The network for 'regulation of transforming growth factor beta receptor signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of transforming growth factor beta receptor signaling pathway

Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway.

NameDescriptionProbabilityFunc Analog Organism
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)1.000
SMAD7SMAD family member 71.000
SMAD4SMAD family member 41.000
FHL2four and a half LIM domains 21.000
SMURF1SMAD specific E3 ubiquitin protein ligase 11.000
SMURF2SMAD specific E3 ubiquitin protein ligase 21.000
SMAD1SMAD family member 11.000
SKILSKI-like oncogene1.000
SMAD3SMAD family member 30.999
SMAD2SMAD family member 20.999
FN1fibronectin 10.998
ENGendoglin0.998
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.989
TP53tumor protein p530.973
CREBBPCREB binding protein0.972
PTK2PTK2 protein tyrosine kinase 20.968
TGFB1transforming growth factor, beta 10.967
ABI2abl-interactor 20.966
TGFBR1transforming growth factor, beta receptor 10.961
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.948
EP300E1A binding protein p3000.946
PXNpaxillin0.939
COL1A1collagen, type I, alpha 10.922
CXXC5CXXC finger protein 50.892
PIAS4protein inhibitor of activated STAT, 40.879
MMP14matrix metallopeptidase 14 (membrane-inserted)0.876
WWP2WW domain containing E3 ubiquitin protein ligase 20.873
TBX5T-box 50.864
PAX3paired box 30.836
SMAD5SMAD family member 50.831
TPBGtrophoblast glycoprotein0.816
PDIA3protein disulfide isomerase family A, member 30.797
ITGAVintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)0.771
POU3F2POU class 3 homeobox 20.770
COL4A1collagen, type IV, alpha 10.757
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.730
SPARCsecreted protein, acidic, cysteine-rich (osteonectin)0.725
SKIv-ski sarcoma viral oncogene homolog (avian)0.698
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.672
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.670
CTBP1C-terminal binding protein 10.653
TLN1talin 10.606
MAGEF1melanoma antigen family F, 10.602
ARandrogen receptor0.581
COL3A1collagen, type III, alpha 10.577
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.572
LAMC1laminin, gamma 1 (formerly LAMB2)0.572
ZFYVE9zinc finger, FYVE domain containing 90.568
PTPRCprotein tyrosine phosphatase, receptor type, C0.550
FBXL12F-box and leucine-rich repeat protein 120.542
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.519
CAV1caveolin 1, caveolae protein, 22kDa0.502
PMLpromyelocytic leukemia0.497
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.462
COL1A2collagen, type I, alpha 20.433
BCAR1breast cancer anti-estrogen resistance 10.417
HIPK2homeodomain interacting protein kinase 20.410
TGFB3transforming growth factor, beta 30.405
MTMR4myotubularin related protein 40.403
VCLvinculin0.396
DLG1discs, large homolog 1 (Drosophila)0.395
FLNAfilamin A, alpha0.352
COL4A2collagen, type IV, alpha 20.349
POU5F1POU class 5 homeobox 10.334
ITGA3integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)0.329
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.318
DCUN1D1DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)0.310
NEDD4neural precursor cell expressed, developmentally down-regulated 40.296
SNX33sorting nexin 330.295
IGFBP3insulin-like growth factor binding protein 30.288
SNX6sorting nexin 60.288
ITGB5integrin, beta 50.285
AEBP1AE binding protein 10.284
NRP1neuropilin 10.280
TRIM33tripartite motif containing 330.271
SIRT1sirtuin 10.269
NCK2NCK adaptor protein 20.264
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.263
COL5A1collagen, type V, alpha 10.259
SNX2sorting nexin 20.252
TGFB1I1transforming growth factor beta 1 induced transcript 10.250
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.248
STRADASTE20-related kinase adaptor alpha0.247
CALD1caldesmon 10.246
TIMP3TIMP metallopeptidase inhibitor 30.241
FSTL1follistatin-like 10.238
THBS1thrombospondin 10.234
ILKintegrin-linked kinase0.213
IGFBP5insulin-like growth factor binding protein 50.208
FBXL15F-box and leucine-rich repeat protein 150.203
LUMlumican0.200
PIAS1protein inhibitor of activated STAT, 10.199
SH3D19SH3 domain containing 190.194
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.194
TGIF1TGFB-induced factor homeobox 10.193
ERBB2IPerbb2 interacting protein0.192
COL6A1collagen, type VI, alpha 10.168
COL6A3collagen, type VI, alpha 30.157
MXRA5matrix-remodelling associated 50.155
FOXD3forkhead box D30.155
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
daf-11Protein DAF-110.636
cat-1Protein CAT-10.408
tax-4Protein TAX-40.285
unc-9Protein UNC-90.169
osm-3Protein OSM-30.166
daf-1Protein DAF-10.159
che-2Protein CHE-20.147
osm-6Protein OSM-60.124
che-1Protein CHE-10.120
osm-5Protein OSM-50.089
gcy-22Protein GCY-220.079
egl-18Protein EGL-180.072
R05G6.10Protein R05G6.100.055
che-13Protein CHE-130.042
che-3Protein CHE-30.040
eat-4Protein EAT-40.039
vab-3Protein VAB-30.038
unc-36Protein UNC-360.035
faah-1Protein FAAH-10.028
tax-2Protein TAX-20.027
unc-7Protein UNC-70.027
daf-7Protein DAF-70.022
daf-4Protein DAF-40.022
che-11Protein CHE-110.022
haly-1Protein HALY-10.022
osm-1Protein OSM-10.019
mboa-3Protein MBOA-30.019
math-26Protein MATH-260.018
inx-2Protein INX-20.018
syx-3Protein SYX-30.017
egl-8Protein EGL-80.017
CELE_C08F11.13Protein C08F11.130.017
itr-1Protein ITR-10.016
hsp-4Protein HSP-40.016
daf-10Protein DAF-100.016
daf-12Protein DAF-120.016
odr-3Protein ODR-30.014
tag-320Protein TAG-3200.014
sma-6Protein SMA-60.014
aak-2Protein AAK-20.014
lin-25Protein LIN-250.013
bar-1Protein BAR-10.012
vab-8Protein VAB-80.012
svh-2Protein SVH-20.012
cat-4Protein CAT-40.011
gsp-4Protein GSP-40.011
pqn-62Protein PQN-620.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
MadMothers against dpp0.996
babobaboon0.973
DadDaughters against dpp0.941
tkvthickveins0.774
Akt1CG4006 gene product from transcript CG4006-RA0.635
cicubitus interruptus0.527
mewmultiple edematous wings0.464
CG11347CG11347 gene product from transcript CG11347-RE0.370
shnschnurri0.357
sogshort gastrulation0.296
Pi3K92ECG4141 gene product from transcript CG4141-RB0.262
gbbglass bottom boat0.165
mib1mind bomb 10.135
EgfrEpidermal growth factor receptor0.135
Cdc42CG12530 gene product from transcript CG12530-RA0.124
fngfringe0.117
grogroucho0.104
Pk61CProtein kinase 61C0.101
stysprouty0.100
panpangolin0.092
arrarrow0.080
knknot0.071
foxoforkhead box, sub-group O0.067
NrtNeurotactin0.062
ifinflated0.061
tefutelomere fusion0.056
svrsilver0.055
unc-104CG8566 gene product from transcript CG8566-RB0.052
saxsaxophone0.049
Rpn6Proteasome p44.5 subunit0.047
netCG11450 gene product from transcript CG11450-RB0.044
ash2absent, small, or homeotic discs 20.044
kek5kekkon50.043
ababrupt0.043
mysmyospheroid0.040
eyaeyes absent0.040
UbqnUbiquilin0.040
htlheartless0.036
Sir2CG5216 gene product from transcript CG5216-RA0.034
weeCG4488 gene product from transcript CG4488-RA0.031
neurneuralized0.029
SmoxSmad on X0.028
trbltribbles0.028
twitwist0.028
MicalMolecule interacting with CasL0.027
witwishful thinking0.027
CtBPC-terminal Binding Protein0.026
neuroliginCG13772 gene product from transcript CG13772-RA0.025
A2bp1Ataxin-2 binding protein 10.025
CG31122CG31122 gene product from transcript CG31122-RA0.024
exexpanded0.024
kaykayak0.023
fwdfour wheel drive0.022
maskmultiple ankyrin repeats single KH domain0.022
LaspCG3849 gene product from transcript CG3849-RB0.021
sbbscribbler0.021
NetBNetrin-B0.021
Irk2Inwardly rectifying potassium channel 20.020
putpunt0.019
Ras85DRas oncogene at 85D0.019
par-6CG5884 gene product from transcript CG5884-RA0.019
brkbrinker0.019
VAChTCG32848 gene product from transcript CG32848-RA0.019
zfh1Zn finger homeodomain 10.019
Socs36ESuppressor of cytokine signaling at 36E0.019
Atg1Autophagy-specific gene 10.018
CspCysteine string protein0.017
cv-2crossveinless 20.017
tldtolloid0.016
pr-set7CG3307 gene product from transcript CG3307-RC0.016
tarataranis0.016
dlg1discs large 10.015
toktolkin0.015
myoglianinCG1838 gene product from transcript CG1838-RD0.015
wunwunen0.015
dawdawdle0.015
scbscab0.015
hthhomothorax0.014
hhairy0.014
Kr-h1Kruppel homolog 10.014
LamCLamin C0.014
belbelle0.014
CG14614CG14614 gene product from transcript CG14614-RA0.014
AdarAdenosine deaminase acting on RNA0.013
Plc21CPhospholipase C at 21C0.013
ctcut0.013
paraparalytic0.012
Eip74EFEcdysone-induced protein 74EF0.012
dppdecapentaplegic0.012
Gyc76CGuanylyl cyclase at 76C0.012
Eip93FCG18389 gene product from transcript CG18389-RB0.012
SdcSyndecan0.012
CG6701CG6701 gene product from transcript CG6701-RD0.012
twstwins0.012
CG6051CG6051 gene product from transcript CG6051-RB0.011
argosCG4531 gene product from transcript CG4531-RA0.011
RhoGAP100FCG1976 gene product from transcript CG1976-RB0.011
sosine oculis0.011
emcextra macrochaetae0.011
Stat92ESignal-transducer and activator of transcription protein at 92E0.011
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.948
Tgfb2transforming growth factor, beta 20.919
Smad3MAD homolog 3 (Drosophila)0.913
Apcadenomatosis polyposis coli0.901
Ptenphosphatase and tensin homolog0.897
Smad4MAD homolog 4 (Drosophila)0.881
Dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.880
Smad7MAD homolog 7 (Drosophila)0.850
Nodalnodal0.826
Fgfr2fibroblast growth factor receptor 20.806
Tgfbr2transforming growth factor, beta receptor II0.781
Bgnbiglycan0.760
Smad6MAD homolog 6 (Drosophila)0.721
Ctnnb1catenin (cadherin associated protein), beta 10.720
Thbs1thrombospondin 10.706
Lumlumican0.683
Mdm2transformed mouse 3T3 cell double minute 20.661
Nr3c1nuclear receptor subfamily 3, group C, member 10.661
Tgfbr1transforming growth factor, beta receptor I0.641
Axin1axin 10.586
Map3k7mitogen-activated protein kinase kinase kinase 70.585
Bmp4bone morphogenetic protein 40.548
Fgf10fibroblast growth factor 100.542
Chrdchordin0.511
Rb1retinoblastoma 10.497
Gpc3glypican 30.480
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.475
BrafBraf transforming gene0.462
Onecut1one cut domain, family member 10.442
Fmodfibromodulin0.414
Acvrl1activin A receptor, type II-like 10.393
Nf1neurofibromatosis 10.386
Cdx2caudal type homeobox 20.375
Acvr1activin A receptor, type 10.375
Amhr2anti-Mullerian hormone type 2 receptor0.370
Trp63transformation related protein 630.367
Smad1MAD homolog 1 (Drosophila)0.358
Ptrfpolymerase I and transcript release factor0.348
Itgb3integrin beta 30.336
Axin2axin20.331
Gata6GATA binding protein 60.330
Pkd2polycystic kidney disease 20.316
Gdnfglial cell line derived neurotrophic factor0.306
Smad2MAD homolog 2 (Drosophila)0.287
Wnt4wingless-related MMTV integration site 40.275
Trp53transformation related protein 530.263
Msh2mutS homolog 2 (E. coli)0.258
Fgf8fibroblast growth factor 80.252
Nos1nitric oxide synthase 1, neuronal0.251
Meox2mesenchyme homeobox 20.232
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.223
Adam12a disintegrin and metallopeptidase domain 12 (meltrin alpha)0.220
Lhx1LIM homeobox protein 10.207
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.205
Ptpn11protein tyrosine phosphatase, non-receptor type 110.202
Pgrprogesterone receptor0.202
Bmpr2bone morphogenic protein receptor, type II (serine/threonine kinase)0.200
Adam15a disintegrin and metallopeptidase domain 15 (metargidin)0.198
Fgfr1fibroblast growth factor receptor 10.197
Rargretinoic acid receptor, gamma0.196
Lef1lymphoid enhancer binding factor 10.192
Col1a1collagen, type I, alpha 10.188
Nos3nitric oxide synthase 3, endothelial cell0.184
Rarbretinoic acid receptor, beta0.181
Pitx2paired-like homeodomain transcription factor 20.181
Vhlvon Hippel-Lindau tumor suppressor0.179
Itga3integrin alpha 30.179
Gnaqguanine nucleotide binding protein, alpha q polypeptide0.178
Arandrogen receptor0.174
Pax8paired box gene 80.173
Retret proto-oncogene0.171
Prlrprolactin receptor0.169
Vegfavascular endothelial growth factor A0.167
Fgf5fibroblast growth factor 50.165
Igf2insulin-like growth factor 20.165
Wlswntless homolog (Drosophila)0.164
Fzd1frizzled homolog 1 (Drosophila)0.162
Nognoggin0.160
Foxf1aforkhead box F1a0.159
Bmpr1abone morphogenetic protein receptor, type 1A0.158
Lepleptin0.154
Trp73transformation related protein 730.151
Tcf21transcription factor 210.151
Gab2growth factor receptor bound protein 2-associated protein 20.149
Plin1perilipin 10.147
Fgf15fibroblast growth factor 150.144
Ece1endothelin converting enzyme 10.142
Dkk1dickkopf homolog 1 (Xenopus laevis)0.140
Cdkn2acyclin-dependent kinase inhibitor 2A0.137
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.137
Rararetinoic acid receptor, alpha0.136
Twist2twist homolog 2 (Drosophila)0.136
Chukconserved helix-loop-helix ubiquitous kinase0.136
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.133
Hey2hairy/enhancer-of-split related with YRPW motif 20.132
Loxlysyl oxidase0.130
Tgfbr3transforming growth factor, beta receptor III0.129
Ptk7PTK7 protein tyrosine kinase 70.127
Sox4SRY-box containing gene 40.126
Fgf2fibroblast growth factor 20.124
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Lamc1laminin, gamma 10.240
Bgnbiglycan0.128
Pecam1platelet/endothelial cell adhesion molecule 10.116
Loxl1lysyl oxidase-like 10.102
Col1a1collagen, type I, alpha 10.080
Pmepa1prostate transmembrane protein, androgen induced 10.076
Stat6signal transducer and activator of transcription 60.063
Slco2a1solute carrier organic anion transporter family, member 2a10.060
Crtapcartilage associated protein0.052
Copb1coatomer protein complex, subunit beta 10.051
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.050
Col3a1collagen, type III, alpha 10.050
Lumlumican0.047
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.045
Ggt5gamma-glutamyltransferase 50.043
Ece1endothelin converting enzyme 10.043
Elnelastin0.041
Nos3nitric oxide synthase 3, endothelial cell0.038
Rararetinoic acid receptor, alpha0.037
Pdia4protein disulfide isomerase family A, member 40.036
Atp1b3ATPase, Na+/K+ transporting, beta 3 polypeptide0.034
Tgfbr2transforming growth factor, beta receptor II0.034
Cishcytokine inducible SH2-containing protein0.030
Aoc3amine oxidase, copper containing 3 (vascular adhesion protein 1)0.028
Cpsf2cleavage and polyadenylation specific factor 20.027
Metmet proto-oncogene0.026
Elk3ELK3, ETS-domain protein0.025
Jak2Janus kinase 20.023
Mafbv-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)0.023
Fstl1follistatin-like 10.022
Ncanneurocan0.021
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.020
Fbln5fibulin 50.019
Plod1procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 10.018
Socs2suppressor of cytokine signaling 20.018
Il1rapinterleukin 1 receptor accessory protein0.018
Serpinh1serine (or cysteine) peptidase inhibitor, clade H, member 10.017
Gsk3bglycogen synthase kinase 3 beta0.017
Setd8-ps1SET domain containing (lysine methyltransferase) 8, pseudogene 10.017
Smad7SMAD family member 70.016
Dptdermatopontin0.016
Hsp90b1heat shock protein 90, beta, member 10.016
Ecm1extracellular matrix protein 10.016
Uso1USO1 homolog, vesicle docking protein (yeast)0.016
Lyve1lymphatic vessel endothelial hyaluronan receptor 10.016
Loxlysyl oxidase0.016
Synposynaptopodin0.015
Col12a1collagen, type XII, alpha 10.015
Tgm2transglutaminase 2, C polypeptide0.014
Gja4gap junction protein, alpha 40.014
Cald1caldesmon 10.014
Tspan18tetraspanin 180.014
Col5a2collagen, type V, alpha 20.014
Sox17SRY (sex determining region Y)-box 170.013
Lama5laminin, alpha 50.013
Agtr1aangiotensin II receptor, type 1a0.013
Adra2badrenergic, alpha-2B-, receptor0.013
Mmp23matrix metallopeptidase 230.013
Lrp1low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)0.013
Flt1FMS-related tyrosine kinase 10.012
Lmcd1LIM and cysteine-rich domains 10.012
Mfap5microfibrillar associated protein 50.012
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.012
Ctrb1chymotrypsinogen B10.012
Acta2smooth muscle alpha-actin0.012
Akt1s1AKT1 substrate 1 (proline-rich)0.012
Col5a1collagen, type V, alpha 10.011
Sf1splicing factor 10.011
Cdc42ep1CDC42 effector protein (Rho GTPase binding) 10.011
Ptprkprotein tyrosine phosphatase, receptor type, K, extracellular region0.010
Dusp6dual specificity phosphatase 60.010
Tp53tumor protein p530.010
Prkchprotein kinase C, eta0.010
Bmp1bone morphogenetic protein 10.010
Col1a2collagen, type I, alpha 20.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism