The network for 'response to transforming growth factor beta' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to transforming growth factor beta

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus.

NameDescriptionProbabilityFunc Analog Organism
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)1.000
SMURF2SMAD specific E3 ubiquitin protein ligase 21.000
SMAD3SMAD family member 31.000
SMAD7SMAD family member 71.000
SMAD4SMAD family member 41.000
SMAD2SMAD family member 20.999
SKILSKI-like oncogene0.996
JUNjun proto-oncogene0.996
FN1fibronectin 10.994
FHL2four and a half LIM domains 20.993
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.992
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.986
PTK2PTK2 protein tyrosine kinase 20.978
TP53tumor protein p530.978
FOSFBJ murine osteosarcoma viral oncogene homolog0.976
HIPK2homeodomain interacting protein kinase 20.967
JUNBjun B proto-oncogene0.954
COL1A1collagen, type I, alpha 10.953
FYNFYN oncogene related to SRC, FGR, YES0.926
SIRT1sirtuin 10.900
SMAD1SMAD family member 10.899
HIPK3homeodomain interacting protein kinase 30.896
COL4A1collagen, type IV, alpha 10.893
TGFBR1transforming growth factor, beta receptor 10.882
EP300E1A binding protein p3000.876
FLNAfilamin A, alpha0.822
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.810
SNX6sorting nexin 60.804
ERBB2IPerbb2 interacting protein0.794
ITGAVintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)0.769
TGFB1transforming growth factor, beta 10.766
WWP2WW domain containing E3 ubiquitin protein ligase 20.754
ESR1estrogen receptor 10.749
PDIA3protein disulfide isomerase family A, member 30.749
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.726
MAP2K4mitogen-activated protein kinase kinase 40.693
HCKhemopoietic cell kinase0.673
MMP14matrix metallopeptidase 14 (membrane-inserted)0.672
SYKspleen tyrosine kinase0.649
COL3A1collagen, type III, alpha 10.620
SNX33sorting nexin 330.610
COL6A1collagen, type VI, alpha 10.581
ITGA3integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)0.577
POU3F2POU class 3 homeobox 20.552
SPARCsecreted protein, acidic, cysteine-rich (osteonectin)0.533
ABI2abl-interactor 20.527
FLNBfilamin B, beta0.520
TCF4transcription factor 40.497
WWP1WW domain containing E3 ubiquitin protein ligase 10.495
TRIM33tripartite motif containing 330.482
SMURF1SMAD specific E3 ubiquitin protein ligase 10.481
ATF3activating transcription factor 30.476
SP1Sp1 transcription factor0.471
CAV1caveolin 1, caveolae protein, 22kDa0.469
BMP2bone morphogenetic protein 20.452
VCAM1vascular cell adhesion molecule 10.445
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.445
PIAS4protein inhibitor of activated STAT, 40.441
ATF2activating transcription factor 20.430
SOCS3suppressor of cytokine signaling 30.424
CXXC5CXXC finger protein 50.417
WIPF1WAS/WASL interacting protein family, member 10.415
MAPK8mitogen-activated protein kinase 80.413
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.408
TPBGtrophoblast glycoprotein0.402
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.399
BCAR1breast cancer anti-estrogen resistance 10.389
LAMC1laminin, gamma 1 (formerly LAMB2)0.384
IRF2BP1interferon regulatory factor 2 binding protein 10.383
SNX1sorting nexin 10.373
NOSTRINnitric oxide synthase trafficker0.344
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.334
MDM2Mdm2 p53 binding protein homolog (mouse)0.334
COL1A2collagen, type I, alpha 20.323
HDAC4histone deacetylase 40.320
FKBP1AFK506 binding protein 1A, 12kDa0.319
DUSP1dual specificity phosphatase 10.317
DDR2discoidin domain receptor tyrosine kinase 20.316
TBX5T-box 50.314
PDCD6IPprogrammed cell death 6 interacting protein0.311
ARandrogen receptor0.297
ZMYM2zinc finger, MYM-type 20.297
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.296
FBLN1fibulin 10.296
MIB1mindbomb homolog 1 (Drosophila)0.293
SUMO1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)0.293
RANBP9RAN binding protein 90.292
NCK2NCK adaptor protein 20.289
GRB7growth factor receptor-bound protein 70.288
TGFB3transforming growth factor, beta 30.286
LCKlymphocyte-specific protein tyrosine kinase0.286
LAMB1laminin, beta 10.276
PPP1R15Aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.273
PMLpromyelocytic leukemia0.272
HUWE1HECT, UBA and WWE domain containing 10.264
SMAD5SMAD family member 50.263
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
daf-11Protein DAF-110.696
daf-1Protein DAF-10.234
egl-8Protein EGL-80.186
cat-1Protein CAT-10.176
osm-3Protein OSM-30.132
lin-1Protein LIN-10.110
osm-6Protein OSM-60.082
ceh-20Protein CEH-200.081
gcy-22Protein GCY-220.068
daf-4Protein DAF-40.049
R05G6.10Protein R05G6.100.049
eps-8Protein EPS-80.047
ncam-1Protein NCAM-10.043
osm-5Protein OSM-50.043
nhr-25Protein NHR-250.043
twk-18Protein TWK-180.038
hlh-30Protein HLH-300.038
cpn-3Protein CPN-30.037
lin-25Protein LIN-250.035
mig-6Protein MIG-60.033
che-3Protein CHE-30.030
vab-8Protein VAB-80.030
aha-1Protein AHA-10.030
ztf-22Protein ZTF-220.030
daf-3Protein DAF-30.029
egl-18Protein EGL-180.027
Y40C5A.1Protein Y40C5A.10.027
unc-73Protein UNC-730.026
aak-2Protein AAK-20.025
pkg-1Protein PKG-10.025
cyd-1Protein CYD-10.024
peb-1Protein PEB-10.024
rgs-7Protein RGS-70.023
pat-3Protein PAT-30.023
emb-9Protein EMB-90.022
unc-9Protein UNC-90.021
F13H6.1Protein F13H6.10.020
tag-52Protein TAG-520.020
dlk-1Protein DLK-10.019
che-13Protein CHE-130.018
mab-31Protein MAB-310.017
rbc-1Protein RBC-10.017
R10E4.1Protein R10E4.10.016
pod-2Protein POD-20.016
K02C4.5Protein K02C4.50.016
zyg-8Protein ZYG-80.015
pry-1Protein PRY-10.015
par-5Protein PAR-50.015
sma-6Protein SMA-60.015
sym-4Protein SYM-40.015
ric-19Protein RIC-190.014
tax-4Protein TAX-40.014
C43H6.4Protein C43H6.40.014
unc-7Protein UNC-70.013
CELE_Y24F12A.1Protein Y24F12A.10.013
math-4Protein MATH-40.013
daf-7Protein DAF-70.013
tax-2Protein TAX-20.013
vhp-1Protein VHP-10.013
zig-1Protein ZIG-10.013
daf-5Protein DAF-50.013
T03G6.3Protein T03G6.30.012
CELE_T05B11.1Protein T05B11.10.012
abl-1Protein ABL-10.012
vab-19Protein VAB-190.012
odr-3Protein ODR-30.012
vang-1Protein VANG-10.012
faah-1Protein FAAH-10.012
che-2Protein CHE-20.012
eya-1Protein EYA-10.012
vab-3Protein VAB-30.011
unc-83Protein UNC-830.011
mab-5Protein MAB-50.011
C13C4.6Protein C13C4.60.011
Y66D12A.8Protein Y66D12A.80.011
dnj-27Protein DNJ-270.011
let-2Protein LET-20.011
daf-12Protein DAF-120.011
tag-135Protein TAG-1350.010
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
fras1Fraser syndrome 10.135
yes1v-yes-1 Yamaguchi sarcoma viral oncogene homolog 10.044
tbx1T-box 10.043
tnnt2atroponin T2a, cardiac0.037
col1a1acollagen, type I, alpha 1a0.031
lmo4aLIM domain only 4a0.029
ephb4beph receptor B4b0.028
myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.027
ahr2aryl hydrocarbon receptor 20.027
alcamaactivated leukocyte cell adhesion molecule a0.024
fgf8afibroblast growth factor 8 a0.024
tp53tumor protein p530.021
tgfb1atransforming growth factor, beta 1a0.021
ctnnb1catenin (cadherin-associated protein), beta 10.021
sumo3aSMT3 suppressor of mif two 3 homolog 3a0.020
rbfox2RNA binding protein, fox-1 homolog (C. elegans) 20.017
plcg1phospholipase C, gamma 10.017
tcf12transcription factor 120.017
bmpr1aabone morphogenetic protein receptor, type 1aa0.016
itgb1aintegrin, beta 1a0.016
ef1aelongation factor 1-alpha0.016
spry4sprouty (Drosophila) homolog 40.016
bocbrother of CDO0.016
sox11bSRY-box containing gene 11b0.015
fbn2bfibrillin 2b0.014
oepone-eyed pinhead0.012
wnt11rwingless-type MMTV integration site family, member 11, related0.012
mapk15mitogen-activated protein kinase 150.012
ctgfconnective tissue growth factor0.012
rnf41ring finger protein 410.011
prkciprotein kinase C, iota0.011
mapk1mitogen-activated protein kinase 10.011
bmp2abone morphogenetic protein 2a0.011
tp53bp2tumor protein p53 binding protein, 20.011
lmx1b.2LIM homeobox transcription factor 1, beta 20.011
apcadenomatosis polyposis coli0.011
col5a1procollagen, type V, alpha 10.010
cdh4cadherin 4, retinal0.010
edn1endothelin 10.010
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
DadDaughters against dpp0.677
MadMothers against dpp0.552
Rac1CG2248 gene product from transcript CG2248-RA0.419
gbbglass bottom boat0.272
CspCysteine string protein0.182
EgfrEpidermal growth factor receptor0.178
aopanterior open0.178
Rab5Rab-protein 50.174
cicubitus interruptus0.159
mewmultiple edematous wings0.150
Pi3K92ECG4141 gene product from transcript CG4141-RB0.141
argosCG4531 gene product from transcript CG4531-RA0.122
HcfHost cell factor0.118
Rho1CG8416 gene product from transcript CG8416-RB0.115
Plc21CPhospholipase C at 21C0.114
Akt1CG4006 gene product from transcript CG4006-RA0.107
sogshort gastrulation0.066
Nrx-IVNeurexin IV0.064
Cdc42CG12530 gene product from transcript CG12530-RA0.062
LanB1CG7123 gene product from transcript CG7123-RA0.061
GpdhGlycerol 3 phosphate dehydrogenase0.059
cwoclockwork orange0.059
faffat facets0.056
fwdfour wheel drive0.055
dcodiscs overgrown0.054
ik2IkappaB kinase-like 20.053
PvrPDGF- and VEGF-receptor related0.049
LanALaminin A0.048
VAChTCG32848 gene product from transcript CG32848-RA0.047
Socs36ESuppressor of cytokine signaling at 36E0.044
cdicenter divider0.043
p53CG33336 gene product from transcript CG33336-RB0.042
svpseven up0.041
ash2absent, small, or homeotic discs 20.036
nompCno mechanoreceptor potential C0.035
rictorrapamycin-insensitive companion of Tor0.035
E(spl)Enhancer of split0.034
Pk61CProtein kinase 61C0.034
CG11347CG11347 gene product from transcript CG11347-RE0.033
foxoforkhead box, sub-group O0.031
LnkCG17367 gene product from transcript CG17367-RC0.031
RhoGAP100FCG1976 gene product from transcript CG1976-RB0.031
neuroliginCG13772 gene product from transcript CG13772-RA0.031
pr-set7CG3307 gene product from transcript CG3307-RC0.030
SnooSno oncogene0.030
RicRas which interacts with Calmodulin0.029
nufnuclear fallout0.029
Rpn6Proteasome p44.5 subunit0.029
Sir2CG5216 gene product from transcript CG5216-RA0.028
l(2)gllethal (2) giant larvae0.028
Gyc76CGuanylyl cyclase at 76C0.027
LanB2Laminin B20.027
CG11534CG11534 gene product from transcript CG11534-RA0.027
Gs1Glutamine synthetase 10.026
Stat92ESignal-transducer and activator of transcription protein at 92E0.026
Spf45CG17540 gene product from transcript CG17540-RB0.025
mib1mind bomb 10.025
Su(dx)Suppressor of deltex0.024
Gprk2G protein-coupled receptor kinase 20.023
CG13604CG13604 gene product from transcript CG13604-RD0.022
sosine oculis0.022
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Tgfbr2transforming growth factor, beta receptor II0.998
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.950
Bmp4bone morphogenetic protein 40.934
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.916
Gli2GLI-Kruppel family member GLI20.911
Thbs1thrombospondin 10.894
Csf1colony stimulating factor 1 (macrophage)0.894
Smad6MAD homolog 6 (Drosophila)0.877
Axin1axin 10.871
Sfrp2secreted frizzled-related protein 20.859
Tgfb2transforming growth factor, beta 20.833
Smad4MAD homolog 4 (Drosophila)0.820
Smad3MAD homolog 3 (Drosophila)0.785
Tgfb1transforming growth factor, beta 10.771
Cyr61cysteine rich protein 610.747
Apcadenomatosis polyposis coli0.745
Ascl1achaete-scute complex homolog 1 (Drosophila)0.734
Lef1lymphoid enhancer binding factor 10.702
Neurod1neurogenic differentiation 10.615
Map3k7mitogen-activated protein kinase kinase kinase 70.601
Nr5a1nuclear receptor subfamily 5, group A, member 10.588
Emx1empty spiracles homolog 1 (Drosophila)0.578
Col4a1collagen, type IV, alpha 10.557
Trp53transformation related protein 530.554
Amhr2anti-Mullerian hormone type 2 receptor0.536
Tgfbr1transforming growth factor, beta receptor I0.525
Fstl1follistatin-like 10.513
Smad7MAD homolog 7 (Drosophila)0.510
Gdf11growth differentiation factor 110.500
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.497
JunJun oncogene0.481
Wnt6wingless-related MMTV integration site 60.479
Nr3c1nuclear receptor subfamily 3, group C, member 10.476
Pax6paired box gene 60.473
Col1a1collagen, type I, alpha 10.470
Bmp7bone morphogenetic protein 70.463
Mdm2transformed mouse 3T3 cell double minute 20.456
Nos3nitric oxide synthase 3, endothelial cell0.453
Loxlysyl oxidase0.447
Col6a2collagen, type VI, alpha 20.441
Gas1growth arrest specific 10.438
Ptenphosphatase and tensin homolog0.432
Mfap5microfibrillar associated protein 50.427
Inhbainhibin beta-A0.416
Smosmoothened homolog (Drosophila)0.413
Nf1neurofibromatosis 10.398
Tcfap2atranscription factor AP-2, alpha0.396
Col5a2collagen, type V, alpha 20.395
Gpc3glypican 30.386
Ror2receptor tyrosine kinase-like orphan receptor 20.385
Insrinsulin receptor0.369
Gdf5growth differentiation factor 50.364
Ccr2chemokine (C-C motif) receptor 20.341
Fgf8fibroblast growth factor 80.339
Ccl2chemokine (C-C motif) ligand 20.337
Gdnfglial cell line derived neurotrophic factor0.332
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.331
Hic1hypermethylated in cancer 10.327
Ror1receptor tyrosine kinase-like orphan receptor 10.322
Yap1yes-associated protein 10.318
Vegfavascular endothelial growth factor A0.318
Pkd1polycystic kidney disease 1 homolog0.316
Ptk2PTK2 protein tyrosine kinase 20.314
Bmpr1abone morphogenetic protein receptor, type 1A0.311
Wt1Wilms tumor 1 homolog0.308
Mapk14mitogen-activated protein kinase 140.303
Rarbretinoic acid receptor, beta0.297
Otx2orthodenticle homolog 2 (Drosophila)0.293
Ephb2Eph receptor B20.291
Fbn1fibrillin 10.289
Acvrl1activin A receptor, type II-like 10.288
Mef2amyocyte enhancer factor 2A0.286
Cnn1calponin 10.285
Smad1MAD homolog 1 (Drosophila)0.283
Rassf5Ras association (RalGDS/AF-6) domain family member 50.280
Fgf5fibroblast growth factor 50.279
Sox4SRY-box containing gene 40.278
Msx2homeobox, msh-like 20.276
Rock2Rho-associated coiled-coil containing protein kinase 20.274
Twist2twist homolog 2 (Drosophila)0.272
Dag1dystroglycan 10.268
Hey2hairy/enhancer-of-split related with YRPW motif 20.264
Acvr1activin A receptor, type 10.262
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.254
Sh2b3SH2B adaptor protein 30.251
Postnperiostin, osteoblast specific factor0.251
E2f1E2F transcription factor 10.249
Fn1fibronectin 10.247
Ltbp1latent transforming growth factor beta binding protein 10.247
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Col1a1collagen, type I, alpha 10.894
Col3a1collagen, type III, alpha 10.686
Col4a1collagen, type IV, alpha 10.570
Col5a2collagen, type V, alpha 20.563
Loxl1lysyl oxidase-like 10.452
Loxlysyl oxidase0.433
Npr3natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)0.315
Col5a1collagen, type V, alpha 10.309
Atf3activating transcription factor 30.307
Cxcl2chemokine (C-X-C motif) ligand 20.289
Col14a1collagen, type XIV, alpha 10.251
Col1a2collagen, type I, alpha 20.242
Ece1endothelin converting enzyme 10.234
Serpinh1serine (or cysteine) peptidase inhibitor, clade H, member 10.209
Postnperiostin, osteoblast specific factor0.198
Ccl20chemokine (C-C motif) ligand 200.175
Hipk3homeodomain interacting protein kinase 30.153
Il1rapinterleukin 1 receptor accessory protein0.147
Tgfb1transforming growth factor, beta 10.139
Lamc1laminin, gamma 10.130
Ccdc80coiled-coil domain containing 800.127
Fstl1follistatin-like 10.127
Mfap4microfibrillar-associated protein 40.126
Pcolceprocollagen C-endopeptidase enhancer0.125
Slit3slit homolog 3 (Drosophila)0.120
Slco2a1solute carrier organic anion transporter family, member 2a10.119
Il1binterleukin 1 beta0.117
Fndc1fibronectin type III domain containing 10.109
Ptgfrprostaglandin F receptor0.109
Ppp1r15aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.109
Rgs1regulator of G-protein signaling 10.106
Metmet proto-oncogene0.103
Fosl1fos-like antigen 10.102
Il2rbinterleukin 2 receptor, beta0.101
Il6interleukin 60.096
Ccr2chemokine (C-C motif) receptor 20.094
F2rl1coagulation factor II (thrombin) receptor-like 10.092
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.090
Emp1epithelial membrane protein 10.086
Nox4NADPH oxidase 40.085
Pde3aphosphodiesterase 3A, cGMP inhibited0.084
Tgfb3transforming growth factor, beta 30.083
Bcl2B-cell CLL/lymphoma 20.081
Gja4gap junction protein, alpha 40.080
Ccl4chemokine (C-C motif) ligand 40.079
Pmepa1prostate transmembrane protein, androgen induced 10.078
Igf2rinsulin-like growth factor 2 receptor0.078
Mpeg1macrophage expressed 10.078
Col12a1collagen, type XII, alpha 10.078
Smad7SMAD family member 70.076
Rgs19regulator of G-protein signaling 190.075
Mfap5microfibrillar associated protein 50.069
Flt1FMS-related tyrosine kinase 10.069
Il1r1interleukin 1 receptor, type I0.068
Ccl3chemokine (C-C motif) ligand 30.066
Bcar1breast cancer anti-estrogen resistance 10.065
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.063
Cxcl3chemokine (C-X-C motif) ligand 30.063
Igsf6immunoglobulin superfamily, member 60.061
Mmp12matrix metallopeptidase 120.061
Col8a1collagen, type VIII, alpha 10.060
Hapln1hyaluronan and proteoglycan link protein 10.058
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.058
Myl7myosin, light chain 7, regulatory0.057
Myl9myosin, light chain 9, regulatory0.057
Tnxbtenascin XB0.056
Svs1seminal vesicle secretory protein 10.056
Sparcsecreted protein, acidic, cysteine-rich (osteonectin)0.056
Fcgr2aFc fragment of IgG, low affinity IIa, receptor (CD32)0.055
Tgfbr2transforming growth factor, beta receptor II0.055
Pde5aphosphodiesterase 5A, cGMP-specific0.055
Nid2nidogen 20.055
Galr2galanin receptor 20.054
Pecam1platelet/endothelial cell adhesion molecule 10.053
Cd14CD14 molecule0.053
Hes2hairy and enhancer of split 2 (Drosophila)0.052
S1pr2sphingosine-1-phosphate receptor 20.052
Cxcl10chemokine (C-X-C motif) ligand 100.051
Dusp1dual specificity phosphatase 10.051
Ltbp4latent transforming growth factor beta binding protein 40.049
Runx1runt-related transcription factor 10.049
Ggt5gamma-glutamyltransferase 50.049
Il1rninterleukin 1 receptor antagonist0.049
Sirpasignal-regulatory protein alpha0.048
Rararetinoic acid receptor, alpha0.048
Hspa1aheat shock 70kD protein 1A0.047
Pla2g2aphospholipase A2, group IIA (platelets, synovial fluid)0.046
Col15a1collagen, type XV, alpha 10.046
Ccr1chemokine (C-C motif) receptor 10.046
Cmklr1chemokine-like receptor 10.045
Ncr1natural cytotoxicity triggering receptor 10.045
Ntf4neurotrophin 40.044
Myh9myosin, heavy chain 9, non-muscle0.044
Cd44Cd44 molecule0.044
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism