypeptide 220.010
Vom1r105vomeronasal 1 receptor 1050.010
ND4NADH dehydrogenase subunit 40.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism