The network for 'citrate metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

citrate metabolic process

The chemical reactions and pathways involving citrate, 2-hydroxy-1,2,3-propanetricarboyxlate. Citrate is widely distributed in nature and is an important intermediate in the TCA cycle and the glyoxylate cycle.

NameDescriptionProbabilityFunc Analog Organism
HDAC2histone deacetylase 20.999
HDAC1histone deacetylase 10.998
PDHA1pyruvate dehydrogenase (lipoamide) alpha 10.823
IDH3Aisocitrate dehydrogenase 3 (NAD+) alpha0.778
PTPN1protein tyrosine phosphatase, non-receptor type 10.712
PRKAR2Aprotein kinase, cAMP-dependent, regulatory, type II, alpha0.494
NCAPGnon-SMC condensin I complex, subunit G0.457
ACO2aconitase 2, mitochondrial0.414
GOT2glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)0.387
SIN3ASIN3 homolog A, transcription regulator (yeast)0.366
DLATdihydrolipoamide S-acetyltransferase0.357
INSRinsulin receptor0.312
PFDN1prefoldin subunit 10.293
PDHXpyruvate dehydrogenase complex, component X0.275
ATP5BATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide0.275
IDH3Gisocitrate dehydrogenase 3 (NAD+) gamma0.271
AIFM1apoptosis-inducing factor, mitochondrion-associated, 10.266
USPL1ubiquitin specific peptidase like 10.265
SDHAsuccinate dehydrogenase complex, subunit A, flavoprotein (Fp)0.252
DNMT3BDNA (cytosine-5-)-methyltransferase 3 beta0.244
NCAPD2non-SMC condensin I complex, subunit D20.243
PDHBpyruvate dehydrogenase (lipoamide) beta0.236
FHfumarate hydratase0.213
C3orf15chromosome 3 open reading frame 150.210
GOT1glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)0.210
MDH2malate dehydrogenase 2, NAD (mitochondrial)0.168
EGFRepidermal growth factor receptor0.160
NDUFS2NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)0.159
PTPRBprotein tyrosine phosphatase, receptor type, B0.152
RBBP4retinoblastoma binding protein 40.129
HDAC3histone deacetylase 30.121
JAK2Janus kinase 20.119
AFG3L2AFG3 ATPase family gene 3-like 2 (S. cerevisiae)0.106
HADHhydroxyacyl-CoA dehydrogenase0.106
PTPN3protein tyrosine phosphatase, non-receptor type 30.094
BCAR1breast cancer anti-estrogen resistance 10.091
SUCLG1succinate-CoA ligase, alpha subunit0.086
MTA3metastasis associated 1 family, member 30.078
MDM2Mdm2 p53 binding protein homolog (mouse)0.077
STAP2signal transducing adaptor family member 20.069
IL2RBinterleukin 2 receptor, beta0.068
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.060
OXA1Loxidase (cytochrome c) assembly 1-like0.060
TUBA1Atubulin, alpha 1a0.055
PTPN2protein tyrosine phosphatase, non-receptor type 20.053
IDH3Bisocitrate dehydrogenase 3 (NAD+) beta0.051
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.050
CUX1cut-like homeobox 10.049
PTPN9protein tyrosine phosphatase, non-receptor type 90.049
GPIglucose-6-phosphate isomerase0.048
C21orf33chromosome 21 open reading frame 330.045
MTA2metastasis associated 1 family, member 20.045
CHD4chromodomain helicase DNA binding protein 40.044
PRKCAprotein kinase C, alpha0.042
NFS1NFS1 nitrogen fixation 1 homolog (S. cerevisiae)0.037
JAK1Janus kinase 10.036
DHX30DEAH (Asp-Glu-Ala-His) box polypeptide 300.036
COQ9coenzyme Q9 homolog (S. cerevisiae)0.033
HADHAhydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit0.032
SOCS2suppressor of cytokine signaling 20.031
IDH2isocitrate dehydrogenase 2 (NADP+), mitochondrial0.030
ATP5A1ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle0.029
UHRF2ubiquitin-like with PHD and ring finger domains 20.029
RBBP7retinoblastoma binding protein 70.027
TXN2thioredoxin 20.026
PRMT2protein arginine methyltransferase 20.026
FAF1Fas (TNFRSF6) associated factor 10.024
ADRBK1adrenergic, beta, receptor kinase 10.024
MYCBPc-myc binding protein0.024
PURApurine-rich element binding protein A0.024
STARD7StAR-related lipid transfer (START) domain containing 70.023
SAMM50sorting and assembly machinery component 50 homolog (S. cerevisiae)0.022
USP7ubiquitin specific peptidase 7 (herpes virus-associated)0.022
IRS1insulin receptor substrate 10.021
SIRT2sirtuin 20.021
MIPEPmitochondrial intermediate peptidase0.021
DUSP7dual specificity phosphatase 70.021
ASNA1arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)0.021
MECRmitochondrial trans-2-enoyl-CoA reductase0.021
LRRC47leucine rich repeat containing 470.021
EPORerythropoietin receptor0.020
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.020
EXT2exostosin 20.020
GATAD2AGATA zinc finger domain containing 2A0.019
DYRK1Adual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A0.019
E2F3E2F transcription factor 30.019
GHRgrowth hormone receptor0.019
E2F2E2F transcription factor 20.018
MFN2mitofusin 20.018
BREbrain and reproductive organ-expressed (TNFRSF1A modulator)0.018
GPD1Lglycerol-3-phosphate dehydrogenase 1-like0.018
UQCRC1ubiquinol-cytochrome c reductase core protein I0.018
UQCRC2ubiquinol-cytochrome c reductase core protein II0.017
RCOR1REST corepressor 10.017
KAT2BK(lysine) acetyltransferase 2B0.017
AHRaryl hydrocarbon receptor0.016
LATlinker for activation of T cells0.016
BCL11BB-cell CLL/lymphoma 11B (zinc finger protein)0.016
GATAD2BGATA zinc finger domain containing 2B0.016
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
PyKPyruvate kinase0.124
CG3731CG3731 gene product from transcript CG3731-RA0.063
l(1)G0334lethal (1) G03340.061
CG6439CG6439 gene product from transcript CG6439-RA0.054
ND42NADH:ubiquinone reductase 42kD subunit precursor0.049
CG5261CG5261 gene product from transcript CG5261-RB0.040
CG8036CG8036 gene product from transcript CG8036-RB0.034
MpcpMitochondrial phosphate carrier protein0.034
ND75NADH:ubiquinone reductase 75kD subunit precursor0.031
l(1)G0156lethal (1) G01560.030
skapskpA associated protein0.029
VhaSFDVacuolar H[+]-ATPase SFD subunit0.028
e(y)3enhancer of yellow 30.023
CG5214CG5214 gene product from transcript CG5214-RA0.021
CG7920CG7920 gene product from transcript CG7920-RA0.021
CG7430CG7430 gene product from transcript CG7430-RA0.019
CG1746CG1746 gene product from transcript CG1746-RA0.017
CG9140CG9140 gene product from transcript CG9140-RA0.017
vigvasa intronic gene0.016
CG14290CG14290 gene product from transcript CG14290-RB0.015
CycGCyclin G0.015
CortactinCG3637 gene product from transcript CG3637-RA0.015
CG9399CG9399 gene product from transcript CG9399-RC0.014
inx2innexin 20.014
CG12140CG12140 gene product from transcript CG12140-RA0.014
CG5028CG5028 gene product from transcript CG5028-RB0.014
CG11876CG11876 gene product from transcript CG11876-RA0.013
SdhBSuccinate dehydrogenase B0.013
CG9090CG9090 gene product from transcript CG9090-RA0.013
ATPsyn-gammaATP synthase-gamma chain0.013
CG12091CG12091 gene product from transcript CG12091-RA0.013
CG5703CG5703 gene product from transcript CG5703-RA0.013
AlasAminolevulinate synthase0.013
CG12162CG12162 gene product from transcript CG12162-RA0.012
CG4774CG4774 gene product from transcript CG4774-RB0.012
GdhGlutamate dehydrogenase0.011
CG4538CG4538 gene product from transcript CG4538-RA0.011
Cap-GCG34438 gene product from transcript CG34438-RF0.011
Dp1Dodeca-satellite-binding protein 10.011
Act79BActin 79B0.011
CG5903CG5903 gene product from transcript CG5903-RA0.011
SuURSuppressor of Under-Replication0.011
SdhASuccinate dehydrogenase A0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Stat5asignal transducer and activator of transcription 5A1.000
Stat5bsignal transducer and activator of transcription 5B0.999
Cyc1cytochrome c-10.993
Atp5a1ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 10.992
Mdh2malate dehydrogenase 2, NAD (mitochondrial)0.989
Cscitrate synthase0.988
Aco2aconitase 2, mitochondrial0.981
Irf9interferon regulatory factor 90.978
Ndufa9NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 90.970
Ndufv1NADH dehydrogenase (ubiquinone) flavoprotein 10.957
Stat3signal transducer and activator of transcription 30.952
Esr1estrogen receptor 1 (alpha)0.882
Leprleptin receptor0.868
Atp5bATP synthase, H+ transporting mitochondrial F1 complex, beta subunit0.826
Ndufs1NADH dehydrogenase (ubiquinone) Fe-S protein 10.805
Fh1fumarate hydratase 10.797
Uqcrc1ubiquinol-cytochrome c reductase core protein 10.786
Stat1signal transducer and activator of transcription 10.698
Uqcrc2ubiquinol cytochrome c reductase core protein 20.661
Uqcrfs1ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 10.657
Ghrgrowth hormone receptor0.631
Il6stinterleukin 6 signal transducer0.574
Sdhdsuccinate dehydrogenase complex, subunit D, integral membrane protein0.561
Ndufb6NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 60.548
Suclg1succinate-CoA ligase, GDP-forming, alpha subunit0.528
Foxp3forkhead box P30.512
Trp53transformation related protein 530.504
Arandrogen receptor0.496
Dlatdihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)0.482
Ndufs7NADH dehydrogenase (ubiquinone) Fe-S protein 70.477
Ndufs2NADH dehydrogenase (ubiquinone) Fe-S protein 20.453
Kitkit oncogene0.422
Ndufb5NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 50.347
Atp5oATP synthase, H+ transporting, mitochondrial F1 complex, O subunit0.344
Trim21tripartite motif-containing 210.339
Stat6signal transducer and activator of transcription 60.327
Ogdhoxoglutarate dehydrogenase (lipoamide)0.321
Stat2signal transducer and activator of transcription 20.259
Il1r1interleukin 1 receptor, type I0.249
Tgfb1transforming growth factor, beta 10.205
Idh3aisocitrate dehydrogenase 3 (NAD+) alpha0.199
Sdhcsuccinate dehydrogenase complex, subunit C, integral membrane protein0.198
Ahraryl-hydrocarbon receptor0.195
Sin3atranscriptional regulator, SIN3A (yeast)0.188
Samm50sorting and assembly machinery component 50 homolog (S. cerevisiae)0.184
Ndufv2NADH dehydrogenase (ubiquinone) flavoprotein 20.170
Trap1TNF receptor-associated protein 10.166
Slc25a4solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 40.160
Ndufa10NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 100.160
Irgm2immunity-related GTPase family M member 20.159
Il4rainterleukin 4 receptor, alpha0.158
Ndufab1NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 10.151
TapbpTAP binding protein0.134
Egln3EGL nine homolog 3 (C. elegans)0.128
Myd88myeloid differentiation primary response gene 880.118
Idh3bisocitrate dehydrogenase 3 (NAD+) beta0.116
Cox15COX15 homolog, cytochrome c oxidase assembly protein (yeast)0.112
1300001I01RikRIKEN cDNA 1300001I01 gene0.110
Idh3gisocitrate dehydrogenase 3 (NAD+), gamma0.103
Lgals9lectin, galactose binding, soluble 90.103
Cdkn1bcyclin-dependent kinase inhibitor 1B0.101
Sdhbsuccinate dehydrogenase complex, subunit B, iron sulfur (Ip)0.099
Aifm1apoptosis-inducing factor, mitochondrion-associated 10.098
Coq7demethyl-Q 70.097
Ppargperoxisome proliferator activated receptor gamma0.096
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.094
Parp14poly (ADP-ribose) polymerase family, member 140.093
Il10interleukin 100.091
Igtpinterferon gamma induced GTPase0.089
Ifnar2interferon (alpha and beta) receptor 20.089
Prlrprolactin receptor0.086
Nckap1lNCK associated protein 1 like0.085
Vdac1voltage-dependent anion channel 10.083
Igf1insulin-like growth factor 10.082
Tsc2tuberous sclerosis 20.078
Afg3l2AFG3(ATPase family gene 3)-like 2 (yeast)0.076
Uba7ubiquitin-like modifier activating enzyme 70.075
Adaradenosine deaminase, RNA-specific0.073
Coq5coenzyme Q5 homolog, methyltransferase (yeast)0.073
Ncoa3nuclear receptor coactivator 30.071
Sdhasuccinate dehydrogenase complex, subunit A, flavoprotein (Fp)0.068
Irgm1immunity-related GTPase family M member 10.068
Nfil3nuclear factor, interleukin 3, regulated0.068
Ezh2enhancer of zeste homolog 2 (Drosophila)0.067
Siah2seven in absentia 20.064
Il6interleukin 60.064
Gnrh1gonadotropin releasing hormone 10.064
Usp18ubiquitin specific peptidase 180.063
Nr2f2nuclear receptor subfamily 2, group F, member 20.062
Pnpla2patatin-like phospholipase domain containing 20.062
Ndufs3NADH dehydrogenase (ubiquinone) Fe-S protein 30.061
Mavsmitochondrial antiviral signaling protein0.061
Eif2ak2eukaryotic translation initiation factor 2-alpha kinase 20.060
Cav1caveolin 1, caveolae protein0.058
H2-K1histocompatibility 2, K1, K region0.055
Cd28CD28 antigen0.055
Atp5c1ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 10.054
Cox5acytochrome c oxidase, subunit Va0.054
Acat1acetyl-Coenzyme A acetyltransferase 10.052
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Atp5a1ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle0.938
Uqcrfs1ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 10.919
Idh3Bisocitrate dehydrogenase 3 (NAD+) beta0.897
Sdhasuccinate dehydrogenase complex, subunit A, flavoprotein (Fp)0.651
Cyc1cytochrome c-10.555
Aco2aconitase 2, mitochondrial0.477
Fh1fumarate hydratase 10.448
Timm17atranslocase of inner mitochondrial membrane 17 homolog A (yeast)0.386
Ndufv1NADH dehydrogenase (ubiquinone) flavoprotein 10.332
Ndufs2NADH dehydrogenase (ubiquinone) Fe-S protein 20.278
Atp5bATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide0.197
Mdh2malate dehydrogenase 2, NAD (mitochondrial)0.189
Slc25a3solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 30.138
Ndufs1NADH dehydrogenase (ubiquinone) Fe-S protein 10.096
Adkadenosine kinase0.092
Sdhdsuccinate dehydrogenase complex, subunit D, integral membrane protein0.078
Ndufs3NADH dehydrogenase (ubiquinone) Fe-S protein 30.075
Gfm1G elongation factor, mitochondrial 10.073
Idh3gisocitrate dehydrogenase 3 (NAD), gamma0.062
Sdhcsuccinate dehydrogenase complex, subunit C, integral membrane protein0.054
Acat1acetyl-coenzyme A acetyltransferase 10.049
Mdh1malate dehydrogenase 1, NAD (soluble)0.045
Atp5c1ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 10.044
Slc25a11solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 110.039
Acat3acetyl-Coenzyme A acetyltransferase 30.039
Ghitmgrowth hormone inducible transmembrane protein0.033
Vdac2voltage-dependent anion channel 20.031
Fasnfatty acid synthase0.031
Pfkmphosphofructokinase, muscle0.028
AuhAU RNA binding protein/enoyl-coenzyme A hydratase0.027
Ndufb8NADH dehydrogenase (ubiquinone) 1 beta subcomplex 80.027
Hadhbhydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit0.025
Aldh6a1aldehyde dehydrogenase 6 family, member A10.021
Vdac1voltage-dependent anion channel 10.020
Mccc2methylcrotonoyl-Coenzyme A carboxylase 2 (beta)0.018
Cscitrate synthase0.018
Dlstdihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)0.018
RGD1302996hypothetical protein MGC:158540.017
Akr1c14aldo-keto reductase family 1, member C140.015
Got1glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)0.015
Ociad1OCIA domain containing 10.014
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.014
Suclg1succinate-CoA ligase, alpha subunit0.014
Tecrtrans-2,3-enoyl-CoA reductase0.014
Gpamglycerol-3-phosphate acyltransferase, mitochondrial0.014
Pde4dipphosphodiesterase 4D interacting protein0.013
Slc25a4solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 40.013
Vegfavascular endothelial growth factor A0.013
Atp5g3ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)0.012
Atp6v1e1ATPase, H+ transporting, lysosomal V1 subunit E10.011
Slc25a12solute carrier family 25 (mitochondrial carrier, Aralar), member 120.011
Isoc1isochorismatase domain containing 10.011
Nntnicotinamide nucleotide transhydrogenase0.010
Sqlesqualene epoxidase0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism