The network for 'cellular response to radiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cellular response to radiation

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation.

NameDescriptionProbabilityFunc Analog Organism
TP53tumor protein p530.981
BRCA1breast cancer 1, early onset0.942
MDM2Mdm2 p53 binding protein homolog (mouse)0.899
CHEK1CHK1 checkpoint homolog (S. pombe)0.896
HSPB1heat shock 27kDa protein 10.875
CRYABcrystallin, alpha B0.862
TEKTEK tyrosine kinase, endothelial0.697
ARRB1arrestin, beta 10.690
HIST1H2BGhistone cluster 1, H2bg0.666
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.645
SMAD4SMAD family member 40.617
CUL4Acullin 4A0.507
YY1YY1 transcription factor0.502
BCL2B-cell CLL/lymphoma 20.448
RUVBL1RuvB-like 1 (E. coli)0.443
INO80INO80 homolog (S. cerevisiae)0.400
XIAPX-linked inhibitor of apoptosis0.385
HIST1H1Chistone cluster 1, H1c0.383
HIST1H2AJhistone cluster 1, H2aj0.353
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.344
WRNWerner syndrome, RecQ helicase-like0.340
DDB1damage-specific DNA binding protein 1, 127kDa0.338
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.337
MAP3K5mitogen-activated protein kinase kinase kinase 50.316
HIST1H2AIhistone cluster 1, H2ai0.301
BCL2L11BCL2-like 11 (apoptosis facilitator)0.264
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.262
SMURF2SMAD specific E3 ubiquitin protein ligase 20.260
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.257
BTRCbeta-transducin repeat containing0.246
CFLARCASP8 and FADD-like apoptosis regulator0.243
CRYBB2crystallin, beta B20.223
FBXW11F-box and WD repeat domain containing 110.219
RHOAras homolog gene family, member A0.219
HDAC6histone deacetylase 60.218
HSPB2heat shock 27kDa protein 20.218
CASP8caspase 8, apoptosis-related cysteine peptidase0.214
CRYGCcrystallin, gamma C0.210
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.200
GADD45GIP1growth arrest and DNA-damage-inducible, gamma interacting protein 10.200
BAK1BCL2-antagonist/killer 10.195
SKP1S-phase kinase-associated protein 10.194
SMAD3SMAD family member 30.184
JUNjun proto-oncogene0.182
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.177
IRAK2interleukin-1 receptor-associated kinase 20.173
TAL1T-cell acute lymphocytic leukemia 10.169
CAV1caveolin 1, caveolae protein, 22kDa0.158
DUSP1dual specificity phosphatase 10.147
MAP2K4mitogen-activated protein kinase kinase 40.147
SNTA1syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)0.140
CASP9caspase 9, apoptosis-related cysteine peptidase0.136
ARHGAP1Rho GTPase activating protein 10.135
HIST1H3Dhistone cluster 1, H3d0.135
NRP1neuropilin 10.134
RAD51RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)0.128
NMIN-myc (and STAT) interactor0.127
CASP10caspase 10, apoptosis-related cysteine peptidase0.126
HIPK2homeodomain interacting protein kinase 20.122
TNFAIP1tumor necrosis factor, alpha-induced protein 1 (endothelial)0.120
HSPB8heat shock 22kDa protein 80.120
CHEK2CHK2 checkpoint homolog (S. pombe)0.116
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.114
SIRT1sirtuin 10.111
INCENPinner centromere protein antigens 135/155kDa0.110
RIPK2receptor-interacting serine-threonine kinase 20.103
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.101
UHRF2ubiquitin-like with PHD and ring finger domains 20.099
ARNTLaryl hydrocarbon receptor nuclear translocator-like0.098
EP300E1A binding protein p3000.096
CCNE1cyclin E10.094
ARRB2arrestin, beta 20.093
PLCG1phospholipase C, gamma 10.093
DTLdenticleless homolog (Drosophila)0.093
HIST1H2BJhistone cluster 1, H2bj0.093
OTUB1OTU domain, ubiquitin aldehyde binding 10.093
WWOXWW domain containing oxidoreductase0.092
HIST1H2BIhistone cluster 1, H2bi0.092
ARandrogen receptor0.089
FADDFas (TNFRSF6)-associated via death domain0.088
PSMD11proteasome (prosome, macropain) 26S subunit, non-ATPase, 110.087
BCL2L1BCL2-like 10.087
BAXBCL2-associated X protein0.086
HIST1H2BEhistone cluster 1, H2be0.086
RYBPRING1 and YY1 binding protein0.086
CASP3caspase 3, apoptosis-related cysteine peptidase0.086
RAD17RAD17 homolog (S. pombe)0.086
BHLHE40basic helix-loop-helix family, member e400.085
HIST1H2BFhistone cluster 1, H2bf0.085
RAD52RAD52 homolog (S. cerevisiae)0.082
NLRC4NLR family, CARD domain containing 40.080
CREBBPCREB binding protein0.078
IFI16interferon, gamma-inducible protein 160.076
RICTORRPTOR independent companion of MTOR, complex 20.075
CDC25Acell division cycle 25 homolog A (S. pombe)0.074
IL4Rinterleukin 4 receptor0.074
HIST1H2BDhistone cluster 1, H2bd0.074
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
CELE_ZK829.7Protein ZK829.70.012
fan-1Protein FAN-10.011
C44E4.5Protein C44E4.50.011
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
gnat2guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 20.719
opn1lw1opsin 1 (cone pigments), long-wave-sensitive, 10.670
gc3guanylyl cyclase 30.667
opn1sw1opsin 1 (cone pigments), short-wave-sensitive 10.645
gnat1guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 10.621
arr3aarrestin 3a, retinal (X-arrestin)0.475
rx1retinal homeobox gene 10.471
opn1sw2opsin 1 (cone pigments), short-wave-sensitive 20.433
opn1mw1opsin 1 (cone pigments), medium-wave-sensitive, 10.431
opn4lopsin 4, like0.348
gucy2fguanylate cyclase 2F, retinal0.324
grk7aG-protein-coupled receptor kinase 7a0.301
cry5cryptochrome 50.282
pde6cphosphodiesterase 6C, cGMP-specific, cone, alpha prime0.268
guca1cguanylate cyclase activator 1C0.261
crb1crumbs homolog 1 (Drosophila)0.259
opn4aopsin 4a (melanopsin)0.257
cdh1cadherin 1, epithelial0.249
opn4x1opsin 4x10.240
bbc3BCL2 binding component 30.234
itgb1aintegrin, beta 1a0.217
mychmyelocytomatosis oncogene homolog0.207
nbl1neuroblastoma, suppression of tumorigenicity 10.192
crb2bcrumbs homolog 2b0.191
kif17kinesin family member 170.190
notch2notch homolog 20.183
epb41l5erythrocyte membrane protein band 4.1 like 50.175
rdh5retinol dehydrogenase 5 (11-cis/9-cis)0.172
guca1dguanylate cyclase activator 1d0.164
wlswntless homolog (Drosophila)0.162
rasl11bRAS-like, family 11, member B0.154
otx5orthodenticle homolog 50.152
gins2GINS complex subunit 20.149
gc2guanylyl cyclase 20.133
baxabcl2-associated X protein, a0.132
crxcone-rod homeobox0.132
crb3acrumbs homolog 3a0.131
cry-dashcryptochrome DASH0.130
arr3barrestin 3b, retinal (X-arrestin)0.128
aanat2arylalkylamine N-acetyltransferase0.123
dkk1adickkopf 1a0.120
crb3bcrumbs homolog 3b0.120
grk1bG protein-coupled receptor kinase 1 b0.113
nrlneural retina leucine zipper0.105
cluap1clusterin associated protein 10.103
mpp5bmembrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5b)0.100
chatcholine acetyltransferase0.092
fzd7afrizzled homolog 7a0.089
cyp26a1cytochrome P450, subfamily XXVIA, polypeptide 10.089
pola2polymerase (DNA directed), alpha 20.087
fn1fibronectin 10.086
zfyve26zinc finger, FYVE domain containing 260.085
per2period homolog 2 (Drosophila)0.084
pdzd7aPDZ domain containing 7a0.083
dhrs3adehydrogenase/reductase (SDR family) member 3a0.083
sagaS-antigen; retina and pineal gland (arrestin) a0.083
rp2retinitis pigmentosa 2 (X-linked recessive)0.081
tfap2ctranscription factor AP-2 gamma (activating enhancer binding protein 2 gamma)0.080
cxadrcoxsackie virus and adenovirus receptor0.078
ivns1abpainfluenza virus NS1A binding protein a0.077
celsr3cadherin, EGF LAG seven-pass G-type receptor 30.074
rx2retinal homeobox gene 20.074
irbpinterphotoreceptor retinoid-binding protein0.074
pdlim1PDZ and LIM domain 1 (elfin)0.074
cdiptCDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)0.073
guk1guanylate kinase 10.072
cdc45CDC45 cell division cycle 45 homolog (S. cerevisiae)0.070
hirip3HIRA interacting protein 30.070
atf3activating transcription factor 30.069
pik3ip1phosphoinositide-3-kinase interacting protein 10.068
sgk1serum/glucocorticoid regulated kinase 10.068
wdr76WD repeat domain 760.067
xpcxeroderma pigmentosum, complementation group C0.066
scn1basodium channel, voltage-gated, type I, beta a0.066
cplx4acomplexin 4a0.065
hnrprheterogeneous nuclear ribonucleoprotein R0.064
lin7alin-7 homolog A (C. elegans)0.062
arf1ADP-ribosylation factor 10.062
postnperiostin, osteoblast specific factor0.062
parapinopsinbparapinopsin b0.061
fesfeline sarcoma oncogene0.061
dync1h1dynein, cytoplasmic 1, heavy chain 10.060
spry4sprouty (Drosophila) homolog 40.060
ift57intraflagellar transport protein 570.059
gadd45ggrowth arrest and DNA-damage-inducible, gamma0.059
cx52.6connexin 52.60.059
rtn4rreticulon 4 receptor0.058
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
inaDinactivation no afterpotential D1.000
trptransient receptor potential0.999
Arr2Arrestin 20.983
inaCinactivation no afterpotential C0.973
Gbeta76CG protein beta-subunit 76C0.971
norpAno receptor potential A0.960
ninaCneither inactivation nor afterpotential C0.939
ninaAneither inactivation nor afterpotential A0.935
Rh3Rhodopsin 30.860
Arr1Arrestin 10.841
Gyc-89DbGuanylyl cyclase at 89Db0.800
Rh6Rhodopsin 60.795
ninaEneither inactivation nor afterpotential E0.773
inaF-DCG42563 gene product from transcript CG42563-RB0.745
Rh5Rhodopsin 50.671
Hsp27Heat shock protein 270.656
rdgBretinal degeneration B0.645
elavembryonic lethal abnormal vision0.635
rdgCretinal degeneration C0.551
tadrtorn and diminished rhabdomeres0.489
mus205mutagen-sensitive 2050.421
FhosCG42610 gene product from transcript CG42610-RC0.417
CngCyclic-nucleotide-gated ion channel protein0.409
rdgAretinal degeneration A0.384
CG1572CG1572 gene product from transcript CG1572-RA0.352
stumpsCG31317 gene product from transcript CG31317-RC0.339
l(2)gllethal (2) giant larvae0.311
CG13704CG13704 gene product from transcript CG13704-RA0.309
CalxNa/Ca-exchange protein0.295
ImpL2Ecdysone-inducible gene L20.293
dcodiscs overgrown0.285
TimpTissue inhibitor of metalloproteases0.280
Gyc-89DaGuanylyl cyclase at 89Da0.278
CG14686CG14686 gene product from transcript CG14686-RA0.270
SuURSuppressor of Under-Replication0.269
Sin3ACG8815 gene product from transcript CG8815-RC0.259
Tsp42ElTetraspanin 42El0.257
Galpha49BG protein alpha49B0.242
Gyc88EGuanylyl cyclase at 88E0.228
CG6191CG6191 gene product from transcript CG6191-RA0.224
Ggamma30AG protein gamma30A0.206
Tsp42EfTetraspanin 42Ef0.204
Tsp42EjTetraspanin 42Ej0.201
CG9628CG9628 gene product from transcript CG9628-RA0.200
CG1681CG1681 gene product from transcript CG1681-RA0.189
debcldeath executioner Bcl-2 homologue0.174
Tsp42EiTetraspanin 42Ei0.172
p53CG33336 gene product from transcript CG33336-RB0.172
mus101mutagen-sensitive 1010.162
Dsp1Dorsal switch protein 10.151
Tsp29FbTetraspanin 29Fb0.150
Esyt2CG6643 gene product from transcript CG6643-RA0.146
G-salpha60AG protein salpha 60A0.141
mei-9meiotic 90.140
shakBshaking B0.137
Pk61CProtein kinase 61C0.136
mubmushroom-body expressed0.135
Eip63EEcdysone-induced protein 63E0.135
CG9772CG9772 gene product from transcript CG9772-RB0.135
MED4Mediator complex subunit 40.130
Tsp42EhTetraspanin 42Eh0.128
Vap-33-1CG5014 gene product from transcript CG5014-RB0.124
CG5524CG5524 gene product from transcript CG5524-RA0.122
sxcsuper sex combs0.121
myoglianinCG1838 gene product from transcript CG1838-RD0.118
MadMothers against dpp0.118
Rm62CG10279 gene product from transcript CG10279-RD0.116
CG8086CG8086 gene product from transcript CG8086-RF0.115
CRMPCollapsin Response Mediator Protein0.114
Bj1Bj1 protein0.113
rad50CG6339 gene product from transcript CG6339-RD0.111
RhoGEF2CG9635 gene product from transcript CG9635-RF0.109
CG5273CG5273 gene product from transcript CG5273-RA0.106
Ggamma1G protein gamma 10.103
nbsCG6754 gene product from transcript CG6754-RC0.100
CG5973CG5973 gene product from transcript CG5973-RA0.100
osaCG7467 gene product from transcript CG7467-RD0.098
ric8aCG15797 gene product from transcript CG15797-RA0.098
nrv3nervana 30.093
l(2)efllethal (2) essential for life0.091
CG9990CG9990 gene product from transcript CG9990-RA0.090
RecQ5homolog of RecQ0.089
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 531.000
Ptenphosphatase and tensin homolog1.000
Bcl2B-cell leukemia/lymphoma 20.998
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.985
Kitkit oncogene0.968
Brca2breast cancer 20.954
BaxBCL2-associated X protein0.894
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.851
Brca1breast cancer 10.825
Stat5asignal transducer and activator of transcription 5A0.813
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.756
Apcadenomatosis polyposis coli0.715
Ptpn11protein tyrosine phosphatase, non-receptor type 110.714
Nfatc3nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 30.713
Sirt1sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)0.700
Mapk8mitogen-activated protein kinase 80.683
Rbl1retinoblastoma-like 1 (p107)0.678
Ep300E1A binding protein p3000.657
Notch2Notch gene homolog 2 (Drosophila)0.636
CblCasitas B-lineage lymphoma0.577
Arandrogen receptor0.538
Trp73transformation related protein 730.535
Trp63transformation related protein 630.535
Prkdcprotein kinase, DNA activated, catalytic polypeptide0.513
Msh2mutS homolog 2 (E. coli)0.480
Tgfb1transforming growth factor, beta 10.472
Vhlvon Hippel-Lindau tumor suppressor0.467
Cyldcylindromatosis (turban tumor syndrome)0.456
DbpD site albumin promoter binding protein0.446
Bcl2l1BCL2-like 10.444
Dicer1Dicer1, Dcr-1 homolog (Drosophila)0.428
BrafBraf transforming gene0.406
Itgb1integrin beta 1 (fibronectin receptor beta)0.397
Mdm2transformed mouse 3T3 cell double minute 20.356
Kitlkit ligand0.353
Atf2activating transcription factor 20.346
Ncoa3nuclear receptor coactivator 30.331
Dclk1doublecortin-like kinase 10.319
Foxp3forkhead box P30.315
Nfe2l2nuclear factor, erythroid derived 2, like 20.312
Ptk2PTK2 protein tyrosine kinase 20.309
Mdm4transformed mouse 3T3 cell double minute 40.309
Sfrp2secreted frizzled-related protein 20.267
Stat3signal transducer and activator of transcription 30.252
Stat5bsignal transducer and activator of transcription 5B0.250
Thrathyroid hormone receptor alpha0.245
Sp1trans-acting transcription factor 10.244
Rxraretinoid X receptor alpha0.239
Gna11guanine nucleotide binding protein, alpha 110.237
Mcm4minichromosome maintenance deficient 4 homolog (S. cerevisiae)0.231
Egr2early growth response 20.227
Ahraryl-hydrocarbon receptor0.226
Pax2paired box gene 20.212
Thrbthyroid hormone receptor beta0.204
Mapk14mitogen-activated protein kinase 140.204
Sav1salvador homolog 1 (Drosophila)0.203
Gucy1b3guanylate cyclase 1, soluble, beta 30.195
Nr2e1nuclear receptor subfamily 2, group E, member 10.186
Notch1Notch gene homolog 1 (Drosophila)0.170
FosFBJ osteosarcoma oncogene0.169
Sfrp1secreted frizzled-related protein 10.156
Runx1runt related transcription factor 10.148
Chd2chromodomain helicase DNA binding protein 20.143
Med1mediator complex subunit 10.136
Ifngr1interferon gamma receptor 10.136
Nab2Ngfi-A binding protein 20.132
Flt4FMS-like tyrosine kinase 40.132
Usp9xubiquitin specific peptidase 9, X chromosome0.131
Ghrgrowth hormone receptor0.129
Smn1survival motor neuron 10.126
Lifleukemia inhibitory factor0.124
Clockcircadian locomotor output cycles kaput0.124
Kdrkinase insert domain protein receptor0.121
Mcm2minichromosome maintenance deficient 2 mitotin (S. cerevisiae)0.120
Wwtr1WW domain containing transcription regulator 10.116
Stat6signal transducer and activator of transcription 60.113
Leprleptin receptor0.111
Pik3cbphosphatidylinositol 3-kinase, catalytic, beta polypeptide0.110
Lystlysosomal trafficking regulator0.106
Polepolymerase (DNA directed), epsilon0.105
Huwe1HECT, UBA and WWE domain containing 10.103
Aipl1aryl hydrocarbon receptor-interacting protein-like 10.103
Suz12suppressor of zeste 12 homolog (Drosophila)0.100
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.095
Pvrl3poliovirus receptor-related 30.092
Pola1polymerase (DNA directed), alpha 10.092
Zmym5zinc finger, MYM-type 50.090
Plxnd1plexin D10.088
Gnai2guanine nucleotide binding protein (G protein), alpha inhibiting 20.087
Nek2NIMA (never in mitosis gene a)-related expressed kinase 20.086
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.082
Rbl2retinoblastoma-like 20.082
Nr3c1nuclear receptor subfamily 3, group C, member 10.081
Cdca7cell division cycle associated 70.080
Foxo1forkhead box O10.080
Cdc6cell division cycle 6 homolog (S. cerevisiae)0.079
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism