The network for 'regulation of defense response to virus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of defense response to virus

Any process that modulates the frequency, rate or extent of the antiviral response of a cell or organism.

NameDescriptionProbabilityFunc Analog Organism
DDX58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.998
IFI44interferon-induced protein 440.988
IFIT3interferon-induced protein with tetratricopeptide repeats 30.985
IFIT1interferon-induced protein with tetratricopeptide repeats 10.983
EIF2AK2eukaryotic translation initiation factor 2-alpha kinase 20.980
SP110SP110 nuclear body protein0.922
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.909
IFIT2interferon-induced protein with tetratricopeptide repeats 20.908
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.903
DDX60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.861
ISG15ISG15 ubiquitin-like modifier0.811
IFIT5interferon-induced protein with tetratricopeptide repeats 50.808
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.798
SAMD9sterile alpha motif domain containing 90.797
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.766
IFI44Linterferon-induced protein 44-like0.701
OAS22'-5'-oligoadenylate synthetase 2, 69/71kDa0.677
IFIH1interferon induced with helicase C domain 10.660
STAT1signal transducer and activator of transcription 1, 91kDa0.639
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.636
SP100SP100 nuclear antigen0.551
EPSTI1epithelial stromal interaction 1 (breast)0.530
NMIN-myc (and STAT) interactor0.513
SMURF2SMAD specific E3 ubiquitin protein ligase 20.486
MX1myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)0.467
PRKRAprotein kinase, interferon-inducible double stranded RNA dependent activator0.467
OAS12',5'-oligoadenylate synthetase 1, 40/46kDa0.415
NLRC4NLR family, CARD domain containing 40.396
CREBBPCREB binding protein0.392
SMAD4SMAD family member 40.367
PILRApaired immunoglobin-like type 2 receptor alpha0.365
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.354
RSAD2radical S-adenosyl methionine domain containing 20.352
IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon0.347
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.292
HERC5hect domain and RLD 50.281
PLSCR1phospholipid scramblase 10.258
IL4Rinterleukin 4 receptor0.256
PTPN6protein tyrosine phosphatase, non-receptor type 60.255
TMEM173transmembrane protein 1730.242
IL23Ainterleukin 23, alpha subunit p190.242
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.237
CHUKconserved helix-loop-helix ubiquitous kinase0.235
OASL2'-5'-oligoadenylate synthetase-like0.227
MAP3K14mitogen-activated protein kinase kinase kinase 140.222
TRIM22tripartite motif containing 220.214
MED15mediator complex subunit 150.203
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.197
MX2myxovirus (influenza virus) resistance 2 (mouse)0.190
PARP9poly (ADP-ribose) polymerase family, member 90.180
LILRA1leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 10.160
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.155
XAF1XIAP associated factor 10.151
PCBP1poly(rC) binding protein 10.149
ATG3ATG3 autophagy related 3 homolog (S. cerevisiae)0.146
TRIM21tripartite motif containing 210.142
USP18ubiquitin specific peptidase 180.131
CASP8caspase 8, apoptosis-related cysteine peptidase0.128
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.113
OAS32'-5'-oligoadenylate synthetase 3, 100kDa0.111
GBP1guanylate binding protein 1, interferon-inducible0.107
LILRB3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 30.106
APOL6apolipoprotein L, 60.105
TRIM39tripartite motif containing 390.100
LILRA2leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 20.098
NFKBIBnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta0.094
MEFVMediterranean fever0.093
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.092
RTP4receptor (chemosensory) transporter protein 40.090
IRF9interferon regulatory factor 90.087
TRAF3TNF receptor-associated factor 30.086
UBE2D4ubiquitin-conjugating enzyme E2D 4 (putative)0.083
WWP2WW domain containing E3 ubiquitin protein ligase 20.078
MAVSmitochondrial antiviral signaling protein0.077
DHX30DEAH (Asp-Glu-Ala-His) box polypeptide 300.075
WWP1WW domain containing E3 ubiquitin protein ligase 10.075
IRF7interferon regulatory factor 70.071
RNF11ring finger protein 110.070
TRIM5tripartite motif containing 50.070
XIAPX-linked inhibitor of apoptosis0.068
TRIM25tripartite motif containing 250.067
DICER1dicer 1, ribonuclease type III0.067
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.066
DAXXdeath-domain associated protein0.062
IL15interleukin 150.062
CRADDCASP2 and RIPK1 domain containing adaptor with death domain0.057
NOD2nucleotide-binding oligomerization domain containing 20.057
CYLDcylindromatosis (turban tumor syndrome)0.056
TDRD7tudor domain containing 70.055
ZNF263zinc finger protein 2630.055
EIF2C2eukaryotic translation initiation factor 2C, 20.054
CXCL10chemokine (C-X-C motif) ligand 100.054
IFI27interferon, alpha-inducible protein 270.053
CXCL11chemokine (C-X-C motif) ligand 110.053
ZC3HAV1zinc finger CCCH-type, antiviral 10.052
TYMPthymidine phosphorylase0.052
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.052
SAMD9Lsterile alpha motif domain containing 9-like0.052
SCNN1Bsodium channel, nonvoltage-gated 1, beta0.050
RANBP3RAN binding protein 30.050
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
caspacaspase a0.073
s100a10bS100 calcium binding protein A10b0.040
ef1aelongation factor 1-alpha0.033
yes1v-yes-1 Yamaguchi sarcoma viral oncogene homolog 10.025
ddx42DEAD (Asp-Glu-Ala-Asp) box polypeptide 420.025
prkar1aaprotein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a0.022
snx4sorting nexin 40.022
il6rinterleukin 6 receptor0.020
plk3polo-like kinase 3 (Drosophila)0.019
tlr21toll-like receptor 210.018
unc5cunc-5 homolog C (C. elegans)0.018
LOC557072caspase recruitment domain-containing protein 11-like0.017
relv-rel reticuloendotheliosis viral oncogene homolog0.017
atp6v1baATPase, H+ transporting, lysosomal, V1 subunit B, member a0.017
myl1myosin, light chain 1, alkali; skeletal, fast0.017
arhgdigRho GDP dissociation inhibitor (GDI) gamma0.016
il6stinterleukin 6 signal transducer0.015
plekha1pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 10.014
glcebglucuronyl C5-epimerase b0.014
timp2atissue inhibitor of metalloproteinase 2a0.014
tfe3btranscription factor binding to IGHM enhancer 3b0.014
LOC566020Gig2-like protein DreO0.014
xrn25'-3' exoribonuclease 20.014
atg13ATG13 autophagy related 13 homolog (S. cerevisiae)0.013
stamsignal transducing adaptor molecule (SH3 domain and ITAM motif) 10.013
acvr2aactivin receptor IIa0.013
polbpolymerase (DNA directed), beta0.012
capns1bcalpain, small subunit 1 b0.012
card14caspase recruitment domain family, member 140.012
cdh5cadherin 50.012
sec24cSEC24 family, member C (S. cerevisiae)0.012
gabarapaGABA(A) receptor-associated protein a0.011
styk1serine/threonine/tyrosine kinase 10.011
mecp2methyl CpG binding protein 20.011
acta1bactin, alpha 1b, skeletal muscle0.011
anxa1bannexin A1b0.011
wnt5awingless-type MMTV integration site family, member 5a0.011
nod1nucleotide-binding oligomerization domain containing 10.011
flot2aflotillin 2a0.011
krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.011
pobpartial optokinetic response b0.011
mmp2matrix metalloproteinase 20.011
anxa13annexin A130.011
cdkn1acyclin-dependent kinase inhibitor 1A0.011
tfe3atranscription factor binding to IGHM enhancer 3a0.011
ppp1cbprotein phosphatase 1, catalytic subunit, beta isoform0.011
maf1MAF1 homolog (S. cerevisiae)0.011
hmgb2ahigh-mobility group box 2a0.011
lrmplymphoid-restricted membrane protein0.010
actc1bactin, alpha, cardiac muscle 1b0.010
ddr2bdiscoidin domain receptor family, member 2b0.010
tnni2b.2troponin I, skeletal, fast 2b.20.010
cd40lgCD40 ligand0.010
tsen54tRNA splicing endonuclease 54 homolog (S. cerevisiae)0.010
pmp22aperipheral myelin protein 22a0.010
nfkbiaanuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a0.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
BG4CG12297 gene product from transcript CG12297-RA0.958
ird5immune response deficient 50.924
DreddDeath related ced-3/Nedd2-like protein0.822
Tak1TGF-beta activated kinase 10.750
Toll-7CG8595 gene product from transcript CG8595-RA0.741
imdimmune deficiency0.637
Mpk2CG5475 gene product from transcript CG5475-RB0.473
Atg13Autophagy-specific gene 130.285
18w18 wheeler0.275
Atg18Autophagy-specific gene 180.260
CG16718CG16718 gene product from transcript CG16718-RA0.241
Myd88CG2078 gene product from transcript CG2078-RA0.224
Toll-6CG7250 gene product from transcript CG7250-RA0.168
Atg7Autophagy-specific gene 70.163
ird1immune response deficient 10.150
AGO2Argonaute 20.135
Sox14Sox box protein 140.104
TolloCG6890 gene product from transcript CG6890-RA0.075
p38bCG7393 gene product from transcript CG7393-RA0.061
Vps16AVacuolar protein sorting 16A0.059
CG7611CG7611 gene product from transcript CG7611-RJ0.051
RASSF8CG5053 gene product from transcript CG5053-RA0.050
ced-6CG11804 gene product from transcript CG11804-RC0.044
Pi3K59FPhosphotidylinositol 3 kinase 59F0.039
CG10650CG10650 gene product from transcript CG10650-RA0.034
PGRP-LCPeptidoglycan recognition protein LC0.033
PGRP-LEPeptidoglycan recognition protein LE0.032
Traf6TNF-receptor-associated factor 60.032
CG1021CG1021 gene product from transcript CG1021-RE0.028
CG5794CG5794 gene product from transcript CG5794-RB0.025
Atg9Autophagy-specific gene 90.024
Mekk1CG7717 gene product from transcript CG7717-RB0.023
HsfHeat shock factor0.023
CG32185CG32185 gene product from transcript CG32185-RA0.020
Tsp29FaTetraspanin 29Fa0.020
CG2924CG2924 gene product from transcript CG2924-RA0.019
Atg8aAutophagy-specific gene 8a0.018
bibbig brain0.018
Atg2Autophagy-specific gene 20.017
ParpPoly-(ADP-ribose) polymerase0.017
l(3)05822lethal (3) 058220.017
Mt2Methyltransferase 20.016
NT1Neurotrophin 10.015
CG13482CG13482 gene product from transcript CG13482-RA0.014
Patr-1Protein associated with topo II related - 10.013
Tsp42EcTetraspanin 42Ec0.013
CG17107CG17107 gene product from transcript CG17107-RA0.013
DuoxDual oxidase0.013
NotumCG13076 gene product from transcript CG13076-RB0.013
CG13323CG13323 gene product from transcript CG13323-RA0.013
StamSignal transducing adaptor molecule0.012
unc79CG5237 gene product from transcript CG5237-RB0.012
Nipped-BCG17704 gene product from transcript CG17704-RI0.012
certceramide transfer protein0.012
CG12974CG12974 gene product from transcript CG12974-RA0.012
CG17746CG17746 gene product from transcript CG17746-RA0.011
lambdaTryCG12350 gene product from transcript CG12350-RA0.011
Atg5Autophagy-specific gene 50.011
CG15152CG15152 gene product from transcript CG15152-RA0.011
MESR6Misexpression suppressor of ras 60.010
Hip1Huntingtin interacting protein 10.010
Atf-2Activating transcription factor-20.010
p53CG33336 gene product from transcript CG33336-RB0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Casp4caspase 4, apoptosis-related cysteine peptidase0.997
Trim30atripartite motif-containing 30A0.984
Gbp7guanylate binding protein 70.940
Iigp1interferon inducible GTPase 10.833
Ddx60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.820
Parp14poly (ADP-ribose) polymerase family, member 140.788
Ikbkginhibitor of kappaB kinase gamma0.781
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.706
Trim21tripartite motif-containing 210.689
Ikbkbinhibitor of kappaB kinase beta0.684
Aim2absent in melanoma 20.666
Ifi203interferon activated gene 2030.647
Irgm1immunity-related GTPase family M member 10.612
Ighimmunoglobulin heavy chain complex0.607
Stat1signal transducer and activator of transcription 10.599
Sp100nuclear antigen Sp1000.598
Stat3signal transducer and activator of transcription 30.578
Gbp2guanylate binding protein 20.550
Mavsmitochondrial antiviral signaling protein0.526
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.516
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.487
Gbp3guanylate binding protein 30.480
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.427
Usp18ubiquitin specific peptidase 180.427
Traf6TNF receptor-associated factor 60.424
Cd40CD40 antigen0.421
Uba7ubiquitin-like modifier activating enzyme 70.412
Rsad2radical S-adenosyl methionine domain containing 20.409
Mndalmyeloid nuclear differentiation antigen like0.407
Myd88myeloid differentiation primary response gene 880.393
PycardPYD and CARD domain containing0.376
Tnftumor necrosis factor0.374
Stat5bsignal transducer and activator of transcription 5B0.366
Trim30dtripartite motif-containing 30D0.327
Gbp10guanylate-binding protein 100.310
Pyhin1pyrin and HIN domain family, member 10.295
Irf9interferon regulatory factor 90.290
Ifi44interferon-induced protein 440.283
Rtp4receptor transporter protein 40.274
Igtpinterferon gamma induced GTPase0.270
Irgm2immunity-related GTPase family M member 20.262
Gbp5guanylate binding protein 50.252
Map3k7mitogen-activated protein kinase kinase kinase 70.249
Irf1interferon regulatory factor 10.237
Trp53transformation related protein 530.231
Cyldcylindromatosis (turban tumor syndrome)0.228
Ikzf1IKAROS family zinc finger 10.216
Ifi47interferon gamma inducible protein 470.213
Map3k14mitogen-activated protein kinase kinase kinase 140.212
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.196
Tgtp2T-cell specific GTPase 20.189
Stat5asignal transducer and activator of transcription 5A0.181
Ifit3interferon-induced protein with tetratricopeptide repeats 30.179
Unc93b1unc-93 homolog B1 (C. elegans)0.174
Birc3baculoviral IAP repeat-containing 30.168
Tnfaip3tumor necrosis factor, alpha-induced protein 30.165
Irf7interferon regulatory factor 70.163
Casp1caspase 10.163
Samd9lsterile alpha motif domain containing 9-like0.154
Eif2ak2eukaryotic translation initiation factor 2-alpha kinase 20.154
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.145
Oasl22'-5' oligoadenylate synthetase-like 20.142
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.137
Ciitaclass II transactivator0.133
Gbp6guanylate binding protein 60.129
Tnfsf10tumor necrosis factor (ligand) superfamily, member 100.125
Ifih1interferon induced with helicase C domain 10.124
Mx1myxovirus (influenza virus) resistance 10.113
Trim12atripartite motif-containing 12A0.111
Pmlpromyelocytic leukemia0.103
D14Ertd668eDNA segment, Chr 14, ERATO Doi 668, expressed0.103
Lyz2lysozyme 20.102
Dock2dedicator of cyto-kinesis 20.102
FasFas (TNF receptor superfamily member 6)0.096
Ifit2interferon-induced protein with tetratricopeptide repeats 20.096
Ifit1interferon-induced protein with tetratricopeptide repeats 10.093
Foxp3forkhead box P30.092
Herc6hect domain and RLD 60.086
Cd19CD19 antigen0.086
Sfpi1SFFV proviral integration 10.085
Stat2signal transducer and activator of transcription 20.079
Traf2TNF receptor-associated factor 20.079
Traf3TNF receptor-associated factor 30.078
Map3k8mitogen-activated protein kinase kinase kinase 80.078
Bcl3B-cell leukemia/lymphoma 30.076
Slfn8schlafen 80.075
Ms4a4cmembrane-spanning 4-domains, subfamily A, member 4C0.074
Samhd1SAM domain and HD domain, 10.074
Csf1colony stimulating factor 1 (macrophage)0.072
Mndamyeloid cell nuclear differentiation antigen0.070
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.069
Zbp1Z-DNA binding protein 10.069
Ptpn6protein tyrosine phosphatase, non-receptor type 60.068
Ddx58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.067
Cmpk2cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial0.060
Tor3atorsin family 3, member A0.056
Dhx58DEXH (Asp-Glu-X-His) box polypeptide 580.054
Cxcl10chemokine (C-X-C motif) ligand 100.051
Gvin1GTPase, very large interferon inducible 10.048
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Rpl10aribosomal protein L10A0.013
LOC100359498ribosomal protein L35a-like0.012
Rpl7aribosomal protein L7a0.011
Rps11ribosomal protein S110.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism