The network for 'astrocyte development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

astrocyte development

The process aimed at the progression of an astrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function.

NameDescriptionProbabilityFunc Analog Organism
CHD3chromodomain helicase DNA binding protein 30.276
SOX10SRY (sex determining region Y)-box 100.246
DRD2dopamine receptor D20.196
NAMPTnicotinamide phosphoribosyltransferase0.164
PAX3paired box 30.133
KIAA0408KIAA04080.040
PDLIM1PDZ and LIM domain 10.038
NFATC2nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 20.032
FABP4fatty acid binding protein 4, adipocyte0.023
ADORA1adenosine A1 receptor0.021
SETDB1SET domain, bifurcated 10.019
NECAB2N-terminal EF-hand calcium binding protein 20.018
TCHPtrichoplein, keratin filament binding0.018
USPL1ubiquitin specific peptidase like 10.016
LGALS1lectin, galactoside-binding, soluble, 10.013
CRPC-reactive protein, pentraxin-related0.013
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.012
ING5inhibitor of growth family, member 50.012
CYP2E1cytochrome P450, family 2, subfamily E, polypeptide 10.012
GOPCgolgi-associated PDZ and coiled-coil motif containing0.011
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Pax3paired box gene 30.836
Pax2paired box gene 20.751
Emx2empty spiracles homolog 2 (Drosophila)0.691
Otx2orthodenticle homolog 2 (Drosophila)0.652
Isl1ISL1 transcription factor, LIM/homeodomain0.643
Shhsonic hedgehog0.635
Eya1eyes absent 1 homolog (Drosophila)0.628
Pnpla2patatin-like phospholipase domain containing 20.592
Sall4sal-like 4 (Drosophila)0.542
Drd2dopamine receptor D20.476
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.456
Sox2SRY-box containing gene 20.441
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.422
NanogNanog homeobox0.415
Klklotho0.385
Ptpn11protein tyrosine phosphatase, non-receptor type 110.369
Fgf8fibroblast growth factor 80.347
Fgfr2fibroblast growth factor receptor 20.329
Gli3GLI-Kruppel family member GLI30.323
Pax6paired box gene 60.266
Nognoggin0.264
Sall3sal-like 3 (Drosophila)0.261
Neflneurofilament, light polypeptide0.242
Desdesmin0.230
Adrb3adrenergic receptor, beta 30.219
Adrb1adrenergic receptor, beta 10.213
Sall1sal-like 1 (Drosophila)0.210
Sox9SRY-box containing gene 90.207
Foxg1forkhead box G10.203
Msx1homeobox, msh-like 10.187
Tcfap2atranscription factor AP-2, alpha0.178
Bmp4bone morphogenetic protein 40.176
Ppargperoxisome proliferator activated receptor gamma0.174
Rargretinoic acid receptor, gamma0.160
Tcfcp2l1transcription factor CP2-like 10.159
Sox10SRY-box containing gene 100.158
Sox1SRY-box containing gene 10.154
Leprleptin receptor0.151
Gbx2gastrulation brain homeobox 20.140
Retret proto-oncogene0.139
Fgf10fibroblast growth factor 100.132
Kcnq1potassium voltage-gated channel, subfamily Q, member 10.128
Chd7chromodomain helicase DNA binding protein 70.123
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.116
Wnt7awingless-related MMTV integration site 7A0.105
Insm1insulinoma-associated 10.102
Dlx5distal-less homeobox 50.102
Atoh7atonal homolog 7 (Drosophila)0.094
Pax1paired box gene 10.093
Lmx1aLIM homeobox transcription factor 1 alpha0.091
Atp2b2ATPase, Ca++ transporting, plasma membrane 20.082
Sult4a1sulfotransferase family 4A, member 10.081
Bdnfbrain derived neurotrophic factor0.080
Rxraretinoid X receptor alpha0.078
Hmx3H6 homeobox 30.078
Hoxb1homeobox B10.077
Foxd2forkhead box D20.076
Rararetinoic acid receptor, alpha0.075
Nkx2-2NK2 transcription factor related, locus 2 (Drosophila)0.075
Tbx10T-box 100.074
Hoxd3homeobox D30.074
Pplperiplakin0.074
Fgf4fibroblast growth factor 40.073
Tbx1T-box 10.072
Gli2GLI-Kruppel family member GLI20.068
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.065
Chrdchordin0.064
Kcnma1potassium large conductance calcium-activated channel, subfamily M, alpha member 10.064
Plcg1phospholipase C, gamma 10.063
Fgf3fibroblast growth factor 30.063
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.062
Neurog3neurogenin 30.062
Wt1Wilms tumor 1 homolog0.061
C1ql1complement component 1, q subcomponent-like 10.059
Hand2heart and neural crest derivatives expressed transcript 20.059
Nid1nidogen 10.059
CrpC-reactive protein, pentraxin-related0.058
Wnt1wingless-related MMTV integration site 10.056
Hoxa1homeobox A10.056
Nf1neurofibromatosis 10.055
Vav2vav 2 oncogene0.055
Vegfavascular endothelial growth factor A0.055
Nkx1-2NK1 transcription factor related, locus 2 (Drosophila)0.054
Zeb1zinc finger E-box binding homeobox 10.054
Vangl2vang-like 2 (van gogh, Drosophila)0.053
ND6NADH dehydrogenase subunit 60.052
Ednraendothelin receptor type A0.052
Apoa1apolipoprotein A-I0.051
Arandrogen receptor0.050
Esrrbestrogen related receptor, beta0.049
Agtr1aangiotensin II receptor, type 1a0.049
Sox3SRY-box containing gene 30.048
Mogmyelin oligodendrocyte glycoprotein0.048
Serpina1bserine (or cysteine) preptidase inhibitor, clade A, member 1B0.047
Dlx1distal-less homeobox 10.047
Hoxd11homeobox D110.046
F9coagulation factor IX0.046
En1engrailed 10.045
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.044
Itih3inter-alpha trypsin inhibitor, heavy chain 30.043
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Mt1ametallothionein 1a0.704
Mgpmatrix Gla protein0.220
Ifitm3interferon induced transmembrane protein 30.219
Anxa5annexin A50.154
Anxa2annexin A20.107
Sparcsecreted protein, acidic, cysteine-rich (osteonectin)0.083
Unc5bunc-5 homolog B (C. elegans)0.076
Cx3cr1chemokine (C-X3-C motif) receptor 10.074
Smad3SMAD family member 30.069
Ptafrplatelet-activating factor receptor0.069
Loxlysyl oxidase0.066
Timp1TIMP metallopeptidase inhibitor 10.064
A2malpha-2-macroglobulin0.063
Sstr4somatostatin receptor 40.055
Strnstriatin, calmodulin binding protein0.055
Capn2calpain 20.051
Aqp9aquaporin 90.046
Dnaja3DnaJ (Hsp40) homolog, subfamily A, member 30.042
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.037
Adora1adenosine A1 receptor0.036
Fn1fibronectin 10.036
Kcnq3potassium voltage-gated channel, KQT-like subfamily, member 30.036
Timp2TIMP metallopeptidase inhibitor 20.033
Il1ainterleukin 1 alpha0.032
Litaflipopolysaccharide-induced TNF factor0.031
Eif2b4eukaryotic translation initiation factor 2B, subunit 4 delta0.031
Lgals3lectin, galactoside-binding, soluble, 30.031
Nfascneurofascin0.031
Klk6kallikrein related-peptidase 60.030
Mlc1megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)0.030
S100a6S100 calcium binding protein A60.029
Epb4.1l2erythrocyte membrane protein band 4.1-like 20.028
Prp2proline rich protein 20.028
Cyp2a1cytochrome P450, family 2, subfamily a, polypeptide 10.028
C3complement component 30.028
Ddr1discoidin domain receptor tyrosine kinase 10.028
Slc1a2solute carrier family 1 (glial high affinity glutamate transporter), member 20.028
Itih3inter-alpha trypsin inhibitor, heavy chain 30.027
Anxa1annexin A10.026
S100a10S100 calcium binding protein A100.025
Hrkharakiri, BCL2 interacting protein (contains only BH3 domain)0.025
Gfra1GDNF family receptor alpha 10.025
Magmyelin-associated glycoprotein0.025
Lgals1lectin, galactoside-binding, soluble, 10.025
Mt3metallothionein 30.025
Calb2calbindin 20.023
Slc7a2solute carrier family 7 (cationic amino acid transporter, y+ system), member 20.023
S100a4S100 calcium-binding protein A40.023
Slc29a2solute carrier family 29 (nucleoside transporters), member 20.022
Cbscystathionine beta synthase0.022
Ednrbendothelin receptor type B0.021
Fstl1follistatin-like 10.021
Fabp7fatty acid binding protein 7, brain0.021
Gzmbgranzyme B0.021
Fgf2fibroblast growth factor 20.021
RGD1309537similar to Myosin regulatory light chain 2-A, smooth muscle isoform (Myosin RLC-A)0.021
RorbRAR-related orphan receptor B0.021
Ptprz1protein tyrosine phosphatase, receptor-type, Z polypeptide 10.020
Col5a2collagen, type V, alpha 20.020
Pmp22peripheral myelin protein 220.019
Ttc27tetratricopeptide repeat domain 270.019
Cd9CD9 molecule0.019
Hapln1hyaluronan and proteoglycan link protein 10.019
Epha3Eph receptor A30.019
Ugt2bUDP glycosyltransferase 2 family, polypeptide B0.019
Itgb1integrin, beta 10.018
Tfip11tuftelin interacting protein 110.018
Prkcdbpprotein kinase C, delta binding protein0.018
Akr1c18aldo-keto reductase family 1, member C180.018
Col1a2collagen, type I, alpha 20.018
Ceacam10carcinoembryonic antigen-related cell adhesion molecule 100.017
Calucalumenin0.017
Slc1a3solute carrier family 1 (glial high affinity glutamate transporter), member 30.017
Rhovras homolog gene family, member V0.017
Il1rapinterleukin 1 receptor accessory protein0.017
Nfyanuclear transcription factor-Y alpha0.017
Cd63Cd63 molecule0.017
Aqp4aquaporin 40.017
GperG protein-coupled estrogen receptor 10.017
Cyp2d4cytochrome P450, family 2, subfamily d, polypeptide 40.017
Slc2a1solute carrier family 2 (facilitated glucose transporter), member 10.016
Pax6paired box 60.016
Grm1glutamate receptor, metabotropic 10.016
Dcndecorin0.016
Metmet proto-oncogene0.016
Igfbp7insulin-like growth factor binding protein 70.016
LOC691153hypothetical protein LOC6911530.016
Exoc3exocyst complex component 30.015
Olig1oligodendrocyte transcription factor 10.015
Apoa5apolipoprotein A-V0.015
Eif2b1eukaryotic translation initiation factor 2B, subunit 1 alpha0.015
Ntsr2neurotensin receptor 20.015
Taglntransgelin0.015
Drd2dopamine receptor D20.015
Plcb2phospholipase C, beta 20.015
Adora2aadenosine A2a receptor0.015
LOC689128hypothetical protein LOC6891280.015
Lcatlecithin cholesterol acyltransferase0.014
Slit1slit homolog 1 (Drosophila)0.014
Prdm2PR domain containing 2, with ZNF domain0.014
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism