The network for 'intrinsic apoptotic signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

intrinsic apoptotic signaling pathway

A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP).

NameDescriptionProbabilityFunc Analog Organism
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide1.000
TP53tumor protein p531.000
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)1.000
BCL2B-cell CLL/lymphoma 21.000
HDAC1histone deacetylase 10.999
MDM2Mdm2 p53 binding protein homolog (mouse)0.999
BRCA1breast cancer 1, early onset0.999
CASP8caspase 8, apoptosis-related cysteine peptidase0.998
UBCubiquitin C0.996
RB1retinoblastoma 10.995
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.994
ESR1estrogen receptor 10.993
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.990
TP53BP2tumor protein p53 binding protein, 20.989
BCL2L1BCL2-like 10.983
MDM4Mdm4 p53 binding protein homolog (mouse)0.979
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.976
NBNnibrin0.973
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.970
SIN3ASIN3 homolog A, transcription regulator (yeast)0.969
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.968
SQSTM1sequestosome 10.968
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.957
EGFRepidermal growth factor receptor0.954
MAP3K5mitogen-activated protein kinase kinase kinase 50.953
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.948
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.948
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.947
XIAPX-linked inhibitor of apoptosis0.946
EP300E1A binding protein p3000.945
AKT1v-akt murine thymoma viral oncogene homolog 10.937
FASFas (TNF receptor superfamily, member 6)0.937
RBL1retinoblastoma-like 1 (p107)0.927
USP7ubiquitin specific peptidase 7 (herpes virus-associated)0.918
CHEK2CHK2 checkpoint homolog (S. pombe)0.918
ATMataxia telangiectasia mutated0.916
CAV1caveolin 1, caveolae protein, 22kDa0.913
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.905
SFNstratifin0.904
BTRCbeta-transducin repeat containing0.903
PMLpromyelocytic leukemia0.900
H2AFXH2A histone family, member X0.893
BAXBCL2-associated X protein0.871
CFLARCASP8 and FADD-like apoptosis regulator0.871
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.866
DAXXdeath-domain associated protein0.865
PTPN1protein tyrosine phosphatase, non-receptor type 10.858
FADDFas (TNFRSF6)-associated via death domain0.849
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.841
CDK2cyclin-dependent kinase 20.839
PPP1CCprotein phosphatase 1, catalytic subunit, gamma isozyme0.835
BCL2L11BCL2-like 11 (apoptosis facilitator)0.834
RPS27ribosomal protein S270.833
SFPQsplicing factor proline/glutamine-rich0.828
BIDBH3 interacting domain death agonist0.821
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.816
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.815
PPP2R1Aprotein phosphatase 2, regulatory subunit A, alpha0.813
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.801
RYBPRING1 and YY1 binding protein0.795
RBBP8retinoblastoma binding protein 80.793
CASP10caspase 10, apoptosis-related cysteine peptidase0.779
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.772
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.765
PPP1CAprotein phosphatase 1, catalytic subunit, alpha isozyme0.753
ANXA1annexin A10.743
S100A4S100 calcium binding protein A40.736
FANCD2Fanconi anemia, complementation group D20.726
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.720
HNRNPKheterogeneous nuclear ribonucleoprotein K0.719
PPP2R5Cprotein phosphatase 2, regulatory subunit B', gamma0.714
TGIF1TGFB-induced factor homeobox 10.708
HSP90B1heat shock protein 90kDa beta (Grp94), member 10.705
BNIP3BCL2/adenovirus E1B 19kDa interacting protein 30.704
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.700
E2F3E2F transcription factor 30.698
BIRC2baculoviral IAP repeat containing 20.698
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.697
MRE11AMRE11 meiotic recombination 11 homolog A (S. cerevisiae)0.695
IER3immediate early response 30.674
CHEK1CHK1 checkpoint homolog (S. pombe)0.671
TRAF2TNF receptor-associated factor 20.654
TRADDTNFRSF1A-associated via death domain0.652
RAD50RAD50 homolog (S. cerevisiae)0.647
S100A9S100 calcium binding protein A90.626
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.624
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.617
DHX9DEAH (Asp-Glu-Ala-His) box polypeptide 90.595
CASP3caspase 3, apoptosis-related cysteine peptidase0.594
UBE3Aubiquitin protein ligase E3A0.582
BIRC3baculoviral IAP repeat containing 30.581
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.577
GSK3Bglycogen synthase kinase 3 beta0.571
OPTNoptineurin0.557
ATF4activating transcription factor 4 (tax-responsive enhancer element B67)0.550
CREBBPCREB binding protein0.546
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.536
TNFAIP3tumor necrosis factor, alpha-induced protein 30.535
SOCS1suppressor of cytokine signaling 10.534
RASSF5Ras association (RalGDS/AF-6) domain family member 50.528
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
aldh1a2aldehyde dehydrogenase 1 family, member A20.460
ptgs2aprostaglandin-endoperoxide synthase 2a0.249
bcl2l1bcl2-like 10.134
pknox1.1pbx/knotted 1 homeobox 1.10.098
baxabcl2-associated X protein, a0.090
efna5aephrin A5a0.058
odc1ornithine decarboxylase 10.051
nr3c1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.051
cdkn1acyclin-dependent kinase inhibitor 1A0.046
dctdopachrome tautomerase0.038
bmpr1aabone morphogenetic protein receptor, type 1aa0.036
bcl2B-cell leukemia/lymphoma 20.034
cxcr4bchemokine (C-X-C motif), receptor 4b0.034
rhoabras homolog gene family, member Ab0.034
nrp2bneuropilin 2b0.034
mychmyelocytomatosis oncogene homolog0.034
eve1even-skipped-like10.032
gpiaglucose phosphate isomerase a0.031
dnmt5DNA (cytosine-5-)-methyltransferase 50.030
scn1basodium channel, voltage-gated, type I, beta a0.029
lamc1laminin, gamma 10.029
ncor1nuclear receptor co-repressor 10.029
ptger4aprostaglandin E receptor 4 (subtype EP4) a0.029
chatcholine acetyltransferase0.028
myod1myogenic differentiation 10.027
terttelomerase reverse transcriptase0.027
nos2bnitric oxide synthase 2b, inducible0.026
ncapgnon-SMC condensin I complex, subunit G0.026
ctnnb1catenin (cadherin-associated protein), beta 10.026
stc1lstanniocalcin 1, like0.025
myf5myogenic factor 50.025
gata5GATA-binding protein 50.025
mmp9matrix metalloproteinase 90.024
LOC100150924DNA polymerase subunit gamma-1-like0.024
mcl1amyeloid cell leukemia sequence 1a0.024
ef1aelongation factor 1-alpha0.024
pola2polymerase (DNA directed), alpha 20.023
fgfr1afibroblast growth factor receptor 1a0.023
s100v2S100 calcium binding protein V20.023
cxcl12bchemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)0.023
per2period homolog 2 (Drosophila)0.023
trpv4transient receptor potential cation channel, subfamily V, member 40.023
mapk14amitogen-activated protein kinase 14a0.022
ssbp3bsingle stranded DNA binding protein 3b0.022
mitfamicrophthalmia-associated transcription factor a0.022
bactin1bactin10.022
ywhabltyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like0.021
socs1suppressor of cytokine signaling 10.021
ca8carbonic anhydrase VIII0.021
rps12ribosomal protein S120.020
hand2heart and neural crest derivatives expressed transcript 20.020
efna2ephrin A20.020
bmp4bone morphogenetic protein 40.020
eno2enolase 20.019
grn2granulin 20.019
wnt11rwingless-type MMTV integration site family, member 11, related0.019
pmaip1phorbol-12-myristate-13-acetate-induced protein 10.019
mpxmyeloid-specific peroxidase0.018
znf703zinc finger protein 7030.018
bnip3lbBCL2/adenovirus E1B interacting protein 3-like b0.018
gja3gap junction protein, alpha 30.018
mfn2mitofusin 20.018
ssrp1astructure specific recognition protein 1a0.018
rps26lribosomal protein S26, like0.018
rps27aribosomal protein S27a0.018
fauaFinkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed a0.017
bidaBH3 interacting domain death agonist0.017
nrarpanotch-regulated ankyrin repeat protein a0.017
chukconserved helix-loop-helix ubiquitous kinase0.017
unguracil-DNA glycosylase0.017
jupjunction plakoglobin0.017
sf1splicing factor 10.016
ahi1Abelson helper integration site 10.016
opn4aopsin 4a (melanopsin)0.016
sod1superoxide dismutase 1, soluble0.016
zgc:165373zgc:1653730.016
slc2a10solute carrier family 2 (facilitated glucose transporter), member 100.016
csnk1dacasein kinase 1, delta a0.016
junjun proto-oncogene0.016
zgc:55671zgc:556710.016
wdhd1WD repeat and HMG-box DNA binding protein 10.016
zgc:92648zgc:926480.016
pcnaproliferating cell nuclear antigen0.015
nr1h3nuclear receptor subfamily 1, group H, member 30.015
zgc:92775zgc:927750.015
fzd7afrizzled homolog 7a0.015
eif4a1aeukaryotic translation initiation factor 4A, isoform 1A0.015
hyou1hypoxia up-regulated 10.015
brd2abromodomain-containing 2a0.015
cyp26a1cytochrome P450, subfamily XXVIA, polypeptide 10.015
il1binterleukin 1, beta and interleukin 1, beta0.015
zgc:113210zgc:1132100.015
hnf4ahepatocyte nuclear factor 4, alpha0.015
zgc:66326zgc:663260.015
nap1l1nucleosome assembly protein 1, like 10.015
esco2establishment of cohesion 1 homolog 20.014
ctbp2lC-terminal binding protein 2, like0.014
ptger2aprostaglandin E receptor 2a (subtype EP2)0.014
hellshelicase, lymphoid-specific0.014
egr1early growth response 10.014
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
p53CG33336 gene product from transcript CG33336-RB0.996
parkparkin0.952
RbfRetinoblastoma-family protein0.713
Dcp-1Death caspase-10.603
loqsloquacious0.579
rprreaper0.495
ththread0.489
p38bCG7393 gene product from transcript CG7393-RA0.333
WWrinkled0.319
cindrCIN85 and CD2AP orthologue0.314
imdimmune deficiency0.300
spasspastin0.284
bskbasket0.271
E2fE2F transcription factor0.262
DpDP transcription factor0.229
ykiyorkie0.227
alphalphabet0.217
RASSF8CG5053 gene product from transcript CG5053-RA0.185
AGO2Argonaute 20.184
porinCG6647 gene product from transcript CG6647-RA0.169
M6CG7540 gene product from transcript CG7540-RA0.149
HtrA2CG8464 gene product from transcript CG8464-RA0.143
tefutelomere fusion0.136
p120ctnAdherens junction protein p1200.123
MAGECG10059 gene product from transcript CG10059-RA0.122
RicRas which interacts with Calmodulin0.119
Dlc90FDynein light chain 90F0.115
dupdouble parked0.114
Trx-2thioredoxin-20.113
tudtudor0.099
rlrolled0.098
Ptp61FProtein tyrosine phosphatase 61F0.094
brkbrinker0.081
CG8155CG8155 gene product from transcript CG8155-RA0.078
bratbrain tumor0.076
OsbpOxysterol binding protein0.075
awdabnormal wing discs0.071
Hsp83Heat shock protein 830.070
mus205mutagen-sensitive 2050.065
hipkhomeodomain interacting protein kinase0.063
Ulp1CG12359 gene product from transcript CG12359-RA0.060
DrefDNA replication-related element factor0.060
shishibire0.057
gbbglass bottom boat0.057
Arr1Arrestin 10.057
CG1021CG1021 gene product from transcript CG1021-RE0.055
SodSuperoxide dismutase0.055
pr-set7CG3307 gene product from transcript CG3307-RC0.054
CatCatalase0.053
Mnn1Menin 10.052
X11LCG5675 gene product from transcript CG5675-RB0.051
Pink1PTEN-induced putative kinase 10.051
Atx2Ataxin-20.050
bchsblue cheese0.049
cln3CG5582 gene product from transcript CG5582-RA0.047
G-salpha60AG protein salpha 60A0.046
Letm1CG4589 gene product from transcript CG4589-RB0.046
trxtrithorax0.045
AGO1Argonaute-10.044
FBX011FBX011 ortholog0.044
Sin3ACG8815 gene product from transcript CG8815-RC0.043
CG8885CG8885 gene product from transcript CG8885-RA0.043
TORCCG6064 gene product from transcript CG6064-RA0.042
CblCG7037 gene product from transcript CG7037-RB0.042
APP-BP1beta-Amyloid precursor protein binding protein 10.041
sdscalloped0.040
Deaf1Deformed epidermal autoregulatory factor-10.039
Hsp26Heat shock protein 260.038
spinspinster0.038
nmonemo0.038
sinaseven in absentia0.038
bunbunched0.037
exexpanded0.037
Jafrac2thioredoxin peroxidase 20.036
srpk79Dserine-arginine protein kinase at 79D0.036
Prx5Peroxiredoxin 50.036
dj-1betaCG1349 gene product from transcript CG1349-RA0.035
kluklumpfuss0.035
CtBPC-terminal Binding Protein0.034
ninaEneither inactivation nor afterpotential E0.034
HsfHeat shock factor0.032
Caf1-180CG12109 gene product from transcript CG12109-RB0.031
debcldeath executioner Bcl-2 homologue0.031
Smg5CG8954 gene product from transcript CG8954-RA0.031
LacLachesin0.031
fs(2)ltoPP43female sterile (2) ltoPP430.031
Jafrac1thioredoxin peroxidase 10.031
CG11347CG11347 gene product from transcript CG11347-RE0.030
cpocouch potato0.029
14-3-3epsilonCG31196 gene product from transcript CG31196-RA0.028
lokloki0.028
S6kRPS6-p70-protein kinase0.028
CG1347CG1347 gene product from transcript CG1347-RB0.028
CG3847CG3847 gene product from transcript CG3847-RA0.028
eggeggless0.028
mei-P26CG12218 gene product from transcript CG12218-RA0.028
Hsp27Heat shock protein 270.028
mus201mutagen-sensitive 2010.027
MoeMoesin0.027
Hsp22Heat shock protein 220.026
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 531.000
Ptenphosphatase and tensin homolog0.999
Rb1retinoblastoma 10.997
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.992
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.990
Mdm2transformed mouse 3T3 cell double minute 20.989
Apcadenomatosis polyposis coli0.971
Cdkn1bcyclin-dependent kinase inhibitor 1B0.970
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.965
FasFas (TNF receptor superfamily member 6)0.965
Atmataxia telangiectasia mutated homolog (human)0.958
Tnftumor necrosis factor0.958
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.938
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.931
SkilSKI-like0.929
Brca2breast cancer 20.913
Brca1breast cancer 10.904
Casp4caspase 4, apoptosis-related cysteine peptidase0.872
Ldb3LIM domain binding 30.845
Cdkn2acyclin-dependent kinase inhibitor 2A0.836
Traf6TNF receptor-associated factor 60.831
Msh2mutS homolog 2 (E. coli)0.817
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.798
Leprleptin receptor0.796
Prkceprotein kinase C, epsilon0.796
Map3k7mitogen-activated protein kinase kinase kinase 70.784
E2f1E2F transcription factor 10.756
Ikbkbinhibitor of kappaB kinase beta0.751
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.747
Ighimmunoglobulin heavy chain complex0.744
Tlr4toll-like receptor 40.743
Dab1disabled homolog 1 (Drosophila)0.741
Ncoa3nuclear receptor coactivator 30.737
Pnp2purine-nucleoside phosphorylase 20.720
Casp8caspase 80.713
XiapX-linked inhibitor of apoptosis0.706
Hcn4hyperpolarization-activated, cyclic nucleotide-gated K+ 40.701
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.700
Rbl1retinoblastoma-like 1 (p107)0.673
Nfe2l2nuclear factor, erythroid derived 2, like 20.669
Nbnnibrin0.659
Mcm4minichromosome maintenance deficient 4 homolog (S. cerevisiae)0.654
Cxcl13chemokine (C-X-C motif) ligand 130.621
Tcf3transcription factor 30.615
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.603
Cdk4cyclin-dependent kinase 40.603
Sirt1sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)0.603
Map3k14mitogen-activated protein kinase kinase kinase 140.597
Mdh2malate dehydrogenase 2, NAD (mitochondrial)0.583
Atf4activating transcription factor 40.565
Mcl1myeloid cell leukemia sequence 10.563
Ccnd1cyclin D10.563
Stat3signal transducer and activator of transcription 30.561
Mdm4transformed mouse 3T3 cell double minute 40.555
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.544
Cdkn2dcyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)0.519
Ltblymphotoxin B0.516
Ikzf1IKAROS family zinc finger 10.507
BaxBCL2-associated X protein0.497
Ptgs2prostaglandin-endoperoxide synthase 20.494
Arid1bAT rich interactive domain 1B (SWI-like)0.485
Hnrnpuheterogeneous nuclear ribonucleoprotein U0.472
Bcl2l1BCL2-like 10.462
Gbp5guanylate binding protein 50.443
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.439
Ctnnb1catenin (cadherin associated protein), beta 10.428
Tnfaip3tumor necrosis factor, alpha-induced protein 30.413
Mapk8mitogen-activated protein kinase 80.404
Trib3tribbles homolog 3 (Drosophila)0.403
Cd40CD40 antigen0.393
Atp5bATP synthase, H+ transporting mitochondrial F1 complex, beta subunit0.382
Stk4serine/threonine kinase 40.378
Cdkn2ccyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)0.365
Cftrcystic fibrosis transmembrane conductance regulator homolog0.364
Csf1colony stimulating factor 1 (macrophage)0.361
Tgfbr1transforming growth factor, beta receptor I0.347
Cyc1cytochrome c-10.340
Suz12suppressor of zeste 12 homolog (Drosophila)0.334
Ezh2enhancer of zeste homolog 2 (Drosophila)0.334
Ptpn11protein tyrosine phosphatase, non-receptor type 110.332
Smarca2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 20.331
Pold3polymerase (DNA-directed), delta 3, accessory subunit0.327
Il7interleukin 70.326
Casp1caspase 10.326
Hdac2histone deacetylase 20.322
Terf1telomeric repeat binding factor 10.321
Tmpothymopoietin0.317
Kitkit oncogene0.316
Myd88myeloid differentiation primary response gene 880.313
Tfdp2transcription factor Dp 20.313
Sin3atranscriptional regulator, SIN3A (yeast)0.311
Cul4acullin 4A0.303
Trp63transformation related protein 630.297
Traf2TNF receptor-associated factor 20.293
Rassf5Ras association (RalGDS/AF-6) domain family member 50.292
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.284
Tgfbr2transforming growth factor, beta receptor II0.279
Atp5a1ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 10.274
Cxcr4chemokine (C-X-C motif) receptor 40.273
Becn1beclin 1, autophagy related0.272
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
S100a8S100 calcium binding protein A80.090
S100a9S100 calcium binding protein A90.052
Mapk3mitogen activated protein kinase 30.023
Tp53tumor protein p530.014
Ireb2iron responsive element binding protein 20.011
Exoc5exocyst complex component 50.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism