The network for 'intracellular steroid hormone receptor signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

intracellular steroid hormone receptor signaling pathway

A series of molecular signals generated as a consequence of a intracellular steroid hormone receptor binding to one of its physiological ligands.

NameDescriptionProbabilityFunc Analog Organism
ESR1estrogen receptor 11.000
CREBBPCREB binding protein0.999
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.992
NCOA1nuclear receptor coactivator 10.988
MED1mediator complex subunit 10.984
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.963
SMAD4SMAD family member 40.949
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.939
RXRAretinoid X receptor, alpha0.925
CDK19cyclin-dependent kinase 190.920
HDAC1histone deacetylase 10.855
MED15mediator complex subunit 150.837
NCOR1nuclear receptor corepressor 10.798
RBFOX2RNA binding protein, fox-1 homolog (C. elegans) 20.727
ATXN1ataxin 10.706
POU5F1POU class 5 homeobox 10.687
EP300E1A binding protein p3000.673
SP1Sp1 transcription factor0.618
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.607
MDM2Mdm2 p53 binding protein homolog (mouse)0.607
CDK8cyclin-dependent kinase 80.594
SMURF2SMAD specific E3 ubiquitin protein ligase 20.576
TRIM39tripartite motif containing 390.568
ARandrogen receptor0.532
MED10mediator complex subunit 100.512
MED29mediator complex subunit 290.505
QKIquaking homolog, KH domain RNA binding (mouse)0.469
PPP5Cprotein phosphatase 5, catalytic subunit0.467
RNF5ring finger protein 50.447
NCOR2nuclear receptor corepressor 20.404
GSK3Bglycogen synthase kinase 3 beta0.384
ESR2estrogen receptor 2 (ER beta)0.378
SKP1S-phase kinase-associated protein 10.377
MED24mediator complex subunit 240.366
SMAD1SMAD family member 10.349
SMAD2SMAD family member 20.348
NCOA6nuclear receptor coactivator 60.348
SMAD3SMAD family member 30.332
MED12mediator complex subunit 120.318
EGFRepidermal growth factor receptor0.315
MED6mediator complex subunit 60.295
WWP2WW domain containing E3 ubiquitin protein ligase 20.293
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.287
RBPMSRNA binding protein with multiple splicing0.286
ARID1AAT rich interactive domain 1A (SWI-like)0.285
FOXD3forkhead box D30.271
HNRNPKheterogeneous nuclear ribonucleoprotein K0.260
CHORDC1cysteine and histidine-rich domain (CHORD) containing 10.251
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.249
RNF11ring finger protein 110.249
PAK1p21 protein (Cdc42/Rac)-activated kinase 10.246
RORARAR-related orphan receptor A0.225
BIRC2baculoviral IAP repeat containing 20.224
ESRRGestrogen-related receptor gamma0.215
CNOT6LCCR4-NOT transcription complex, subunit 6-like0.214
SKILSKI-like oncogene0.203
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.199
HNF4Ahepatocyte nuclear factor 4, alpha0.198
DAXXdeath-domain associated protein0.195
CAV1caveolin 1, caveolae protein, 22kDa0.185
PPIDpeptidylprolyl isomerase D0.183
HSPA8heat shock 70kDa protein 80.175
SPDEFSAM pointed domain containing ets transcription factor0.175
RB1retinoblastoma 10.168
VEZF1vascular endothelial zinc finger 10.164
HSPH1heat shock 105kDa/110kDa protein 10.162
NPM1nucleophosmin (nucleolar phosphoprotein B23, numatrin)0.159
MED16mediator complex subunit 160.158
ARHGEF7Rho guanine nucleotide exchange factor (GEF) 70.148
UBA1ubiquitin-like modifier activating enzyme 10.144
ARID1BAT rich interactive domain 1B (SWI1-like)0.143
REREarginine-glutamic acid dipeptide (RE) repeats0.139
AHSA1AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)0.139
SAFB2scaffold attachment factor B20.138
MTA1metastasis associated 10.136
CNOT8CCR4-NOT transcription complex, subunit 80.133
LDB1LIM domain binding 10.122
SMAD9SMAD family member 90.116
E2F1E2F transcription factor 10.115
PTBP1polypyrimidine tract binding protein 10.113
SMARCC2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 20.108
SMURF1SMAD specific E3 ubiquitin protein ligase 10.107
TOPORStopoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase0.104
IGF1Rinsulin-like growth factor 1 receptor0.103
CLOCKclock homolog (mouse)0.103
UBE2D1ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)0.102
MED21mediator complex subunit 210.098
ARNTLaryl hydrocarbon receptor nuclear translocator-like0.097
DDX5DEAD (Asp-Glu-Ala-Asp) box polypeptide 50.097
HNRNPH2heterogeneous nuclear ribonucleoprotein H2 (H')0.096
MTA3metastasis associated 1 family, member 30.094
SLMAPsarcolemma associated protein0.094
CUEDC2CUE domain containing 20.093
CNOT6CCR4-NOT transcription complex, subunit 60.093
DDX17DEAD (Asp-Glu-Ala-Asp) box polypeptide 170.092
RNF111ring finger protein 1110.092
NR0B2nuclear receptor subfamily 0, group B, member 20.088
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.088
SFNstratifin0.081
C16orf53chromosome 16 open reading frame 530.080
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
sox9bSRY-box containing gene 9b0.626
rarabretinoic acid receptor, alpha b0.511
per2period homolog 2 (Drosophila)0.504
hspa4aheat shock protein 4a0.283
frem3Fras1 related extracellular matrix 30.170
gata6GATA-binding protein 60.160
otpborthopedia homolog b0.153
clockclock0.148
egr1early growth response 10.144
ncor2nuclear receptor co-repressor 20.123
cry2bcryptochrome 2b0.122
jhdm1dajumonji C domain containing histone demethylase 1 homolog Da (S. cerevisiae)0.112
tomm34translocase of outer mitochondrial membrane 340.112
rag1recombination activating gene 10.106
lrpprcleucine-rich PPR-motif containing0.092
fgfrl1bfibroblast growth factor receptor-like 1b0.090
hspa9heat shock protein 90.086
nkx2.3NK2 transcription factor related 30.083
lratblecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)0.080
trnau1apltRNA selenocysteine 1 associated protein 1, like0.077
srsf1aserine/arginine-rich splicing factor 1a0.070
prmt5protein arginine methyltransferase 50.067
chchd10coiled-coil-helix-coiled-coil-helix domain containing 100.065
arntl1baryl hydrocarbon receptor nuclear translocator-like 1b0.063
fzd7bfrizzled homolog 7b0.063
nr1d2bnuclear receptor subfamily 1, group D, member 2b0.062
pdx1pancreatic and duodenal homeobox 10.062
ccna2cyclin A20.053
th2tyrosine hydroxylase 20.053
hoxb2ahomeo box B2a0.050
hsd17b10hydroxysteroid (17-beta) dehydrogenase 100.048
ntrk3bneurotrophic tyrosine kinase, receptor, type 3b0.046
LOC100149007zinc finger protein 319-like0.045
esr2bestrogen receptor 2b0.042
ahsa1lAHA1, activator of heat shock protein ATPase homolog 1, like0.042
wnt9bwingless-type MMTV integration site family, member 9B0.042
eftud2elongation factor Tu GTP binding domain containing 20.042
esr1estrogen receptor 10.041
cry1acryptochrome 1a0.039
zgc:55582zgc:555820.039
rltprRGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing0.038
shbgsex hormone binding globulin0.037
meis1myeloid ecotropic viral integration 10.036
irx4biroquois homeobox protein 4b0.035
gatsl2GATS protein-like 20.034
tbx2aT-box gene 2a0.033
trim13tripartite motif-containing 130.033
igf1insulin-like growth factor 10.032
hspd1heat shock 60kD protein 1 (chaperonin)0.032
fesfeline sarcoma oncogene0.032
si:dkey-97i18.2si:dkey-97i18.20.031
znf259zinc finger protein 2590.031
pmpcapeptidase (mitochondrial processing) alpha0.030
hoxc4ahomeo box C4a0.030
mtnr1bamelatonin receptor type 1B a0.029
srsf11serine/arginine-rich splicing factor 110.029
acin1aapoptotic chromatin condensation inducer 1a0.029
api5apoptosis inhibitor 50.028
znf395bzinc finger protein 395b0.028
foxi3aforkhead box I3a0.027
ldb1aLIM-domain binding factor 1a0.027
spata2spermatogenesis associated 20.027
ascl1aachaete-scute complex-like 1a (Drosophila)0.026
chrm2acholinergic receptor, muscarinic 2a0.025
kcnj1potassium inwardly-rectifying channel, subfamily J, member 10.024
satb2SATB homeobox 20.024
mstnbmyostatin b0.024
nup50nucleoporin 500.023
chrna4cholinergic receptor, nicotinic, alpha 40.023
idh3aisocitrate dehydrogenase 3 (NAD+) alpha0.023
nkx2.1aNK2 homeobox 1a0.023
tymsthymidylate synthase0.023
brd2abromodomain-containing 2a0.022
camk2g1calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 10.022
ncs1aneuronal calcium sensor 1a0.022
clock3clock homolog 3 (mouse)0.022
cnr1cannabinoid receptor 10.022
npntnephronectin0.021
nkx2.2aNK2 transcription factor related 2a0.021
dlatdihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)0.021
cyp19a1bcytochrome P450, family 19, subfamily A, polypeptide 1b0.021
tufmTu translation elongation factor, mitochondrial0.021
arxaristaless related homeobox0.021
otx5orthodenticle homolog 50.020
starsteroidogenic acute regulatory protein0.020
ubinataxin-1 ubiquitin-like interacting protein0.020
hnrnpmheterogeneous nuclear ribonucleoprotein M0.020
srsf2serine/arginine-rich splicing factor 20.020
prdx2peroxiredoxin 20.020
si:ch211-59d15.5si:ch211-59d15.50.020
vdravitamin D receptor a0.019
syce2synaptonemal complex central element protein 20.019
sim2single-minded homolog 2 (Drosophila)0.019
flt4fms-related tyrosine kinase 40.019
nr2f1anuclear receptor subfamily 2, group F, member 1a0.019
acvr1bactivin A receptor, type IB0.019
tfap2btranscription factor AP-2 beta0.018
chatcholine acetyltransferase0.018
gcm2glial cells missing homolog 2 (Drosophila)0.018
hs6st1aheparan sulfate 6-O-sulfotransferase 1a0.018
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
uspultraspiracle0.409
Snr1Snf5-related 10.271
IswiImitation SWI0.225
scnyscrawny0.088
wocwithout children0.077
ktokohtalo0.073
cnccap-n-collar0.068
smt3CG4494 gene product from transcript CG4494-RA0.065
nejnejire0.062
Caf1Chromatin assembly factor 1 subunit0.061
MED27Mediator complex subunit 270.060
vflvielfaltig0.053
tarataranis0.050
ytryantar0.046
ash1absent, small, or homeotic discs 10.045
MAN1CG3167 gene product from transcript CG3167-RA0.045
SfmbtScm-related gene containing four mbt domains0.041
hklhook-like0.040
mormoira0.035
ftz-f1ftz transcription factor 10.032
TBPHCG10327 gene product from transcript CG10327-RC0.032
MED6Mediator complex subunit 60.028
B52CG10851 gene product from transcript CG10851-RB0.028
ChroChromator0.028
dcodiscs overgrown0.028
CG16778CG16778 gene product from transcript CG16778-RA0.027
Hrb98DEHeterogeneous nuclear ribonucleoprotein at 98DE0.025
ebiCG4063 gene product from transcript CG4063-RA0.023
ClkClock0.023
pr-set7CG3307 gene product from transcript CG3307-RC0.023
Suv4-20CG13363 gene product from transcript CG13363-RA0.022
CG7971CG7971 gene product from transcript CG7971-RC0.022
cdmcadmus0.021
crolcrooked legs0.019
CG18811CG18811 gene product from transcript CG18811-RA0.018
eyeyeless0.018
liclicorne0.018
Hsc70-3Heat shock protein cognate 30.018
MED20Mediator complex subunit 200.018
Adk2Adenylate kinase-20.017
eveeven skipped0.017
grimCG4345 gene product from transcript CG4345-RA0.017
CG1646CG1646 gene product from transcript CG1646-RH0.016
discodisconnected0.016
eggeggless0.016
crycryptochrome0.016
CG6751CG6751 gene product from transcript CG6751-RA0.016
PsiP-element somatic inhibitor0.015
cgcombgap0.015
Su(var)2-HP2CG12864 gene product from transcript CG12864-RB0.015
Exp6Exportin 60.015
Su(var)2-10Suppressor of variegation 2-100.015
gcmglial cells missing0.014
sec6CG5341 gene product from transcript CG5341-RA0.014
emsempty spiracles0.013
knknot0.013
Vha36CG8186 gene product from transcript CG8186-RA0.013
Su(var)3-7Suppressor of variegation 3-70.013
Ten-aTenascin accessory0.013
Bap170Brahma associated protein 170kD0.013
Jarid2CG3654 gene product from transcript CG3654-RD0.013
tlltailless0.013
nubnubbin0.012
pholpleiohomeotic like0.012
G9aCG2995 gene product from transcript CG2995-RA0.012
CG11347CG11347 gene product from transcript CG11347-RE0.012
E(z)Enhancer of zeste0.012
CG32479CG32479 gene product from transcript CG32479-RA0.012
CG4857CG4857 gene product from transcript CG4857-RD0.012
hephhephaestus0.012
timeoutCG7855 gene product from transcript CG7855-RA0.012
mei-P26CG12218 gene product from transcript CG12218-RA0.012
kiskismet0.012
CG34400CG34400 gene product from transcript CG34400-RD0.012
cwoclockwork orange0.012
CG11093CG11093 gene product from transcript CG11093-RB0.012
DscamDown syndrome cell adhesion molecule0.012
Mi-2CG8103 gene product from transcript CG8103-RA0.011
lunaCG33473 gene product from transcript CG33473-RB0.011
larkCG8597 gene product from transcript CG8597-RD0.011
pds5CG17509 gene product from transcript CG17509-RA0.011
ShawShaker cognate w0.011
mbf1multiprotein bridging factor 10.011
CG10638CG10638 gene product from transcript CG10638-RA0.011
Sin3ACG8815 gene product from transcript CG8815-RC0.011
domedomeless0.011
slmbsupernumerary limbs0.011
HsfHeat shock factor0.011
Sir2CG5216 gene product from transcript CG5216-RA0.011
Hsp83Heat shock protein 830.010
BRWD3CG31132 gene product from transcript CG31132-RA0.010
CG31122CG31122 gene product from transcript CG31122-RA0.010
ash2absent, small, or homeotic discs 20.010
tlkTousled-like kinase0.010
Spt6CG12225 gene product from transcript CG12225-RA0.010
Hr46Hormone receptor-like in 460.010
CamCalmodulin0.010
toytwin of eyeless0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Arntlaryl hydrocarbon receptor nuclear translocator-like1.000
Clockcircadian locomotor output cycles kaput0.998
Per2period homolog 2 (Drosophila)0.998
Cry2cryptochrome 2 (photolyase-like)0.947
Ptenphosphatase and tensin homolog0.938
Leprleptin receptor0.840
Ghrgrowth hormone receptor0.808
Arandrogen receptor0.783
Esr1estrogen receptor 1 (alpha)0.767
Pax8paired box gene 80.741
Cry1cryptochrome 1 (photolyase-like)0.673
Thrbthyroid hormone receptor beta0.601
Prlrprolactin receptor0.567
Retret proto-oncogene0.505
Grb10growth factor receptor bound protein 100.492
Rac1RAS-related C3 botulinum substrate 10.414
Ppargc1aperoxisome proliferative activated receptor, gamma, coactivator 1 alpha0.399
Cdkn1bcyclin-dependent kinase inhibitor 1B0.390
Ahraryl-hydrocarbon receptor0.379
Sirt1sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)0.379
Per1period homolog 1 (Drosophila)0.365
Hdac2histone deacetylase 20.321
Insrinsulin receptor0.311
Lepleptin0.297
Drd2dopamine receptor D20.281
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.274
Apcadenomatosis polyposis coli0.246
Tcfcp2l1transcription factor CP2-like 10.210
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.209
Tgfb1transforming growth factor, beta 10.204
Ptpn11protein tyrosine phosphatase, non-receptor type 110.192
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.190
Duox2dual oxidase 20.186
Kat2aK(lysine) acetyltransferase 2A0.186
Chordc1cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 10.182
AxlAXL receptor tyrosine kinase0.178
Mbd3methyl-CpG binding domain protein 30.177
CblCasitas B-lineage lymphoma0.176
Kiss1KiSS-1 metastasis-suppressor0.173
Lhcgrluteinizing hormone/choriogonadotropin receptor0.170
Ncoa1nuclear receptor coactivator 10.161
Esr2estrogen receptor 2 (beta)0.155
Hsph1heat shock 105kDa/110kDa protein 10.142
Nr5a1nuclear receptor subfamily 5, group A, member 10.140
Nr3c1nuclear receptor subfamily 3, group C, member 10.139
Mll3myeloid/lymphoid or mixed-lineage leukemia 30.138
Igf1insulin-like growth factor 10.136
Nrg1neuregulin 10.131
Foxa2forkhead box A20.130
Thrathyroid hormone receptor alpha0.129
Ncoa6nuclear receptor coactivator 60.127
Ep300E1A binding protein p3000.125
Amhr2anti-Mullerian hormone type 2 receptor0.124
Rxraretinoid X receptor alpha0.121
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.121
Nr0b1nuclear receptor subfamily 0, group B, member 10.121
Fshrfollicle stimulating hormone receptor0.120
Ncor1nuclear receptor co-repressor 10.115
Csnk1ecasein kinase 1, epsilon0.114
Arrb1arrestin, beta 10.113
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.112
Esrrbestrogen related receptor, beta0.110
Cgaglycoprotein hormones, alpha subunit0.105
Mta2metastasis-associated gene family, member 20.103
Cd247CD247 antigen0.102
Egr2early growth response 20.101
Hnrnph1heterogeneous nuclear ribonucleoprotein H10.098
Timp1tissue inhibitor of metalloproteinase 10.098
Smad3MAD homolog 3 (Drosophila)0.096
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.095
Ncoa2nuclear receptor coactivator 20.095
Mta1metastasis associated 10.091
Stat3signal transducer and activator of transcription 30.091
Trim28tripartite motif-containing 280.086
Kiss1rKISS1 receptor0.085
Gtf2igeneral transcription factor II I0.084
Cyp19a1cytochrome P450, family 19, subfamily a, polypeptide 10.084
Iqcb1IQ calmodulin-binding motif containing 10.083
Irs2insulin receptor substrate 20.078
Gfra1glial cell line derived neurotrophic factor family receptor alpha 10.078
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.073
Sin3atranscriptional regulator, SIN3A (yeast)0.072
Csf1colony stimulating factor 1 (macrophage)0.070
Adam17a disintegrin and metallopeptidase domain 170.070
Ikzf1IKAROS family zinc finger 10.069
Egfrepidermal growth factor receptor0.069
Sall4sal-like 4 (Drosophila)0.066
Ednraendothelin receptor type A0.066
Usp2ubiquitin specific peptidase 20.065
Mll1myeloid/lymphoid or mixed-lineage leukemia 10.065
Nos3nitric oxide synthase 3, endothelial cell0.064
Mixl1Mix1 homeobox-like 1 (Xenopus laevis)0.063
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.060
Prpf8pre-mRNA processing factor 80.059
Bdnfbrain derived neurotrophic factor0.058
Dicer1Dicer1, Dcr-1 homolog (Drosophila)0.057
Nf1neurofibromatosis 10.057
Cdk4cyclin-dependent kinase 40.056
BlnkB-cell linker0.056
Polr2apolymerase (RNA) II (DNA directed) polypeptide A0.056
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Hspa5heat shock protein 50.027
Hsph1heat shock 105/110 protein 10.022
Stip1stress-induced phosphoprotein 10.014
Hsp90b1heat shock protein 90, beta, member 10.012
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism