IMP: Integrative Multi-species Prediction

The network for 'response to copper ion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to copper ion

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus.

Homo sapiens

Name	Description	Probability
MT1F	metallothionein 1F	1.000
MT1E	metallothionein 1E	1.000
MT2A	metallothionein 2A	1.000
MT1H	metallothionein 1H	1.000
MT1X	metallothionein 1X	0.999
MT1G	metallothionein 1G	0.540
BCL2L1	BCL2-like 1	0.513
SPRY4	sprouty homolog 4 (Drosophila)	0.465
PDZD11	PDZ domain containing 11	0.224
MT1M	metallothionein 1M	0.183
IL1R1	interleukin 1 receptor, type I	0.162
KATNAL1	katanin p60 subunit A-like 1	0.095
AGXT2	alanine--glyoxylate aminotransferase 2	0.068
MAPK14	mitogen-activated protein kinase 14	0.063
GPR50	G protein-coupled receptor 50	0.043
APOA1	apolipoprotein A-I	0.042
BAK1	BCL2-antagonist/killer 1	0.037
FBLN5	fibulin 5	0.035
IL1RAP	interleukin 1 receptor accessory protein	0.031
EFEMP2	EGF containing fibulin-like extracellular matrix protein 2	0.030
CCNA2	cyclin A2	0.026
ATP6V0C	ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c	0.026
RNF144B	ring finger protein 144B	0.025
CCL20	chemokine (C-C motif) ligand 20	0.021
CFL1	cofilin 1 (non-muscle)	0.020
MDFI	MyoD family inhibitor	0.018
IL1RN	interleukin 1 receptor antagonist	0.017
MT1B	metallothionein 1B	0.017
CAV1	caveolin 1, caveolae protein, 22kDa	0.017
HSD17B4	hydroxysteroid (17-beta) dehydrogenase 4	0.017
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.015
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.015
EHHADH	enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase	0.014
BAD	BCL2-associated agonist of cell death	0.013
SCP2	sterol carrier protein 2	0.013
ARPC4	actin related protein 2/3 complex, subunit 4, 20kDa	0.013
CDK2	cyclin-dependent kinase 2	0.013
NFKBIZ	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.013
BBS1	Bardet-Biedl syndrome 1	0.013
MAPK1	mitogen-activated protein kinase 1	0.013
HIPK3	homeodomain interacting protein kinase 3	0.012
ABCD3	ATP-binding cassette, sub-family D (ALD), member 3	0.012
RNR2	l-rRNA	0.012
SNCAIP	synuclein, alpha interacting protein	0.012
MAPT	microtubule-associated protein tau	0.011
ADAMTSL4	ADAMTS-like 4	0.010

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Caenorhabditis elegans

Name	Description	Probability	Func Analog Organism

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Danio rerio

Name	Description	Probability
pdlim5	PDZ and LIM domain 5	0.724
acadl	acyl-Coenzyme A dehydrogenase, long chain	0.505
atp6v1h	ATPase, H+ transporting, lysosomal, V1 subunit H	0.387
comta	catechol-O-methyltransferase a	0.316
limk1	LIM domain kinase 1	0.310
pdlim2	PDZ and LIM domain 2 (mystique)	0.293
acox1	acyl-Coenzyme A oxidase 1, palmitoyl	0.271
sod1	superoxide dismutase 1, soluble	0.204
slc3a2	solute carrier family 3, member 2	0.200
gpia	glucose phosphate isomerase a	0.185
pdlim4	PDZ and LIM domain 4	0.174
tnfa	tumor necrosis factor a (TNF superfamily, member 2)	0.165
bcl2	B-cell leukemia/lymphoma 2	0.151
rhag	Rhesus blood group-associated glycoprotein	0.142
acat1	acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase)	0.140
sepp1a	selenoprotein P, plasma, 1a	0.126
try	trypsin	0.118
atp6v1e1b	ATPase, H+ transporting, lysosomal, V1 subunit E isoform 1b	0.110
mt2	metallothionein 2	0.107
hadha	hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase, alpha subunit	0.104
sid4	secreted immunoglobulin domain 4	0.101
atp7a	ATPase, Cu++ transporting, alpha polypeptide	0.101
cdipt	CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)	0.097
limk2	LIM domain kinase 2	0.092
atpif1	ATPase inhibitory factor 1	0.081
she	Src homology 2 domain containing E	0.078
gclc	glutamate-cysteine ligase, catalytic subunit	0.077
pdlim3b	PDZ and LIM domain 3b	0.073
urod	uroporphyrinogen decarboxylase	0.071
atp1a1	ATPase, Na+/K+ transporting, alpha 1 polypeptide	0.069
tgfbr2	transforming growth factor, beta receptor II	0.067
atp6v0ca	ATPase, H+ transporting, lysosomal, V0 subunit c, a	0.064
LOC790901	glucose-dependent insulinotropic polypeptide	0.063
npc1	Niemann-Pick disease, type C1	0.061
tfr1a	transferrin receptor 1a	0.061
rbm19	RNA binding motif protein 19	0.060
trim33	tripartite motif-containing 33	0.056
zgc:110775	zgc:110775	0.054
rnasel1	ribonuclease like 1	0.053
csad	cysteine sulfinic acid decarboxylase	0.052
hbae1	hemoglobin alpha embryonic-1	0.051
sod2	superoxide dismutase 2, mitochondrial	0.050
kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.049
stat1b	signal transducer and activator of transcription 1b	0.048
COX1	cytochrome c oxidase subunit I	0.047
atp6ap1	ATPase, H+ transporting, lysosomal accessory protein 1	0.047
glrx5	glutaredoxin 5 homolog (S. cerevisiae)	0.045
aldh2b	aldehyde dehydrogenase 2b	0.045
rtn1a	reticulon 1a	0.044
herpud1	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1	0.043
acsl4a	acyl-CoA synthetase long-chain family member 4a	0.043
hcrt	hypocretin (orexin) neuropeptide precursor	0.042
spsb1	splA/ryanodine receptor domain and SOCS box containing 1	0.042
wnt2bb	wingless-type MMTV integration site family, member 2Bb	0.041
kdrl	kinase insert domain receptor like	0.040
igfbp1a	insulin-like growth factor binding protein 1a	0.039
ldha	lactate dehydrogenase A4	0.039
si:dkeyp-7c9.1	si:dkeyp-7c9.1	0.039
scp2	sterol carrier protein 2	0.039
cpt2	carnitine palmitoyltransferase II	0.038
vps33b	vacuolar protein sorting 33B	0.037
entpd2a.1	ectonucleoside triphosphate diphosphohydrolase 2 a.1	0.037
disc1	disrupted in schizophrenia 1	0.036
mafk	v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)	0.035
mmp9	matrix metalloproteinase 9	0.035
pdlim3a	PDZ and LIM domain 3a	0.034
acp5b	acid phosphatase 5b, tartrate resistant	0.034
ctsl1a	cathepsin L, 1 a	0.033
lndc1	ly6/neurotoxin domain containing 1	0.033
gata6	GATA-binding protein 6	0.032
prkcz	protein kinase C, zeta	0.032
gstt1a	glutathione S-transferase theta 1a	0.032
rnasel2	ribonuclease like 2	0.031
rogdi	rogdi homolog (Drosophila)	0.031
chchd10	coiled-coil-helix-coiled-coil-helix domain containing 10	0.030
lgmn	legumain	0.030
stc1l	stanniocalcin 1, like	0.029
rpl23a	ribosomal protein L23a	0.029
entpd8	ectonucleoside triphosphate diphosphohydrolase 8	0.028
fcer1g	Fc receptor, IgE, high affinity I, gamma polypeptide	0.027
ndfip1	Nedd4 family interacting protein 1	0.027
cdh17	cadherin 17, LI cadherin (liver-intestine)	0.027
etfdh	electron-transferring-flavoprotein dehydrogenase	0.027
si:dkey-88p24.9	si:dkey-88p24.9	0.026
ckbb	creatine kinase, brain b	0.026
wnt9b	wingless-type MMTV integration site family, member 9B	0.026
map2k4b	mitogen-activated protein kinase kinase 4b	0.026
zgc:195195	zgc:195195	0.026
sars	seryl-tRNA synthetase	0.026
gstp1	glutathione S-transferase pi	0.025
pdlim7	PDZ and LIM domain 7	0.025
smyd3	SET and MYND domain containing 3	0.025
ctsf	cathepsin F	0.025
pou4f1	POU domain, class 4, transcription factor 1	0.025
coq3	coenzyme Q3 homolog, methyltransferase (yeast)	0.025
fbxl14b	F-box and leucine-rich repeat protein 14b	0.024
hspd1	heat shock 60kD protein 1 (chaperonin)	0.024
si:dkey-273o13.1	si:dkey-273o13.1	0.024
LOC556849	ectonucleoside triphosphate diphosphohydrolase 5-like	0.024
cnga5	cyclic nucleotide gated channel alpha 5	0.024

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Drosophila melanogaster

Name	Description	Probability
Yp3	Yolk protein 3	0.187
LvpH	Larval visceral protein H	0.097
CG14837	CG14837 gene product from transcript CG14837-RC	0.076
betaTry	betaTrypsin	0.072
CG6277	CG6277 gene product from transcript CG6277-RA	0.070
CG6283	CG6283 gene product from transcript CG6283-RA	0.070
CG18180	CG18180 gene product from transcript CG18180-RA	0.062
CG2107	CG2107 gene product from transcript CG2107-RA	0.058
NLaz	Neural Lazarillo	0.056
CG14820	CG14820 gene product from transcript CG14820-RA	0.054
l(3)82Fd	CG32464 gene product from transcript CG32464-RR	0.054
Lip3	CG8823 gene product from transcript CG8823-RA	0.053
TSG101	tumor suppressor protein 101	0.052
Dredd	Death related ced-3/Nedd2-like protein	0.050
CG7916	CG7916 gene product from transcript CG7916-RA	0.044
CG13792	CG13792 gene product from transcript CG13792-RA	0.043
Cat	Catalase	0.042
Spn77Bb	Serpin 77Bb	0.039
CG14119	CG14119 gene product from transcript CG14119-RA	0.038
CG13160	CG13160 gene product from transcript CG13160-RA	0.038
Adh	Alcohol dehydrogenase	0.037
Cyp4d21	CG6730 gene product from transcript CG6730-RA	0.036
CG11897	CG11897 gene product from transcript CG11897-RA	0.036
CG3011	CG3011 gene product from transcript CG3011-RA	0.036
CG10425	CG10425 gene product from transcript CG10425-RA	0.036
Jon99Ci	Jonah 99Ci	0.035
CG8690	CG8690 gene product from transcript CG8690-RA	0.035
Cyp6g1	CG8453 gene product from transcript CG8453-RA	0.034
Cyp12a4	CG6042 gene product from transcript CG6042-RA	0.034
Tak1	TGF-beta activated kinase 1	0.034
CG6271	CG6271 gene product from transcript CG6271-RA	0.033
CG5945	CG5945 gene product from transcript CG5945-RA	0.033
DJ-1alpha	CG6646 gene product from transcript CG6646-RA	0.032
Cyp12a5	CG11821 gene product from transcript CG11821-RA	0.031
CG8997	CG8997 gene product from transcript CG8997-RA	0.031
DopR	Dopamine receptor	0.030
NAAT1	Nutrient Amino Acid Transporter 1	0.030
CG14247	CG14247 gene product from transcript CG14247-RA	0.030
fu12	CG17608 gene product from transcript CG17608-RA	0.030
CG6996	CG6996 gene product from transcript CG6996-RB	0.030
CG13253	CG13253 gene product from transcript CG13253-RB	0.030
Npc2c	Niemann-Pick type C-2c	0.030
CG10361	CG10361 gene product from transcript CG10361-RA	0.029
CG3267	CG3267 gene product from transcript CG3267-RA	0.029
Ptp10D	Protein tyrosine phosphatase 10D	0.029
DmsR-2	Dromyosuppressin receptor 2	0.029
CG17189	CG17189 gene product from transcript CG17189-RA	0.028
NPFR1	neuropeptide F receptor	0.028
CG7548	CG7548 gene product from transcript CG7548-RA	0.028
CG12483	CG12483 gene product from transcript CG12483-RA	0.028
CG12374	CG12374 gene product from transcript CG12374-RA	0.027
Cyp305a1	CG8733 gene product from transcript CG8733-RA	0.027
CG6295	CG6295 gene product from transcript CG6295-RA	0.027
BG642163	CG34102 gene product from transcript CG34102-RA	0.027
CG1444	CG1444 gene product from transcript CG1444-RA	0.027
CG9672	CG9672 gene product from transcript CG9672-RA	0.027
CG18745	CG18745 gene product from transcript CG18745-RA	0.027
CG7912	CG7912 gene product from transcript CG7912-RA	0.027
cln3	CG5582 gene product from transcript CG5582-RA	0.027
CG17300	CG17300 gene product from transcript CG17300-RA	0.027
tobi	target of brain insulin	0.026
CG5162	CG5162 gene product from transcript CG5162-RA	0.026
CG8093	CG8093 gene product from transcript CG8093-RA	0.026
CG17664	CG17664 gene product from transcript CG17664-RA	0.026
CG18094	CG18094 gene product from transcript CG18094-RA	0.026
CG14506	CG14506 gene product from transcript CG14506-RA	0.026
CG30360	CG30360 gene product from transcript CG30360-RC	0.026
Cyp6a2	Cytochrome P450-6a2	0.026
ImpE1	Ecdysone-inducible gene E1	0.025
CG1443	CG1443 gene product from transcript CG1443-RA	0.025
CG7970	CG7970 gene product from transcript CG7970-RA	0.025
CG8451	CG8451 gene product from transcript CG8451-RA	0.025
ST6Gal	Sialyltransferase	0.025
bgm	bubblegum	0.025
Pabp2	CG2163 gene product from transcript CG2163-RA	0.025
CG7953	CG7953 gene product from transcript CG7953-RA	0.024
Tsp42Eg	Tetraspanin 42Eg	0.024
CG5568	CG5568 gene product from transcript CG5568-RA	0.024
CG15650	CG15650 gene product from transcript CG15650-RA	0.024
CG11796	CG11796 gene product from transcript CG11796-RA	0.024
l(2)k01209	lethal (2) k01209	0.024
Mpk2	CG5475 gene product from transcript CG5475-RB	0.024
CG7530	CG7530 gene product from transcript CG7530-RB	0.024
CG4363	CG4363 gene product from transcript CG4363-RA	0.024
burs	bursicon	0.024
CG9027	CG9027 gene product from transcript CG9027-RD	0.024
Tsp42Ei	Tetraspanin 42Ei	0.024
CG7579	CG7579 gene product from transcript CG7579-RA	0.024
CG31871	CG31871 gene product from transcript CG31871-RA	0.024
ETHR	CG5911 gene product from transcript CG5911-RB	0.024
CG11486	CG11486 gene product from transcript CG11486-RG	0.024
trio	CG18214 gene product from transcript CG18214-RA	0.024
png	pan gu	0.024
CG18516	CG18516 gene product from transcript CG18516-RA	0.023
TotA	Turandot A	0.023
CG13255	CG13255 gene product from transcript CG13255-RA	0.023
l(2)k16918	lethal (2) k16918	0.023
CG16898	CG16898 gene product from transcript CG16898-RA	0.023
bcd	bicoid	0.023
MTF-1	Metal response element-binding Transcription Factor-1	0.023

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Mus musculus

Name	Description	Probability
Mt2	metallothionein 2	0.678
Mt1	metallothionein 1	0.633
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.447
Cp	ceruloplasmin	0.253
Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.153
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.120
Steap3	STEAP family member 3	0.109
Slc39a4	solute carrier family 39 (zinc transporter), member 4	0.094
Nfe2l2	nuclear factor, erythroid derived 2, like 2	0.085
Apoe	apolipoprotein E	0.074
Scp2	sterol carrier protein 2, liver	0.067
Atp6v0b	ATPase, H+ transporting, lysosomal V0 subunit B	0.067
Ccr2	chemokine (C-C motif) receptor 2	0.062
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.060
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.058
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.054
Slc31a1	solute carrier family 31, member 1	0.053
Atp7a	ATPase, Cu++ transporting, alpha polypeptide	0.052
Tlr4	toll-like receptor 4	0.048
Irf1	interferon regulatory factor 1	0.047
Hbb-b2	hemoglobin, beta adult minor chain	0.044
Bax	BCL2-associated X protein	0.044
Lox	lysyl oxidase	0.043
Fas	Fas (TNF receptor superfamily member 6)	0.043
Etfa	electron transferring flavoprotein, alpha polypeptide	0.037
Il1b	interleukin 1 beta	0.037
2010106G01Rik	RIKEN cDNA 2010106G01 gene	0.036
Aldh6a1	aldehyde dehydrogenase family 6, subfamily A1	0.034
Ccl2	chemokine (C-C motif) ligand 2	0.034
Cd44	CD44 antigen	0.034
Atp6v0c	ATPase, H+ transporting, lysosomal V0 subunit C	0.033
Myd88	myeloid differentiation primary response gene 88	0.033
Egfl7	EGF-like domain 7	0.033
Lrrc59	leucine rich repeat containing 59	0.032
Cyp2d26	cytochrome P450, family 2, subfamily d, polypeptide 26	0.032
Hmox1	heme oxygenase (decycling) 1	0.031
Kit	kit oncogene	0.030
Hsd17b4	hydroxysteroid (17-beta) dehydrogenase 4	0.030
Pklr	pyruvate kinase liver and red blood cell	0.030
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.029
Etfdh	electron transferring flavoprotein, dehydrogenase	0.028
Hfe	hemochromatosis	0.028
Idh1	isocitrate dehydrogenase 1 (NADP+), soluble	0.026
Lpin1	lipin 1	0.024
Cyb5	cytochrome b-5	0.024
Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.023
Mmp9	matrix metallopeptidase 9	0.023
Chpt1	choline phosphotransferase 1	0.022
Hsdl2	hydroxysteroid dehydrogenase like 2	0.022
Nfkbiz	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.021
Grina	glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)	0.020
Spna1	spectrin alpha 1	0.020
Clu	clusterin	0.020
Vamp2	vesicle-associated membrane protein 2	0.020
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.020
Stx1a	syntaxin 1A (brain)	0.020
Wwtr1	WW domain containing transcription regulator 1	0.019
Ngfr	nerve growth factor receptor (TNFR superfamily, member 16)	0.019
Prkch	protein kinase C, eta	0.019
Ccna2	cyclin A2	0.019
Tfrc	transferrin receptor	0.019
Phyh	phytanoyl-CoA hydroxylase	0.019
Serpine1	serine (or cysteine) peptidase inhibitor, clade E, member 1	0.019
Atp7b	ATPase, Cu++ transporting, beta polypeptide	0.019
Hadh	hydroxyacyl-Coenzyme A dehydrogenase	0.018
Lyst	lysosomal trafficking regulator	0.018
Atp6ap1	ATPase, H+ transporting, lysosomal accessory protein 1	0.018
Fbxl5	F-box and leucine-rich repeat protein 5	0.017
Prnp	prion protein	0.017
Sgca	sarcoglycan, alpha (dystrophin-associated glycoprotein)	0.017
Nphs2	nephrosis 2 homolog, podocin (human)	0.017
Gabarap	gamma-aminobutyric acid receptor associated protein	0.017
Apoa2	apolipoprotein A-II	0.017
Gpr98	G protein-coupled receptor 98	0.017
Slc3a2	solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2	0.017
Lyz2	lysozyme 2	0.017
Atox1	ATX1 (antioxidant protein 1) homolog 1 (yeast)	0.016
Serpina3n	serine (or cysteine) peptidase inhibitor, clade A, member 3N	0.016
5730469M10Rik	RIKEN cDNA 5730469M10 gene	0.016
Tgfbr1	transforming growth factor, beta receptor I	0.016
Ptger4	prostaglandin E receptor 4 (subtype EP4)	0.016
Bcl3	B-cell leukemia/lymphoma 3	0.016
Gdnf	glial cell line derived neurotrophic factor	0.015
Cpt1a	carnitine palmitoyltransferase 1a, liver	0.015
Ephx2	epoxide hydrolase 2, cytoplasmic	0.015
Wbp2	WW domain binding protein 2	0.015
Serpind1	serine (or cysteine) peptidase inhibitor, clade D, member 1	0.015
Dvl3	dishevelled 3, dsh homolog (Drosophila)	0.015
Vhl	von Hippel-Lindau tumor suppressor	0.015
Napa	N-ethylmaleimide sensitive fusion protein attachment protein alpha	0.015
Ptpn23	protein tyrosine phosphatase, non-receptor type 23	0.015
Slc4a1	solute carrier family 4 (anion exchanger), member 1	0.014
Pcsk4	proprotein convertase subtilisin/kexin type 4	0.014
Alas2	aminolevulinic acid synthase 2, erythroid	0.014
Gc	group specific component	0.014
Fbp1	fructose bisphosphatase 1	0.014
Slc11a2	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	0.014
Lcn2	lipocalin 2	0.014
Il1r1	interleukin 1 receptor, type I	0.014
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.014

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Rattus norvegicus

Name	Description	Probability	Func Analog Organism
Psmb1	proteasome (prosome, macropain) subunit, beta type 1	0.011

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Saccharomyces cerevisiae

Name	Description	Probability
YCR102C	hypothetical protein	0.699
AQY2	Aqy2p	0.174
YLR460C	hypothetical protein	0.072
FRE1	Fre1p	0.018
SIT1	Sit1p	0.013
DDI1	Ddi1p	0.012
YKR011C	hypothetical protein	0.011