The network for 'pituitary gland development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

pituitary gland development

The progression of the pituitary gland over time from its initial formation until its mature state. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands.

NameDescriptionProbabilityFunc Analog Organism
BMP2bone morphogenetic protein 21.000
TAL1T-cell acute lymphocytic leukemia 11.000
BMPR1Abone morphogenetic protein receptor, type IA0.999
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.998
PAX3paired box 30.988
DAXXdeath-domain associated protein0.957
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.934
SOX2SRY (sex determining region Y)-box 20.927
SMAD7SMAD family member 70.921
BMP7bone morphogenetic protein 70.900
TCF4transcription factor 40.894
NR4A1nuclear receptor subfamily 4, group A, member 10.891
PTCH1patched 10.876
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.873
SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.838
FGFR1fibroblast growth factor receptor 10.820
FSTL1follistatin-like 10.738
ARandrogen receptor0.723
CTNND1catenin (cadherin-associated protein), delta 10.590
SOX11SRY (sex determining region Y)-box 110.583
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.568
PRMT6protein arginine methyltransferase 60.546
NOTCH1notch 10.531
PSEN1presenilin 10.523
MTA3metastasis associated 1 family, member 30.514
FOXD3forkhead box D30.473
PAX8paired box 80.471
SALL2sal-like 2 (Drosophila)0.461
AXIN1axin 10.449
HIC1hypermethylated in cancer 10.443
HIPK2homeodomain interacting protein kinase 20.442
MDFIMyoD family inhibitor0.402
GLIS2GLIS family zinc finger 20.392
ATXN1Lataxin 1-like0.361
MSX2msh homeobox 20.355
JUPjunction plakoglobin0.345
SPENspen homolog, transcriptional regulator (Drosophila)0.307
LHX2LIM homeobox 20.299
MARCKSL1MARCKS-like 10.289
SUV39H2suppressor of variegation 3-9 homolog 2 (Drosophila)0.273
RBPMSRNA binding protein with multiple splicing0.268
ZIC1Zic family member 1 (odd-paired homolog, Drosophila)0.268
RASSF1Ras association (RalGDS/AF-6) domain family member 10.266
FOXG1forkhead box G10.263
POU3F2POU class 3 homeobox 20.257
VHLvon Hippel-Lindau tumor suppressor0.254
FGF1fibroblast growth factor 1 (acidic)0.226
SUV39H1suppressor of variegation 3-9 homolog 1 (Drosophila)0.220
PAX6paired box 60.211
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.209
SFRP1secreted frizzled-related protein 10.196
FOXC1forkhead box C10.196
SMAD5SMAD family member 50.195
SLC9A3R2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 20.190
SIX3SIX homeobox 30.189
SOX21SRY (sex determining region Y)-box 210.182
EYA2eyes absent homolog 2 (Drosophila)0.172
BMP4bone morphogenetic protein 40.171
JAG1jagged 10.167
NGFRnerve growth factor receptor0.166
HDAC2histone deacetylase 20.163
TBX2T-box 20.163
CREBBPCREB binding protein0.161
RCOR1REST corepressor 10.161
FZD1frizzled homolog 1 (Drosophila)0.160
PTPRJprotein tyrosine phosphatase, receptor type, J0.158
SOX9SRY (sex determining region Y)-box 90.157
SNAI1snail homolog 1 (Drosophila)0.152
PKP4plakophilin 40.146
MSX1msh homeobox 10.146
HOXD9homeobox D90.146
WHSC1L1Wolf-Hirschhorn syndrome candidate 1-like 10.143
SMAD4SMAD family member 40.142
GSK3Bglycogen synthase kinase 3 beta0.141
NEUROD1neurogenic differentiation 10.140
FOXF1forkhead box F10.136
FRMD5FERM domain containing 50.135
FOXC2forkhead box C2 (MFH-1, mesenchyme forkhead 1)0.134
INHBBinhibin, beta B0.124
POU5F1POU class 5 homeobox 10.123
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.123
STK36serine/threonine kinase 360.116
MTA1metastasis associated 10.116
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.115
SMOsmoothened homolog (Drosophila)0.115
KAT2BK(lysine) acetyltransferase 2B0.115
CHD4chromodomain helicase DNA binding protein 40.112
MEIS1Meis homeobox 10.111
SMAD2SMAD family member 20.109
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.109
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.108
HOXD13homeobox D130.106
DVL2dishevelled, dsh homolog 2 (Drosophila)0.105
FOXO3forkhead box O30.104
OTPorthopedia homeobox0.103
LMX1ALIM homeobox transcription factor 1, alpha0.101
ZHX1zinc fingers and homeoboxes 10.099
ZIC3Zic family member 3 (odd-paired homolog, Drosophila)0.099
ZNF830zinc finger protein 8300.098
NKX2-2NK2 homeobox 20.096
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
shhasonic hedgehog a1.000
fgf8afibroblast growth factor 8 a0.998
fgf3fibroblast growth factor 30.997
bmp4bone morphogenetic protein 40.994
eya1eyes absent homolog 10.983
rx3retinal homeobox gene 30.979
tbx1T-box 10.975
ascl1aachaete-scute complex-like 1a (Drosophila)0.965
sox2SRY-box containing gene 20.964
pax2apaired box gene 2a0.963
nkx2.2aNK2 transcription factor related 2a0.929
tfap2atranscription factor AP-2 alpha0.928
gli1GLI-Kruppel family member 10.833
zic2azic family member 2 (odd-paired homolog, Drosophila), a0.833
foxi1forkhead box I10.829
mibmind bomb0.824
pitx2paired-like homeodomain transcription factor 20.747
notch1anotch homolog 1a0.735
ntlano tail a0.723
prdm1aPR domain containing 1a, with ZNF domain0.676
foxa2forkhead box A20.654
six3asine oculis homeobox homolog 3a0.603
foxd3forkhead box D30.555
cdh2cadherin 2, neuronal0.525
foxg1aforkhead box G1a0.525
dlx3bdistal-less homeobox gene 3b0.484
gli2aGLI-Kruppel family member GLI2a0.484
dkk1bdickkopf 1b0.481
six1bsine oculis homeobox homolog 1b0.479
bmp2bbone morphogenetic protein 2b0.478
dzip1DAZ interacting protein 10.472
dbx1adeveloping brain homeobox 1a0.435
flhfloating head0.423
fezf2FEZ family zinc finger 20.423
six3bsine oculis homeobox homolog 3b0.384
dlx2adistal-less homeobox gene 2a0.380
six4asine oculis homeobox homolog 4a0.352
nkx2.1aNK2 homeobox 1a0.351
msxcmuscle segment homeobox C0.333
otpborthopedia homolog b0.320
ndr2nodal-related 20.296
sox3SRY-box containing gene 30.263
grhl2bgrainyhead-like 2b (Drosophila)0.254
pou1f1POU domain, class 1, transcription factor 10.242
pcdh8protocadherin 80.226
dlx4bdistal-less homeobox gene 4b0.224
rx2retinal homeobox gene 20.223
nipblbnovel protein similar to vertebrate Nipped-B homolog and nipped-b homolog b (Drosophila)0.213
foxe3forkhead box E30.213
hmx4H6 family homeobox 40.208
tcf7transcription factor 7 (T-cell specific, HMG-box)0.202
otx2orthodenticle homolog 20.187
fzd8afrizzled homolog 8a0.177
nos1nitric oxide synthase 1 (neuronal)0.174
klf4Kruppel-like factor 40.164
cyp26c1cytochrome P450, family 26, subfamily C, polypeptide 10.159
lhx5LIM homeobox 50.144
wnt11wingless-type MMTV integration site family, member 110.144
ptch2patched 20.137
arxaristaless related homeobox0.131
pax6apaired box gene 6a0.130
tp63tumor protein p630.125
wnt5bwingless-type MMTV integration site family, member 5b0.124
foxd5forkhead box D50.122
irx1biroquois homeobox protein 1, b0.121
pax6bpaired box gene 6b0.119
hoxb1bhomeo box B1b0.116
otx1borthodenticle homolog 1b0.115
lhx6LIM homeobox 60.115
extl3exostoses (multiple)-like 30.111
sox17SRY-box containing gene 170.107
zic1zic family member 1 (odd-paired homolog, Drosophila)0.105
emx1empty spiracles homeobox 10.102
gbx2gastrulation brain homeo box 20.102
ptch1patched 10.101
gli2bGLI-Kruppel family member GLI2b0.097
msgn1mesogenin 10.096
nr2e1nuclear receptor subfamily 2, group E, member 10.095
sox19aSRY-box containing gene 19a0.089
nkx2.2bNK2 transcription factor related 2b0.085
zic3zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)0.082
pitx3paired-like homeodomain transcription factor 30.081
rereaarginine-glutamic acid dipeptide (RE) repeats a0.078
lhx1aLIM homeobox 1a0.076
dlx5adistal-less homeobox gene 5a0.075
tll1tolloid-like 10.074
lhx2bLIM homeobox 2b0.070
pax8paired box gene 80.069
foxa3forkhead box A30.066
otpaorthopedia homolog a0.065
gbx1gastrulation brain homeobox 10.065
neurodneurogenic differentiation0.064
neurog1neurogenin 10.064
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog1.000
Otx2orthodenticle homolog 2 (Drosophila)1.000
Gli3GLI-Kruppel family member GLI31.000
Fgfr2fibroblast growth factor receptor 21.000
Pax2paired box gene 21.000
Fgf8fibroblast growth factor 81.000
Pax3paired box gene 31.000
Sox9SRY-box containing gene 91.000
Rargretinoic acid receptor, gamma1.000
Pitx2paired-like homeodomain transcription factor 21.000
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)1.000
Hand1heart and neural crest derivatives expressed transcript 11.000
Eya1eyes absent 1 homolog (Drosophila)1.000
Tcfap2atranscription factor AP-2, alpha1.000
Six1sine oculis-related homeobox 1 homolog (Drosophila)1.000
Hand2heart and neural crest derivatives expressed transcript 20.999
Tbx1T-box 10.999
Fgf10fibroblast growth factor 100.999
Isl1ISL1 transcription factor, LIM/homeodomain0.999
Bmp4bone morphogenetic protein 40.999
Foxc1forkhead box C10.999
Sox2SRY-box containing gene 20.999
Lhx1LIM homeobox protein 10.998
Hoxa1homeobox A10.998
Msx1homeobox, msh-like 10.998
Pax6paired box gene 60.998
Dlx5distal-less homeobox 50.997
Ctnnb1catenin (cadherin associated protein), beta 10.996
Rarbretinoic acid receptor, beta0.996
Fgfr1fibroblast growth factor receptor 10.996
Gbx2gastrulation brain homeobox 20.996
Prrx1paired related homeobox 10.995
Fgfr3fibroblast growth factor receptor 30.995
Hoxd13homeobox D130.994
Lmx1bLIM homeobox transcription factor 1 beta0.994
Emx1empty spiracles homolog 1 (Drosophila)0.993
Pitx1paired-like homeodomain transcription factor 10.992
Foxc2forkhead box C20.989
Gli2GLI-Kruppel family member GLI20.987
Pax8paired box gene 80.986
Emx2empty spiracles homolog 2 (Drosophila)0.983
Foxg1forkhead box G10.980
Tbx3T-box 30.979
Wnt3awingless-related MMTV integration site 3A0.974
Lef1lymphoid enhancer binding factor 10.970
Gscgoosecoid homeobox0.968
Tgfbr2transforming growth factor, beta receptor II0.967
Alx4aristaless-like homeobox 40.967
Smosmoothened homolog (Drosophila)0.967
Pou5f1POU domain, class 5, transcription factor 10.963
Lmx1aLIM homeobox transcription factor 1 alpha0.959
Hoxa2homeobox A20.959
Bmp7bone morphogenetic protein 70.948
Lhx3LIM homeobox protein 30.948
Ascl1achaete-scute complex homolog 1 (Drosophila)0.947
Acvr1activin A receptor, type 10.940
En1engrailed 10.937
Gdnfglial cell line derived neurotrophic factor0.933
Retret proto-oncogene0.929
Msx2homeobox, msh-like 20.926
Wt1Wilms tumor 1 homolog0.921
Fgf3fibroblast growth factor 30.910
Otx1orthodenticle homolog 1 (Drosophila)0.909
Ror2receptor tyrosine kinase-like orphan receptor 20.905
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.896
Rararetinoic acid receptor, alpha0.895
Wnt1wingless-related MMTV integration site 10.891
Gata4GATA binding protein 40.887
Chd7chromodomain helicase DNA binding protein 70.876
Vegfavascular endothelial growth factor A0.874
Insm1insulinoma-associated 10.866
Pthlhparathyroid hormone-like peptide0.866
Phox2bpaired-like homeobox 2b0.857
Sall4sal-like 4 (Drosophila)0.851
Sall3sal-like 3 (Drosophila)0.850
Ednraendothelin receptor type A0.848
Pou3f3POU domain, class 3, transcription factor 30.847
Nkx2-1NK2 homeobox 10.846
Hoxd3homeobox D30.845
Sox11SRY-box containing gene 110.845
Prrx2paired related homeobox 20.840
Foxf1aforkhead box F1a0.837
Fgf15fibroblast growth factor 150.835
Zic3zinc finger protein of the cerebellum 30.832
Six3sine oculis-related homeobox 3 homolog (Drosophila)0.826
Hes5hairy and enhancer of split 5 (Drosophila)0.825
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.818
Lhx5LIM homeobox protein 50.813
Atoh7atonal homolog 7 (Drosophila)0.802
Foxh1forkhead box H10.793
Ptenphosphatase and tensin homolog0.786
Hoxa3homeobox A30.773
Nkx2-2NK2 transcription factor related, locus 2 (Drosophila)0.773
Alx3aristaless-like homeobox 30.767
Pitx3paired-like homeodomain transcription factor 30.750
Drd2dopamine receptor D20.749
Twist2twist homolog 2 (Drosophila)0.743
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Pax8paired box 80.038
Mipmajor intrinsic protein of lens fiber0.023
Fam65afamily with sequence similarity 65, member A0.020
Cyp2g1cytochrome P450, family 2, subfamily g, polypeptide 10.020
Ahraryl hydrocarbon receptor0.016
Thtyrosine hydroxylase0.015
UncxUNC homeobox0.015
Ecel1endothelin converting enzyme-like 10.014
Slc28a1solute carrier family 28 (sodium-coupled nucleoside transporter), member 10.014
Akap14A kinase (PRKA) anchor protein 140.013
Gja5gap junction protein, alpha 50.013
Hoxa2homeo box A20.013
Krt5keratin 50.012
Avpr1barginine vasopressin receptor 1B0.012
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.012
Gja3gap junction protein, alpha 30.012
Scn9asodium channel, voltage-gated, type IX, alpha0.011
Gfapglial fibrillary acidic protein0.010
Mllt4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.010
Mfrpmembrane frizzled-related protein0.010
Grik1glutamate receptor, ionotropic, kainate 10.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism