The network for 'extraocular skeletal muscle development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

extraocular skeletal muscle development

The process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus.

NameDescriptionProbabilityFunc Analog Organism
POU5F1POU class 5 homeobox 11.000
MDFIMyoD family inhibitor1.000
WWP2WW domain containing E3 ubiquitin protein ligase 20.999
ARandrogen receptor0.998
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.996
SOX2SRY (sex determining region Y)-box 20.990
PAX7paired box 70.985
CSRP3cysteine and glycine-rich protein 3 (cardiac LIM protein)0.984
RBPMSRNA binding protein with multiple splicing0.969
MNX1motor neuron and pancreas homeobox 10.961
SRFserum response factor (c-fos serum response element-binding transcription factor)0.952
EYA2eyes absent homolog 2 (Drosophila)0.893
SIX2SIX homeobox 20.882
LBX1ladybird homeobox 10.855
FOXC2forkhead box C2 (MFH-1, mesenchyme forkhead 1)0.852
CDX2caudal type homeobox 20.839
FOXH1forkhead box H10.803
HOXB9homeobox B90.802
PITX2paired-like homeodomain 20.786
FOXF2forkhead box F20.764
TAL1T-cell acute lymphocytic leukemia 10.759
SOX1SRY (sex determining region Y)-box 10.729
PTF1Apancreas specific transcription factor, 1a0.685
TBX1T-box 10.665
HES2hairy and enhancer of split 2 (Drosophila)0.626
HIC1hypermethylated in cancer 10.623
ONECUT1one cut homeobox 10.618
BARX1BARX homeobox 10.605
FOXL1forkhead box L10.599
GSCgoosecoid homeobox0.599
HOXD9homeobox D90.598
FOXD3forkhead box D30.588
GDF7growth differentiation factor 70.584
INHBBinhibin, beta B0.547
FOXE1forkhead box E1 (thyroid transcription factor 2)0.547
LHX1LIM homeobox 10.523
PDX1pancreatic and duodenal homeobox 10.513
TP73tumor protein p730.488
HOXD12homeobox D120.475
POU4F1POU class 4 homeobox 10.463
HMX1H6 family homeobox 10.445
MYOGmyogenin (myogenic factor 4)0.440
HOXB13homeobox B130.432
VSX1visual system homeobox 10.430
SMAD1SMAD family member 10.430
SFRP5secreted frizzled-related protein 50.417
FGF8fibroblast growth factor 8 (androgen-induced)0.410
SIM2single-minded homolog 2 (Drosophila)0.387
FOXA2forkhead box A20.365
HOXD11homeobox D110.336
FOXC1forkhead box C10.330
RAXretina and anterior neural fold homeobox0.329
MYOD1myogenic differentiation 10.324
EN1engrailed homeobox 10.323
SIX1SIX homeobox 10.302
FZD8frizzled homolog 8 (Drosophila)0.300
PITX1paired-like homeodomain 10.298
POU4F2POU class 4 homeobox 20.280
IHHIndian hedgehog0.280
FOXD2forkhead box D20.275
SIX6SIX homeobox 60.275
FOXF1forkhead box F10.274
ESR2estrogen receptor 2 (ER beta)0.268
HOXD1homeobox D10.261
FOXB1forkhead box B10.257
WNT3Awingless-type MMTV integration site family, member 3A0.257
NKX3-2NK3 homeobox 20.240
AQP5aquaporin 50.238
POU3F1POU class 3 homeobox 10.237
OPRD1opioid receptor, delta 10.236
FGF3fibroblast growth factor 30.232
DIO3deiodinase, iodothyronine, type III0.231
OTPorthopedia homeobox0.231
CCDC85Bcoiled-coil domain containing 85B0.231
DLX4distal-less homeobox 40.228
COL2A1collagen, type II, alpha 10.216
VSX2visual system homeobox 20.206
FEVFEV (ETS oncogene family)0.201
HOXC8homeobox C80.200
OTOP3otopetrin 30.196
NKX2-1NK2 homeobox 10.196
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.192
HOXC13homeobox C130.187
TBX2T-box 20.178
BHLHE23basic helix-loop-helix family, member e230.177
KAZALD1Kazal-type serine peptidase inhibitor domain 10.176
LHX5LIM homeobox 50.175
HOXD13homeobox D130.173
TCF15transcription factor 15 (basic helix-loop-helix)0.173
OTX2orthodenticle homeobox 20.166
HOXA11homeobox A110.160
ADRB1adrenergic, beta-1-, receptor0.151
HMX3H6 family homeobox 30.148
UNCXUNC homeobox0.144
GCM2glial cells missing homolog 2 (Drosophila)0.143
PYYpeptide YY0.139
HOXA1homeobox A10.135
NKX2-4NK2 homeobox 40.135
ARID3CAT rich interactive domain 3C (BRIGHT-like)0.134
GATA5GATA binding protein 50.129
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
myod1myogenic differentiation 10.987
pcdh8protocadherin 80.848
myf5myogenic factor 50.704
eng2aengrailed 2a0.551
myogmyogenin0.458
six1bsine oculis homeobox homolog 1b0.352
ephb3aeph receptor B3a0.329
six4asine oculis homeobox homolog 4a0.268
eya1eyes absent homolog 10.168
dlx3bdistal-less homeobox gene 3b0.115
otx2orthodenticle homolog 20.109
hsp90a.1heat shock protein 90-alpha 10.107
ntn1bnetrin 1b0.088
hoxb6ahomeo box B6a0.084
unc45bunc-45 homolog B (C. elegans)0.076
six1asine oculis homeobox homolog 1a0.069
rx3retinal homeobox gene 30.065
ptprfprotein tyrosine phosphatase, receptor type, F0.064
isl2aislet2a0.058
pitx3paired-like homeodomain transcription factor 30.049
frem3Fras1 related extracellular matrix 30.049
sema3aasemaphorin 3aa0.047
mef2dmyocyte enhancer factor 2d0.045
hhiphedgehog interacting protein0.044
si:dkey-204a24.9si:dkey-204a24.90.042
foxg1aforkhead box G1a0.041
her1hairy-related 10.041
nkx3.2NK3 homeobox 20.041
zbtb22bzinc finger and BTB domain containing 22b0.040
gh1growth hormone 10.040
par1paraxis0.039
rbfox1lRNA binding protein, fox-1 homolog (C. elegans) 1-like0.039
ddx26bDEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B0.038
hoxd4ahomeo box D4a0.037
dlx4bdistal-less homeobox gene 4b0.036
pax8paired box gene 80.033
tnnt1troponin T1, skeletal, slow0.033
hey1hairy/enhancer-of-split related with YRPW motif 10.033
barhl2BarH-like 20.032
zgc:92218zgc:922180.032
dmddystrophin0.031
hmx4H6 family homeobox 40.030
hoxb5bhomeo box B5b0.028
spawsouthpaw0.028
lbx2ladybird homeobox homolog 2 (Drosophila)0.028
lhx3LIM homeobox 30.028
rapsnreceptor-associated protein of the synapse, 43kD0.028
smyd1bSET and MYND domain containing 1b0.028
tbx24T-box 240.027
twist1atwist1a0.026
tnfrsfatumor necrosis factor receptor superfamily, member a0.026
klf4Kruppel-like factor 40.025
epb4.1l4erythrocyte protein band 4.1-like 40.025
myhc4myosin heavy chain 40.024
hoxb5ahomeo box B5a0.024
six2asine oculis-related homeobox 2a0.023
tnfsf10l3tumor necrosis factor (ligand) superfamily, member 10 like 30.023
lft2lefty20.023
arxaristaless related homeobox0.022
myhz1.1myosin, heavy polypeptide 1.1, skeletal muscle0.022
myhz2myosin, heavy polypeptide 2, fast muscle specific0.021
cldn1claudin 10.021
grhl2bgrainyhead-like 2b (Drosophila)0.021
chrna1cholinergic receptor, nicotinic, alpha polypeptide 10.019
jam3bjunctional adhesion molecule 3b0.019
sox1aSRY-box containing gene 1a0.019
tlx2T-cell leukemia, homeobox 20.019
or115-15odorant receptor, family F, subfamily 115, member 150.019
ret1receptor tyrosine kinase0.018
dmrt2adoublesex and mab-3 related transcription factor 2a0.018
tp63tumor protein p630.018
irx1biroquois homeobox protein 1, b0.018
dlx5adistal-less homeobox gene 5a0.018
pitx2paired-like homeodomain transcription factor 20.018
eya4eyes absent homolog 4 (Drosophila)0.017
tp73tumor protein p730.017
cxcl12achemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)0.017
asb2bankyrin repeat and SOCS box-containing 2b0.016
foxc1bforkhead box C1b0.016
ryr1bryanodine receptor 1b (skeletal)0.016
eif3haeukaryotic translation initiation factor 3, subunit H, a0.016
sox10SRY-box containing gene 100.015
bmperBMP binding endothelial regulator0.015
hspb1heat shock protein, alpha-crystallin-related, 10.015
lamb2laminin, beta 2 (laminin S)0.015
fem1cfem-1 homolog c (C.elegans)0.014
ctsl1bcathepsin L, 1 b0.014
zgc:153061zgc:1530610.014
matn1matrilin 10.014
dkk1bdickkopf 1b0.013
hoxb3ahomeo box B3a0.013
eya2eyes absent homolog 2 (Drosophila)0.013
irx4biroquois homeobox protein 4b0.013
nrp1aneuropilin 1a0.013
zgc:136894zgc:1368940.013
nr2f5nuclear receptor subfamily 2, group F, member 50.013
stac3SH3 and cysteine rich domain 30.012
pea3ETS-domain transcription factor pea30.012
six3bsine oculis homeobox homolog 3b0.012
gbx2gastrulation brain homeo box 20.012
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Pax3paired box gene 30.947
Eya1eyes absent 1 homolog (Drosophila)0.732
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.687
Pax7paired box gene 70.686
Lhx3LIM homeobox protein 30.634
Myf6myogenic factor 60.578
Tbx1T-box 10.573
Fgfr2fibroblast growth factor receptor 20.541
Shhsonic hedgehog0.499
En1engrailed 10.497
Tbx4T-box 40.468
Sox9SRY-box containing gene 90.463
Tbx15T-box 150.457
Gli3GLI-Kruppel family member GLI30.439
Foxc1forkhead box C10.430
Prrx1paired related homeobox 10.409
Isl1ISL1 transcription factor, LIM/homeodomain0.368
Bmp4bone morphogenetic protein 40.342
Ednraendothelin receptor type A0.331
Thrbthyroid hormone receptor beta0.328
Pax6paired box gene 60.321
Tcfap2atranscription factor AP-2, alpha0.305
Myogmyogenin0.299
Fgf10fibroblast growth factor 100.279
Kcnj11potassium inwardly rectifying channel, subfamily J, member 110.269
Vangl2vang-like 2 (van gogh, Drosophila)0.263
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.259
Mybphmyosin binding protein H0.237
Ptpn11protein tyrosine phosphatase, non-receptor type 110.236
Pax8paired box gene 80.201
Lmx1bLIM homeobox transcription factor 1 beta0.189
Gscgoosecoid homeobox0.181
Hoxa2homeobox A20.174
Drd2dopamine receptor D20.172
Ryr1ryanodine receptor 1, skeletal muscle0.165
Smpd3sphingomyelin phosphodiesterase 3, neutral0.163
Gata4GATA binding protein 40.140
Runx2runt related transcription factor 20.137
Msx1homeobox, msh-like 10.136
Fgf8fibroblast growth factor 80.135
Tbx3T-box 30.125
Zfpm2zinc finger protein, multitype 20.117
Foxc2forkhead box C20.116
Tgfb2transforming growth factor, beta 20.109
Rargretinoic acid receptor, gamma0.098
Foxe3forkhead box E30.098
Atp2a1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.096
Btbd17BTB (POZ) domain containing 170.093
Meox2mesenchyme homeobox 20.090
Cdh23cadherin 23 (otocadherin)0.089
Pitx2paired-like homeodomain transcription factor 20.089
Sox2SRY-box containing gene 20.087
Kcnma1potassium large conductance calcium-activated channel, subfamily M, alpha member 10.086
Otx2orthodenticle homolog 2 (Drosophila)0.082
Tnnt3troponin T3, skeletal, fast0.081
Insm1insulinoma-associated 10.074
Rarbretinoic acid receptor, beta0.073
Hrchistidine rich calcium binding protein0.070
Alx4aristaless-like homeobox 40.064
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.063
Rapsnreceptor-associated protein of the synapse0.062
Sim2single-minded homolog 2 (Drosophila)0.058
Tnnc2troponin C2, fast0.057
Hand2heart and neural crest derivatives expressed transcript 20.054
Cacnb2calcium channel, voltage-dependent, beta 2 subunit0.054
Myod1myogenic differentiation 10.053
Cav3caveolin 30.053
Six2sine oculis-related homeobox 2 homolog (Drosophila)0.052
Gli2GLI-Kruppel family member GLI20.051
Rhbdl3rhomboid, veinlet-like 3 (Drosophila)0.049
Hand1heart and neural crest derivatives expressed transcript 10.049
Ebf3early B-cell factor 30.046
Nos1nitric oxide synthase 1, neuronal0.043
Tcf15transcription factor 150.043
Nognoggin0.040
Rxraretinoid X receptor alpha0.039
Lbx1ladybird homeobox homolog 1 (Drosophila)0.037
Twist2twist homolog 2 (Drosophila)0.037
Lmx1aLIM homeobox transcription factor 1 alpha0.037
Cacnb4calcium channel, voltage-dependent, beta 4 subunit0.036
Prop1paired like homeodomain factor 10.035
Msx2homeobox, msh-like 20.034
Prrx2paired related homeobox 20.033
Dnahc11dynein, axonemal, heavy chain 110.033
Chd7chromodomain helicase DNA binding protein 70.033
Cgaglycoprotein hormones, alpha subunit0.033
Foxd3forkhead box D30.033
Lgr4leucine-rich repeat-containing G protein-coupled receptor 40.032
Nr5a1nuclear receptor subfamily 5, group A, member 10.032
Lhx4LIM homeobox protein 40.032
Zic3zinc finger protein of the cerebellum 30.031
Wnt1wingless-related MMTV integration site 10.030
Cdh15cadherin 150.030
Eef1a2eukaryotic translation elongation factor 1 alpha 20.030
Shox2short stature homeobox 20.030
Foxd2forkhead box D20.030
Cfc1cripto, FRL-1, cryptic family 10.030
Tnni2troponin I, skeletal, fast 20.030
Foxh1forkhead box H10.029
Dlx5distal-less homeobox 50.029
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism