The network for 'modification of morphology or physiology of other organism' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

modification of morphology or physiology of other organism

The process in which an organism effects a change in the structure or processes of a second organism.

NameDescriptionProbabilityFunc Analog Organism
SP1Sp1 transcription factor0.999
BCL2B-cell CLL/lymphoma 20.994
SMAD3SMAD family member 30.990
BCL2L1BCL2-like 10.985
IL8interleukin 80.981
RARAretinoic acid receptor, alpha0.963
SMAD7SMAD family member 70.960
SMAD2SMAD family member 20.947
GABPAGA binding protein transcription factor, alpha subunit 60kDa0.868
CXCL2chemokine (C-X-C motif) ligand 20.845
CXCL3chemokine (C-X-C motif) ligand 30.833
JUNjun proto-oncogene0.815
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.780
CCR5chemokine (C-C motif) receptor 50.762
NOSTRINnitric oxide synthase trafficker0.754
ESR1estrogen receptor 10.709
RRAGCRas-related GTP binding C0.704
SMARCD1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 10.703
BAXBCL2-associated X protein0.676
BCL2L11BCL2-like 11 (apoptosis facilitator)0.629
NCOA1nuclear receptor coactivator 10.613
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.576
SOX10SRY (sex determining region Y)-box 100.513
PTPN1protein tyrosine phosphatase, non-receptor type 10.488
CREBBPCREB binding protein0.448
HMGA1high mobility group AT-hook 10.440
FOSFBJ murine osteosarcoma viral oncogene homolog0.426
HCFC1host cell factor C1 (VP16-accessory protein)0.416
NCOR1nuclear receptor corepressor 10.415
IL6interleukin 6 (interferon, beta 2)0.414
CCL2chemokine (C-C motif) ligand 20.414
CCL4chemokine (C-C motif) ligand 40.407
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.405
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.398
ARandrogen receptor0.373
RPS6KA5ribosomal protein S6 kinase, 90kDa, polypeptide 50.334
SMURF2SMAD specific E3 ubiquitin protein ligase 20.328
SIN3ASIN3 homolog A, transcription regulator (yeast)0.304
MED25mediator complex subunit 250.302
RXRAretinoid X receptor, alpha0.287
IL1Binterleukin 1, beta0.286
SKILSKI-like oncogene0.284
ANGangiogenin, ribonuclease, RNase A family, 50.245
SMARCE1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 10.242
CCL8chemokine (C-C motif) ligand 80.216
RNASE4ribonuclease, RNase A family, 40.213
CXCL6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.211
WWP2WW domain containing E3 ubiquitin protein ligase 20.198
ARID1BAT rich interactive domain 1B (SWI1-like)0.194
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.184
FOXD3forkhead box D30.144
DPP4dipeptidyl-peptidase 40.142
CXCL9chemokine (C-X-C motif) ligand 90.137
EP300E1A binding protein p3000.130
ATF3activating transcription factor 30.130
SMAD1SMAD family member 10.123
CCL3chemokine (C-C motif) ligand 30.123
IRS1insulin receptor substrate 10.122
CXCL5chemokine (C-X-C motif) ligand 50.118
CCL13chemokine (C-C motif) ligand 130.116
FCN2ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)0.115
BADBCL2-associated agonist of cell death0.114
CXCL10chemokine (C-X-C motif) ligand 100.112
SS18synovial sarcoma translocation, chromosome 180.111
KDM6Alysine (K)-specific demethylase 6A0.106
YY1YY1 transcription factor0.106
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.105
PMAIP1phorbol-12-myristate-13-acetate-induced protein 10.100
CCR7chemokine (C-C motif) receptor 70.098
SOX2SRY (sex determining region Y)-box 20.097
JUNBjun B proto-oncogene0.094
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.093
SFPQsplicing factor proline/glutamine-rich0.091
ARID2AT rich interactive domain 2 (ARID, RFX-like)0.090
TGFB1transforming growth factor, beta 10.090
RBBP4retinoblastoma binding protein 40.089
LAMTOR1late endosomal/lysosomal adaptor, MAPK and MTOR activator 10.086
SPOPspeckle-type POZ protein0.084
SMAD5SMAD family member 50.083
SREBF2sterol regulatory element binding transcription factor 20.082
TCF4transcription factor 40.082
BAK1BCL2-antagonist/killer 10.077
PROX1prospero homeobox 10.077
LATlinker for activation of T cells0.075
RRAGDRas-related GTP binding D0.074
CCL19chemokine (C-C motif) ligand 190.074
CCL20chemokine (C-C motif) ligand 200.073
SKIv-ski sarcoma viral oncogene homolog (avian)0.071
CAV1caveolin 1, caveolae protein, 22kDa0.069
NCOR2nuclear receptor corepressor 20.068
SMAD4SMAD family member 40.067
RAB6ARAB6A, member RAS oncogene family0.067
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.067
TOP1topoisomerase (DNA) I0.066
GRB10growth factor receptor-bound protein 100.065
TNFtumor necrosis factor0.065
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
smp-1Protein SMP-10.028
nhr-32Protein NHR-320.025
unc-37Protein UNC-370.019
CELE_B0285.3Protein B0285.30.019
nhr-122Protein NHR-1220.017
R186.7Protein R186.70.016
nhr-109Protein NHR-1090.016
tag-51Protein TAG-510.015
bath-36Protein BATH-360.015
bar-1Protein BAR-10.014
pept-3Protein PEPT-30.014
vhp-1Protein VHP-10.014
btb-9Protein BTB-90.013
T13H5.4Protein T13H5.40.013
mdf-1Protein MDF-10.013
brp-1Protein BRP-10.013
egl-18Protein EGL-180.013
lin-35Protein LIN-350.012
dnc-4Protein DNC-40.012
zfp-1Protein ZFP-10.012
hmg-4Protein HMG-40.012
bath-38Protein BATH-380.012
cec-5Protein CEC-50.012
lsy-22Protein LSY-220.012
apb-3Protein APB-30.011
atg-2Protein ATG-20.011
T20B12.7Protein T20B12.70.011
CELE_F54D5.5Protein F54D5.50.011
elt-2Protein ELT-20.011
cpna-1Protein CPNA-10.011
F12F6.1Protein F12F6.10.011
kle-2Protein KLE-20.011
unc-43Protein UNC-430.011
cfim-2Protein CFIM-20.011
dph-1Protein DPH-10.011
aex-5Protein AEX-50.010
nhr-49Protein NHR-490.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
tp53tumor protein p530.223
mmp13amatrix metalloproteinase 13a0.074
pcsk5aproprotein convertase subtilisin/kexin type 5a0.070
vdravitamin D receptor a0.058
lamc1laminin, gamma 10.052
trim13tripartite motif-containing 130.052
shmt2serine hydroxymethyltransferase 2 (mitochondrial)0.048
epas1bendothelial PAS domain protein 1b0.047
tgfbr2transforming growth factor, beta receptor II0.046
ext1bexostoses (multiple) 1b0.046
sfpqsplicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)0.044
mcl1amyeloid cell leukemia sequence 1a0.044
mychmyelocytomatosis oncogene homolog0.043
axin1axin 10.043
tcf12transcription factor 120.043
ywhaqbtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b0.039
hhiphedgehog interacting protein0.038
mcl1bmyeloid cell leukemia sequence 1b0.038
mibmind bomb0.034
prpf8pre-mRNA processing factor 80.034
hnrnpabheterogeneous nuclear ribonucleoprotein A/B0.034
wlswntless homolog (Drosophila)0.033
spry4sprouty (Drosophila) homolog 40.033
hes6hairy and enhancer of split 6 (Drosophila)0.032
mknk2bMAP kinase-interacting serine/threonine kinase 2b0.032
srsf2serine/arginine-rich splicing factor 20.032
cxcr4bchemokine (C-X-C motif), receptor 4b0.032
itgavintegrin, alpha V0.031
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.031
mdm2transformed 3T3 cell double minute 2 homolog (mouse)0.030
bmp1abone morphogenetic protein 1a0.029
epb41l5erythrocyte membrane protein band 4.1 like 50.029
pacsin3protein kinase C and casein kinase substrate in neurons 30.029
lama1laminin, alpha 10.029
baxabcl2-associated X protein, a0.028
gnb1aguanine nucleotide binding protein (G protein), beta polypeptide 1a0.028
ewsr1aEwing sarcoma breakpoint region 1a0.028
her11hairy-related 110.028
bcl2B-cell leukemia/lymphoma 20.027
ptp4a3protein tyrosine phosphatase type IVA, member 30.027
alcamaactivated leukocyte cell adhesion molecule a0.027
lhx2bLIM homeobox 2b0.027
tfe3atranscription factor binding to IGHM enhancer 3a0.026
slc2a11lsolute carrier family 2 (facilitated glucose transporter), member 11-like0.026
kdrlkinase insert domain receptor like0.026
LOC567131calcitonin gene-related peptide type 1 receptor-like0.026
gadd45aagrowth arrest and DNA-damage-inducible, alpha, a0.025
ldb1aLIM-domain binding factor 1a0.025
cd209CD209 molecule0.025
igf1rbinsulin-like growth factor 1b receptor0.025
pyyapeptide YYa0.025
lamb2laminin, beta 2 (laminin S)0.025
ccng1cyclin G10.024
appaamyloid beta (A4) precursor protein a0.024
cldn15laclaudin 15-like a0.024
kcnh2potassium voltage-gated channel, subfamily H (eag-related), member 20.024
rnd1lRho family GTPase 1 like0.024
tob1atransducer of ERBB2, 1a0.023
insrbinsulin receptor b0.023
rbfox2RNA binding protein, fox-1 homolog (C. elegans) 20.023
cdk7cyclin-dependent kinase 70.023
lass2LAG1 homolog, ceramide synthase 2 (S. cerevisiae)0.023
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.023
slc7a6ossolute carrier family 7, member 6 opposite strand0.023
mef2camyocyte enhancer factor 2ca0.022
faddFas (tnfrsf6)-associated via death domain0.022
gpr126G protein-coupled receptor 1260.022
hdac4histone deacetylase 40.022
adipor2adiponectin receptor 20.022
krml2.2Kreisler (mouse) maf-related leucine zipper homolog 2.20.022
yes1v-yes-1 Yamaguchi sarcoma viral oncogene homolog 10.022
slc25a14solute carrier family 25 (mitochondrial carrier, brain), member 140.022
wt1bwilms tumor 1b0.022
rargaretinoic acid receptor gamma a0.021
cflarCASP8 and FADD-like apoptosis regulator0.021
nfe2l2nuclear factor (erythroid-derived 2)-like 20.021
tardbpTAR DNA binding protein0.021
ripk2receptor-interacting serine-threonine kinase 20.021
ptpraprotein tyrosine phosphatase, receptor type, A0.021
dhx15DEAH (Asp-Glu-Ala-His) box polypeptide 150.021
slc12a2solute carrier family 12 (potassium/chloride transporters), member 20.021
snrnp70small nuclear ribonucleoprotein 70 (U1)0.021
ddx6DEAD (Asp-Glu-Ala-Asp) box polypeptide 60.021
npy8arneuropeptide Y receptor Y8a0.021
mical3flavoprotein oxidoreductase MICAL30.021
mapk3mitogen-activated protein kinase 30.020
trim3atripartite motif-containing 3a0.020
atp2b4ATPase, Ca++ transporting, plasma membrane 40.020
fzd7bfrizzled homolog 7b0.020
tjp2btight junction protein 2b (zona occludens 2)0.020
tspan3atetraspanin 3a0.020
wnt3awingless-type MMTV integration site family, member 3A0.020
ilf3binterleukin enhancer binding factor 3b0.020
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Rpb11CG6840 gene product from transcript CG6840-RA0.019
LSm7CG13277 gene product from transcript CG13277-RA0.012
E2f2E2F transcription factor 20.012
Cbp20cap binding protein 200.011
RpL19Ribosomal protein L190.011
RpL9Ribosomal protein L90.011
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Smarcc1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.969
Ccl2chemokine (C-C motif) ligand 20.948
Nos2nitric oxide synthase 2, inducible0.852
Ctsgcathepsin G0.651
Ccr2chemokine (C-C motif) receptor 20.632
Tgfb1transforming growth factor, beta 10.568
Ngpneutrophilic granule protein0.563
Trp53transformation related protein 530.498
Ifnginterferon gamma0.450
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.441
S100a9S100 calcium binding protein A9 (calgranulin B)0.431
Cd44CD44 antigen0.429
Cxcl2chemokine (C-X-C motif) ligand 20.413
Ccl4chemokine (C-C motif) ligand 40.330
S100a8S100 calcium binding protein A8 (calgranulin A)0.328
Tlr4toll-like receptor 40.326
FaslFas ligand (TNF superfamily, member 6)0.305
Csf3rcolony stimulating factor 3 receptor (granulocyte)0.301
Il10interleukin 100.289
Cd8aCD8 antigen, alpha chain0.270
Campcathelicidin antimicrobial peptide0.225
Ccl3chemokine (C-C motif) ligand 30.219
Il6interleukin 60.219
Mmp8matrix metallopeptidase 80.215
Irg1immunoresponsive gene 10.185
Socs1suppressor of cytokine signaling 10.148
Il1rninterleukin 1 receptor antagonist0.144
Clec4dC-type lectin domain family 4, member d0.143
Tlr2toll-like receptor 20.142
Ccl7chemokine (C-C motif) ligand 70.141
C5ar1complement component 5a receptor 10.130
Bcl2B-cell leukemia/lymphoma 20.128
Tnfaip3tumor necrosis factor, alpha-induced protein 30.122
Arid1aAT rich interactive domain 1A (SWI-like)0.121
Slpisecretory leukocyte peptidase inhibitor0.120
Ccr5chemokine (C-C motif) receptor 50.119
Myd88myeloid differentiation primary response gene 880.117
Prg2proteoglycan 2, bone marrow0.110
Mmp9matrix metallopeptidase 90.096
Csf1colony stimulating factor 1 (macrophage)0.095
Slfn4schlafen 40.091
Il18rapinterleukin 18 receptor accessory protein0.090
Cpa3carboxypeptidase A3, mast cell0.085
Tnfaip2tumor necrosis factor, alpha-induced protein 20.083
Atf3activating transcription factor 30.082
Cxcr2chemokine (C-X-C motif) receptor 20.080
Selpselectin, platelet0.080
Ccl22chemokine (C-C motif) ligand 220.079
Vdrvitamin D receptor0.073
Il2rbinterleukin 2 receptor, beta chain0.070
Tbxas1thromboxane A synthase 1, platelet0.067
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.066
Ptgs2prostaglandin-endoperoxide synthase 20.066
Siglec1sialic acid binding Ig-like lectin 1, sialoadhesin0.066
Tcf7transcription factor 7, T-cell specific0.062
Ubdubiquitin D0.061
Cxcl1chemokine (C-X-C motif) ligand 10.059
Ifitm6interferon induced transmembrane protein 60.059
Akr1c6aldo-keto reductase family 1, member C60.058
Slfn1schlafen 10.057
Csf2colony stimulating factor 2 (granulocyte-macrophage)0.056
Trem3triggering receptor expressed on myeloid cells 30.055
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.053
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.053
Clec4eC-type lectin domain family 4, member e0.052
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.052
Ncr1natural cytotoxicity triggering receptor 10.052
Tnftumor necrosis factor0.050
Nkg7natural killer cell group 7 sequence0.050
Batfbasic leucine zipper transcription factor, ATF-like0.049
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.049
Cd14CD14 antigen0.049
Elaneelastase, neutrophil expressed0.049
Tgfbr2transforming growth factor, beta receptor II0.049
Icam1intercellular adhesion molecule 10.047
Pdcd1programmed cell death 10.045
Ccl12chemokine (C-C motif) ligand 120.044
Gzmbgranzyme B0.043
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.043
Fcgr1Fc receptor, IgG, high affinity I0.041
Chi3l1chitinase 3-like 10.040
Cd33CD33 antigen0.040
Cma1chymase 1, mast cell0.040
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.040
Rtp4receptor transporter protein 40.040
Ube2l6ubiquitin-conjugating enzyme E2L 60.039
Sp1trans-acting transcription factor 10.039
Niacr1niacin receptor 10.039
Pax2paired box gene 20.038
Fpr1formyl peptide receptor 10.038
Gpr84G protein-coupled receptor 840.037
Gzmfgranzyme F0.037
Elavl1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.036
Soat2sterol O-acyltransferase 20.036
Ppargperoxisome proliferator activated receptor gamma0.036
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.036
Mapk3mitogen-activated protein kinase 30.036
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Mmp13matrix metallopeptidase 130.025
Stat6signal transducer and activator of transcription 60.019
Klrd1killer cell lectin-like receptor, subfamily D, member 10.018
Fosl1fos-like antigen 10.017
FosFBJ osteosarcoma oncogene0.012
Il1ainterleukin 1 alpha0.011
Mmp3matrix metallopeptidase 30.010
Atf3activating transcription factor 30.010
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism