The network for 'regulation of protein stability' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of protein stability

Any process that affects the structure and integrity of a protein by altering the likelihood of its degradation or aggregation.

NameDescriptionProbabilityFunc Analog Organism
TP53tumor protein p531.000
RASSF5Ras association (RalGDS/AF-6) domain family member 50.982
MDM2Mdm2 p53 binding protein homolog (mouse)0.973
RNF11ring finger protein 110.973
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.957
STK3serine/threonine kinase 30.888
STK4serine/threonine kinase 40.851
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.831
RB1retinoblastoma 10.821
HDAC1histone deacetylase 10.802
COPS2COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)0.665
DAXXdeath-domain associated protein0.655
COPS8COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)0.632
MDM4Mdm4 p53 binding protein homolog (mouse)0.607
SMAD7SMAD family member 70.595
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.594
MED1mediator complex subunit 10.547
COPS5COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)0.503
BIRC2baculoviral IAP repeat containing 20.447
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.417
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.408
USP7ubiquitin specific peptidase 7 (herpes virus-associated)0.371
PBX1pre-B-cell leukemia homeobox 10.370
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.365
BCL2L1BCL2-like 10.348
SIRT1sirtuin 10.336
RASSF1Ras association (RalGDS/AF-6) domain family member 10.332
MOBKL1BMOB1, Mps One Binder kinase activator-like 1B (yeast)0.331
SMAD2SMAD family member 20.319
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.314
GFERgrowth factor, augmenter of liver regeneration0.297
CUL1cullin 10.297
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.297
FBXW11F-box and WD repeat domain containing 110.285
TRRAPtransformation/transcription domain-associated protein0.281
CD81CD81 molecule0.275
RASSF3Ras association (RalGDS/AF-6) domain family member 30.273
PDIA3protein disulfide isomerase family A, member 30.269
SMURF2SMAD specific E3 ubiquitin protein ligase 20.266
BTRCbeta-transducin repeat containing0.249
MOBKL1AMOB1, Mps One Binder kinase activator-like 1A (yeast)0.249
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.240
CUL2cullin 20.240
CHEK1CHK1 checkpoint homolog (S. pombe)0.229
SMAD1SMAD family member 10.226
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.222
RAD51RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)0.211
PAX3paired box 30.206
EP300E1A binding protein p3000.201
HNRNPDheterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)0.192
RYBPRING1 and YY1 binding protein0.188
XIAPX-linked inhibitor of apoptosis0.186
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.184
HUWE1HECT, UBA and WWE domain containing 10.183
PIAS1protein inhibitor of activated STAT, 10.182
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.181
PCGF2polycomb group ring finger 20.179
MLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.171
SMAD4SMAD family member 40.165
POU5F1POU class 5 homeobox 10.146
GBAglucosidase, beta, acid0.145
KPNA3karyopherin alpha 3 (importin alpha 4)0.141
TRIM33tripartite motif containing 330.139
RNF111ring finger protein 1110.138
SGCDsarcoglycan, delta (35kDa dystrophin-associated glycoprotein)0.136
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.135
PRNPprion protein0.134
RING1ring finger protein 10.131
ID3inhibitor of DNA binding 3, dominant negative helix-loop-helix protein0.131
PSEN1presenilin 10.131
COG4component of oligomeric golgi complex 40.129
RNF138ring finger protein 1380.128
CCDC101coiled-coil domain containing 1010.127
TRIM21tripartite motif containing 210.127
OTUB1OTU domain, ubiquitin aldehyde binding 10.127
ZNF496zinc finger protein 4960.126
ACACAacetyl-CoA carboxylase alpha0.122
BAG2BCL2-associated athanogene 20.121
SOD1superoxide dismutase 1, soluble0.120
UBE2Bubiquitin-conjugating enzyme E2B (RAD6 homolog)0.117
BRCA1breast cancer 1, early onset0.112
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.109
ABI1abl-interactor 10.109
ARandrogen receptor0.109
RASSF2Ras association (RalGDS/AF-6) domain family member 20.108
SYNCRIPsynaptotagmin binding, cytoplasmic RNA interacting protein0.107
CDK1cyclin-dependent kinase 10.107
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.106
RAD51L1RAD51-like 1 (S. cerevisiae)0.105
PDIA4protein disulfide isomerase family A, member 40.104
CKS1BCDC28 protein kinase regulatory subunit 1B0.104
STX7syntaxin 70.104
ARRB1arrestin, beta 10.103
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.103
TCF12transcription factor 120.100
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.099
TADA3transcriptional adaptor 30.098
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
spr-5Protein SPR-50.031
unc-53Protein UNC-530.030
csn-5Protein CSN-50.028
csn-3Protein CSN-30.027
spc-1Protein SPC-10.026
lin-23Protein LIN-230.025
eif-3.BProtein EIF-3.B0.024
csn-1Protein CSN-10.024
acs-4Protein ACS-40.023
mbk-1Protein MBK-10.023
mat-3Protein MAT-30.023
rsd-2Protein RSD-20.023
unc-54Protein UNC-540.023
CELE_R02D3.3Protein R02D3.30.022
nfi-1Protein NFI-10.022
gsp-1Protein GSP-10.022
CELE_C38D4.9Protein C38D4.90.021
pqn-59Protein PQN-590.021
snr-4Protein SNR-40.021
olrn-1Protein OLRN-10.021
kin-19Protein KIN-190.021
snr-2Protein SNR-20.021
cst-2Protein CST-20.020
cpg-8Protein CPG-80.020
his-24Protein HIS-240.020
snr-5Protein SNR-50.020
egl-13Protein EGL-130.019
cyn-4Protein CYN-40.019
F28B3.1Protein F28B3.10.019
B0511.6Protein B0511.60.019
lag-1Protein LAG-10.019
cst-1Protein CST-10.019
sdc-1Protein SDC-10.019
ftt-2Protein FTT-20.019
dnj-23Protein DNJ-230.019
goa-1Protein GOA-10.018
T08G11.1Protein T08G11.10.018
CELE_F53C11.4Protein F53C11.40.018
spr-1Protein SPR-10.018
atg-18Protein ATG-180.018
nap-1Protein NAP-10.018
K10B4.3Protein K10B4.30.018
unc-73Protein UNC-730.018
hmg-1.2Protein HMG-1.20.018
egl-36Protein EGL-360.018
F58B3.7Protein F58B3.70.018
prp-21Protein PRP-210.018
C37H5.6Protein C37H5.60.018
ztf-7Protein ZTF-70.018
ags-3Protein AGS-30.018
B0361.3Protein B0361.30.018
C34F6.10Protein C34F6.100.017
rab-1Protein RAB-10.017
CELE_C17E4.6Protein C17E4.60.017
cyk-7Protein CYK-70.017
afd-1Protein AFD-10.017
egl-23Protein EGL-230.017
gei-4Protein GEI-40.017
Y43C5B.2Protein Y43C5B.20.017
hif-1Protein HIF-10.017
CELE_C18C4.5Protein C18C4.50.017
gsy-1Protein GSY-10.017
F40F4.7Protein F40F4.70.017
cul-3Protein CUL-30.017
daf-21Protein DAF-210.017
ubr-1Protein UBR-10.017
rfc-2Protein RFC-20.017
pha-4Protein PHA-40.017
unc-60Protein UNC-600.017
CELE_Y106G6D.7Protein Y106G6D.70.017
nhr-32Protein NHR-320.017
B0041.5Protein B0041.50.017
egl-18Protein EGL-180.017
figl-1Protein FIGL-10.017
lin-7Protein LIN-70.017
abcf-2Protein ABCF-20.017
eya-1Protein EYA-10.017
let-756Protein LET-7560.017
zfp-3Protein ZFP-30.016
pdhb-1Protein PDHB-10.016
rpn-2Protein RPN-20.016
taf-6.1Protein TAF-6.10.016
tba-1Protein TBA-10.016
F46G10.1Protein F46G10.10.016
C35D10.7Protein C35D10.70.016
adr-1Protein ADR-10.016
mop-25.2Protein MOP-25.20.016
CELE_F56D5.6Protein F56D5.60.016
cyd-1Protein CYD-10.016
nuo-5Protein NUO-50.016
egl-15Protein EGL-150.016
sel-9Protein SEL-90.016
C28G1.5Protein C28G1.50.016
csn-4Protein CSN-40.016
abi-1Protein ABI-10.016
prp-8Protein PRP-80.016
chd-7Protein CHD-70.016
mex-5Protein MEX-50.016
ced-4Protein CED-40.016
gmeb-1Protein GMEB-10.016
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
skpACG16983 gene product from transcript CG16983-RD0.839
CG32581CG32581 gene product from transcript CG32581-RB0.171
cicubitus interruptus0.141
numbCG3779 gene product from transcript CG3779-RB0.140
Rac1CG2248 gene product from transcript CG2248-RA0.119
MadMothers against dpp0.100
pUf68poly U binding factor 68kD0.094
Rab11Rab-protein 110.081
CSN3COP9 complex homolog subunit 30.073
Hdac3Histone deacetylase 30.070
Cdk5Cyclin-dependent kinase 50.061
PtenCG5671 gene product from transcript CG5671-RB0.058
CSN4COP9 complex homolog subunit 40.057
His1:CG33813CG33813 gene product from transcript CG33813-RA0.056
idaimaginal discs arrested0.055
CSN8COP9 complex homolog subunit 80.055
sds22CG5851 gene product from transcript CG5851-RA0.054
His1:CG31617CG31617 gene product from transcript CG31617-RA0.054
CSN5COP9 complex homolog subunit 50.049
His1:CG33849CG33849 gene product from transcript CG33849-RA0.047
His1:CG33843CG33843 gene product from transcript CG33843-RA0.047
p53CG33336 gene product from transcript CG33336-RB0.047
His1:CG33801CG33801 gene product from transcript CG33801-RA0.046
jubAjuba LIM protein0.046
His1:CG33840CG33840 gene product from transcript CG33840-RA0.045
His1:CG33819CG33819 gene product from transcript CG33819-RA0.045
His1:CG33852CG33852 gene product from transcript CG33852-RA0.045
His1:CG33825CG33825 gene product from transcript CG33825-RA0.045
His1:CG33816CG33816 gene product from transcript CG33816-RA0.044
His1:CG33846CG33846 gene product from transcript CG33846-RA0.044
His1:CG33855CG33855 gene product from transcript CG33855-RA0.044
His1:CG33822CG33822 gene product from transcript CG33822-RA0.044
His1:CG33831CG33831 gene product from transcript CG33831-RA0.044
His1:CG33828CG33828 gene product from transcript CG33828-RA0.044
His1:CG33837CG33837 gene product from transcript CG33837-RA0.043
His1:CG33834CG33834 gene product from transcript CG33834-RA0.043
His1:CG33804CG33804 gene product from transcript CG33804-RA0.043
pashapartner of drosha0.042
G-oalpha47AG protein oalpha 47A0.042
His1:CG33807CG33807 gene product from transcript CG33807-RA0.042
His1:CG33861CG33861 gene product from transcript CG33861-RA0.042
CycCCyclin C0.041
His1:CG33858CG33858 gene product from transcript CG33858-RA0.041
CkIIalphaCasein kinase II alpha subunit0.040
His1:CG33810CG33810 gene product from transcript CG33810-RA0.040
His1:CG33864CG33864 gene product from transcript CG33864-RA0.040
Gienovel GTPase indispensable for equal segregation of chromosomes0.038
Ube3aUbiquitin protein ligase E3A0.038
gbbglass bottom boat0.036
Su(z)12CG8013 gene product from transcript CG8013-RA0.034
Vap-33-1CG5014 gene product from transcript CG5014-RB0.034
Cdk4Cyclin-dependent kinase 40.033
Pp2A-29BProtein phosphatase 2A at 29B0.032
Ras85DRas oncogene at 85D0.032
CycDCyclin D0.031
Eps-15Epidermal growth factor receptor pathway substrate clone 150.031
CG11985CG11985 gene product from transcript CG11985-RA0.030
CG9316CG9316 gene product from transcript CG9316-RA0.028
Prosbeta3Proteasome beta3 subunit0.028
EgfrEpidermal growth factor receptor0.028
ovoCG6824 gene product from transcript CG6824-RE0.028
alienCG9556 gene product from transcript CG9556-RB0.028
mib1mind bomb 10.027
UbcD2Ubiquitin conjugating enzyme 20.027
CG9425CG9425 gene product from transcript CG9425-RB0.026
RagACG11968 gene product from transcript CG11968-RA0.026
enokenoki mushroom0.026
14-3-3epsilonCG31196 gene product from transcript CG31196-RA0.025
l(3)01239lethal (3) 012390.025
l(1)10Bblethal (1) 10Bb0.024
l(1)G0007lethal (1) G00070.024
dltdiscs lost0.022
Su(H)Suppressor of Hairless0.021
PknProtein kinase related to protein kinase N0.020
CG33680CG33680 gene product from transcript CG33680-RA0.020
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 531.000
Mdm2transformed mouse 3T3 cell double minute 20.999
Ctnnb1catenin (cadherin associated protein), beta 10.997
Apcadenomatosis polyposis coli0.993
Ptenphosphatase and tensin homolog0.990
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.987
Shhsonic hedgehog0.979
Nf1neurofibromatosis 10.974
Fgfr1fibroblast growth factor receptor 10.912
Pbx1pre B-cell leukemia transcription factor 10.909
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.879
Mdm4transformed mouse 3T3 cell double minute 40.859
Bcl2B-cell leukemia/lymphoma 20.851
Id3inhibitor of DNA binding 30.817
Smad4MAD homolog 4 (Drosophila)0.813
Bmp4bone morphogenetic protein 40.727
Rnf2ring finger protein 20.722
Sox9SRY-box containing gene 90.707
Itgb1integrin beta 1 (fibronectin receptor beta)0.670
Axin1axin 10.645
Id1inhibitor of DNA binding 10.608
Ikzf1IKAROS family zinc finger 10.607
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.574
Lrrk2leucine-rich repeat kinase 20.530
BaxBCL2-associated X protein0.475
Kdm2blysine (K)-specific demethylase 2B0.451
Gps1G protein pathway suppressor 10.425
Pim1proviral integration site 10.423
BrafBraf transforming gene0.404
Cry2cryptochrome 2 (photolyase-like)0.399
Cul1cullin 10.397
Smad3MAD homolog 3 (Drosophila)0.389
DaxxFas death domain-associated protein0.378
Rb1retinoblastoma 10.363
Tcf4transcription factor 40.362
Fgfr2fibroblast growth factor receptor 20.355
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.339
Ptch1patched homolog 10.337
Gnai2guanine nucleotide binding protein (G protein), alpha inhibiting 20.331
Polr2apolymerase (RNA) II (DNA directed) polypeptide A0.325
Skp1aS-phase kinase-associated protein 1A0.324
Bmpr1abone morphogenetic protein receptor, type 1A0.318
Appamyloid beta (A4) precursor protein0.318
Prnpprion protein0.315
Kitlkit ligand0.315
Cbx5chromobox homolog 5 (Drosophila HP1a)0.313
Hand2heart and neural crest derivatives expressed transcript 20.311
Gsk3bglycogen synthase kinase 3 beta0.303
Gli3GLI-Kruppel family member GLI30.295
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.293
Msx1homeobox, msh-like 10.282
Smad6MAD homolog 6 (Drosophila)0.280
Prrx1paired related homeobox 10.279
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.278
Hbb-b1hemoglobin, beta adult major chain0.274
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.267
Hprthypoxanthine guanine phosphoribosyl transferase0.263
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.257
Ppp2caprotein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform0.250
Gli2GLI-Kruppel family member GLI20.248
Bmp7bone morphogenetic protein 70.242
Notch2Notch gene homolog 2 (Drosophila)0.239
Cd44CD44 antigen0.235
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.234
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.232
Dicer1Dicer1, Dcr-1 homolog (Drosophila)0.232
Rxraretinoid X receptor alpha0.227
Bmpr2bone morphogenic protein receptor, type II (serine/threonine kinase)0.219
Prkar1aprotein kinase, cAMP dependent regulatory, type I, alpha0.219
Rspo2R-spondin 2 homolog (Xenopus laevis)0.218
Hand1heart and neural crest derivatives expressed transcript 10.216
Cdkn2ccyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)0.216
ArhgdiaRho GDP dissociation inhibitor (GDI) alpha0.210
Tcf3transcription factor 30.205
Pkd2polycystic kidney disease 20.202
Nf2neurofibromatosis 20.201
Suds3suppressor of defective silencing 3 homolog (S. cerevisiae)0.201
Brca1breast cancer 10.192
Ywhahtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.182
Cdkn2acyclin-dependent kinase inhibitor 2A0.177
Tsc1tuberous sclerosis 10.174
Cdc42cell division cycle 42 homolog (S. cerevisiae)0.170
Tcf7l1transcription factor 7-like 1 (T-cell specific, HMG box)0.169
Rac1RAS-related C3 botulinum substrate 10.167
Hoxd13homeobox D130.166
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.164
Bak1BCL2-antagonist/killer 10.161
PycardPYD and CARD domain containing0.161
Trp63transformation related protein 630.160
Fgf8fibroblast growth factor 80.159
Pim3proviral integration site 30.155
Per1period homolog 1 (Drosophila)0.153
Cdkn1bcyclin-dependent kinase inhibitor 1B0.150
Kitkit oncogene0.148
Cbfa2t3core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)0.147
Thbs1thrombospondin 10.145
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
LOC100359498ribosomal protein L35a-like0.082
Rpl10aribosomal protein L10A0.078
Rpl3ribosomal protein L30.047
Hspe1heat shock protein 1 (chaperonin 10)0.036
Rps17ribosomal protein S170.029
Prmt1protein arginine methyltransferase 10.026
Rpl28ribosomal protein L280.019
Rpl5ribosomal protein L50.015
Rnf4ring finger protein 40.014
Arf4ADP-ribosylation factor 40.013
Atp5j2ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F20.012
Rpl36aribosomal protein L36a0.011
RGD1307752similar to RIKEN cDNA 1110008F130.011
Copb1coatomer protein complex, subunit beta 10.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism