The network for 'trna aminoacylation for protein translation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

trna aminoacylation for protein translation

The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis.

NameDescriptionProbabilityFunc Analog Organism
IARSisoleucyl-tRNA synthetase1.000
GARSglycyl-tRNA synthetase1.000
EPRSglutamyl-prolyl-tRNA synthetase1.000
MARSmethionyl-tRNA synthetase1.000
AARSalanyl-tRNA synthetase1.000
YARStyrosyl-tRNA synthetase1.000
ASNSasparagine synthetase (glutamine-hydrolyzing)1.000
AIMP2aminoacyl tRNA synthetase complex-interacting multifunctional protein 21.000
SARSseryl-tRNA synthetase0.995
RARSarginyl-tRNA synthetase0.995
CARScysteinyl-tRNA synthetase0.992
NARSasparaginyl-tRNA synthetase0.991
TARSthreonyl-tRNA synthetase0.982
KARSlysyl-tRNA synthetase0.849
LARSleucyl-tRNA synthetase0.726
SHMT2serine hydroxymethyltransferase 2 (mitochondrial)0.696
XPOTexportin, tRNA (nuclear export receptor for tRNAs)0.691
CEBPGCCAAT/enhancer binding protein (C/EBP), gamma0.600
MTHFD2methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase0.452
EIF2S2eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa0.414
AIMP1aminoacyl tRNA synthetase complex-interacting multifunctional protein 10.191
DARSaspartyl-tRNA synthetase0.175
ATF4activating transcription factor 4 (tax-responsive enhancer element B67)0.167
ATIC5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase0.157
LONP1lon peptidase 1, mitochondrial0.130
PSAT1phosphoserine aminotransferase 10.078
WARStryptophanyl-tRNA synthetase0.068
TRIB3tribbles homolog 3 (Drosophila)0.060
TIMM44translocase of inner mitochondrial membrane 44 homolog (yeast)0.059
METTL13methyltransferase like 130.049
EIF3CLeukaryotic translation initiation factor 3, subunit C-like0.048
SLC3A2solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 20.046
CADcarbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase0.045
EIF2B3eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa0.044
BOP1block of proliferation 10.038
ALG3asparagine-linked glycosylation 3, alpha-1,3- mannosyltransferase homolog (S. cerevisiae)0.036
PUF60poly-U binding splicing factor 60KDa0.033
C12orf44chromosome 12 open reading frame 440.030
ECSITECSIT homolog (Drosophila)0.029
OTUD5OTU domain containing 50.029
CNOcappuccino homolog (mouse)0.029
IPO4importin 40.028
XPO5exportin 50.025
HSPA9heat shock 70kDa protein 9 (mortalin)0.025
LARS2leucyl-tRNA synthetase 2, mitochondrial0.022
SLC7A5solute carrier family 7 (cationic amino acid transporter, y+ system), member 50.022
EIF2B2eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa0.021
PFASphosphoribosylformylglycinamidine synthase0.021
TBL3transducin (beta)-like 30.020
RPTORregulatory associated protein of MTOR, complex 10.019
PCK2phosphoenolpyruvate carboxykinase 2 (mitochondrial)0.018
HYOU1hypoxia up-regulated 10.018
WDR46WD repeat domain 460.017
SLC7A1solute carrier family 7 (cationic amino acid transporter, y+ system), member 10.015
GOT1glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)0.014
C10orf2chromosome 10 open reading frame 20.013
ALG8asparagine-linked glycosylation 8, alpha-1,3-glucosyltransferase homolog (S. cerevisiae)0.013
AATFapoptosis antagonizing transcription factor0.013
MTORmechanistic target of rapamycin (serine/threonine kinase)0.012
EEF1E1eukaryotic translation elongation factor 1 epsilon 10.011
HARS2histidyl-tRNA synthetase 2, mitochondrial (putative)0.011
DNAJA3DnaJ (Hsp40) homolog, subfamily A, member 30.011
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Aats-tyrTyrosyl-tRNA synthetase0.908
Aats-thrThreonyl-tRNA synthetase0.701
Hsc70-5Heat shock protein cognate 50.666
Aats-trpTryptophanyl-tRNA synthetase0.631
Aats-leuLeucyl-tRNA synthetase0.551
CG17259CG17259 gene product from transcript CG17259-RA0.540
Aats-aspAspartyl-tRNA synthetase0.454
Aats-glyGlycyl-tRNA synthetase0.342
Aats-asnAsparaginyl-tRNA synthetase0.239
Srp54kSignal recognition particle protein 54k0.200
Srp68CG5064 gene product from transcript CG5064-RA0.198
Aats-metMethionyl-tRNA synthetase0.195
Aats-proProlyl-tRNA synthetase0.168
l(2)k01209lethal (2) k012090.130
Aats-gluproGlutamyl-prolyl-tRNA synthetase0.112
Trxr-1Thioredoxin reductase-10.102
l(2)37Cclethal (2) 37Cc0.088
CG4679CG4679 gene product from transcript CG4679-RA0.065
CG1703CG1703 gene product from transcript CG1703-RA0.053
Aats-glnGlutaminyl-tRNA synthetase0.047
CG2076CG2076 gene product from transcript CG2076-RA0.045
RFeSPRieske iron-sulfur protein0.043
Aats-valValyl-tRNA synthetase0.039
Aats-hisHistidyl-tRNA synthetase0.037
Gcn2CG1609 gene product from transcript CG1609-RA0.034
CG13393CG13393 gene product from transcript CG13393-RA0.032
beta'Copbeta'-coatomer protein0.031
CG11771CG11771 gene product from transcript CG11771-RA0.030
CG2263CG2263 gene product from transcript CG2263-RA0.028
EfTuMElongation factor Tu mitochondrial0.028
eIF2B-epsilonCG3806 gene product from transcript CG3806-RB0.028
CG33123CG33123 gene product from transcript CG33123-RA0.028
CG42630CG42630 gene product from transcript CG42630-RA0.027
oxoxen0.027
Aats-alaAlanyl-tRNA synthetase0.025
CG4389CG4389 gene product from transcript CG4389-RA0.024
Elp1Elongator complex protein 10.022
Aats-ileIsoleucyl-tRNA synthetase0.021
Drp1Dynamin related protein 10.019
Dph5Diphthamide methyltransferase0.019
nmdno mitochondrial derivative0.018
CG7791CG7791 gene product from transcript CG7791-RA0.017
l(3)02640lethal (3) 026400.017
eRF1eukaryotic release factor 10.017
l(2)03709lethal (2) 037090.017
sec3CG3885 gene product from transcript CG3885-RA0.016
eIF-3p66Eukaryotic initiation factor 3 p66 subunit0.014
CG8531CG8531 gene product from transcript CG8531-RA0.014
Aats-cysCysteinyl-tRNA synthetase0.013
CG8728CG8728 gene product from transcript CG8728-RA0.013
CG3267CG3267 gene product from transcript CG3267-RA0.013
SrpRbetaSignal recognition particle receptor beta0.013
CG5789CG5789 gene product from transcript CG5789-RA0.012
CG5525CG5525 gene product from transcript CG5525-RA0.012
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Garsglycyl-tRNA synthetase0.994
Narsasparaginyl-tRNA synthetase0.977
Larsleucyl-tRNA synthetase0.958
Dus1ldihydrouridine synthase 1-like (S. cerevisiae)0.804
Tarsthreonyl-tRNA synthetase0.785
Eif3ceukaryotic translation initiation factor 3, subunit C0.732
Eprsglutamyl-prolyl-tRNA synthetase0.722
Marsmethionine-tRNA synthetase0.697
Aarsalanyl-tRNA synthetase0.694
Rarsarginyl-tRNA synthetase0.606
Yarstyrosyl-tRNA synthetase0.581
Farsbphenylalanyl-tRNA synthetase, beta subunit0.580
Eif3deukaryotic translation initiation factor 3, subunit D0.512
Iarsisoleucine-tRNA synthetase0.476
Ddx1DEAD (Asp-Glu-Ala-Asp) box polypeptide 10.193
Sarsseryl-aminoacyl-tRNA synthetase0.185
Asnsasparagine synthetase0.149
Cct5chaperonin containing Tcp1, subunit 5 (epsilon)0.099
Xpotexportin, tRNA (nuclear export receptor for tRNAs)0.099
Lrpprcleucine-rich PPR-motif containing0.067
Fam98afamily with sequence similarity 98, member A0.058
Hspa9heat shock protein 90.054
Cpsf3cleavage and polyadenylation specificity factor 30.053
Tcp1t-complex protein 10.047
Eif3geukaryotic translation initiation factor 3, subunit G0.045
Srp68signal recognition particle 680.044
Wdr36WD repeat domain 360.042
Eif2b4eukaryotic translation initiation factor 2B, subunit 4 delta0.035
Cct7chaperonin containing Tcp1, subunit 7 (eta)0.034
Dohhdeoxyhypusine hydroxylase/monooxygenase0.032
Lonp1lon peptidase 1, mitochondrial0.030
Eif2b3eukaryotic translation initiation factor 2B, subunit 30.030
Psmc5protease (prosome, macropain) 26S subunit, ATPase 50.025
Mrps18bmitochondrial ribosomal protein S18B0.024
Nsun2NOL1/NOP2/Sun domain family member 20.022
Psmd12proteasome (prosome, macropain) 26S subunit, non-ATPase, 120.021
Aatfapoptosis antagonizing transcription factor0.021
Supt5hsuppressor of Ty 5 homolog (S. cerevisiae)0.020
Ruvbl1RuvB-like protein 10.020
Mlh1mutL homolog 1 (E. coli)0.019
Eif5aeukaryotic translation initiation factor 5A0.019
Atad3aATPase family, AAA domain containing 3A0.019
Atf4activating transcription factor 40.018
Abce1ATP-binding cassette, sub-family E (OABP), member 10.018
Rrp12ribosomal RNA processing 12 homolog (S. cerevisiae)0.018
Cfdp1craniofacial development protein 10.017
Ttc27tetratricopeptide repeat domain 270.017
Carscysteinyl-tRNA synthetase0.017
Wdr74WD repeat domain 740.017
Drg2developmentally regulated GTP binding protein 20.016
Polr2bpolymerase (RNA) II (DNA directed) polypeptide B0.016
Exosc9exosome component 90.016
Gtf2f1general transcription factor IIF, polypeptide 10.016
Fastkd2FAST kinase domains 20.015
Ftsj3FtsJ homolog 3 (E. coli)0.015
Las1lLAS1-like (S. cerevisiae)0.015
Bms1BMS1 homolog, ribosome assembly protein (yeast)0.015
Cops4COP9 (constitutive photomorphogenic) homolog, subunit 4 (Arabidopsis thaliana)0.015
Ppp1r7protein phosphatase 1, regulatory (inhibitor) subunit 70.014
Vcpvalosin containing protein0.014
Mrpl3mitochondrial ribosomal protein L30.014
Xrcc5X-ray repair complementing defective repair in Chinese hamster cells 50.013
Ncbp1nuclear cap binding protein subunit 10.013
Elac2elaC homolog 2 (E. coli)0.013
Nop14NOP14 nucleolar protein homolog (yeast)0.013
Orc5origin recognition complex, subunit 50.013
Slc3a2solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 20.013
BccipBRCA2 and CDKN1A interacting protein0.013
C1qbpcomplement component 1, q subcomponent binding protein0.012
Ddx54DEAD (Asp-Glu-Ala-Asp) box polypeptide 540.012
Faf1Fas-associated factor 10.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Yarstyrosyl-tRNA synthetase0.917
Eif3beukaryotic translation initiation factor 3, subunit B0.746
Marsmethionine-tRNA synthetase0.498
Eif3ceukaryotic translation initiation factor 3, subunit C0.497
Garsglycyl-tRNA synthetase0.488
Tarsthreonyl-tRNA synthetase0.465
Aarsalanyl-tRNA synthetase0.281
Carscysteinyl-tRNA synthetase0.253
Cct3chaperonin containing Tcp1, subunit 3 (gamma)0.169
Sarsseryl-tRNA synthetase0.085
Psmd2proteasome (prosome, macropain) 26S subunit, non-ATPase, 20.050
Ddx1DEAD (Asp-Glu-Ala-Asp) box polypeptide 10.049
Nmt1N-myristoyltransferase 10.048
Aatfapoptosis antagonizing transcription factor0.039
Abce1ATP-binding cassette, subfamily E (OABP), member 10.032
Asnsasparagine synthetase0.031
Cpsf3cleavage and polyadenylation specificity factor 30.027
Warstryptophanyl-tRNA synthetase0.022
LOC100360406rCG34104-like0.021
LOC362855P550.018
Pno1partner of NOB1 homolog (S. cerevisiae)0.017
Tmem69transmembrane protein 690.016
Larsleucyl-tRNA synthetase0.016
Fastkd2FAST kinase domains 20.015
Psmd12proteasome (prosome, macropain) 26S subunit, non-ATPase, 120.015
Anapc5anaphase-promoting complex subunit 50.015
Farsbphenylalanyl-tRNA synthetase, beta subunit0.014
Cirh1acirrhosis, autosomal recessive 1A (cirhin)0.014
Ipo4importin 40.013
Eef1geukaryotic translation elongation factor 1 gamma0.013
Nsfl1cNSFL1 (p97) cofactor (p47)0.012
Tcp1t-complex 10.012
Faf1Fas (TNFRSF6) associated factor 10.012
Eif2deukaryotic translation initiation factor 2D0.012
Eif2b3eukaryotic translation initiation factor 2B, subunit 30.011
Abcf1ATP-binding cassette, subfamily F (GCN20), member 10.011
Ubxn4UBX domain protein 40.011
Elac2elaC homolog 2 (E. coli)0.011
Tmem177transmembrane protein 1770.010
Eprsglutamyl-prolyl-tRNA synthetase0.010
Iarsisoleucyl-tRNA synthetase0.010
Vcpvalosin-containing protein0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
CDC60Cdc60p0.981
GUS1Gus1p0.972
VAS1Vas1p0.967
ILS1Ils1p0.944
THS1Ths1p0.913
SES1Ses1p0.903
IFM1Ifm1p0.873
MSE1Mse1p0.864
DYS1Dys1p0.862
DED81Ded81p0.814
KRS1Krs1p0.791
FRS2Frs2p0.699
SLM5Slm5p0.657
TYS1Tys1p0.643
HTS1Hts1p0.611
YHR020Whypothetical protein0.586
MES1Mes1p0.560
MSF1Msf1p0.544
ASN2Asn2p0.535
GRS1Grs1p0.455
ALA1Ala1p0.431
GLN4Gln4p0.361
AIM10Aim10p0.325
YDR341Chypothetical protein0.318
MRF1Mrf1p0.305
FRS1Frs1p0.257
GCN20Gcn20p0.256
KAP104Kap104p0.248
KEL3Kel3p0.238
MSD1Msd1p0.236
YNL247Whypothetical protein0.235
MRP20Mrp20p0.228
GUA1Gua1p0.226
YFH7Yfh7p0.197
RSM23Rsm23p0.187
COQ1Coq1p0.183
SUB2Sub2p0.166
TCM62Tcm62p0.144
MEF1Mef1p0.139
GUF1Guf1p0.129
SUP35Sup35p0.123
PET112Pet112p0.123
ADE6Ade6p0.114
GYL1Gyl1p0.109
DBP5Dbp5p0.106
AGC1Agc1p0.099
CTM1Ctm1p0.086
ISM1Ism1p0.082
CYM1Cym1p0.080
DPS1Dps1p0.077
MST1Mst1p0.071
MAP2Map2p0.059
MSY1Msy1p0.059
LEU9Leu9p0.055
NAM2Nam2p0.054
IMD2Imd2p0.051
THR4Thr4p0.047
ACO2Aco2p0.047
OLA1Ola1p0.047
LYS21Lys21p0.046
YLR264C-Ahypothetical protein0.045
AAP1Aap1p0.045
SSZ1Ssz1p0.044
ILV3Ilv3p0.043
SRD1Srd1p0.042
MDN1Mdn1p0.041
NMT1Nmt1p0.040
RPS20Rps20p0.039
YOL038C-Ahypothetical protein0.038
MSR1Msr1p0.037
DPH5Dph5p0.036
ART10Art10p0.036
MAS2Mas2p0.036
YNR040Whypothetical protein0.034
YLR162Whypothetical protein0.033
FMP25Fmp25p0.033
MRPL1Mrpl1p0.032
MER1Mer1p0.032
CUP1-1Cup1-1p0.031
ASN1Asn1p0.031
RPG1Rpg1p0.031
UBP16Ubp16p0.030
YRB1Yrb1p0.029
URA3Ura3p0.029
EMC1Emc1p0.028
HXT3Hxt3p0.028
IBA57Iba57p0.028
ARP10Arp10p0.028
PRO2Pro2p0.028
YPR157Whypothetical protein0.027
FMP30Fmp30p0.027
LEU2Leu2p0.027
CPD1Cpd1p0.026
ATP6Atp6p0.026
YAR068Whypothetical protein0.026
YLR132Chypothetical protein0.026
COX10Cox10p0.026
HOHop0.026
SPL2Spl2p0.025
YLR363W-Ahypothetical protein0.025