The network for 'negative regulation of stress activated protein kinase signaling cascade' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of stress activated protein kinase signaling cascade

Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade.

NameDescriptionProbabilityFunc Analog Organism
MAP3K7mitogen-activated protein kinase kinase kinase 70.874
MAPK8mitogen-activated protein kinase 80.843
ZNF43zinc finger protein 430.777
MAP2K4mitogen-activated protein kinase kinase 40.753
CREBBPCREB binding protein0.692
MAPK1mitogen-activated protein kinase 10.597
CREB1cAMP responsive element binding protein 10.578
MAPK14mitogen-activated protein kinase 140.452
CALM1calmodulin 1 (phosphorylase kinase, delta)0.452
ZNF253zinc finger protein 2530.405
ZNF273zinc finger protein 2730.373
CCNE1cyclin E10.244
ILKintegrin-linked kinase0.231
NCOR1nuclear receptor corepressor 10.216
MLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.213
SIRT1sirtuin 10.198
ZNF746zinc finger protein 7460.180
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.174
ZNF675zinc finger protein 6750.168
CHUKconserved helix-loop-helix ubiquitous kinase0.168
SMAD2SMAD family member 20.156
AXIN1axin 10.153
PPP6Cprotein phosphatase 6, catalytic subunit0.147
ARandrogen receptor0.120
MAP2K7mitogen-activated protein kinase kinase 70.119
ZNF254zinc finger protein 2540.118
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.099
ZNF91zinc finger protein 910.096
WWOXWW domain containing oxidoreductase0.088
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.073
PPARAperoxisome proliferator-activated receptor alpha0.068
CSNK1Ecasein kinase 1, epsilon0.068
ZNF430zinc finger protein 4300.064
ZNF708zinc finger protein 7080.062
ATF2activating transcription factor 20.058
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.050
ZNF93zinc finger protein 930.047
ZNF85zinc finger protein 850.045
JUNjun proto-oncogene0.044
ARRB2arrestin, beta 20.044
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.044
ZNF117zinc finger protein 1170.043
RALBv-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)0.043
NCOA1nuclear receptor coactivator 10.043
MAPK3mitogen-activated protein kinase 30.041
PPP1R2protein phosphatase 1, regulatory (inhibitor) subunit 20.041
KAT2BK(lysine) acetyltransferase 2B0.039
RPS6KA3ribosomal protein S6 kinase, 90kDa, polypeptide 30.038
TAB2TGF-beta activated kinase 1/MAP3K7 binding protein 20.037
CAV1caveolin 1, caveolae protein, 22kDa0.036
NR2E3nuclear receptor subfamily 2, group E, member 30.036
NDEL1nudE nuclear distribution gene E homolog (A. nidulans)-like 10.036
PPP2R5Cprotein phosphatase 2, regulatory subunit B', gamma0.035
GSK3Bglycogen synthase kinase 3 beta0.035
DUSP1dual specificity phosphatase 10.035
ZNF680zinc finger protein 6800.035
MAP2K1mitogen-activated protein kinase kinase 10.034
RALBP1ralA binding protein 10.034
HDAC3histone deacetylase 30.033
LIMD1LIM domains containing 10.030
ZNF107zinc finger protein 1070.028
TRAF6TNF receptor-associated factor 60.028
DEAF1deformed epidermal autoregulatory factor 1 (Drosophila)0.027
SGK3serum/glucocorticoid regulated kinase family, member 30.026
ZNF92zinc finger protein 920.026
SIN3ASIN3 homolog A, transcription regulator (yeast)0.026
ACTR3ARP3 actin-related protein 3 homolog (yeast)0.024
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.024
MAP3K1mitogen-activated protein kinase kinase kinase 10.022
NCOA2nuclear receptor coactivator 20.021
NCK2NCK adaptor protein 20.021
SKILSKI-like oncogene0.021
LPXNleupaxin0.021
SLX1BSLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)0.021
CBLCCas-Br-M (murine) ecotropic retroviral transforming sequence c0.020
RNF11ring finger protein 110.019
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)0.019
TWF2twinfilin, actin-binding protein, homolog 2 (Drosophila)0.019
CAPZA2capping protein (actin filament) muscle Z-line, alpha 20.019
RAB21RAB21, member RAS oncogene family0.019
NCOR2nuclear receptor corepressor 20.019
RCHY1ring finger and CHY zinc finger domain containing 10.019
EIF4Eeukaryotic translation initiation factor 4E0.019
CD2APCD2-associated protein0.019
RAB10RAB10, member RAS oncogene family0.018
PPP2R2Aprotein phosphatase 2, regulatory subunit B, alpha0.018
TRAF5TNF receptor-associated factor 50.018
KIAA1377KIAA13770.018
PRKACAprotein kinase, cAMP-dependent, catalytic, alpha0.018
DLG1discs, large homolog 1 (Drosophila)0.018
NCOA6nuclear receptor coactivator 60.017
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.017
GPS2G protein pathway suppressor 20.016
ANXA7annexin A70.016
GNB1guanine nucleotide binding protein (G protein), beta polypeptide 10.016
CACNA1Ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.016
RANBP3RAN binding protein 30.016
PPP1CCprotein phosphatase 1, catalytic subunit, gamma isozyme0.015
AKT1v-akt murine thymoma viral oncogene homolog 10.015
TOX4TOX high mobility group box family member 40.014
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
PGRP-SAPeptidoglycan recognition protein SA0.303
skpACG16983 gene product from transcript CG16983-RD0.198
p38bCG7393 gene product from transcript CG7393-RA0.158
PGRP-LCPeptidoglycan recognition protein LC0.146
AttAAttacin-A0.130
Akt1CG4006 gene product from transcript CG4006-RA0.110
foxoforkhead box, sub-group O0.108
RelRelish0.082
Pi3K92ECG4141 gene product from transcript CG4141-RB0.074
CG18594CG18594 gene product from transcript CG18594-RA0.057
PGRP-SC1aCG14746 gene product from transcript CG14746-RA0.050
Sp7Serine protease 70.047
Mst98CaMale-specific RNA 98Ca0.045
PGRP-SDCG7496 gene product from transcript CG7496-RA0.043
S6kRPS6-p70-protein kinase0.042
pirkpoor Imd response upon knock-in0.041
EndoGIEndonuclease G inhibitor0.039
cazcabeza0.036
PGRP-SC1bCG8577 gene product from transcript CG8577-RA0.036
Mpk2CG5475 gene product from transcript CG5475-RB0.034
CG10743CG10743 gene product from transcript CG10743-RB0.033
CG15917CG15917 gene product from transcript CG15917-RA0.031
IlkIntegrin linked kinase0.030
bbgbig bang0.028
RhebCG1081 gene product from transcript CG1081-RA0.028
CG9316CG9316 gene product from transcript CG9316-RA0.026
PGRP-LFPeptidoglycan recognition protein LF0.024
Sop2Suppressor of profilin 20.024
grassGram-positive Specific Serine protease0.024
CG14614CG14614 gene product from transcript CG14614-RA0.024
CG4168CG4168 gene product from transcript CG4168-RA0.024
CG42863CG42863 gene product from transcript CG42863-RB0.024
Myo31DFMyosin 31DF0.023
CG17107CG17107 gene product from transcript CG17107-RA0.023
fwdfour wheel drive0.023
fonfondue0.023
wndwallenda0.022
kermitCG11546 gene product from transcript CG11546-RB0.020
DrsDrosomycin0.019
Kap-alpha3karyopherin alpha30.019
savsalvador0.019
dshdishevelled0.018
CG9902CG9902 gene product from transcript CG9902-RA0.018
CG32528CG32528 gene product from transcript CG32528-RA0.018
bazbazooka0.018
Spn1Serine protease inhibitor 10.018
upd2unpaired 20.018
SPESpatzle-Processing Enzyme0.018
JraJun-related antigen0.017
CG17273CG17273 gene product from transcript CG17273-RA0.017
Mob2CG11711 gene product from transcript CG11711-RC0.016
captcapulet0.016
ntcnutcracker0.016
NaamNicotinamide amidase0.016
eaterCG6124 gene product from transcript CG6124-RB0.015
CG14317CG14317 gene product from transcript CG14317-RA0.015
CG18745CG18745 gene product from transcript CG18745-RA0.015
PGRP-LBPeptidoglycan recognition protein LB0.015
dawdawdle0.015
PtenCG5671 gene product from transcript CG5671-RB0.014
bskbasket0.014
Cht11CG3044 gene product from transcript CG3044-RA0.014
CG3847CG3847 gene product from transcript CG3847-RA0.014
spiritSerine Protease Immune Response Integrator0.014
CG17184CG17184 gene product from transcript CG17184-RB0.014
Hsc70-4Heat shock protein cognate 40.014
Rab5Rab-protein 50.014
Tsp42EfTetraspanin 42Ef0.014
grpgrapes0.014
nudECG8104 gene product from transcript CG8104-RB0.013
X11LCG5675 gene product from transcript CG5675-RB0.013
rokRho-kinase0.013
pshpersephone0.013
Top1Topoisomerase 10.013
CG31146CG31146 gene product from transcript CG31146-RD0.013
hephemipterous0.013
CG9184CG9184 gene product from transcript CG9184-RB0.013
dmdiminutive0.012
cpbcapping protein beta0.012
PvrPDGF- and VEGF-receptor related0.012
RagACG11968 gene product from transcript CG11968-RA0.012
modSPmodular serine protease0.012
Rab7Rab-protein 70.012
CG13641CG13641 gene product from transcript CG13641-RA0.012
Mst84DcMale-specific RNA 84Dc0.012
Eip71CDEcdysone-induced protein 28/29kD0.012
cindrCIN85 and CD2AP orthologue0.011
Pink1PTEN-induced putative kinase 10.011
dldorsal0.011
coroCG9446 gene product from transcript CG9446-RC0.011
LmptLimpet0.011
CG15814CG15814 gene product from transcript CG15814-RB0.010
slsmall wing0.010
CG32369CG32369 gene product from transcript CG32369-RA0.010
Aplip1APP-like protein interacting protein 10.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Rab1bRAB1B, member RAS oncogene family0.092
Vdac1voltage-dependent anion channel 10.055
Hsph1heat shock 105/110 protein 10.053
Ube2bubiquitin-conjugating enzyme E2B (RAD6 homolog, S. cerevisiae)0.046
Jtbjumping translocation breakpoint0.043
Fgfr1Fibroblast growth factor receptor 10.043
Nr1d2nuclear receptor subfamily 1, group D, member 20.043
Cops7aCOP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)0.043
Ptp4a2protein tyrosine phosphatase 4a20.040
LOC100364212heterogeneous nuclear ribonucleoprotein K-like0.038
Chordc1cysteine and histidine-rich domain (CHORD)-containing 10.038
Serinc1serine incorporator 10.038
Gnb2guanine nucleotide binding protein (G protein), beta polypeptide 20.037
Mgst1microsomal glutathione S-transferase 10.037
Arl5aADP-ribosylation factor-like 5A0.034
Cltcclathrin, heavy chain (Hc)0.034
Hist1h1ahistone cluster 1, H1a0.033
Mapk8ip1mitogen-activated protein kinase 8 interacting protein 10.032
Cyfip2cytoplasmic FMR1 interacting protein 20.031
Gsta3glutathione S-transferase A30.031
SnrkSNF related kinase0.030
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.029
DbpD site of albumin promoter (albumin D-box) binding protein0.029
Vegfavascular endothelial growth factor A0.029
Pik3r2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.029
Gna12guanine nucleotide binding protein (G protein) alpha 120.028
Mapk3mitogen activated protein kinase 30.028
Atp2b1ATPase, Ca++ transporting, plasma membrane 10.027
Usf2upstream transcription factor 2, c-fos interacting0.027
Epn1Epsin 10.026
Dlgap4discs, large homolog-associated protein 4 (Drosophila)0.026
Eef2eukaryotic translation elongation factor 20.026
Pdp1pyruvate dehyrogenase phosphatase catalytic subunit 10.026
Gsrglutathione reductase0.025
Gprc5aG protein-coupled receptor, family C, group 5, member A0.025
Ctnnd2catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)0.025
Homer1homer homolog 1 (Drosophila)0.024
Oaz2ornithine decarboxylase antizyme 20.024
Cadcarbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase0.024
Zranb2zinc finger, RAN-binding domain containing 20.023
Acyp2acylphosphatase 2, muscle type0.022
Klf9Kruppel-like factor 90.022
Eif2c2eukaryotic translation initiation factor 2C, 20.022
Ppardperoxisome proliferator-activated receptor delta0.022
Tsc22d3TSC22 domain family, member 30.022
Ptp4a1protein tyrosine phosphatase type IVA, member 10.022
Pak1p21 protein (Cdc42/Rac)-activated kinase 10.022
Arf5ADP-ribosylation factor 50.021
Nfixnuclear factor I/X (CCAAT-binding transcription factor)0.021
Syt4synaptotagmin IV0.021
Gria2glutamate receptor, ionotropic, AMPA 20.021
Atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.021
March5membrane-associated ring finger (C3HC4) 50.020
Gstm1glutathione S-transferase mu 10.020
Csde1cold shock domain containing E1, RNA binding0.020
Eef1a2eukaryotic translation elongation factor 1 alpha 20.020
Ccnd3cyclin D30.020
Cyp11a1cytochrome P450, family 11, subfamily a, polypeptide 10.020
Ccdc92coiled-coil domain containing 920.020
Txnl1thioredoxin-like 10.020
Ucp2uncoupling protein 2 (mitochondrial, proton carrier)0.020
Mapk6mitogen-activated protein kinase 60.019
Plauplasminogen activator, urokinase0.019
Rasgrp1RAS guanyl releasing protein 1 (calcium and DAG-regulated)0.019
Pip4k2aphosphatidylinositol-5-phosphate 4-kinase, type II, alpha0.019
Znf394zinc finger protein 3940.019
Pdha1pyruvate dehydrogenase (lipoamide) alpha 10.019
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.019
Clec11aC-type lectin domain family 11, member a0.019
Dnajb9DnaJ (Hsp40) homolog, subfamily B, member 90.019
Ppm1bprotein phosphatase 1B, magnesium dependent, beta isoform0.018
Sncasynuclein, alpha (non A4 component of amyloid precursor)0.018
AktipAKT interacting protein0.018
JunJun oncogene0.018
Amfrautocrine motility factor receptor0.018
Ube2d2ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)0.018
Pgrprogesterone receptor0.018
Dnajc5DnaJ (Hsp40) homolog, subfamily C, member 50.018
Pim3pim-3 oncogene0.018
Pcsk2proprotein convertase subtilisin/kexin type 20.018
Map2k1mitogen activated protein kinase kinase 10.018
Stxbp1syntaxin binding protein 10.018
Sox4SRY (sex determining region Y)-box 40.018
Prkacbprotein kinase, cAMP dependent, catalytic, beta0.018
Ppp2r1aprotein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform0.017
Cry2cryptochrome 2 (photolyase-like)0.017
Rab5aRAB5A, member RAS oncogene family0.017
Pctk1PCTAIRE protein kinase 10.017
Chac1ChaC, cation transport regulator homolog 1 (E. coli)0.017
Rab15RAB15, member RAS oncogene family0.017
Pkiaprotein kinase (cAMP-dependent, catalytic) inhibitor alpha0.017
Cenpicentromere protein I0.017
St13suppression of tumorigenicity 130.017
Ckmt1creatine kinase, mitochondrial 10.016
Map2k4mitogen activated protein kinase kinase 40.016
Ccnd1cyclin D10.016
Spon1spondin 1, extracellular matrix protein0.016
Hspa4heat shock protein 40.016
Git1G protein-coupled receptor kinase interacting ArfGAP 10.016
Ythdf3YTH domain family, member 30.016
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism