The network for 'execution phase of apoptosis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

execution phase of apoptosis

A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.

NameDescriptionProbabilityFunc Analog Organism
BCL2B-cell CLL/lymphoma 21.000
CASP8caspase 8, apoptosis-related cysteine peptidase0.976
BCL2L1BCL2-like 10.963
XIAPX-linked inhibitor of apoptosis0.916
CASP3caspase 3, apoptosis-related cysteine peptidase0.891
BCL2L11BCL2-like 11 (apoptosis facilitator)0.888
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.828
CASP10caspase 10, apoptosis-related cysteine peptidase0.819
FASLGFas ligand (TNF superfamily, member 6)0.628
CFLARCASP8 and FADD-like apoptosis regulator0.598
BIDBH3 interacting domain death agonist0.580
SNX6sorting nexin 60.522
CASP9caspase 9, apoptosis-related cysteine peptidase0.499
FASFas (TNF receptor superfamily, member 6)0.493
SYVN1synovial apoptosis inhibitor 1, synoviolin0.451
SOCS3suppressor of cytokine signaling 30.375
FKBP1AFK506 binding protein 1A, 12kDa0.356
APAF1apoptotic peptidase activating factor 10.327
BAXBCL2-associated X protein0.312
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.302
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.263
FADDFas (TNFRSF6)-associated via death domain0.234
DFFADNA fragmentation factor, 45kDa, alpha polypeptide0.230
TGFB1transforming growth factor, beta 10.224
BADBCL2-associated agonist of cell death0.222
BAK1BCL2-antagonist/killer 10.218
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.200
CCL5chemokine (C-C motif) ligand 50.194
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.183
CRADDCASP2 and RIPK1 domain containing adaptor with death domain0.177
BMP2bone morphogenetic protein 20.170
PMAIP1phorbol-12-myristate-13-acetate-induced protein 10.166
TRAF1TNF receptor-associated factor 10.150
POU5F1POU class 5 homeobox 10.147
STRN4striatin, calmodulin binding protein 40.146
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.141
DFFBDNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)0.137
EXOSC3exosome component 30.124
CCR2chemokine (C-C motif) receptor 20.122
TP53tumor protein p530.119
CASP4caspase 4, apoptosis-related cysteine peptidase0.115
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.093
FZR1fizzy/cell division cycle 20 related 1 (Drosophila)0.092
IL2RBinterleukin 2 receptor, beta0.083
BIRC2baculoviral IAP repeat containing 20.081
FNBP1formin binding protein 10.081
ENGendoglin0.077
CCR5chemokine (C-C motif) receptor 50.075
LRRK2leucine-rich repeat kinase 20.074
TNFSF10tumor necrosis factor (ligand) superfamily, member 100.071
IFNGinterferon, gamma0.070
PRKG1protein kinase, cGMP-dependent, type I0.065
STK4serine/threonine kinase 40.065
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.065
ARHGEF7Rho guanine nucleotide exchange factor (GEF) 70.064
CXCR6chemokine (C-X-C motif) receptor 60.058
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.055
GDF5growth differentiation factor 50.053
RASSF1Ras association (RalGDS/AF-6) domain family member 10.052
CCL22chemokine (C-C motif) ligand 220.047
EXOSC2exosome component 20.045
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.043
TGFBR1transforming growth factor, beta receptor 10.042
SMPD1sphingomyelin phosphodiesterase 1, acid lysosomal0.042
BIKBCL2-interacting killer (apoptosis-inducing)0.041
GATA4GATA binding protein 40.041
DIS3DIS3 mitotic control homolog (S. cerevisiae)0.040
FAM40Bfamily with sequence similarity 40, member B0.039
EXOSC10exosome component 100.038
ACVR1activin A receptor, type I0.037
BBC3BCL2 binding component 30.037
CXCR3chemokine (C-X-C motif) receptor 30.036
STRN3striatin, calmodulin binding protein 30.036
PRKRAprotein kinase, interferon-inducible double stranded RNA dependent activator0.034
C4orf14chromosome 4 open reading frame 140.034
CXCL9chemokine (C-X-C motif) ligand 90.033
MAPK8mitogen-activated protein kinase 80.032
CDC14BCDC14 cell division cycle 14 homolog B (S. cerevisiae)0.032
EXOSC4exosome component 40.031
FSTL1follistatin-like 10.030
STRNstriatin, calmodulin binding protein0.030
IRF4interferon regulatory factor 40.030
TGFB3transforming growth factor, beta 30.029
CD40LGCD40 ligand0.029
RANBP3RAN binding protein 30.026
CCR7chemokine (C-C motif) receptor 70.026
BECN1beclin 1, autophagy related0.026
CBLBCas-Br-M (murine) ecotropic retroviral transforming sequence b0.026
NLRC4NLR family, CARD domain containing 40.025
XAB2XPA binding protein 20.025
NMIN-myc (and STAT) interactor0.024
ABCF3ATP-binding cassette, sub-family F (GCN20), member 30.024
LTAlymphotoxin alpha (TNF superfamily, member 1)0.024
IL16interleukin 16 (lymphocyte chemoattractant factor)0.024
CXCR4chemokine (C-X-C motif) receptor 40.024
EIF2AK2eukaryotic translation initiation factor 2-alpha kinase 20.023
SLAMF7SLAM family member 70.023
SLMAPsarcolemma associated protein0.022
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.022
CCR4chemokine (C-C motif) receptor 40.022
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
ththread0.831
imdimmune deficiency0.579
rprreaper0.450
NcNedd2-like caspase0.353
cazcabeza0.181
p53CG33336 gene product from transcript CG33336-RB0.158
Dcp-1Death caspase-10.149
ArkApaf-1-related-killer0.110
S6kRPS6-p70-protein kinase0.108
AGO2Argonaute 20.102
Drep-2DNA fragmentation factor-related protein 20.063
grimCG4345 gene product from transcript CG4345-RA0.059
IceCG7788 gene product from transcript CG7788-RA0.056
tefutelomere fusion0.048
bratbrain tumor0.048
scnyscrawny0.045
PcPolycomb0.042
Rrp42CG8395 gene product from transcript CG8395-RA0.040
CG11347CG11347 gene product from transcript CG11347-RE0.039
Rpp30RNaseP protein p300.032
cmetCENP-meta0.031
sklsickle0.030
mib1mind bomb 10.027
DNApol-alpha60DNA polymerase alpha 60kD0.026
GmdGDP-mannose 4,6-dehydratase0.026
CG8636CG8636 gene product from transcript CG8636-RA0.024
CG5854CG5854 gene product from transcript CG5854-RA0.024
cathDCG1548 gene product from transcript CG1548-RA0.024
Drep-4DNA fragmentation factor-related protein 40.023
ik2IkappaB kinase-like 20.023
Sox14Sox box protein 140.023
LnkCG17367 gene product from transcript CG17367-RC0.022
egreiger0.021
hpohippo0.021
pixpixie0.016
nctnicastrin0.015
Sep4Septin 40.015
Ptp69DProtein tyrosine phosphatase 69D0.012
Pi3K92ECG4141 gene product from transcript CG4141-RB0.012
myoglianinCG1838 gene product from transcript CG1838-RD0.011
rinrasputin0.011
RpS20Ribosomal protein S200.010
lin19lin-19-like0.010
Uba1Ubiquitin activating enzyme 10.010
MED31Mediator complex subunit 310.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Gbp5guanylate binding protein 50.750
PycardPYD and CARD domain containing0.487
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.363
Gopcgolgi associated PDZ and coiled-coil motif containing0.356
Casp4caspase 4, apoptosis-related cysteine peptidase0.191
Hcn4hyperpolarization-activated, cyclic nucleotide-gated K+ 40.165
Ighimmunoglobulin heavy chain complex0.122
Ikbkbinhibitor of kappaB kinase beta0.119
Dlg4discs, large homolog 4 (Drosophila)0.116
Bcl2B-cell leukemia/lymphoma 20.089
DffbDNA fragmentation factor, beta subunit0.086
Il18interleukin 180.075
Ikbkginhibitor of kappaB kinase gamma0.070
Casp1caspase 10.066
Wnt5awingless-related MMTV integration site 5A0.052
SharpinSHANK-associated RH domain interacting protein0.046
Axin1axin 10.046
NmiN-myc (and STAT) interactor0.044
Dlg1discs, large homolog 1 (Drosophila)0.044
Akt1thymoma viral proto-oncogene 10.042
Rnf31ring finger protein 310.040
Pard3par-3 (partitioning defective 3) homolog (C. elegans)0.038
Prkab1protein kinase, AMP-activated, beta 1 non-catalytic subunit0.037
Adam10a disintegrin and metallopeptidase domain 100.034
Plin1perilipin 10.032
Prc1protein regulator of cytokinesis 10.032
Ldb3LIM domain binding 30.029
Ehmt2euchromatic histone lysine N-methyltransferase 20.029
Cd28CD28 antigen0.029
Tgfbr1transforming growth factor, beta receptor I0.028
Fzd8frizzled homolog 8 (Drosophila)0.028
Safbscaffold attachment factor B0.027
Erhenhancer of rudimentary homolog (Drosophila)0.027
Tbx3T-box 30.027
Dlg2discs, large homolog 2 (Drosophila)0.026
Atrataxia telangiectasia and Rad3 related0.026
Casp8caspase 80.025
Cxcl9chemokine (C-X-C motif) ligand 90.025
H2afzH2A histone family, member Z0.025
Scn5asodium channel, voltage-gated, type V, alpha0.024
Dckdeoxycytidine kinase0.023
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.022
Bag6BCL2-associated athanogene 60.022
Gnb2guanine nucleotide binding protein (G protein), beta 20.022
Bak1BCL2-antagonist/killer 10.022
Mtx2metaxin 20.021
Mobkl1bMOB1, Mps One Binder kinase activator-like 1B (yeast)0.021
Rbl1retinoblastoma-like 1 (p107)0.020
Gpc3glypican 30.020
ArhgdiaRho GDP dissociation inhibitor (GDI) alpha0.020
Becn1beclin 1, autophagy related0.020
Nfyanuclear transcription factor-Y alpha0.019
Sardhsarcosine dehydrogenase0.019
Apaf1apoptotic peptidase activating factor 10.019
Csnk1g2casein kinase 1, gamma 20.019
Add1adducin 1 (alpha)0.019
Ighmbp2immunoglobulin mu binding protein 20.018
Hif1ahypoxia inducible factor 1, alpha subunit0.018
Sfrp2secreted frizzled-related protein 20.018
Eya2eyes absent 2 homolog (Drosophila)0.017
Coro1bcoronin, actin binding protein 1B0.017
Rbm42RNA binding motif protein 420.017
Aim2absent in melanoma 20.017
Ctdnep1CTD nuclear envelope phosphatase 10.016
Hsf1heat shock factor 10.016
Sfrp1secreted frizzled-related protein 10.016
Hmgb1high mobility group box 10.016
Bbc3BCL2 binding component 30.016
Fjx1four jointed box 1 (Drosophila)0.016
Tlr4toll-like receptor 40.016
Hmgb2high mobility group box 20.016
Akt2thymoma viral proto-oncogene 20.016
Pygo2pygopus 20.015
Ptprn2protein tyrosine phosphatase, receptor type, N polypeptide 20.015
Hibch3-hydroxyisobutyryl-Coenzyme A hydrolase0.015
Gja5gap junction protein, alpha 50.015
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.015
Cideacell death-inducing DNA fragmentation factor, alpha subunit-like effector A0.015
Droshadrosha, ribonuclease type III0.015
Vhlvon Hippel-Lindau tumor suppressor0.015
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.015
Fam96afamily with sequence similarity 96, member A0.015
Rbck1RanBP-type and C3HC4-type zinc finger containing 10.014
Tspan12tetraspanin 120.014
Mfap2microfibrillar-associated protein 20.014
Smosmoothened homolog (Drosophila)0.014
Varsvalyl-tRNA synthetase0.014
Cd40CD40 antigen0.014
Ptgfrprostaglandin F receptor0.014
Hcfc1host cell factor C10.014
Nsa2NSA2 ribosome biogenesis homolog (S. cerevisiae)0.014
Nclnnicalin homolog (zebrafish)0.014
Adprhl2ADP-ribosylhydrolase like 20.014
Tfamtranscription factor A, mitochondrial0.014
Ldb1LIM domain binding 10.014
Tmpothymopoietin0.014
Tead2TEA domain family member 20.014
Nr1h2nuclear receptor subfamily 1, group H, member 20.014
Agap3ArfGAP with GTPase domain, ankyrin repeat and PH domain 30.013
Mll1myeloid/lymphoid or mixed-lineage leukemia 10.013
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Capza2capping protein (actin filament) muscle Z-line, alpha 20.017
Copb1coatomer protein complex, subunit beta 10.016
Fyttd1forty-two-three domain containing 10.015
Sec62SEC62 homolog (S. cerevisiae)0.014
LOC682967similar to Protein disulfide-isomerase TXNDC10 precursor (Thioredoxin domain-containing protein 10)0.014
Atp5oATP synthase, H+ transporting, mitochondrial F1 complex, O subunit0.014
Atp5hATP synthase, H+ transporting, mitochondrial F0 complex, subunit d0.014
Ddx3xDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked0.013
Psma2proteasome (prosome, macropain) subunit, alpha type 20.013
Eif3meukaryotic translation initiation factor 3, subunit M0.013
Sfrs11splicing factor, arginine/serine-rich 110.013
Ndufb10NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 100.013
Pnrc2proline-rich nuclear receptor coactivator 20.012
Paip2poly(A) binding protein interacting protein 20.012
Tax1bp1Tax1 (human T-cell leukemia virus type I) binding protein 10.011
Narg1NMDA receptor regulated 10.011
Tcea1transcription elongation factor A (SII) 10.010
Hiat1hippocampus abundant gene transcript 10.010
Atp5lATP synthase, H+ transporting, mitochondrial F0 complex, subunit G0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism