The network for 'response to copper ion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to copper ion

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus.

NameDescriptionProbabilityFunc Analog Organism
MT1Fmetallothionein 1F1.000
MT1Emetallothionein 1E1.000
MT2Ametallothionein 2A1.000
MT1Hmetallothionein 1H1.000
MT1Xmetallothionein 1X0.999
MT1Gmetallothionein 1G0.540
BCL2L1BCL2-like 10.513
SPRY4sprouty homolog 4 (Drosophila)0.465
PDZD11PDZ domain containing 110.224
MT1Mmetallothionein 1M0.183
IL1R1interleukin 1 receptor, type I0.162
KATNAL1katanin p60 subunit A-like 10.095
AGXT2alanine--glyoxylate aminotransferase 20.068
MAPK14mitogen-activated protein kinase 140.063
GPR50G protein-coupled receptor 500.043
APOA1apolipoprotein A-I0.042
BAK1BCL2-antagonist/killer 10.037
FBLN5fibulin 50.035
IL1RAPinterleukin 1 receptor accessory protein0.031
EFEMP2EGF containing fibulin-like extracellular matrix protein 20.030
CCNA2cyclin A20.026
ATP6V0CATPase, H+ transporting, lysosomal 16kDa, V0 subunit c0.026
RNF144Bring finger protein 144B0.025
CCL20chemokine (C-C motif) ligand 200.021
CFL1cofilin 1 (non-muscle)0.020
MDFIMyoD family inhibitor0.018
IL1RNinterleukin 1 receptor antagonist0.017
MT1Bmetallothionein 1B0.017
CAV1caveolin 1, caveolae protein, 22kDa0.017
HSD17B4hydroxysteroid (17-beta) dehydrogenase 40.017
BCL2L11BCL2-like 11 (apoptosis facilitator)0.015
MMP14matrix metallopeptidase 14 (membrane-inserted)0.015
EHHADHenoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase0.014
BADBCL2-associated agonist of cell death0.013
SCP2sterol carrier protein 20.013
ARPC4actin related protein 2/3 complex, subunit 4, 20kDa0.013
CDK2cyclin-dependent kinase 20.013
NFKBIZnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta0.013
BBS1Bardet-Biedl syndrome 10.013
MAPK1mitogen-activated protein kinase 10.013
HIPK3homeodomain interacting protein kinase 30.012
ABCD3ATP-binding cassette, sub-family D (ALD), member 30.012
RNR2l-rRNA0.012
SNCAIPsynuclein, alpha interacting protein0.012
MAPTmicrotubule-associated protein tau0.011
ADAMTSL4ADAMTS-like 40.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
pdlim5PDZ and LIM domain 50.724
acadlacyl-Coenzyme A dehydrogenase, long chain0.505
atp6v1hATPase, H+ transporting, lysosomal, V1 subunit H0.387
comtacatechol-O-methyltransferase a0.316
limk1LIM domain kinase 10.310
pdlim2PDZ and LIM domain 2 (mystique)0.293
acox1acyl-Coenzyme A oxidase 1, palmitoyl0.271
sod1superoxide dismutase 1, soluble0.204
slc3a2solute carrier family 3, member 20.200
gpiaglucose phosphate isomerase a0.185
pdlim4PDZ and LIM domain 40.174
tnfatumor necrosis factor a (TNF superfamily, member 2)0.165
bcl2B-cell leukemia/lymphoma 20.151
rhagRhesus blood group-associated glycoprotein0.142
acat1acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase)0.140
sepp1aselenoprotein P, plasma, 1a0.126
trytrypsin0.118
atp6v1e1bATPase, H+ transporting, lysosomal, V1 subunit E isoform 1b0.110
mt2metallothionein 20.107
hadhahydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase, alpha subunit0.104
sid4secreted immunoglobulin domain 40.101
atp7aATPase, Cu++ transporting, alpha polypeptide0.101
cdiptCDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)0.097
limk2LIM domain kinase 20.092
atpif1ATPase inhibitory factor 10.081
sheSrc homology 2 domain containing E0.078
gclcglutamate-cysteine ligase, catalytic subunit0.077
pdlim3bPDZ and LIM domain 3b0.073
uroduroporphyrinogen decarboxylase0.071
atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.069
tgfbr2transforming growth factor, beta receptor II0.067
atp6v0caATPase, H+ transporting, lysosomal, V0 subunit c, a0.064
LOC790901glucose-dependent insulinotropic polypeptide0.063
npc1Niemann-Pick disease, type C10.061
tfr1atransferrin receptor 1a0.061
rbm19RNA binding motif protein 190.060
trim33tripartite motif-containing 330.056
zgc:110775zgc:1107750.054
rnasel1ribonuclease like 10.053
csadcysteine sulfinic acid decarboxylase0.052
hbae1hemoglobin alpha embryonic-10.051
sod2superoxide dismutase 2, mitochondrial0.050
krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.049
stat1bsignal transducer and activator of transcription 1b0.048
COX1cytochrome c oxidase subunit I0.047
atp6ap1ATPase, H+ transporting, lysosomal accessory protein 10.047
glrx5glutaredoxin 5 homolog (S. cerevisiae)0.045
aldh2baldehyde dehydrogenase 2b0.045
rtn1areticulon 1a0.044
herpud1homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 10.043
acsl4aacyl-CoA synthetase long-chain family member 4a0.043
hcrthypocretin (orexin) neuropeptide precursor0.042
spsb1splA/ryanodine receptor domain and SOCS box containing 10.042
wnt2bbwingless-type MMTV integration site family, member 2Bb0.041
kdrlkinase insert domain receptor like0.040
igfbp1ainsulin-like growth factor binding protein 1a0.039
ldhalactate dehydrogenase A40.039
si:dkeyp-7c9.1si:dkeyp-7c9.10.039
scp2sterol carrier protein 20.039
cpt2carnitine palmitoyltransferase II0.038
vps33bvacuolar protein sorting 33B0.037
entpd2a.1ectonucleoside triphosphate diphosphohydrolase 2 a.10.037
disc1disrupted in schizophrenia 10.036
mafkv-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)0.035
mmp9matrix metalloproteinase 90.035
pdlim3aPDZ and LIM domain 3a0.034
acp5bacid phosphatase 5b, tartrate resistant0.034
ctsl1acathepsin L, 1 a0.033
lndc1ly6/neurotoxin domain containing 10.033
gata6GATA-binding protein 60.032
prkczprotein kinase C, zeta0.032
gstt1aglutathione S-transferase theta 1a0.032
rnasel2ribonuclease like 20.031
rogdirogdi homolog (Drosophila)0.031
chchd10coiled-coil-helix-coiled-coil-helix domain containing 100.030
lgmnlegumain0.030
stc1lstanniocalcin 1, like0.029
rpl23aribosomal protein L23a0.029
entpd8ectonucleoside triphosphate diphosphohydrolase 80.028
fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.027
ndfip1Nedd4 family interacting protein 10.027
cdh17cadherin 17, LI cadherin (liver-intestine)0.027
etfdhelectron-transferring-flavoprotein dehydrogenase0.027
si:dkey-88p24.9si:dkey-88p24.90.026
ckbbcreatine kinase, brain b0.026
wnt9bwingless-type MMTV integration site family, member 9B0.026
map2k4bmitogen-activated protein kinase kinase 4b0.026
zgc:195195zgc:1951950.026
sarsseryl-tRNA synthetase0.026
gstp1glutathione S-transferase pi0.025
pdlim7PDZ and LIM domain 70.025
smyd3SET and MYND domain containing 30.025
ctsfcathepsin F0.025
pou4f1POU domain, class 4, transcription factor 10.025
coq3coenzyme Q3 homolog, methyltransferase (yeast)0.025
fbxl14bF-box and leucine-rich repeat protein 14b0.024
hspd1heat shock 60kD protein 1 (chaperonin)0.024
si:dkey-273o13.1si:dkey-273o13.10.024
LOC556849ectonucleoside triphosphate diphosphohydrolase 5-like0.024
cnga5cyclic nucleotide gated channel alpha 50.024
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Yp3Yolk protein 30.187
LvpHLarval visceral protein H0.097
CG14837CG14837 gene product from transcript CG14837-RC0.076
betaTrybetaTrypsin0.072
CG6277CG6277 gene product from transcript CG6277-RA0.070
CG6283CG6283 gene product from transcript CG6283-RA0.070
CG18180CG18180 gene product from transcript CG18180-RA0.062
CG2107CG2107 gene product from transcript CG2107-RA0.058
NLazNeural Lazarillo0.056
CG14820CG14820 gene product from transcript CG14820-RA0.054
l(3)82FdCG32464 gene product from transcript CG32464-RR0.054
Lip3CG8823 gene product from transcript CG8823-RA0.053
TSG101tumor suppressor protein 1010.052
DreddDeath related ced-3/Nedd2-like protein0.050
CG7916CG7916 gene product from transcript CG7916-RA0.044
CG13792CG13792 gene product from transcript CG13792-RA0.043
CatCatalase0.042
Spn77BbSerpin 77Bb0.039
CG14119CG14119 gene product from transcript CG14119-RA0.038
CG13160CG13160 gene product from transcript CG13160-RA0.038
AdhAlcohol dehydrogenase0.037
Cyp4d21CG6730 gene product from transcript CG6730-RA0.036
CG11897CG11897 gene product from transcript CG11897-RA0.036
CG3011CG3011 gene product from transcript CG3011-RA0.036
CG10425CG10425 gene product from transcript CG10425-RA0.036
Jon99CiJonah 99Ci0.035
CG8690CG8690 gene product from transcript CG8690-RA0.035
Cyp6g1CG8453 gene product from transcript CG8453-RA0.034
Cyp12a4CG6042 gene product from transcript CG6042-RA0.034
Tak1TGF-beta activated kinase 10.034
CG6271CG6271 gene product from transcript CG6271-RA0.033
CG5945CG5945 gene product from transcript CG5945-RA0.033
DJ-1alphaCG6646 gene product from transcript CG6646-RA0.032
Cyp12a5CG11821 gene product from transcript CG11821-RA0.031
CG8997CG8997 gene product from transcript CG8997-RA0.031
DopRDopamine receptor0.030
NAAT1Nutrient Amino Acid Transporter 10.030
CG14247CG14247 gene product from transcript CG14247-RA0.030
fu12CG17608 gene product from transcript CG17608-RA0.030
CG6996CG6996 gene product from transcript CG6996-RB0.030
CG13253CG13253 gene product from transcript CG13253-RB0.030
Npc2cNiemann-Pick type C-2c0.030
CG10361CG10361 gene product from transcript CG10361-RA0.029
CG3267CG3267 gene product from transcript CG3267-RA0.029
Ptp10DProtein tyrosine phosphatase 10D0.029
DmsR-2Dromyosuppressin receptor 20.029
CG17189CG17189 gene product from transcript CG17189-RA0.028
NPFR1neuropeptide F receptor0.028
CG7548CG7548 gene product from transcript CG7548-RA0.028
CG12483CG12483 gene product from transcript CG12483-RA0.028
CG12374CG12374 gene product from transcript CG12374-RA0.027
Cyp305a1CG8733 gene product from transcript CG8733-RA0.027
CG6295CG6295 gene product from transcript CG6295-RA0.027
BG642163CG34102 gene product from transcript CG34102-RA0.027
CG1444CG1444 gene product from transcript CG1444-RA0.027
CG9672CG9672 gene product from transcript CG9672-RA0.027
CG18745CG18745 gene product from transcript CG18745-RA0.027
CG7912CG7912 gene product from transcript CG7912-RA0.027
cln3CG5582 gene product from transcript CG5582-RA0.027
CG17300CG17300 gene product from transcript CG17300-RA0.027
tobitarget of brain insulin0.026
CG5162CG5162 gene product from transcript CG5162-RA0.026
CG8093CG8093 gene product from transcript CG8093-RA0.026
CG17664CG17664 gene product from transcript CG17664-RA0.026
CG18094CG18094 gene product from transcript CG18094-RA0.026
CG14506CG14506 gene product from transcript CG14506-RA0.026
CG30360CG30360 gene product from transcript CG30360-RC0.026
Cyp6a2Cytochrome P450-6a20.026
ImpE1Ecdysone-inducible gene E10.025
CG1443CG1443 gene product from transcript CG1443-RA0.025
CG7970CG7970 gene product from transcript CG7970-RA0.025
CG8451CG8451 gene product from transcript CG8451-RA0.025
ST6GalSialyltransferase0.025
bgmbubblegum0.025
Pabp2CG2163 gene product from transcript CG2163-RA0.025
CG7953CG7953 gene product from transcript CG7953-RA0.024
Tsp42EgTetraspanin 42Eg0.024
CG5568CG5568 gene product from transcript CG5568-RA0.024
CG15650CG15650 gene product from transcript CG15650-RA0.024
CG11796CG11796 gene product from transcript CG11796-RA0.024
l(2)k01209lethal (2) k012090.024
Mpk2CG5475 gene product from transcript CG5475-RB0.024
CG7530CG7530 gene product from transcript CG7530-RB0.024
CG4363CG4363 gene product from transcript CG4363-RA0.024
bursbursicon0.024
CG9027CG9027 gene product from transcript CG9027-RD0.024
Tsp42EiTetraspanin 42Ei0.024
CG7579CG7579 gene product from transcript CG7579-RA0.024
CG31871CG31871 gene product from transcript CG31871-RA0.024
ETHRCG5911 gene product from transcript CG5911-RB0.024
CG11486CG11486 gene product from transcript CG11486-RG0.024
trioCG18214 gene product from transcript CG18214-RA0.024
pngpan gu0.024
CG18516CG18516 gene product from transcript CG18516-RA0.023
TotATurandot A0.023
CG13255CG13255 gene product from transcript CG13255-RA0.023
l(2)k16918lethal (2) k169180.023
CG16898CG16898 gene product from transcript CG16898-RA0.023
bcdbicoid0.023
MTF-1Metal response element-binding Transcription Factor-10.023
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Mt2metallothionein 20.678
Mt1metallothionein 10.633
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.447
Cpceruloplasmin0.253
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.153
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.120
Steap3STEAP family member 30.109
Slc39a4solute carrier family 39 (zinc transporter), member 40.094
Nfe2l2nuclear factor, erythroid derived 2, like 20.085
Apoeapolipoprotein E0.074
Scp2sterol carrier protein 2, liver0.067
Atp6v0bATPase, H+ transporting, lysosomal V0 subunit B0.067
Ccr2chemokine (C-C motif) receptor 20.062
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.060
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.058
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.054
Slc31a1solute carrier family 31, member 10.053
Atp7aATPase, Cu++ transporting, alpha polypeptide0.052
Tlr4toll-like receptor 40.048
Irf1interferon regulatory factor 10.047
Hbb-b2hemoglobin, beta adult minor chain0.044
BaxBCL2-associated X protein0.044
Loxlysyl oxidase0.043
FasFas (TNF receptor superfamily member 6)0.043
Etfaelectron transferring flavoprotein, alpha polypeptide0.037
Il1binterleukin 1 beta0.037
2010106G01RikRIKEN cDNA 2010106G01 gene0.036
Aldh6a1aldehyde dehydrogenase family 6, subfamily A10.034
Ccl2chemokine (C-C motif) ligand 20.034
Cd44CD44 antigen0.034
Atp6v0cATPase, H+ transporting, lysosomal V0 subunit C0.033
Myd88myeloid differentiation primary response gene 880.033
Egfl7EGF-like domain 70.033
Lrrc59leucine rich repeat containing 590.032
Cyp2d26cytochrome P450, family 2, subfamily d, polypeptide 260.032
Hmox1heme oxygenase (decycling) 10.031
Kitkit oncogene0.030
Hsd17b4hydroxysteroid (17-beta) dehydrogenase 40.030
Pklrpyruvate kinase liver and red blood cell0.030
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.029
Etfdhelectron transferring flavoprotein, dehydrogenase0.028
Hfehemochromatosis0.028
Idh1isocitrate dehydrogenase 1 (NADP+), soluble0.026
Lpin1lipin 10.024
Cyb5cytochrome b-50.024
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.023
Mmp9matrix metallopeptidase 90.023
Chpt1choline phosphotransferase 10.022
Hsdl2hydroxysteroid dehydrogenase like 20.022
Nfkbiznuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta0.021
Grinaglutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)0.020
Spna1spectrin alpha 10.020
Cluclusterin0.020
Vamp2vesicle-associated membrane protein 20.020
Map3k8mitogen-activated protein kinase kinase kinase 80.020
Stx1asyntaxin 1A (brain)0.020
Wwtr1WW domain containing transcription regulator 10.019
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.019
Prkchprotein kinase C, eta0.019
Ccna2cyclin A20.019
Tfrctransferrin receptor0.019
Phyhphytanoyl-CoA hydroxylase0.019
Serpine1serine (or cysteine) peptidase inhibitor, clade E, member 10.019
Atp7bATPase, Cu++ transporting, beta polypeptide0.019
Hadhhydroxyacyl-Coenzyme A dehydrogenase0.018
Lystlysosomal trafficking regulator0.018
Atp6ap1ATPase, H+ transporting, lysosomal accessory protein 10.018
Fbxl5F-box and leucine-rich repeat protein 50.017
Prnpprion protein0.017
Sgcasarcoglycan, alpha (dystrophin-associated glycoprotein)0.017
Nphs2nephrosis 2 homolog, podocin (human)0.017
Gabarapgamma-aminobutyric acid receptor associated protein0.017
Apoa2apolipoprotein A-II0.017
Gpr98G protein-coupled receptor 980.017
Slc3a2solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 20.017
Lyz2lysozyme 20.017
Atox1ATX1 (antioxidant protein 1) homolog 1 (yeast)0.016
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.016
5730469M10RikRIKEN cDNA 5730469M10 gene0.016
Tgfbr1transforming growth factor, beta receptor I0.016
Ptger4prostaglandin E receptor 4 (subtype EP4)0.016
Bcl3B-cell leukemia/lymphoma 30.016
Gdnfglial cell line derived neurotrophic factor0.015
Cpt1acarnitine palmitoyltransferase 1a, liver0.015
Ephx2epoxide hydrolase 2, cytoplasmic0.015
Wbp2WW domain binding protein 20.015
Serpind1serine (or cysteine) peptidase inhibitor, clade D, member 10.015
Dvl3dishevelled 3, dsh homolog (Drosophila)0.015
Vhlvon Hippel-Lindau tumor suppressor0.015
NapaN-ethylmaleimide sensitive fusion protein attachment protein alpha0.015
Ptpn23protein tyrosine phosphatase, non-receptor type 230.015
Slc4a1solute carrier family 4 (anion exchanger), member 10.014
Pcsk4proprotein convertase subtilisin/kexin type 40.014
Alas2aminolevulinic acid synthase 2, erythroid0.014
Gcgroup specific component0.014
Fbp1fructose bisphosphatase 10.014
Slc11a2solute carrier family 11 (proton-coupled divalent metal ion transporters), member 20.014
Lcn2lipocalin 20.014
Il1r1interleukin 1 receptor, type I0.014
Tnfaip3tumor necrosis factor, alpha-induced protein 30.014
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Psmb1proteasome (prosome, macropain) subunit, beta type 10.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
YCR102Chypothetical protein0.699
AQY2Aqy2p0.174
YLR460Chypothetical protein0.072
FRE1Fre1p0.018
SIT1Sit1p0.013
DDI1Ddi1p0.012
YKR011Chypothetical protein0.011