The network for 'negative regulation of cytosolic calcium ion concentration' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of cytosolic calcium ion concentration

Any process that decreases the concentration of calcium ions in the cytodol.

NameDescriptionProbabilityFunc Analog Organism
ADORA2Aadenosine A2a receptor0.998
ACTN2actinin, alpha 20.997
SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.927
MPDZmultiple PDZ domain protein0.910
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.873
VAC14Vac14 homolog (S. cerevisiae)0.856
JAK1Janus kinase 10.623
SSTR2somatostatin receptor 20.622
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.619
DLG2discs, large homolog 2 (Drosophila)0.566
CALCAcalcitonin-related polypeptide alpha0.542
JAK2Janus kinase 20.506
SSTR3somatostatin receptor 30.368
MYOZ1myozenin 10.352
AKAP6A kinase (PRKA) anchor protein 60.243
MBNL1muscleblind-like (Drosophila)0.225
IFNGR1interferon gamma receptor 10.210
OSBPL8oxysterol binding protein-like 80.190
IL6Rinterleukin 6 receptor0.190
PRKACAprotein kinase, cAMP-dependent, catalytic, alpha0.183
CHRNA4cholinergic receptor, nicotinic, alpha 40.162
ACACAacetyl-CoA carboxylase alpha0.121
KCNF1potassium voltage-gated channel, subfamily F, member 10.106
CCKBRcholecystokinin B receptor0.106
CDK17cyclin-dependent kinase 170.105
HTR2C5-hydroxytryptamine (serotonin) receptor 2C0.101
NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.098
MTNR1Amelatonin receptor 1A0.096
GAB1GRB2-associated binding protein 10.088
EIF2AK2eukaryotic translation initiation factor 2-alpha kinase 20.082
FSCN2fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)0.082
OPRD1opioid receptor, delta 10.081
KCNJ5potassium inwardly-rectifying channel, subfamily J, member 50.078
FHL2four and a half LIM domains 20.076
PLEKHA1pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 10.075
HNF1AHNF1 homeobox A0.063
ABCC8ATP-binding cassette, sub-family C (CFTR/MRP), member 80.062
KCNA4potassium voltage-gated channel, shaker-related subfamily, member 40.055
BHLHE23basic helix-loop-helix family, member e230.054
LIFleukemia inhibitory factor (cholinergic differentiation factor)0.053
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.052
EMX1empty spiracles homeobox 10.052
GPRASP1G protein-coupled receptor associated sorting protein 10.051
SOX1SRY (sex determining region Y)-box 10.051
NAMPTnicotinamide phosphoribosyltransferase0.049
CRIM1cysteine rich transmembrane BMP regulator 1 (chordin-like)0.049
STAT2signal transducer and activator of transcription 2, 113kDa0.047
SLC6A7solute carrier family 6 (neurotransmitter transporter, L-proline), member 70.047
LIFRleukemia inhibitory factor receptor alpha0.046
CPDcarboxypeptidase D0.045
MAPK12mitogen-activated protein kinase 120.044
CDK5R2cyclin-dependent kinase 5, regulatory subunit 2 (p39)0.044
CRHR1corticotropin releasing hormone receptor 10.043
AHRaryl hydrocarbon receptor0.043
GALR3galanin receptor 30.042
NEUROD2neurogenic differentiation 20.041
DLG1discs, large homolog 1 (Drosophila)0.041
NRIP1nuclear receptor interacting protein 10.041
GRM5glutamate receptor, metabotropic 50.040
KCNJ3potassium inwardly-rectifying channel, subfamily J, member 30.039
GFAPglial fibrillary acidic protein0.039
OSMRoncostatin M receptor0.038
CALYcalcyon neuron-specific vesicular protein0.038
SHANK1SH3 and multiple ankyrin repeat domains 10.037
GNAO1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O0.037
ZNF350zinc finger protein 3500.036
HLFhepatic leukemia factor0.036
TTNtitin0.036
MLNmotilin0.036
CHD1chromodomain helicase DNA binding protein 10.035
ACTL6Bactin-like 6B0.035
ADRA1Dadrenergic, alpha-1D-, receptor0.035
ACHEacetylcholinesterase0.035
OXToxytocin, prepropeptide0.034
PAX7paired box 70.034
EXTL1exostoses (multiple)-like 10.034
HTR2A5-hydroxytryptamine (serotonin) receptor 2A0.034
SIX6SIX homeobox 60.034
ADRA1Badrenergic, alpha-1B-, receptor0.034
FRS2fibroblast growth factor receptor substrate 20.034
TNP2transition protein 2 (during histone to protamine replacement)0.033
GRM1glutamate receptor, metabotropic 10.032
FNDC3Afibronectin type III domain containing 3A0.032
SCARB2scavenger receptor class B, member 20.032
SEZ6Lseizure related 6 homolog (mouse)-like0.032
GPR6G protein-coupled receptor 60.032
NR5A1nuclear receptor subfamily 5, group A, member 10.031
P2RX6purinergic receptor P2X, ligand-gated ion channel, 60.031
FOXD3forkhead box D30.031
IGF1Rinsulin-like growth factor 1 receptor0.031
DENND4ADENN/MADD domain containing 4A0.030
PRKCGprotein kinase C, gamma0.030
GJA4gap junction protein, alpha 4, 37kDa0.030
SYN2synapsin II0.030
BRAPBRCA1 associated protein0.030
PIK3CAphosphoinositide-3-kinase, catalytic, alpha polypeptide0.030
NEURLneuralized homolog (Drosophila)0.030
GHRHRgrowth hormone releasing hormone receptor0.030
SLC22A6solute carrier family 22 (organic anion transporter), member 60.030
OR2AG1olfactory receptor, family 2, subfamily AG, member 10.030
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
pcca-1Protein PCCA-10.169
pde-4Protein PDE-40.128
clp-1Protein CLP-10.047
F35A5.1Protein F35A5.10.044
ogdh-1Protein OGDH-10.037
kcc-1Protein KCC-10.032
CELE_C08H9.2Protein C08H9.20.019
cmd-1Protein CMD-10.018
unc-15Protein UNC-150.018
myo-3Protein MYO-30.018
B0491.5Protein B0491.50.018
immt-1Protein IMMT-10.017
idhb-1Protein IDHB-10.016
nuo-5Protein NUO-50.016
egl-3Protein EGL-30.013
soc-2Protein SOC-20.013
eat-6Protein EAT-60.013
fln-2Protein FLN-20.012
pyc-1Protein PYC-10.012
myo-1Protein MYO-10.011
K09A9.6Protein K09A9.60.011
F01G4.6Protein F01G4.60.011
C16E9.1Protein C16E9.10.010
cah-6Protein CAH-60.010
sca-1Protein SCA-10.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Leprleptin receptor0.792
Kcnq1potassium voltage-gated channel, subfamily Q, member 10.442
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.230
Esr1estrogen receptor 1 (alpha)0.148
Pomcpro-opiomelanocortin-alpha0.114
Npy2rneuropeptide Y receptor Y20.086
Lepleptin0.083
Myo15myosin XV0.075
Kcnma1potassium large conductance calcium-activated channel, subfamily M, alpha member 10.070
Ush1gUsher syndrome 1G homolog (human)0.068
Nos1nitric oxide synthase 1, neuronal0.065
Vdrvitamin D receptor0.058
Vamp2vesicle-associated membrane protein 20.043
Nr3c1nuclear receptor subfamily 3, group C, member 10.042
Drd2dopamine receptor D20.040
Pou4f3POU domain, class 4, transcription factor 30.039
Cdh23cadherin 23 (otocadherin)0.036
Whrnwhirlin0.035
Cnr1cannabinoid receptor 1 (brain)0.032
Esr2estrogen receptor 2 (beta)0.029
Il6interleukin 60.026
Prlrprolactin receptor0.025
Smpd3sphingomyelin phosphodiesterase 3, neutral0.025
Thrbthyroid hormone receptor beta0.025
Stat3signal transducer and activator of transcription 30.025
Ppargperoxisome proliferator activated receptor gamma0.024
Ppargc1aperoxisome proliferative activated receptor, gamma, coactivator 1 alpha0.024
Clstn1calsyntenin 10.022
Ttntitin0.022
Tmc1transmembrane channel-like gene family 10.022
Klklotho0.021
Cdkn1bcyclin-dependent kinase inhibitor 1B0.020
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.019
Dlg4discs, large homolog 4 (Drosophila)0.019
Gria1glutamate receptor, ionotropic, AMPA1 (alpha 1)0.019
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.018
Cyldcylindromatosis (turban tumor syndrome)0.018
Drd1adopamine receptor D1A0.017
Scn1asodium channel, voltage-gated, type I, alpha0.017
Cav1caveolin 1, caveolae protein0.017
Cckbrcholecystokinin B receptor0.016
Arandrogen receptor0.016
Espnespin0.016
Ush1cUsher syndrome 1C homolog (human)0.015
Ghrgrowth hormone receptor0.014
Camk2acalcium/calmodulin-dependent protein kinase II alpha0.014
Spnb2spectrin beta 20.014
Apoeapolipoprotein E0.014
Hbb-b1hemoglobin, beta adult major chain0.014
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.014
Pgrprogesterone receptor0.014
Grxcr1glutaredoxin, cysteine rich 10.014
Tgfb1transforming growth factor, beta 10.013
Cacna1dcalcium channel, voltage-dependent, L type, alpha 1D subunit0.013
Prlhrprolactin releasing hormone receptor0.013
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.012
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.012
Oprk1opioid receptor, kappa 10.012
Nos3nitric oxide synthase 3, endothelial cell0.012
Kcne1potassium voltage-gated channel, Isk-related subfamily, member 10.012
Kcnj6potassium inwardly-rectifying channel, subfamily J, member 60.011
Insrinsulin receptor0.011
Prkccprotein kinase C, gamma0.011
Srrm4serine/arginine repetitive matrix 40.011
Ccl2chemokine (C-C motif) ligand 20.011
Cltcclathrin, heavy polypeptide (Hc)0.011
WwoxWW domain-containing oxidoreductase0.010
Pcdh15protocadherin 150.010
Cacna1bcalcium channel, voltage-dependent, N type, alpha 1B subunit0.010
Bglapbone gamma carboxyglutamate protein0.010
Thrathyroid hormone receptor alpha0.010
Phospho1phosphatase, orphan 10.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Drd1adopamine receptor D1A0.090
Kcnd3potassium voltage-gated channel, Shal-related subfamily, member 30.064
Ank2ankyrin 2, neuronal0.059
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.049
Crhbpcorticotropin releasing hormone binding protein0.034
Crhcorticotropin releasing hormone0.031
Gpr83G protein-coupled receptor 830.031
Dlgap1discs, large (Drosophila) homolog-associated protein 10.030
Trim66tripartite motif-containing 660.029
Scn8asodium channel, voltage gated, type VIII, alpha subunit0.028
Myl1myosin, light chain 10.028
Atxn1ataxin 10.026
Cntn3contactin 3 (plasmacytoma associated)0.026
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.025
Kcng2potassium voltage-gated channel, subfamily G, member 20.025
Arpp21cAMP-regulated phosphoprotein 210.024
Opcmlopioid binding protein/cell adhesion molecule-like0.022
Grm1glutamate receptor, metabotropic 10.022
Hcrtr1hypocretin (orexin) receptor 10.021
Chrna3cholinergic receptor, nicotinic, alpha 30.020
Olr1078olfactory receptor 10780.019
Grin2aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.019
Glp1rglucagon-like peptide 1 receptor0.017
Sdc3syndecan 30.017
CartptCART prepropeptide0.016
Gastgastrin0.016
Gdf9growth differentiation factor 90.016
Kcnc2potassium voltage gated channel, Shaw-related subfamily, member 20.015
Nptx1neuronal pentraxin 10.015
Syt6synaptotagmin VI0.015
Cntnap1contactin associated protein 10.015
Grm8glutamate receptor, metabotropic 80.015
Gabrg1gamma-aminobutyric acid (GABA) A receptor, gamma 10.014
Acanaggrecan0.014
Camk4calcium/calmodulin-dependent protein kinase IV0.014
Nell1NEL-like 1 (chicken)0.014
Myt1lmyelin transcription factor 1-like0.014
Sstr1somatostatin receptor 10.014
Hes2hairy and enhancer of split 2 (Drosophila)0.013
Kcna1potassium voltage-gated channel, shaker-related subfamily, member 10.013
Mamdc4MAM domain containing 40.013
Drd2dopamine receptor D20.013
Olr287olfactory receptor 2870.013
Nr4a3nuclear receptor subfamily 4, group A, member 30.013
Il4interleukin 40.013
Pspparotid secretory protein0.012
Olr414olfactory receptor 4140.012
Snap25synaptosomal-associated protein 250.012
Fosl1fos-like antigen 10.012
Nmur2neuromedin U receptor 20.012
Slc32a1solute carrier family 32 (GABA vesicular transporter), member 10.011
Sorcs3sortilin-related VPS10 domain containing receptor 30.011
Add2adducin 2 (beta)0.011
Htr2a5-hydroxytryptamine (serotonin) receptor 2A0.011
Lalbalactalbumin, alpha0.011
Shank1SH3 and multiple ankyrin repeat domains 10.011
Syt4synaptotagmin IV0.011
Cacng5calcium channel, voltage-dependent, gamma subunit 50.011
Lrrc4bleucine rich repeat containing 4B0.011
Actr2ARP2 actin-related protein 2 homolog (yeast)0.011
Hpcahippocalcin0.011
LOC296235similar to Cystatin S precursor (LM protein)0.011
P2rx2purinergic receptor P2X, ligand-gated ion channel, 20.011
Mfrpmembrane frizzled-related protein0.011
Slc22a8solute carrier family 22 (organic anion transporter), member 80.011
Begainbrain-enriched guanylate kinase-associated0.010
Ptger1prostaglandin E receptor 1 (subtype EP1)0.010
Chrna7cholinergic receptor, nicotinic, alpha 70.010
Prm1protamine 10.010
Prl7d1prolactin family 7, subfamily d, member 10.010
Ryr2ryanodine receptor 2, cardiac0.010
Kcnb1potassium voltage gated channel, Shab-related subfamily, member 10.010
Chrm3cholinergic receptor, muscarinic 30.010
Fgf14fibroblast growth factor 140.010
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism