The network for 'copper ion homeostasis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

copper ion homeostasis

Any process involved in the maintenance of an internal steady state of copper ions within an organism or cell.

NameDescriptionProbabilityFunc Analog Organism
PDZD11PDZ domain containing 110.225
ARFIP2ADP-ribosylation factor interacting protein 20.151
COMMD3COMM domain containing 30.092
COMMD6COMM domain containing 60.058
FKBP1AFK506 binding protein 1A, 12kDa0.052
SOCS1suppressor of cytokine signaling 10.044
PDIA3protein disulfide isomerase family A, member 30.041
SPAG9sperm associated antigen 90.033
CYTH2cytohesin 20.033
OXA1Loxidase (cytochrome c) assembly 1-like0.032
CAPNS1calpain, small subunit 10.026
BACE1beta-site APP-cleaving enzyme 10.022
COMMD4COMM domain containing 40.022
SEC22BSEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)0.022
ARCN1archain 10.020
C4orf14chromosome 4 open reading frame 140.020
DEDDdeath effector domain containing0.020
APBA1amyloid beta (A4) precursor protein-binding, family A, member 10.017
APBB2amyloid beta (A4) precursor protein-binding, family B, member 20.016
ATP6V0D1ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d10.016
ATP6V1FATPase, H+ transporting, lysosomal 14kDa, V1 subunit F0.015
RHOAras homolog gene family, member A0.015
COMMD7COMM domain containing 70.015
APBB1amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)0.014
GSTO1glutathione S-transferase omega 10.014
PRNPprion protein0.014
TNFRSF21tumor necrosis factor receptor superfamily, member 210.013
CUL2cullin 20.013
AIG1androgen-induced 10.013
TRAPPC1trafficking protein particle complex 10.013
APPamyloid beta (A4) precursor protein0.013
TDGF1teratocarcinoma-derived growth factor 10.012
CAP1CAP, adenylate cyclase-associated protein 1 (yeast)0.012
RFWD2ring finger and WD repeat domain 20.012
GGA1golgi-associated, gamma adaptin ear containing, ARF binding protein 10.012
MLF2myeloid leukemia factor 20.012
TCEB2transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)0.012
SORT1sortilin 10.011
ARPC5actin related protein 2/3 complex, subunit 5, 16kDa0.011
RAB1ARAB1A, member RAS oncogene family0.011
MRPS24mitochondrial ribosomal protein S240.011
TRIM55tripartite motif containing 550.011
GLB1galactosidase, beta 10.011
VDAC2voltage-dependent anion channel 20.011
ANXA5annexin A50.011
JUNjun proto-oncogene0.010
TMBIM6transmembrane BAX inhibitor motif containing 60.010
COPS7ACOP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)0.010
ATF3activating transcription factor 30.010
ADIPOR1adiponectin receptor 10.010
NUMBnumb homolog (Drosophila)0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Hsc70-3Heat shock protein cognate 30.072
Ctr1BCopper transporter 1B0.036
VhaM9.7-2CG7625 gene product from transcript CG7625-RA0.027
CG1902CG1902 gene product from transcript CG1902-RA0.025
Trp1Translocation protein 10.020
mtRNApolmitochondrial RNA polymerase0.019
Vha14Vacuolar H[+] ATPase 14kD subunit0.018
CG11093CG11093 gene product from transcript CG11093-RB0.017
Eip93FCG18389 gene product from transcript CG18389-RB0.017
Ctr1ACopper transporter 1A0.015
MTF-1Metal response element-binding Transcription Factor-10.014
NLazNeural Lazarillo0.013
MSBPmembrane steroid binding protein0.012
RhoGDICG7823 gene product from transcript CG7823-RA0.012
l(1)G0156lethal (1) G01560.012
Vha16Vacuolar H[+] ATPase 16kD subunit0.011
CG5482CG5482 gene product from transcript CG5482-RA0.011
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Prnpprion protein1.000
Appamyloid beta (A4) precursor protein0.998
Aplp2amyloid beta (A4) precursor-like protein 20.997
Psen1presenilin 10.984
Clstn1calsyntenin 10.897
Slc39a4solute carrier family 39 (zinc transporter), member 40.886
Slc31a1solute carrier family 31, member 10.676
Atp7aATPase, Cu++ transporting, alpha polypeptide0.462
Rac1RAS-related C3 botulinum substrate 10.380
Atp7bATPase, Cu++ transporting, beta polypeptide0.340
Apoeapolipoprotein E0.208
Ostm1osteopetrosis associated transmembrane protein 10.195
Itm2bintegral membrane protein 2B0.195
Numbnumb gene homolog (Drosophila)0.187
Steap3STEAP family member 30.173
Apbb1amyloid beta (A4) precursor protein-binding, family B, member 10.113
Sparcl1SPARC-like 10.105
Ncam1neural cell adhesion molecule 10.083
P4hbprolyl 4-hydroxylase, beta polypeptide0.076
Npc1Niemann Pick type C10.050
Ctnnb1catenin (cadherin associated protein), beta 10.042
L1camL1 cell adhesion molecule0.036
Atp5bATP synthase, H+ transporting mitochondrial F1 complex, beta subunit0.030
Sqstm1sequestosome 10.030
Capzbcapping protein (actin filament) muscle Z-line, beta0.029
Atox1ATX1 (antioxidant protein 1) homolog 1 (yeast)0.029
Atp1b1ATPase, Na+/K+ transporting, beta 1 polypeptide0.027
Glagalactosidase, alpha0.027
Lsamplimbic system-associated membrane protein0.024
Fbn1fibrillin 10.024
Opcmlopioid binding protein/cell adhesion molecule-like0.023
Ahcyl1S-adenosylhomocysteine hydrolase-like 10.023
Dab1disabled homolog 1 (Drosophila)0.021
Arhgap1Rho GTPase activating protein 10.017
Rhoaras homolog gene family, member A0.017
Mapk8ip1mitogen-activated protein kinase 8 interacting protein 10.016
Laptm4alysosomal-associated protein transmembrane 4A0.015
Dnm1dynamin 10.015
Sar1aSAR1 gene homolog A (S. cerevisiae)0.015
Loxlysyl oxidase0.014
Grb2growth factor receptor bound protein 20.014
Sco2SCO cytochrome oxidase deficient homolog 2 (yeast)0.014
Erp44endoplasmic reticulum protein 440.012
Adam23a disintegrin and metallopeptidase domain 230.012
Nbr1neighbor of Brca1 gene 10.011
Efemp2epidermal growth factor-containing fibulin-like extracellular matrix protein 20.010
Atp6v1aATPase, H+ transporting, lysosomal V1 subunit A0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Rps7ribosomal protein S70.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism