The network for 'respiratory tube development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

respiratory tube development

The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract.

NameDescriptionProbabilityFunc Analog Organism
FGFR2fibroblast growth factor receptor 20.995
FGF1fibroblast growth factor 1 (acidic)0.946
FHL2four and a half LIM domains 20.869
NRP1neuropilin 10.741
SMAD3SMAD family member 30.632
JAG1jagged 10.446
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.444
COL1A1collagen, type I, alpha 10.413
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.346
BMP2bone morphogenetic protein 20.344
NCOR2nuclear receptor corepressor 20.296
ENGendoglin0.226
CREBBPCREB binding protein0.225
FLNAfilamin A, alpha0.185
CYR61cysteine-rich, angiogenic inducer, 610.170
NCOA6nuclear receptor coactivator 60.168
FGFR1fibroblast growth factor receptor 10.152
ESR1estrogen receptor 10.150
SRSF4serine/arginine-rich splicing factor 40.146
BMPR1Abone morphogenetic protein receptor, type IA0.145
PKD2polycystic kidney disease 2 (autosomal dominant)0.144
NCOA2nuclear receptor coactivator 20.144
GH1growth hormone 10.142
SORBS3sorbin and SH3 domain containing 30.122
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.113
GABPAGA binding protein transcription factor, alpha subunit 60kDa0.113
SMAD2SMAD family member 20.107
FGF10fibroblast growth factor 100.091
HNF4Ahepatocyte nuclear factor 4, alpha0.090
PDZD11PDZ domain containing 110.089
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.084
STK3serine/threonine kinase 30.083
RPTORregulatory associated protein of MTOR, complex 10.080
GH2growth hormone 20.072
KAT2BK(lysine) acetyltransferase 2B0.071
POLA2polymerase (DNA directed), alpha 2 (70kD subunit)0.065
CSH1chorionic somatomammotropin hormone 1 (placental lactogen)0.064
TTRtransthyretin0.064
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.063
NCOA1nuclear receptor coactivator 10.063
TGFB1transforming growth factor, beta 10.062
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.059
FSTL1follistatin-like 10.058
RARAretinoic acid receptor, alpha0.058
BMP4bone morphogenetic protein 40.056
SPENspen homolog, transcriptional regulator (Drosophila)0.055
EIF2C1eukaryotic translation initiation factor 2C, 10.055
SRFserum response factor (c-fos serum response element-binding transcription factor)0.055
DMDdystrophin0.053
SIRT1sirtuin 10.051
FGF4fibroblast growth factor 40.049
SMURF1SMAD specific E3 ubiquitin protein ligase 10.046
PDGFCplatelet derived growth factor C0.046
FGF8fibroblast growth factor 8 (androgen-induced)0.045
GATA4GATA binding protein 40.044
NLRC4NLR family, CARD domain containing 40.044
ATXN1Lataxin 1-like0.044
SREBF2sterol regulatory element binding transcription factor 20.044
MAML1mastermind-like 1 (Drosophila)0.043
ID3inhibitor of DNA binding 3, dominant negative helix-loop-helix protein0.041
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.041
NCOR1nuclear receptor corepressor 10.041
FHL3four and a half LIM domains 30.041
PAX8paired box 80.040
SHC2SHC (Src homology 2 domain containing) transforming protein 20.038
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.038
ARandrogen receptor0.037
FOXO1forkhead box O10.037
EP300E1A binding protein p3000.037
RXRAretinoid X receptor, alpha0.036
ACVR1activin A receptor, type I0.035
ATXN1ataxin 10.035
UBR1ubiquitin protein ligase E3 component n-recognin 10.033
TBX5T-box 50.033
ITGB5integrin, beta 50.032
NR4A1nuclear receptor subfamily 4, group A, member 10.032
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.032
EFEMP2EGF containing fibulin-like extracellular matrix protein 20.031
FGF18fibroblast growth factor 180.030
ITGA3integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)0.030
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.030
ELNelastin0.030
BMP7bone morphogenetic protein 70.029
EIF2C2eukaryotic translation initiation factor 2C, 20.029
PPARAperoxisome proliferator-activated receptor alpha0.029
UTRNutrophin0.028
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.027
PUM1pumilio homolog 1 (Drosophila)0.027
SRSF2serine/arginine-rich splicing factor 20.027
U2AF1U2 small nuclear RNA auxiliary factor 10.026
PLCG1phospholipase C, gamma 10.026
CCNE1cyclin E10.026
FOXF1forkhead box F10.025
FGF2fibroblast growth factor 2 (basic)0.025
CSH2chorionic somatomammotropin hormone 20.025
TCF4transcription factor 40.025
PAPOLApoly(A) polymerase alpha0.025
MYOCDmyocardin0.025
HSPG2heparan sulfate proteoglycan 20.023
NFIXnuclear factor I/X (CCAAT-binding transcription factor)0.023
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog1.000
Ptenphosphatase and tensin homolog1.000
Gli2GLI-Kruppel family member GLI20.997
Fgf8fibroblast growth factor 80.996
Jag1jagged 10.991
Vangl2vang-like 2 (van gogh, Drosophila)0.989
Rargretinoic acid receptor, gamma0.985
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.984
Tcf21transcription factor 210.984
Bmp4bone morphogenetic protein 40.982
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.980
Pitx2paired-like homeodomain transcription factor 20.976
Pthlhparathyroid hormone-like peptide0.976
Nr3c1nuclear receptor subfamily 3, group C, member 10.972
Tbx3T-box 30.971
Nkx2-1NK2 homeobox 10.970
Nodalnodal0.967
Fgfr2fibroblast growth factor receptor 20.967
Foxa2forkhead box A20.966
Meox2mesenchyme homeobox 20.961
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.953
Gli3GLI-Kruppel family member GLI30.947
Fgfr1fibroblast growth factor receptor 10.947
Fgfr3fibroblast growth factor receptor 30.938
Sox2SRY-box containing gene 20.937
Nfibnuclear factor I/B0.933
Pax2paired box gene 20.928
Tgfb2transforming growth factor, beta 20.919
Col1a1collagen, type I, alpha 10.917
Sall4sal-like 4 (Drosophila)0.911
Hand2heart and neural crest derivatives expressed transcript 20.904
Smad4MAD homolog 4 (Drosophila)0.902
Hoxa5homeobox A50.900
Ror2receptor tyrosine kinase-like orphan receptor 20.897
Pax3paired box gene 30.896
Tgfbr2transforming growth factor, beta receptor II0.890
Fgf10fibroblast growth factor 100.882
Wt1Wilms tumor 1 homolog0.879
Acvr1activin A receptor, type 10.879
Smad6MAD homolog 6 (Drosophila)0.874
Gata6GATA binding protein 60.858
Apoeapolipoprotein E0.838
Hand1heart and neural crest derivatives expressed transcript 10.830
Gdf1growth differentiation factor 10.825
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.824
Lhx1LIM homeobox protein 10.817
Foxc1forkhead box C10.815
Tbx1T-box 10.812
Flt4FMS-like tyrosine kinase 40.810
Nos3nitric oxide synthase 3, endothelial cell0.802
Fbn1fibrillin 10.801
Emx1empty spiracles homolog 1 (Drosophila)0.800
Tbx2T-box 20.798
Fstl1follistatin-like 10.797
Vegfavascular endothelial growth factor A0.797
Pbx1pre B-cell leukemia transcription factor 10.789
Smad3MAD homolog 3 (Drosophila)0.788
Tgfbr1transforming growth factor, beta receptor I0.783
Gata3GATA binding protein 30.777
Prrx1paired related homeobox 10.773
Foxc2forkhead box C20.770
Hoxa13homeobox A130.762
Nognoggin0.736
Pou5f1POU domain, class 5, transcription factor 10.735
Elnelastin0.728
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.721
Bnc1basonuclin 10.721
Ascl1achaete-scute complex homolog 1 (Drosophila)0.720
Loxlysyl oxidase0.708
Notch1Notch gene homolog 1 (Drosophila)0.707
Pax8paired box gene 80.703
Zeb1zinc finger E-box binding homeobox 10.698
Mll1myeloid/lymphoid or mixed-lineage leukemia 10.697
Myod1myogenic differentiation 10.695
Hspg2perlecan (heparan sulfate proteoglycan 2)0.695
Hif1ahypoxia inducible factor 1, alpha subunit0.691
Wnt11wingless-related MMTV integration site 110.689
Ctgfconnective tissue growth factor0.675
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.672
Tlx2T-cell leukemia, homeobox 20.669
Mapk8mitogen-activated protein kinase 80.668
Wnt6wingless-related MMTV integration site 60.660
Eya1eyes absent 1 homolog (Drosophila)0.659
Otx2orthodenticle homolog 2 (Drosophila)0.654
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.652
Efnb1ephrin B10.649
Fzd8frizzled homolog 8 (Drosophila)0.645
Wnt3awingless-related MMTV integration site 3A0.642
Dvl2dishevelled 2, dsh homolog (Drosophila)0.627
Ptpn11protein tyrosine phosphatase, non-receptor type 110.626
Foxp1forkhead box P10.616
Prrx2paired related homeobox 20.614
Gata4GATA binding protein 40.609
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.605
Foxh1forkhead box H10.599
Nf1neurofibromatosis 10.595
Lmx1aLIM homeobox transcription factor 1 alpha0.589
Sox9SRY-box containing gene 90.584
Pkd1polycystic kidney disease 1 homolog0.582
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.581
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Lyz2lysozyme 20.076
Plod2procollagen lysine, 2-oxoglutarate 5-dioxygenase 20.049
DbpD site of albumin promoter (albumin D-box) binding protein0.047
Id3inhibitor of DNA binding 30.045
Aebp1AE binding protein 10.034
Sox17SRY (sex determining region Y)-box 170.033
Ednraendothelin receptor type A0.032
KitlgKIT ligand0.028
Pipprolactin induced protein0.027
Timp2TIMP metallopeptidase inhibitor 20.026
Foxs1forkhead box S10.026
Col8a1collagen, type VIII, alpha 10.025
Psgb1pregnancy-specific beta 1-glycoprotein0.024
Cd40lgCD40 ligand0.023
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.023
Colec12collectin sub-family member 120.023
Sc4molsterol-C4-methyl oxidase-like0.022
PawrPRKC, apoptosis, WT1, regulator0.022
Loxlysyl oxidase0.022
Chrnb3cholinergic receptor, nicotinic, beta 30.022
Slc5a1solute carrier family 5 (sodium/glucose cotransporter), member 10.021
Mfrpmembrane frizzled-related protein0.021
Synposynaptopodin0.021
Fn1fibronectin 10.021
Sod3superoxide dismutase 3, extracellular0.020
Lamc1laminin, gamma 10.020
Fgf16fibroblast growth factor 160.020
Prl7a4prolactin family 7, subfamily a, member 40.020
Cyp1b1cytochrome P450, family 1, subfamily b, polypeptide 10.020
Gpr116G protein-coupled receptor 1160.020
Pla2g4aphospholipase A2, group IVA (cytosolic, calcium-dependent)0.019
Sox13SRY (sex determining region Y)-box 130.019
S100a3S100 calcium binding protein A30.019
Casp2caspase 20.019
Leprleptin receptor0.019
A3galt2alpha 1,3-galactosyltransferase 20.019
Casp1caspase 10.018
Hist1h1dhistone cluster 1, H1d0.018
Sulf1sulfatase 10.018
Itpr2inositol 1,4,5-triphosphate receptor, type 20.018
Ctsccathepsin C0.018
Crtapcartilage associated protein0.018
Ednrbendothelin receptor type B0.018
Map3k3mitogen activated protein kinase kinase kinase 30.018
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.018
Serpini2serine (or cysteine) peptidase inhibitor, clade I, member 20.017
Lgals7lectin, galactoside-binding, soluble, 70.017
Pou1f1POU class 1 homeobox 10.017
Tgfb2transforming growth factor, beta 20.017
Sc65synaptonemal complex protein SC650.017
Stx2syntaxin 20.017
Cacng5calcium channel, voltage-dependent, gamma subunit 50.017
Pla1aphospholipase A1 member A0.017
Agtr1bangiotensin II receptor, type 1b0.017
Cyp11b1cytochrome P450, family 11, subfamily b, polypeptide 10.017
Casp3caspase 30.016
Wisp1WNT1 inducible signaling pathway protein 10.016
Sult1a1sulfotransferase family, cytosolic, 1A, phenol-preferring, member 10.016
Hyal2hyaluronoglucosaminidase 20.016
Fgf10fibroblast growth factor 100.016
Cfhcomplement factor H0.016
FcgrtFc fragment of IgG, receptor, transporter, alpha0.016
Gja5gap junction protein, alpha 50.016
Omdosteomodulin0.016
Fdpsfarnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)0.016
Bocbiregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein0.016
Cdk2cyclin dependent kinase 20.016
Ctskcathepsin K0.016
Smad7SMAD family member 70.016
Zfxzinc finger protein X-linked0.016
Scpep1serine carboxypeptidase 10.016
Svs1seminal vesicle secretory protein 10.015
Gpc3glypican 30.015
Mrc1mannose receptor, C type 10.015
Postnperiostin, osteoblast specific factor0.015
Lpcat3lysophosphatidylcholine acyltransferase 30.015
Acacbacetyl-Coenzyme A carboxylase beta0.015
Tgfb1transforming growth factor, beta 10.015
Ptgfrnprostaglandin F2 receptor negative regulator0.015
Smcpsperm mitochondria-associated cysteine-rich protein0.015
Olr837olfactory receptor 8370.015
Hoxb8homeo box B80.015
Il17finterleukin 17F0.015
Ltbp1latent transforming growth factor beta binding protein 10.015
Xdhxanthine dehydrogenase0.015
Rnase4ribonuclease, RNase A family 40.015
Fcgr2aFc fragment of IgG, low affinity IIa, receptor (CD32)0.015
Megf6multiple EGF-like-domains 60.015
Nos3nitric oxide synthase 3, endothelial cell0.014
Serping1serine (or cysteine) peptidase inhibitor, clade G, member 10.014
Chrna10cholinergic receptor, nicotinic, alpha 100.014
Ankrd1ankyrin repeat domain 1 (cardiac muscle)0.014
Arntaryl hydrocarbon receptor nuclear translocator0.014
Ccr1chemokine (C-C motif) receptor 10.014
Rgs4regulator of G-protein signaling 40.014
Loxl1lysyl oxidase-like 10.014
Col4a5collagen, type IV, alpha 50.014
Apbb1amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)0.014
Adam17ADAM metallopeptidase domain 170.014
Fam38bfamily with sequence similarity 38, member B0.014
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism