The network for 'isocitrate metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

isocitrate metabolic process

The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle.

NameDescriptionProbabilityFunc Analog Organism
ACO2aconitase 2, mitochondrial0.382
OXA1Loxidase (cytochrome c) assembly 1-like0.381
NDUFS2NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)0.249
GPIglucose-6-phosphate isomerase0.188
VPS28vacuolar protein sorting 28 homolog (S. cerevisiae)0.174
SDHAsuccinate dehydrogenase complex, subunit A, flavoprotein (Fp)0.130
IDH2isocitrate dehydrogenase 2 (NADP+), mitochondrial0.047
ECH1enoyl CoA hydratase 1, peroxisomal0.041
PQBP1polyglutamine binding protein 10.041
IDH3Bisocitrate dehydrogenase 3 (NAD+) beta0.034
DLDdihydrolipoamide dehydrogenase0.033
GOT1glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)0.030
TUFMTu translation elongation factor, mitochondrial0.029
PHB2prohibitin 20.026
BCKDHAbranched chain keto acid dehydrogenase E1, alpha polypeptide0.024
NDUFV1NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa0.023
SUCLG1succinate-CoA ligase, alpha subunit0.023
DCXRdicarbonyl/L-xylulose reductase0.022
MDH2malate dehydrogenase 2, NAD (mitochondrial)0.021
NSFL1CNSFL1 (p97) cofactor (p47)0.020
HIGD2AHIG1 hypoxia inducible domain family, member 2A0.018
PRPF6PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)0.017
TXN2thioredoxin 20.017
DCTN3dynactin 3 (p22)0.015
HMGCR3-hydroxy-3-methylglutaryl-CoA reductase0.013
GRHPRglyoxylate reductase/hydroxypyruvate reductase0.013
UQCRC1ubiquinol-cytochrome c reductase core protein I0.011
SC4MOLsterol-C4-methyl oxidase-like0.011
ETFBelectron-transfer-flavoprotein, beta polypeptide0.010
UBAC1UBA domain containing 10.010
ERI3ERI1 exoribonuclease family member 30.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Sdhasuccinate dehydrogenase complex, subunit A, flavoprotein (Fp)0.460
Atp5c1ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 10.395
Aco2aconitase 2, mitochondrial0.330
Ndufv1NADH dehydrogenase (ubiquinone) flavoprotein 10.313
Ndufs2NADH dehydrogenase (ubiquinone) Fe-S protein 20.208
Mdh2malate dehydrogenase 2, NAD (mitochondrial)0.191
Fh1fumarate hydratase 10.132
Idh3gisocitrate dehydrogenase 3 (NAD), gamma0.070
Slc25a11solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 110.070
Uqcrc2ubiquinol cytochrome c reductase core protein 20.062
Slc25a3solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 30.057
RGD1302996hypothetical protein MGC:158540.048
Prdx3peroxiredoxin 30.046
Timm17atranslocase of inner mitochondrial membrane 17 homolog A (yeast)0.043
Acat1acetyl-coenzyme A acetyltransferase 10.036
Atp5a1ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle0.028
Uqcrc1ubiquinol-cytochrome c reductase core protein I0.024
Ndufs1NADH dehydrogenase (ubiquinone) Fe-S protein 10.023
Ndufa9NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 90.021
Idh3Bisocitrate dehydrogenase 3 (NAD+) beta0.016
Slc25a12solute carrier family 25 (mitochondrial carrier, Aralar), member 120.014
RGD1303003homolog of zebrafish ES10.014
Acox1acyl-Coenzyme A oxidase 1, palmitoyl0.014
Lonp2lon peptidase 2, peroxisomal0.013
Ndufs3NADH dehydrogenase (ubiquinone) Fe-S protein 30.013
Gpiglucose phosphate isomerase0.013
Sdhbsuccinate dehydrogenase complex, subunit B, iron sulfur (Ip)0.011
Mrps30mitochondrial ribosomal protein S300.011
Atp5g1ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9)0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism