The network for 'negative regulation of transforming growth factor beta receptor signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of transforming growth factor beta receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway.

NameDescriptionProbabilityFunc Analog Organism
SMURF2SMAD specific E3 ubiquitin protein ligase 21.000
SMAD4SMAD family member 40.998
SMAD5SMAD family member 50.994
SMAD1SMAD family member 10.993
SMAD2SMAD family member 20.991
SMAD7SMAD family member 70.982
SNX6sorting nexin 60.980
SMAD3SMAD family member 30.965
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.952
TBX5T-box 50.907
ABI2abl-interactor 20.670
TGFBR1transforming growth factor, beta receptor 10.656
TGFB1transforming growth factor, beta 10.630
PTK2PTK2 protein tyrosine kinase 20.627
SNX1sorting nexin 10.599
CAV1caveolin 1, caveolae protein, 22kDa0.544
SMURF1SMAD specific E3 ubiquitin protein ligase 10.511
ZFYVE9zinc finger, FYVE domain containing 90.480
LOXlysyl oxidase0.448
MAGEF1melanoma antigen family F, 10.441
BCAR1breast cancer anti-estrogen resistance 10.430
SNX2sorting nexin 20.423
FHL2four and a half LIM domains 20.338
MDM2Mdm2 p53 binding protein homolog (mouse)0.334
SKILSKI-like oncogene0.284
MAD2L2MAD2 mitotic arrest deficient-like 2 (yeast)0.283
ARandrogen receptor0.231
DLG1discs, large homolog 1 (Drosophila)0.206
CXXC5CXXC finger protein 50.181
NEDD4neural precursor cell expressed, developmentally down-regulated 40.172
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.170
NCK2NCK adaptor protein 20.168
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.162
APOEapolipoprotein E0.156
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.154
PTPN12protein tyrosine phosphatase, non-receptor type 120.151
AQP1aquaporin 1 (Colton blood group)0.150
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.147
FBXL15F-box and leucine-rich repeat protein 150.143
ERBB2IPerbb2 interacting protein0.142
COL6A1collagen, type VI, alpha 10.139
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.139
SKIv-ski sarcoma viral oncogene homolog (avian)0.128
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.121
WWP1WW domain containing E3 ubiquitin protein ligase 10.118
SCNN1Bsodium channel, nonvoltage-gated 1, beta0.115
ITGAVintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)0.115
COL8A1collagen, type VIII, alpha 10.100
SH3D19SH3 domain containing 190.094
DNAJB11DnaJ (Hsp40) homolog, subfamily B, member 110.093
WWP2WW domain containing E3 ubiquitin protein ligase 20.090
PTENphosphatase and tensin homolog0.082
HSP90B1heat shock protein 90kDa beta (Grp94), member 10.081
SPARCsecreted protein, acidic, cysteine-rich (osteonectin)0.080
YAP1Yes-associated protein 10.078
FN1fibronectin 10.075
PARVAparvin, alpha0.075
IGFBP3insulin-like growth factor binding protein 30.071
ROCK1Rho-associated, coiled-coil containing protein kinase 10.069
PRKCDBPprotein kinase C, delta binding protein0.068
KAT2BK(lysine) acetyltransferase 2B0.068
SMAD6SMAD family member 60.067
SH3PXD2ASH3 and PX domains 2A0.066
COL1A1collagen, type I, alpha 10.064
SOX7SRY (sex determining region Y)-box 70.064
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.063
IGFBP5insulin-like growth factor binding protein 50.059
COL3A1collagen, type III, alpha 10.058
MMP14matrix metallopeptidase 14 (membrane-inserted)0.058
FBLN2fibulin 20.055
LTBP2latent transforming growth factor beta binding protein 20.054
ANKRD13Aankyrin repeat domain 13A0.054
ADARB1adenosine deaminase, RNA-specific, B10.049
SPG20spastic paraplegia 20 (Troyer syndrome)0.049
FSTL1follistatin-like 10.049
FBLN1fibulin 10.048
NEDD9neural precursor cell expressed, developmentally down-regulated 90.048
MESDC2mesoderm development candidate 20.045
APPamyloid beta (A4) precursor protein0.044
PSMD11proteasome (prosome, macropain) 26S subunit, non-ATPase, 110.044
COL14A1collagen, type XIV, alpha 10.043
MIB1mindbomb homolog 1 (Drosophila)0.041
PTPN23protein tyrosine phosphatase, non-receptor type 230.041
TIMP3TIMP metallopeptidase inhibitor 30.041
LAMC1laminin, gamma 1 (formerly LAMB2)0.040
CDC42EP1CDC42 effector protein (Rho GTPase binding) 10.040
MFAP2microfibrillar-associated protein 20.039
DCUN1D1DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)0.039
CTSKcathepsin K0.039
RAPGEF2Rap guanine nucleotide exchange factor (GEF) 20.037
THBS2thrombospondin 20.036
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.035
AEBP1AE binding protein 10.034
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
osm-6Protein OSM-60.537
tag-320Protein TAG-3200.306
che-3Protein CHE-30.230
daf-10Protein DAF-100.187
che-13Protein CHE-130.183
osm-5Protein OSM-50.146
osm-3Protein OSM-30.105
T14G8.3Protein T14G8.30.097
CELE_Y44A6D.3Protein Y44A6D.30.093
unc-7Protein UNC-70.078
ncs-2Protein NCS-20.072
imp-2Protein IMP-20.071
eat-4Protein EAT-40.057
CELE_T05E11.3Protein T05E11.30.055
che-2Protein CHE-20.053
osm-1Protein OSM-10.053
uggt-1Protein UGGT-10.046
unc-9Protein UNC-90.039
inx-4Protein INX-40.034
pdi-3Protein PDI-30.027
CELE_C08F11.13Protein C08F11.130.027
E01B7.1Protein E01B7.10.026
T05H10.4Protein T05H10.40.026
cct-6Protein CCT-60.026
eat-6Protein EAT-60.025
pdf-1Protein PDF-10.024
vab-3Protein VAB-30.022
mlt-11Protein MLT-110.021
apc-2Protein APC-20.019
EGAP2.1Protein EGAP2.10.018
che-11Protein CHE-110.017
agef-1Protein AGEF-10.016
tag-123Protein TAG-1230.015
cogc-2Protein COGC-20.015
ostb-1Protein OSTB-10.014
inx-3Protein INX-30.012
che-1Protein CHE-10.012
mec-8Protein MEC-80.012
mec-1Protein MEC-10.011
daf-1Protein DAF-10.010
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
cdoncell adhesion molecule-related/down-regulated by oncogenes0.019
mibmind bomb0.018
unc5bunc-5 homolog B (C. elegans)0.015
tbx1T-box 10.012
bmp2bbone morphogenetic protein 2b0.011
pou5f1POU domain, class 5, transcription factor 10.011
mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.011
msxdmuscle segment homeobox D0.011
acanaaggrecan a0.010
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
MadMothers against dpp1.000
DadDaughters against dpp0.336
gbbglass bottom boat0.254
HcfHost cell factor0.207
cicubitus interruptus0.144
Ras85DRas oncogene at 85D0.139
Stat92ESignal-transducer and activator of transcription protein at 92E0.110
sogshort gastrulation0.108
fwdfour wheel drive0.098
Akt1CG4006 gene product from transcript CG4006-RA0.094
CG11347CG11347 gene product from transcript CG11347-RE0.088
foxoforkhead box, sub-group O0.085
LaspCG3849 gene product from transcript CG3849-RB0.085
Rpn6Proteasome p44.5 subunit0.082
Pi3K92ECG4141 gene product from transcript CG4141-RB0.075
EgfrEpidermal growth factor receptor0.071
l(2)gllethal (2) giant larvae0.063
CG10743CG10743 gene product from transcript CG10743-RB0.062
fs(2)ltoPP43female sterile (2) ltoPP430.052
Sin3ACG8815 gene product from transcript CG8815-RC0.046
ftz-f1ftz transcription factor 10.038
Atg6Autophagy-specific gene 60.038
SaraSmad anchor for receptor activation0.037
CG6650CG6650 gene product from transcript CG6650-RA0.037
neuroliginCG13772 gene product from transcript CG13772-RA0.037
nompCno mechanoreceptor potential C0.035
tsgtwisted gastrulation0.032
CG31122CG31122 gene product from transcript CG31122-RA0.032
cv-ccrossveinless c0.031
CG5854CG5854 gene product from transcript CG5854-RA0.030
Su(H)Suppressor of Hairless0.029
Atg1Autophagy-specific gene 10.028
CG9086CG9086 gene product from transcript CG9086-RA0.028
SnooSno oncogene0.028
Fak56DFocal Adhesion Kinase0.025
InRInsulin-like receptor0.024
E(spl)Enhancer of split0.022
sNPFshort neuropeptide F precursor0.021
CG11286CG11286 gene product from transcript CG11286-RA0.020
Smg6CG6369 gene product from transcript CG6369-RA0.020
ash2absent, small, or homeotic discs 20.019
myoglianinCG1838 gene product from transcript CG1838-RD0.019
RagACG11968 gene product from transcript CG11968-RA0.019
B4CG9239 gene product from transcript CG9239-RA0.019
CG10431CG10431 gene product from transcript CG10431-RA0.018
CG4287CG4287 gene product from transcript CG4287-RB0.018
Pk61CProtein kinase 61C0.018
CG8090CG8090 gene product from transcript CG8090-RB0.018
eyaeyes absent0.017
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ptenphosphatase and tensin homolog0.996
Pax8paired box gene 80.933
Smad7MAD homolog 7 (Drosophila)0.888
Smad6MAD homolog 6 (Drosophila)0.887
Trp53transformation related protein 530.771
Fgf10fibroblast growth factor 100.658
Trp73transformation related protein 730.618
Smad3MAD homolog 3 (Drosophila)0.528
Nr3c1nuclear receptor subfamily 3, group C, member 10.525
Tgfbr1transforming growth factor, beta receptor I0.503
Cdx2caudal type homeobox 20.483
Wnt4wingless-related MMTV integration site 40.467
Arandrogen receptor0.451
Gli2GLI-Kruppel family member GLI20.450
Wnt3awingless-related MMTV integration site 3A0.419
Tgfbr2transforming growth factor, beta receptor II0.396
Gnaqguanine nucleotide binding protein, alpha q polypeptide0.354
Pou3f3POU domain, class 3, transcription factor 30.348
Ptrfpolymerase I and transcript release factor0.341
Rarbretinoic acid receptor, beta0.315
Dkk1dickkopf homolog 1 (Xenopus laevis)0.279
Onecut1one cut domain, family member 10.268
Fgfr2fibroblast growth factor receptor 20.267
Wnt6wingless-related MMTV integration site 60.246
Pkd1polycystic kidney disease 1 homolog0.224
Ctnnb1catenin (cadherin associated protein), beta 10.223
Axin1axin 10.219
Mmp2matrix metallopeptidase 20.218
Lhx1LIM homeobox protein 10.210
Il6stinterleukin 6 signal transducer0.210
Foxa2forkhead box A20.199
Plin1perilipin 10.197
Dag1dystroglycan 10.189
Twist2twist homolog 2 (Drosophila)0.189
Rararetinoic acid receptor, alpha0.186
Mdm2transformed mouse 3T3 cell double minute 20.183
Gdnfglial cell line derived neurotrophic factor0.182
Pdgfaplatelet derived growth factor, alpha0.172
Hsp90b1heat shock protein 90, beta (Grp94), member 10.167
Fzd1frizzled homolog 1 (Drosophila)0.161
Edarectodysplasin-A receptor0.158
Manfmesencephalic astrocyte-derived neurotrophic factor0.153
Bnc1basonuclin 10.153
Fgf15fibroblast growth factor 150.152
Gata6GATA binding protein 60.150
Rargretinoic acid receptor, gamma0.143
Bmpr2bone morphogenic protein receptor, type II (serine/threonine kinase)0.143
Fgf18fibroblast growth factor 180.140
Npc1Niemann Pick type C10.135
Mgpmatrix Gla protein0.120
Smurf1SMAD specific E3 ubiquitin protein ligase 10.119
Map3k7mitogen-activated protein kinase kinase kinase 70.117
Pcsk5proprotein convertase subtilisin/kexin type 50.116
Wnt10bwingless related MMTV integration site 10b0.115
Zfp651zinc finger protein 6510.115
Wnt3wingless-related MMTV integration site 30.113
Tcf7l2transcription factor 7-like 2, T-cell specific, HMG-box0.112
Gdf1growth differentiation factor 10.112
Gab2growth factor receptor bound protein 2-associated protein 20.110
Pgrprogesterone receptor0.110
Amhr2anti-Mullerian hormone type 2 receptor0.110
Nbl1neuroblastoma, suppression of tumorigenicity 10.108
Ptpn11protein tyrosine phosphatase, non-receptor type 110.108
Gsk3bglycogen synthase kinase 3 beta0.106
Tbx3T-box 30.106
Neurog1neurogenin 10.105
Tacr1tachykinin receptor 10.104
Fgfr1fibroblast growth factor receptor 10.104
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.102
Islrimmunoglobulin superfamily containing leucine-rich repeat0.102
Timp2tissue inhibitor of metalloproteinase 20.102
Tcf21transcription factor 210.098
Meox2mesenchyme homeobox 20.095
Dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.092
Dnajb11DnaJ (Hsp40) homolog, subfamily B, member 110.091
Fzd8frizzled homolog 8 (Drosophila)0.090
Wnt11wingless-related MMTV integration site 110.089
Nfatc2nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 20.088
Tbx2T-box 20.088
Emp2epithelial membrane protein 20.086
Mgat3mannoside acetylglucosaminyltransferase 30.086
Apcadenomatosis polyposis coli0.084
Amhanti-Mullerian hormone0.084
Hoxd11homeobox D110.083
Cdkn2acyclin-dependent kinase inhibitor 2A0.082
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Hsp90b1heat shock protein 90, beta, member 10.270
Pdia4protein disulfide isomerase family A, member 40.175
Dnajb11DnaJ (Hsp40) homolog, subfamily B, member 110.024
Pmepa1prostate transmembrane protein, androgen induced 10.023
Pdia6protein disulfide isomerase family A, member 60.020
Hsph1heat shock 105/110 protein 10.020
Emp1epithelial membrane protein 10.018
Ctshcathepsin H0.018
Dnaja1DnaJ (Hsp40) homolog, subfamily A, member 10.017
Pdia3protein disulfide isomerase family A, member 30.017
Becn1beclin 1, autophagy related0.017
Mfap5microfibrillar associated protein 50.016
Creld2cysteine-rich with EGF-like domains 20.015
Lamc1laminin, gamma 10.014
Loxl1lysyl oxidase-like 10.014
Efnb1ephrin B10.014
Pecam1platelet/endothelial cell adhesion molecule 10.014
Col4a1collagen, type IV, alpha 10.014
SnrkSNF related kinase0.014
Fam198bfamily with sequence similarity 198, member B0.013
Loxlysyl oxidase0.012
Psmd5proteasome (prosome, macropain) 26S subunit, non-ATPase, 50.012
Cmklr1chemokine-like receptor 10.012
Hspd1heat shock protein 1 (chaperonin)0.012
Cdh5cadherin 50.012
Gatad1GATA zinc finger domain containing 10.011
Col15a1collagen, type XV, alpha 10.011
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.011
AxlAxl receptor tyrosine kinase0.011
Col5a1collagen, type V, alpha 10.011
Adcy3adenylate cyclase 30.011
Gja4gap junction protein, alpha 40.010
Hspa13heat shock protein 130.010
LOC681996similar to AHA1, activator of heat shock 90kDa protein ATPase homolog 10.010
Anpepalanyl (membrane) aminopeptidase0.010
Ppp2cbprotein phosphatase 2, catalytic subunit, beta isoform0.010
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism