The network for 'hemoglobin biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

hemoglobin biosynthetic process

The chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.

NameDescriptionProbabilityFunc Analog Organism
KLF4Kruppel-like factor 4 (gut)0.886
KLF6Kruppel-like factor 60.805
EGLN1egl nine homolog 1 (C. elegans)0.781
JUNjun proto-oncogene0.549
DUSP1dual specificity phosphatase 10.390
SH3BP4SH3-domain binding protein 40.265
KAT2BK(lysine) acetyltransferase 2B0.259
EGLN3egl nine homolog 3 (C. elegans)0.254
LMO4LIM domain only 40.252
ZFP36zinc finger protein 36, C3H type, homolog (mouse)0.202
FOSFBJ murine osteosarcoma viral oncogene homolog0.124
EPAS1endothelial PAS domain protein 10.122
SSX4synovial sarcoma, X breakpoint 40.111
VHLvon Hippel-Lindau tumor suppressor0.104
EHMT2euchromatic histone-lysine N-methyltransferase 20.101
JUNBjun B proto-oncogene0.084
NR4A2nuclear receptor subfamily 4, group A, member 20.083
SMURF1SMAD specific E3 ubiquitin protein ligase 10.082
CTBP1C-terminal binding protein 10.078
HIPK2homeodomain interacting protein kinase 20.077
IGFBP3insulin-like growth factor binding protein 30.073
RLIMring finger protein, LIM domain interacting0.071
LDHAlactate dehydrogenase A0.071
PPP1R15Aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.061
HIF1ANhypoxia inducible factor 1, alpha subunit inhibitor0.058
NCOA6nuclear receptor coactivator 60.055
SLC4A1solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)0.050
FOXO1forkhead box O10.048
FOSBFBJ murine osteosarcoma viral oncogene homolog B0.047
IER2immediate early response 20.044
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.043
ANXA1annexin A10.043
FOSL2FOS-like antigen 20.036
SDCBPsyndecan binding protein (syntenin)0.035
CTGFconnective tissue growth factor0.034
POU2F1POU class 2 homeobox 10.033
CYR61cysteine-rich, angiogenic inducer, 610.033
RND3Rho family GTPase 30.033
NBR1neighbor of BRCA1 gene 10.032
MYO1Gmyosin IG0.029
HBBhemoglobin, beta0.027
HBG2hemoglobin, gamma G0.027
SAT1spermidine/spermine N1-acetyltransferase 10.026
CPceruloplasmin (ferroxidase)0.026
GABPAGA binding protein transcription factor, alpha subunit 60kDa0.026
RAB8ARAB8A, member RAS oncogene family0.025
SGK1serum/glucocorticoid regulated kinase 10.025
HBA2hemoglobin, alpha 20.025
EGR1early growth response 10.024
AHRaryl hydrocarbon receptor0.024
EGLN2egl nine homolog 2 (C. elegans)0.023
NCOA1nuclear receptor coactivator 10.023
HSPH1heat shock 105kDa/110kDa protein 10.022
NFE2nuclear factor (erythroid-derived 2), 45kDa0.022
ING2inhibitor of growth family, member 20.021
SP1Sp1 transcription factor0.021
EMP1epithelial membrane protein 10.021
PPP5Cprotein phosphatase 5, catalytic subunit0.021
GATA1GATA binding protein 1 (globin transcription factor 1)0.020
HBDhemoglobin, delta0.019
NCOA2nuclear receptor coactivator 20.018
SLC2A14solute carrier family 2 (facilitated glucose transporter), member 140.018
LCN2lipocalin 20.018
ZFAND5zinc finger, AN1-type domain 50.017
TNFAIP3tumor necrosis factor, alpha-induced protein 30.017
RHAGRh-associated glycoprotein0.017
APOMapolipoprotein M0.017
FNDC3Bfibronectin type III domain containing 3B0.016
ATF3activating transcription factor 30.016
CCDC117coiled-coil domain containing 1170.016
ITGA2Bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)0.016
KLF13Kruppel-like factor 130.016
RB1retinoblastoma 10.016
STX7syntaxin 70.016
MYADMmyeloid-associated differentiation marker0.015
FOXO3forkhead box O30.015
EPB42erythrocyte membrane protein band 4.20.015
HBZhemoglobin, zeta0.015
RANBP9RAN binding protein 90.014
PF4platelet factor 40.014
PCMT1protein-L-isoaspartate (D-aspartate) O-methyltransferase0.014
NFKBIZnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta0.014
RAP1BRAP1B, member of RAS oncogene family0.014
CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.014
TFAP2Atranscription factor AP-2 alpha (activating enhancer binding protein 2 alpha)0.013
PELI1pellino homolog 1 (Drosophila)0.013
SLPIsecretory leukocyte peptidase inhibitor0.013
LAMC3laminin, gamma 30.013
CHSY1chondroitin sulfate synthase 10.013
KLF2Kruppel-like factor 2 (lung)0.013
MYL4myosin, light chain 4, alkali; atrial, embryonic0.013
SERPINA3serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 30.013
SOX9SRY (sex determining region Y)-box 90.013
EP300E1A binding protein p3000.013
TCF21transcription factor 210.012
DNAJB1DnaJ (Hsp40) homolog, subfamily B, member 10.012
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
tfr1atransferrin receptor 1a0.894
uroduroporphyrinogen decarboxylase0.264
ppoxprotoporphyrinogen oxidase0.142
hbae3hemoglobin alpha embryonic-30.124
slc11a2solute carrier family 11 (proton-coupled divalent metal ion transporters), member 20.080
slc4a1asolute carrier family 4, anion exchanger, member 1a0.076
hmbsbhydroxymethylbilane synthase, b0.058
gata1aGATA binding protein 1a0.058
slc25a37solute carrier family 25, member 370.053
epb41erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)0.039
elovl5ELOVL family member 5, elongation of long chain fatty acids (yeast)0.029
appaamyloid beta (A4) precursor protein a0.025
trpv6transient receptor potential cation channel, subfamily V, member 60.021
mvpmajor vault protein0.019
fbp1bfructose-1,6-bisphosphatase 1b0.019
inhainhibin, alpha0.017
hbaa1hemoglobin alpha adult-10.015
klf4Kruppel-like factor 40.015
rhagRhesus blood group-associated glycoprotein0.015
trim33tripartite motif-containing 330.015
hdrhematopoietic death receptor0.014
hbae1hemoglobin alpha embryonic-10.014
gng13aguanine nucleotide binding protein (G protein), gamma 13a0.012
gclcglutamate-cysteine ligase, catalytic subunit0.012
pacsin3protein kinase C and casein kinase substrate in neurons 30.012
ctszcathepsin Z0.012
cahzcarbonic anhydrase0.012
itih2inter-alpha (globulin) inhibitor H20.012
etfaelectron-transfer-flavoprotein, alpha polypeptide0.011
atp6v1dATPase, H+ transporting, V1 subunit D and ATPase, H+ transporting, V1 subunit D0.011
cbr1lcarbonyl reductase 1-like0.011
zfpm1zinc finger protein, multitype 10.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Spna1spectrin alpha 10.118
Hbb-b1hemoglobin, beta adult major chain0.028
Ank1ankyrin 1, erythroid0.028
Eporerythropoietin receptor0.021
Slc4a1solute carrier family 4 (anion exchanger), member 10.018
Hbb-b2hemoglobin, beta adult minor chain0.013
Vhlvon Hippel-Lindau tumor suppressor0.012
Slc11a2solute carrier family 11 (proton-coupled divalent metal ion transporters), member 20.012
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism