The network for 'positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

Any process that activates or increases the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway.

NameDescriptionProbabilityFunc Analog Organism
BCL2L1BCL2-like 11.000
BCL2L11BCL2-like 11 (apoptosis facilitator)1.000
BCL2B-cell CLL/lymphoma 21.000
GADD45Agrowth arrest and DNA-damage-inducible, alpha0.997
BAXBCL2-associated X protein0.997
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.996
BADBCL2-associated agonist of cell death0.960
BECN1beclin 1, autophagy related0.941
BIDBH3 interacting domain death agonist0.916
BAK1BCL2-antagonist/killer 10.914
TP53BP2tumor protein p53 binding protein, 20.871
AXIN1axin 10.812
PMAIP1phorbol-12-myristate-13-acetate-induced protein 10.647
PXMP2peroxisomal membrane protein 2, 22kDa0.624
BIKBCL2-interacting killer (apoptosis-inducing)0.613
UBR1ubiquitin protein ligase E3 component n-recognin 10.553
NINninein (GSK3B interacting protein)0.458
FKBP8FK506 binding protein 8, 38kDa0.405
AMBRA1autophagy/beclin-1 regulator 10.313
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.283
HUWE1HECT, UBA and WWE domain containing 10.240
BBC3BCL2 binding component 30.239
PRKACAprotein kinase, cAMP-dependent, catalytic, alpha0.193
PSEN1presenilin 10.181
NR4A1nuclear receptor subfamily 4, group A, member 10.167
ZHX1zinc fingers and homeoboxes 10.113
BICD1bicaudal D homolog 1 (Drosophila)0.111
KIAA1191KIAA11910.095
MAPK8mitogen-activated protein kinase 80.085
LRP6low density lipoprotein receptor-related protein 60.079
MAPTmicrotubule-associated protein tau0.069
DEAF1deformed epidermal autoregulatory factor 1 (Drosophila)0.069
GSK3Bglycogen synthase kinase 3 beta0.056
NAMPTnicotinamide phosphoribosyltransferase0.056
ZFPM1zinc finger protein, multitype 10.051
RPS6KA6ribosomal protein S6 kinase, 90kDa, polypeptide 60.042
PSEN2presenilin 2 (Alzheimer disease 4)0.042
TMEM44transmembrane protein 440.036
LMO4LIM domain only 40.030
APCadenomatous polyposis coli0.028
MTORmechanistic target of rapamycin (serine/threonine kinase)0.028
ATXN3ataxin 30.028
ZNF746zinc finger protein 7460.024
POLD1polymerase (DNA directed), delta 1, catalytic subunit 125kDa0.024
FKBP14FK506 binding protein 14, 22 kDa0.021
RSU1Ras suppressor protein 10.019
NAF1nuclear assembly factor 1 homolog (S. cerevisiae)0.019
SPNS1spinster homolog 1 (Drosophila)0.018
PPP3R1protein phosphatase 3, regulatory subunit B, alpha0.018
ING2inhibitor of growth family, member 20.017
KIAA1543KIAA15430.017
ENTPD6ectonucleoside triphosphate diphosphohydrolase 6 (putative)0.017
DCTN2dynactin 2 (p50)0.016
MZT2Amitotic spindle organizing protein 2A0.016
PPP1R2protein phosphatase 1, regulatory (inhibitor) subunit 20.016
BNIP3BCL2/adenovirus E1B 19kDa interacting protein 30.016
MRPL23mitochondrial ribosomal protein L230.015
IER5immediate early response 50.014
C14orf129chromosome 14 open reading frame 1290.014
SGK3serum/glucocorticoid regulated kinase family, member 30.014
HSPB1heat shock 27kDa protein 10.014
RXRAretinoid X receptor, alpha0.013
CCDC85Bcoiled-coil domain containing 85B0.013
XPNPEP1X-prolyl aminopeptidase (aminopeptidase P) 1, soluble0.012
PICK1protein interacting with PRKCA 10.012
SH3GLB2SH3-domain GRB2-like endophilin B20.012
NRBP1nuclear receptor binding protein 10.012
UBE2D1ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)0.012
BHLHE40basic helix-loop-helix family, member e400.011
HRKharakiri, BCL2 interacting protein (contains only BH3 domain)0.011
PIN1peptidylprolyl cis/trans isomerase, NIMA-interacting 10.011
ADAP1ArfGAP with dual PH domains 10.011
SAT1spermidine/spermine N1-acetyltransferase 10.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Axin1axin 10.969
Ctnnb1catenin (cadherin associated protein), beta 10.831
Mcl1myeloid cell leukemia sequence 10.806
Pdcd6ipprogrammed cell death 6 interacting protein0.704
Lrp6low density lipoprotein receptor-related protein 60.459
Atxn2ataxin 20.384
Mta1metastasis associated 10.382
Apcadenomatosis polyposis coli0.381
Dnm1dynamin 10.271
Gsk3bglycogen synthase kinase 3 beta0.189
Mdm2transformed mouse 3T3 cell double minute 20.130
Lrrk2leucine-rich repeat kinase 20.118
Bcl2l1BCL2-like 10.079
Smad4MAD homolog 4 (Drosophila)0.067
2700094K13RikRIKEN cDNA 2700094K13 gene0.056
Ctnnd2catenin (cadherin associated protein), delta 20.048
Gtf3ageneral transcription factor III A0.044
Pbx1pre B-cell leukemia transcription factor 10.042
Ccnd1cyclin D10.040
RdbpRD RNA-binding protein0.039
Psen1presenilin 10.036
Ugt8aUDP galactosyltransferase 8A0.035
Fam108afamily with sequence similarity 108, member A0.035
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.034
Snrnp25small nuclear ribonucleoprotein 25 (U11/U12)0.034
Syt9synaptotagmin IX0.033
Zcchc18zinc finger, CCHC domain containing 180.030
CadpsCa2+-dependent secretion activator0.030
Mll3myeloid/lymphoid or mixed-lineage leukemia 30.028
Rab1bRAB1B, member RAS oncogene family0.027
Kif1bkinesin family member 1B0.026
Dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.026
Ctnna1catenin (cadherin associated protein), alpha 10.025
Nsmce1non-SMC element 1 homolog (S. cerevisiae)0.024
Klf6Kruppel-like factor 60.024
Polr2ipolymerase (RNA) II (DNA directed) polypeptide I0.023
Htthuntingtin0.022
Rab11aRAB11a, member RAS oncogene family0.022
Itsn1intersectin 1 (SH3 domain protein 1A)0.020
Prkar1aprotein kinase, cAMP dependent regulatory, type I, alpha0.020
Neflneurofilament, light polypeptide0.020
Klf7Kruppel-like factor 7 (ubiquitous)0.019
Stmn2stathmin-like 20.019
Numbnumb gene homolog (Drosophila)0.018
Gsk3aglycogen synthase kinase 3 alpha0.018
Mlf2myeloid leukemia factor 20.018
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.017
Ptprrprotein tyrosine phosphatase, receptor type, R0.017
Nf2neurofibromatosis 20.017
Hist1h1chistone cluster 1, H1c0.016
Pik3r2phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta)0.016
Tax1bp3Tax1 (human T-cell leukemia virus type I) binding protein 30.015
Rab33aRAB33A, member of RAS oncogene family0.014
Acdadrenocortical dysplasia0.014
H2afvH2A histone family, member V0.013
Stub1STIP1 homology and U-Box containing protein 10.013
Elavl4ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)0.013
Dennd1aDENN/MADD domain containing 1A0.013
Med30mediator complex subunit 300.012
Rnf111ring finger 1110.012
Mtmr7myotubularin related protein 70.012
Atp2b1ATPase, Ca++ transporting, plasma membrane 10.012
Mef2amyocyte enhancer factor 2A0.012
Scg5secretogranin V0.012
Mrpl23mitochondrial ribosomal protein L230.011
Celf4CUGBP, Elav-like family member 40.011
Resp18regulated endocrine-specific protein 180.011
Pfn2profilin 20.011
Epn1epsin 10.011
Dact2dapper homolog 2, antagonist of beta-catenin (xenopus)0.011
Aardalanine and arginine rich domain containing protein0.011
Btbd2BTB (POZ) domain containing 20.011
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism