The network for 'regulation of stress activated protein kinase signaling cascade' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of stress activated protein kinase signaling cascade

Any process that modulates the frequency, rate or extent of signaling via a stress-activated protein kinase signaling cascade.

NameDescriptionProbabilityFunc Analog Organism
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.998
EGFRepidermal growth factor receptor0.998
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.997
MAP3K7mitogen-activated protein kinase kinase kinase 70.995
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.987
CSNK1Ecasein kinase 1, epsilon0.985
FN1fibronectin 10.975
SMAD2SMAD family member 20.965
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.961
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.960
BBS10Bardet-Biedl syndrome 100.954
ZNF43zinc finger protein 430.920
TRAF2TNF receptor-associated factor 20.893
GSK3Bglycogen synthase kinase 3 beta0.876
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.873
TRAF1TNF receptor-associated factor 10.872
RIPK2receptor-interacting serine-threonine kinase 20.867
BCAR1breast cancer anti-estrogen resistance 10.837
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.837
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.836
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.831
FYNFYN oncogene related to SRC, FGR, YES0.824
LATlinker for activation of T cells0.784
CALM1calmodulin 1 (phosphorylase kinase, delta)0.783
TRAF6TNF receptor-associated factor 60.783
SHC1SHC (Src homology 2 domain containing) transforming protein 10.778
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.749
GRB2growth factor receptor-bound protein 20.744
MYD88myeloid differentiation primary response gene (88)0.739
MAPK8mitogen-activated protein kinase 80.731
ILKintegrin-linked kinase0.721
CAV1caveolin 1, caveolae protein, 22kDa0.709
TRAF5TNF receptor-associated factor 50.701
PTK2PTK2 protein tyrosine kinase 20.691
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.677
TAB2TGF-beta activated kinase 1/MAP3K7 binding protein 20.660
LCKlymphocyte-specific protein tyrosine kinase0.657
IL1R1interleukin 1 receptor, type I0.647
MAP2K4mitogen-activated protein kinase kinase 40.647
SH3KBP1SH3-domain kinase binding protein 10.637
MAP3K11mitogen-activated protein kinase kinase kinase 110.635
CCR5chemokine (C-C motif) receptor 50.608
MAP2K7mitogen-activated protein kinase kinase 70.595
ZNF253zinc finger protein 2530.595
ZNF273zinc finger protein 2730.592
BLNKB-cell linker0.569
ZNF746zinc finger protein 7460.566
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.544
BMPR1Abone morphogenetic protein receptor, type IA0.533
TNFtumor necrosis factor0.528
MAPK8IP1mitogen-activated protein kinase 8 interacting protein 10.512
RASSF5Ras association (RalGDS/AF-6) domain family member 50.508
CCNE1cyclin E10.500
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.498
AXIN1axin 10.484
GADD45GIP1growth arrest and DNA-damage-inducible, gamma interacting protein 10.480
MAP4K1mitogen-activated protein kinase kinase kinase kinase 10.474
SH3BP2SH3-domain binding protein 20.467
TRADDTNFRSF1A-associated via death domain0.461
STUB1STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase0.461
NRP1neuropilin 10.438
ZNF675zinc finger protein 6750.438
MAP3K1mitogen-activated protein kinase kinase kinase 10.436
VEGFAvascular endothelial growth factor A0.424
CD40CD40 molecule, TNF receptor superfamily member 50.422
PTPN6protein tyrosine phosphatase, non-receptor type 60.419
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.416
BIRC3baculoviral IAP repeat containing 30.408
SQSTM1sequestosome 10.403
PVRL1poliovirus receptor-related 1 (herpesvirus entry mediator C)0.398
ARRB1arrestin, beta 10.398
ZMYND11zinc finger, MYND-type containing 110.397
CCL4chemokine (C-C motif) ligand 40.392
DVL3dishevelled, dsh homolog 3 (Drosophila)0.386
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.384
JUNjun proto-oncogene0.379
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.376
SMAD3SMAD family member 30.375
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.374
STK4serine/threonine kinase 40.373
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.368
IL1Binterleukin 1, beta0.349
ZNF708zinc finger protein 7080.346
CBLBCas-Br-M (murine) ecotropic retroviral transforming sequence b0.337
IRAK2interleukin-1 receptor-associated kinase 20.325
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.322
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.314
MOBKL3MOB1, Mps One Binder kinase activator-like 3 (yeast)0.314
DVL1dishevelled, dsh homolog 1 (Drosophila)0.308
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.306
CREBBPCREB binding protein0.303
TGFB3transforming growth factor, beta 30.300
IRAK1interleukin-1 receptor-associated kinase 10.299
VAV1vav 1 guanine nucleotide exchange factor0.293
SKILSKI-like oncogene0.293
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.292
RPS6KA6ribosomal protein S6 kinase, 90kDa, polypeptide 60.286
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.273
CCL2chemokine (C-C motif) ligand 20.273
RAB21RAB21, member RAS oncogene family0.271
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
cst-1Protein CST-10.085
eor-2Protein EOR-20.046
F21A10.2Protein F21A10.20.022
cst-2Protein CST-20.019
smp-1Protein SMP-10.017
unc-16Protein UNC-160.014
tir-1Protein TIR-10.014
pdl-1Protein PDL-10.014
cap-2Protein CAP-20.013
skn-1Protein SKN-10.012
lat-1Protein LAT-10.011
sta-1Protein STA-10.011
daf-11Protein DAF-110.011
F10G8.8Protein F10G8.80.010
pas-6Protein PAS-60.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
osr1odd-skipped related 1 (Drosophila)0.037
dkk1bdickkopf 1b0.028
pafah1b1bplatelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b0.026
igf1rbinsulin-like growth factor 1b receptor0.021
fzd5frizzled homolog 50.019
rhoabras homolog gene family, member Ab0.019
ephb4beph receptor B4b0.018
dvl2dishevelled, dsh homolog 2 (Drosophila)0.017
pias4aprotein inhibitor of activated STAT, 4a0.014
jag2jagged 20.013
gro1groucho 10.013
tlr3toll-like receptor 30.012
foxa3forkhead box A30.012
irak4interleukin-1 receptor-associated kinase 40.012
gro2groucho 20.011
LOC563527brain-specific angiogenesis inhibitor 1-like0.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Pi3K92ECG4141 gene product from transcript CG4141-RB0.548
PknProtein kinase related to protein kinase N0.410
skpACG16983 gene product from transcript CG16983-RD0.398
PvrPDGF- and VEGF-receptor related0.351
chicoCG5686 gene product from transcript CG5686-RB0.312
Akt1CG4006 gene product from transcript CG4006-RA0.260
l(2)gllethal (2) giant larvae0.254
p38bCG7393 gene product from transcript CG7393-RA0.213
RalaRas-related protein0.170
kibrakibra ortholog0.150
SmoxSmad on X0.148
X11LCG5675 gene product from transcript CG5675-RB0.144
DptBDiptericin B0.142
Liprin-alphaCG11199 gene product from transcript CG11199-RB0.135
ShcSHC-adaptor protein0.125
foxoforkhead box, sub-group O0.107
CG1021CG1021 gene product from transcript CG1021-RE0.106
par-1CG8201 gene product from transcript CG8201-RA0.098
drkdownstream of receptor kinase0.097
spensplit ends0.085
DadDaughters against dpp0.084
RicRas which interacts with Calmodulin0.083
Ras64BRas oncogene at 64B0.080
p53CG33336 gene product from transcript CG33336-RB0.080
Myo31DFMyosin 31DF0.076
SaraSmad anchor for receptor activation0.075
Sir2CG5216 gene product from transcript CG5216-RA0.075
JraJun-related antigen0.074
AblAbl tyrosine kinase0.069
Mpk2CG5475 gene product from transcript CG5475-RB0.066
PcafCG4107 gene product from transcript CG4107-RA0.065
Rab5Rab-protein 50.064
ThorCG8846 gene product from transcript CG8846-RA0.062
Pp2B-14DProtein phosphatase 2B at 14D0.058
p120ctnAdherens junction protein p1200.054
mib1mind bomb 10.054
dcodiscs overgrown0.052
Pink1PTEN-induced putative kinase 10.051
CG16718CG16718 gene product from transcript CG16718-RA0.051
mbcmyoblast city0.050
CG42863CG42863 gene product from transcript CG42863-RB0.049
PGRP-LCPeptidoglycan recognition protein LC0.048
mxcmulti sex combs0.047
tamoCG4057 gene product from transcript CG4057-RA0.047
cicubitus interruptus0.047
OsbpOxysterol binding protein0.046
StimStromal interaction molecule0.045
PGRP-SAPeptidoglycan recognition protein SA0.045
myoglianinCG1838 gene product from transcript CG1838-RD0.044
Sema-1aCG18405 gene product from transcript CG18405-RD0.044
Rab7Rab-protein 70.043
PGRP-SDCG7496 gene product from transcript CG7496-RA0.043
CG10743CG10743 gene product from transcript CG10743-RB0.042
Toll-7CG8595 gene product from transcript CG8595-RA0.042
CG14614CG14614 gene product from transcript CG14614-RA0.042
Tak1TGF-beta activated kinase 10.042
PGRP-LBPeptidoglycan recognition protein LB0.039
RYBPRing and YY1 Binding Protein0.038
CG9902CG9902 gene product from transcript CG9902-RA0.037
coroCG9446 gene product from transcript CG9446-RC0.037
fwdfour wheel drive0.037
PRL-1CG4993 gene product from transcript CG4993-RB0.036
Pk61CProtein kinase 61C0.035
Gyc76CGuanylyl cyclase at 76C0.035
CG1347CG1347 gene product from transcript CG1347-RB0.035
WnkCG7177 gene product from transcript CG7177-RA0.034
PGRP-LFPeptidoglycan recognition protein LF0.034
Atf-2Activating transcription factor-20.033
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Adora2aadenosine A2a receptor0.508
Usf2upstream transcription factor 2, c-fos interacting0.460
Mapk1mitogen activated protein kinase 10.334
Jak1Janus kinase 10.315
Grm7glutamate receptor, metabotropic 70.309
Gria2glutamate receptor, ionotropic, AMPA 20.262
Nckap1NCK-associated protein 10.240
Jtbjumping translocation breakpoint0.218
Serinc1serine incorporator 10.159
Ppp3r1protein phosphatase 3, regulatory subunit B, alpha isoform0.138
Prkacbprotein kinase, cAMP dependent, catalytic, beta0.137
Sqstm1sequestosome 10.133
Myd88myeloid differentiation primary response gene 880.132
Mapk9mitogen-activated protein kinase 90.131
Vegfavascular endothelial growth factor A0.126
Nrasneuroblastoma ras oncogene0.124
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.111
LOC100364212heterogeneous nuclear ribonucleoprotein K-like0.109
Mapk6mitogen-activated protein kinase 60.099
Map2microtubule-associated protein 20.080
Pdp1pyruvate dehyrogenase phosphatase catalytic subunit 10.075
Tgfb2transforming growth factor, beta 20.075
Map2k1mitogen activated protein kinase kinase 10.073
Il1ainterleukin 1 alpha0.072
Arl5aADP-ribosylation factor-like 5A0.071
Mapk8mitogen-activated protein kinase 80.065
Ccl4chemokine (C-C motif) ligand 40.064
Ube2aubiquitin-conjugating enzyme E2A (RAD6 homolog)0.064
Ptp4a2protein tyrosine phosphatase 4a20.064
Fkbp1aFK506 binding protein 1a0.063
Gcnt3glucosaminyl (N-acetyl) transferase 3, mucin type0.062
Gja6gap junction protein, alpha 60.062
Pkiaprotein kinase (cAMP-dependent, catalytic) inhibitor alpha0.059
Grip1glutamate receptor interacting protein 10.059
CebpgCCAAT/enhancer binding protein (C/EBP), gamma0.058
Sh3bp1SH3-domain binding protein 10.058
Rab10RAB10, member RAS oncogene family0.057
Cttnbp2cortactin binding protein 20.056
Prkg2protein kinase, cGMP-dependent, type II0.055
Cyfip2cytoplasmic FMR1 interacting protein 20.054
Syt2synaptotagmin II0.054
Nudt3nudix (nucleoside diphosphate linked moiety X)-type motif 30.054
Il9rinterleukin 9 receptor0.053
Pick1protein interacting with PRKCA 10.052
Masp1mannan-binding lectin serine peptidase 10.052
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.052
Ctdsp1CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 10.051
Paqr5progestin and adipoQ receptor family member V0.050
Ap3s1adaptor-related protein complex 3, sigma 1 subunit0.049
Bcl2l2Bcl2-like 20.047
RhdRh blood group, D antigen0.046
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.046
Homer1homer homolog 1 (Drosophila)0.046
Accn2amiloride-sensitive cation channel 2, neuronal0.045
Mca32mast cell antigen 320.045
Sema6bsema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B0.045
Gna12guanine nucleotide binding protein (G protein) alpha 120.045
DbpD site of albumin promoter (albumin D-box) binding protein0.044
RGD1305793similar to hypothetical protein FLJ201540.044
Cugbp2CUG triplet repeat, RNA binding protein 20.043
Gria3glutamate receptor, ionotrophic, AMPA 30.043
Slc6a15solute carrier family 6 (neutral amino acid transporter), member 150.041
Nek9NIMA (never in mitosis gene a)- related kinase 90.040
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.039
Pfkfb26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 20.039
Vat1vesicle amine transport protein 1 homolog (T californica)0.038
Plscr3phospholipid scramblase 30.037
Il2interleukin 20.036
Nus1nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae)0.036
Cry2cryptochrome 2 (photolyase-like)0.036
Slc24a6solute carrier family 24 (sodium/potassium/calcium exchanger), member 60.035
Fam180afamily with sequence similarity 180, member A0.035
Rps6ka1ribosomal protein S6 kinase polypeptide 10.035
Fgfr1Fibroblast growth factor receptor 10.034
Ets1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)0.034
Nrcamneuronal cell adhesion molecule0.034
Notch3Notch homolog 3 (Drosophila)0.033
March5membrane-associated ring finger (C3HC4) 50.033
Rassf5Ras association (RalGDS/AF-6) domain family member 50.033
Hsph1heat shock 105/110 protein 10.033
Gzmkgranzyme K0.033
Pspparotid secretory protein0.032
Dtx3ldeltex 3-like (Drosophila)0.032
LOC286960preprotrypsinogen IV0.032
Syt4synaptotagmin IV0.032
Dnajc5DnaJ (Hsp40) homolog, subfamily C, member 50.032
Prkcbprotein kinase C, beta0.032
Arrdc1arrestin domain containing 10.031
Gpr4G protein-coupled receptor 40.031
Hmgcs13-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)0.031
Pctk2PCTAIRE protein kinase 20.030
Itgamintegrin, alpha M0.029
Gpc3glypican 30.029
Vdac1voltage-dependent anion channel 10.029
Rapgef4Rap guanine nucleotide exchange factor (GEF) 40.029
Cd247Cd247 molecule0.029
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism