The network for 'cholesterol efflux' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cholesterol efflux

The directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.

NameDescriptionProbabilityFunc Analog Organism
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.959
NFKBIBnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta0.757
APOA1apolipoprotein A-I0.746
C1QAcomplement component 1, q subcomponent, A chain0.612
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.527
IRAK2interleukin-1 receptor-associated kinase 20.456
MED15mediator complex subunit 150.443
APOEapolipoprotein E0.410
TNIP2TNFAIP3 interacting protein 20.390
ABCA1ATP-binding cassette, sub-family A (ABC1), member 10.286
APOC1apolipoprotein C-I0.212
RRAGCRas-related GTP binding C0.211
C1QBcomplement component 1, q subcomponent, B chain0.179
STX12syntaxin 120.177
SNTB2syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)0.176
APBB1amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)0.129
PELI3pellino homolog 3 (Drosophila)0.115
SMOsmoothened homolog (Drosophila)0.112
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.085
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.073
RRAGARas-related GTP binding A0.065
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.061
C1QCcomplement component 1, q subcomponent, C chain0.057
APOA2apolipoprotein A-II0.055
NFKBIEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.051
NCOA1nuclear receptor coactivator 10.049
C7orf59chromosome 7 open reading frame 590.048
LSSlanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)0.045
SMPD1sphingomyelin phosphodiesterase 1, acid lysosomal0.044
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.044
SNX3sorting nexin 30.039
CREBBPCREB binding protein0.039
APOC2apolipoprotein C-II0.039
NSFN-ethylmaleimide-sensitive factor0.038
MSTO1misato homolog 1 (Drosophila)0.038
LCATlecithin-cholesterol acyltransferase0.035
APOBapolipoprotein B (including Ag(x) antigen)0.033
CACNA1Acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit0.032
ANXA4annexin A40.030
TRIM11tripartite motif containing 110.029
DHCR77-dehydrocholesterol reductase0.029
VAMP4vesicle-associated membrane protein 40.026
FOXO3forkhead box O30.025
SCDstearoyl-CoA desaturase (delta-9-desaturase)0.025
LDLRlow density lipoprotein receptor0.022
FCN2ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)0.022
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.021
GPNMBglycoprotein (transmembrane) nmb0.021
OSTM1osteopetrosis associated transmembrane protein 10.020
INSIG1insulin induced gene 10.019
SIGLEC1sialic acid binding Ig-like lectin 1, sialoadhesin0.019
MBL2mannose-binding lectin (protein C) 2, soluble0.019
APOC3apolipoprotein C-III0.018
VAMP8vesicle-associated membrane protein 8 (endobrevin)0.018
CHUKconserved helix-loop-helix ubiquitous kinase0.017
ASAH1N-acylsphingosine amidohydrolase (acid ceramidase) 10.017
PLTPphospholipid transfer protein0.016
TREM2triggering receptor expressed on myeloid cells 20.015
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.015
FASNfatty acid synthase0.015
CCPG1cell cycle progression 10.014
SREBF1sterol regulatory element binding transcription factor 10.014
LAMP2lysosomal-associated membrane protein 20.014
SOCS3suppressor of cytokine signaling 30.014
PRCPprolylcarboxypeptidase (angiotensinase C)0.014
ATP6V1B2ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B20.013
HEXBhexosaminidase B (beta polypeptide)0.013
MVDmevalonate (diphospho) decarboxylase0.013
CREBL2cAMP responsive element binding protein-like 20.013
LIPClipase, hepatic0.013
STX6syntaxin 60.013
ARL6IP5ADP-ribosylation-like factor 6 interacting protein 50.013
CRPC-reactive protein, pentraxin-related0.012
LAMTOR3late endosomal/lysosomal adaptor, MAPK and MTOR activator 30.012
KAT2BK(lysine) acetyltransferase 2B0.012
DUSP23dual specificity phosphatase 230.012
RRAGDRas-related GTP binding D0.012
CSTBcystatin B (stefin B)0.012
PDCD4programmed cell death 4 (neoplastic transformation inhibitor)0.012
C4Bcomplement component 4B (Chido blood group)0.012
HPD4-hydroxyphenylpyruvate dioxygenase0.011
FADS1fatty acid desaturase 10.011
GPLD1glycosylphosphatidylinositol specific phospholipase D10.011
SWAP70SWAP switching B-cell complex 70kDa subunit0.011
SLCO2B1solute carrier organic anion transporter family, member 2B10.011
KAT5K(lysine) acetyltransferase 50.011
SCARB1scavenger receptor class B, member 10.011
BRI3brain protein I30.011
GPR137BG protein-coupled receptor 137B0.011
RAD52RAD52 homolog (S. cerevisiae)0.011
RRP8ribosomal RNA processing 8, methyltransferase, homolog (yeast)0.010
UBL3ubiquitin-like 30.010
MFSD1major facilitator superfamily domain containing 10.010
MVKmevalonate kinase0.010
ACP5acid phosphatase 5, tartrate resistant0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Apoeapolipoprotein E0.997
Abca1ATP-binding cassette, sub-family A (ABC1), member 10.988
Npc1Niemann Pick type C10.975
Apoa1apolipoprotein A-I0.943
Ptenphosphatase and tensin homolog0.887
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.879
Traf6TNF receptor-associated factor 60.874
Kiss1KiSS-1 metastasis-suppressor0.437
Lrp1low density lipoprotein receptor-related protein 10.396
Ldlrlow density lipoprotein receptor0.313
Abcg5ATP-binding cassette, sub-family G (WHITE), member 50.250
Fgfr2fibroblast growth factor receptor 20.239
Ghrgrowth hormone receptor0.235
Abcg8ATP-binding cassette, sub-family G (WHITE), member 80.216
Tbx3T-box 30.209
Abcg1ATP-binding cassette, sub-family G (WHITE), member 10.190
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.178
Rdh8retinol dehydrogenase 80.170
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.160
Myd88myeloid differentiation primary response gene 880.151
Hnf4ahepatic nuclear factor 4, alpha0.149
Apobapolipoprotein B0.146
Gpr116G protein-coupled receptor 1160.132
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.127
Mapk8ip1mitogen-activated protein kinase 8 interacting protein 10.099
Nr0b2nuclear receptor subfamily 0, group B, member 20.083
Cav1caveolin 1, caveolae protein0.082
C3complement component 30.081
Serpinf2serine (or cysteine) peptidase inhibitor, clade F, member 20.080
Ppargperoxisome proliferator activated receptor gamma0.074
Aldobaldolase B, fructose-bisphosphate0.072
Nr5a1nuclear receptor subfamily 5, group A, member 10.072
Lyz2lysozyme 20.069
Foxa2forkhead box A20.066
Nr1h3nuclear receptor subfamily 1, group H, member 30.060
Clockcircadian locomotor output cycles kaput0.059
Zeb1zinc finger E-box binding homeobox 10.055
Pick1protein interacting with C kinase 10.055
Apoa2apolipoprotein A-II0.053
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.052
Fggfibrinogen gamma chain0.050
Cfhcomplement component factor h0.049
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.048
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.048
Atp4aATPase, H+/K+ exchanging, gastric, alpha polypeptide0.048
Klf15Kruppel-like factor 150.047
Lrp6low density lipoprotein receptor-related protein 60.046
Peli2pellino 20.046
Lpllipoprotein lipase0.045
Pltpphospholipid transfer protein0.044
Apoc3apolipoprotein C-III0.042
Fgfr3fibroblast growth factor receptor 30.042
Fabp2fatty acid binding protein 2, intestinal0.040
Stat3signal transducer and activator of transcription 30.040
IhhIndian hedgehog0.040
Pzppregnancy zone protein0.040
Slc12a6solute carrier family 12, member 60.040
Mertkc-mer proto-oncogene tyrosine kinase0.040
Arandrogen receptor0.040
Lrp5low density lipoprotein receptor-related protein 50.039
Dhcr77-dehydrocholesterol reductase0.038
Aqp8aquaporin 80.038
Hoxd10homeobox D100.036
Fbp2fructose bisphosphatase 20.035
Hgdhomogentisate 1, 2-dioxygenase0.034
Slc22a1solute carrier family 22 (organic cation transporter), member 10.034
Lgals2lectin, galactose-binding, soluble 20.034
Cdhr5cadherin-related family member 50.033
Hpd4-hydroxyphenylpyruvic acid dioxygenase0.033
Slc22a2solute carrier family 22 (organic cation transporter), member 20.033
Amhr2anti-Mullerian hormone type 2 receptor0.032
Irak4interleukin-1 receptor-associated kinase 40.032
Arntlaryl hydrocarbon receptor nuclear translocator-like0.031
Ctrb1chymotrypsinogen B10.031
Mogat2monoacylglycerol O-acyltransferase 20.031
Ctnnb1catenin (cadherin associated protein), beta 10.030
Spp2secreted phosphoprotein 20.030
Pcyt1aphosphate cytidylyltransferase 1, choline, alpha isoform0.030
Slc7a9solute carrier family 7 (cationic amino acid transporter, y+ system), member 90.030
Gsk3bglycogen synthase kinase 3 beta0.029
Hand1heart and neural crest derivatives expressed transcript 10.029
Hgfachepatocyte growth factor activator0.029
Col4a4collagen, type IV, alpha 40.029
Otx2orthodenticle homolog 2 (Drosophila)0.029
Slc4a1solute carrier family 4 (anion exchanger), member 10.028
Notch2Notch gene homolog 2 (Drosophila)0.028
Gnrh1gonadotropin releasing hormone 10.027
Srfserum response factor0.027
Lrp2low density lipoprotein receptor-related protein 20.026
Ambpalpha 1 microglobulin/bikunin0.026
Timd2T-cell immunoglobulin and mucin domain containing 20.026
Fgbfibrinogen beta chain0.026
Gli3GLI-Kruppel family member GLI30.026
Cficomplement component factor i0.025
Rab11aRAB11a, member RAS oncogene family0.025
Aspdhaspartate dehydrogenase domain containing0.025
Gata4GATA binding protein 40.024
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cav1caveolin 1, caveolae protein0.896
LOC100362824caveolin 2-like0.892
Cav2caveolin 20.545
Zfp36zinc finger protein 360.151
Ehd2EH-domain containing 20.064
Sdprserum deprivation response0.053
Errfi1ERBB receptor feedback inhibitor 10.050
Emp1epithelial membrane protein 10.045
Cd9CD9 molecule0.029
Pmp22peripheral myelin protein 220.019
Sgk1serum/glucocorticoid regulated kinase 10.018
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.017
Btg2BTG family, member 20.015
Ddit4DNA-damage-inducible transcript 40.014
Nedd4neural precursor cell expressed, developmentally down-regulated 40.012
Cxcr7chemokine (C-X-C motif) receptor 70.011
Gpr116G protein-coupled receptor 1160.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism