The network for 'signal transduction by p53 class mediator' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

signal transduction by p53 class mediator

An intracellular signaling process that is induced by the cell cycle regulator phosphoprotein p53 or an equivalent protein.

NameDescriptionProbabilityFunc Analog Organism
BCL2B-cell CLL/lymphoma 20.982
TP53tumor protein p530.977
BRCA1breast cancer 1, early onset0.968
EP300E1A binding protein p3000.951
RB1retinoblastoma 10.926
CHEK2CHK2 checkpoint homolog (S. pombe)0.829
XIAPX-linked inhibitor of apoptosis0.793
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.754
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.750
BAXBCL2-associated X protein0.647
HIPK2homeodomain interacting protein kinase 20.582
PPP2R5Cprotein phosphatase 2, regulatory subunit B', gamma0.575
MDM2Mdm2 p53 binding protein homolog (mouse)0.553
CASP8caspase 8, apoptosis-related cysteine peptidase0.510
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.475
SIRT1sirtuin 10.403
BCL2L11BCL2-like 11 (apoptosis facilitator)0.398
USP7ubiquitin specific peptidase 7 (herpes virus-associated)0.384
CASP3caspase 3, apoptosis-related cysteine peptidase0.356
ESR1estrogen receptor 10.349
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.328
MAPK14mitogen-activated protein kinase 140.315
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.313
NBNnibrin0.284
MAPK1mitogen-activated protein kinase 10.277
TNIP1TNFAIP3 interacting protein 10.265
WRNWerner syndrome, RecQ helicase-like0.251
CDC5LCDC5 cell division cycle 5-like (S. pombe)0.251
HDAC1histone deacetylase 10.244
SIN3ASIN3 homolog A, transcription regulator (yeast)0.226
CASP2caspase 2, apoptosis-related cysteine peptidase0.218
ATMataxia telangiectasia mutated0.217
PARP1poly (ADP-ribose) polymerase 10.214
SETD7SET domain containing (lysine methyltransferase) 70.210
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.203
OTUB1OTU domain, ubiquitin aldehyde binding 10.198
DAXXdeath-domain associated protein0.190
PPP2R5Aprotein phosphatase 2, regulatory subunit B', alpha0.182
NLRC4NLR family, CARD domain containing 40.182
BCAS2breast carcinoma amplified sequence 20.181
CHEK1CHK1 checkpoint homolog (S. pombe)0.177
CCND3cyclin D30.175
TWIST1twist homolog 1 (Drosophila)0.173
SUMO1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)0.171
CTAG1Bcancer/testis antigen 1B0.171
RPS27ribosomal protein S270.158
CDK2cyclin-dependent kinase 20.157
PMLpromyelocytic leukemia0.141
PAX3paired box 30.140
CASP4caspase 4, apoptosis-related cysteine peptidase0.138
PPP2R1Bprotein phosphatase 2, regulatory subunit A, beta0.136
POU3F2POU class 3 homeobox 20.135
CREBBPCREB binding protein0.134
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.130
NAP1L5nucleosome assembly protein 1-like 50.127
CRADDCASP2 and RIPK1 domain containing adaptor with death domain0.127
DHX9DEAH (Asp-Glu-Ala-His) box polypeptide 90.127
RIN1Ras and Rab interactor 10.126
MAGEA3melanoma antigen family A, 30.124
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.123
DDAH2dimethylarginine dimethylaminohydrolase 20.118
PLK1polo-like kinase 10.114
RUNX1runt-related transcription factor 10.114
NSMCE4Anon-SMC element 4 homolog A (S. cerevisiae)0.114
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.114
IER3immediate early response 30.111
APAF1apoptotic peptidase activating factor 10.107
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.106
DYRK1Adual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A0.105
UHRF2ubiquitin-like with PHD and ring finger domains 20.104
STX5syntaxin 50.104
MYH7Bmyosin, heavy chain 7B, cardiac muscle, beta0.098
PPP2R2Aprotein phosphatase 2, regulatory subunit B, alpha0.097
PSMD2proteasome (prosome, macropain) 26S subunit, non-ATPase, 20.094
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.093
HNRNPMheterogeneous nuclear ribonucleoprotein M0.092
CDT1chromatin licensing and DNA replication factor 10.092
GSK3Bglycogen synthase kinase 3 beta0.092
PPP2R1Aprotein phosphatase 2, regulatory subunit A, alpha0.090
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.088
FASFas (TNF receptor superfamily, member 6)0.087
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.085
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.085
TEKT4tektin 40.083
PPM1Dprotein phosphatase, Mg2+/Mn2+ dependent, 1D0.081
SETD8SET domain containing (lysine methyltransferase) 80.080
MSNmoesin0.080
KAT2BK(lysine) acetyltransferase 2B0.077
HNRNPKheterogeneous nuclear ribonucleoprotein K0.076
E2F1E2F transcription factor 10.073
PPP1CAprotein phosphatase 1, catalytic subunit, alpha isozyme0.073
CFLARCASP8 and FADD-like apoptosis regulator0.073
MSH6mutS homolog 6 (E. coli)0.070
PRKDCprotein kinase, DNA-activated, catalytic polypeptide0.069
LNX1ligand of numb-protein X 10.067
EGR1early growth response 10.066
TNIP2TNFAIP3 interacting protein 20.066
EID2EP300 interacting inhibitor of differentiation 20.065
HNRNPUL1heterogeneous nuclear ribonucleoprotein U-like 10.064
LIMD1LIM domains containing 10.064
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
spc24SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)0.094
zgc:65861zgc:658610.089
gins2GINS complex subunit 20.082
tp53tumor protein p530.078
nolc1nucleolar and coiled-body phosphoprotein 10.069
krt4keratin 40.067
nrp2bneuropilin 2b0.061
smad7MAD, mothers against decapentaplegic homolog 7 (Drosophila)0.060
pola2polymerase (DNA directed), alpha 20.056
surf6surfeit 60.050
ccng1cyclin G10.047
prmt1protein arginine methyltransferase 10.044
dnmt5DNA (cytosine-5-)-methyltransferase 50.044
LOC100536647disintegrin and metalloproteinase domain-containing protein 10-like0.043
ppp4caprotein phosphatase 4 (formerly X), catalytic subunit a0.043
si:dkeyp-50f5.1si:dkeyp-50f5.10.042
bnip3lbBCL2/adenovirus E1B interacting protein 3-like b0.042
irf6interferon regulatory factor 60.040
wlswntless homolog (Drosophila)0.038
zgc:73328zgc:733280.038
smc3structural maintenance of chromosomes 30.038
thoc3THO complex 30.037
tfap2ctranscription factor AP-2 gamma (activating enhancer binding protein 2 gamma)0.036
chek1CHK1 checkpoint homolog (S. pombe)0.036
fstafollistatin a0.035
sema3aasemaphorin 3aa0.034
hugHuG0.033
rnf7ring finger protein 70.033
bcl2l1bcl2-like 10.033
rp2retinitis pigmentosa 2 (X-linked recessive)0.031
eaf2ELL associated factor 20.030
brip1BRCA1 interacting protein C-terminal helicase 10.030
dnajb12DnaJ (Hsp40) homolog, subfamily B, member 120.030
zgc:101661zgc:1016610.029
ogt.2O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) 20.029
card9caspase recruitment domain family, member 90.028
nr3c1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.028
lin7clin-7 homolog C (C. elegans)0.027
mifmacrophage migration inhibitory factor0.026
pds5bPDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)0.026
celf1cugbp, Elav-like family member 10.025
znf703zinc finger protein 7030.025
rnf144abring finger protein 144ab0.025
cdc45CDC45 cell division cycle 45 homolog (S. cerevisiae)0.024
odc1ornithine decarboxylase 10.024
sf3b1splicing factor 3b, subunit 10.024
uspl1ubiquitin specific peptidase like 10.024
vax2ventral anterior homeobox 20.024
gscgoosecoid0.024
si:dkey-77a20.7si:dkey-77a20.70.023
vsx2visual system homeobox 20.023
ccnl1cyclin L10.022
fanciFanconi anemia, complementation group I0.022
hif1anhypoxia-inducible factor 1, alpha subunit inhibitor0.022
pld1aphospholipase D1a0.022
foxi2forkhead box I20.021
rps6kalribosomal protein S6 kinase, like0.021
rbm39aRNA binding motif protein 39a0.021
prmt5protein arginine methyltransferase 50.021
timm13translocase of inner mitochondrial membrane 13 homolog (yeast)0.021
zgc:111944zgc:1119440.021
zgc:92321zgc:923210.021
kif14kinesin family member 140.021
cdh1cadherin 1, epithelial0.020
ankrd13cankyrin repeat domain 13C0.020
chic2cysteine-rich hydrophobic domain 20.020
eif2s1leukaryotic translation initiation factor 2, subunit 1 alpha, like0.020
sass6spindle assembly 6 homolog (C. elegans)0.019
lsm1LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae)0.019
tnfaip1tumor necrosis factor, alpha-induced protein 1 (endothelial)0.019
xrcc1X-ray repair complementing defective repair in Chinese hamster cells 10.019
ube2g2ubiquitin-conjugating enzyme E2G 20.019
rbfox2RNA binding protein, fox-1 homolog (C. elegans) 20.019
orc3origin recognition complex, subunit 30.018
ube2q2ubiquitin-conjugating enzyme E2Q family member 20.018
calm3bcalmodulin 3b (phosphorylase kinase, delta)0.018
nucks1anuclear casein kinase and cyclin-dependent kinase substrate 1a0.018
scrt1bscratch homolog 1, zinc finger protein b (Drosophila)0.018
bbc3BCL2 binding component 30.018
srsf6bserine/arginine-rich splicing factor 6b0.018
igf2ainsulin-like growth factor 2a0.018
pax8paired box gene 80.017
nr2f2nuclear receptor subfamily 2, group F, member 20.017
rps12ribosomal protein S120.017
zff9zinc finger protein 90.017
esco2establishment of cohesion 1 homolog 20.017
eya2eyes absent homolog 2 (Drosophila)0.017
tfe3btranscription factor binding to IGHM enhancer 3b0.017
maeamacrophage erythroblast attacher0.016
hnrnpa0lheterogeneous nuclear ribonucleoprotein A0, like0.016
arhgap11aRho GTPase activating protein 11A0.016
aidaaxin interaction partner and dorsalization antagonist0.016
zgc:114188zgc:1141880.016
notch2notch homolog 20.016
ccz1CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)0.016
LOC555279hypothetical LOC5552790.016
eif1beukaryotic translation initiation factor 1B0.016
acss2acyl-CoA synthetase short-chain family member 20.016
p2rx3bpurinergic receptor P2X, ligand-gated ion channel, 3b0.016
prdm8bPR domain containing 8b0.016
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
ykiyorkie0.311
RASSF8CG5053 gene product from transcript CG5053-RA0.111
scylscylla0.109
p53CG33336 gene product from transcript CG33336-RB0.098
panpangolin0.080
Dcp-1Death caspase-10.049
TORCCG6064 gene product from transcript CG6064-RA0.047
fs(1)hfemale sterile (1) homeotic0.036
tefutelomere fusion0.032
grimCG4345 gene product from transcript CG4345-RA0.029
SmrSmrter0.028
weeCG4488 gene product from transcript CG4488-RA0.024
imdimmune deficiency0.024
kluklumpfuss0.022
18w18 wheeler0.021
hephhephaestus0.020
lidlittle imaginal discs0.020
CG32685CG32685 gene product from transcript CG32685-RC0.019
CG33936CG33936 gene product from transcript CG33936-RB0.019
crolcrooked legs0.018
Pabp2CG2163 gene product from transcript CG2163-RA0.017
CtBPC-terminal Binding Protein0.017
keykenny0.017
dadaughterless0.016
CG9821CG9821 gene product from transcript CG9821-RB0.016
Hrb27CHeterogeneous nuclear ribonucleoprotein at 27C0.015
babobaboon0.015
Ten-mTenascin major0.014
GugGrunge0.013
HcfHost cell factor0.013
Sir2CG5216 gene product from transcript CG5216-RA0.012
CkIalphaCasein kinase Ialpha0.012
dupdouble parked0.012
RelRelish0.011
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 531.000
Mdm2transformed mouse 3T3 cell double minute 21.000
Ptenphosphatase and tensin homolog0.997
Rb1retinoblastoma 10.995
Apcadenomatosis polyposis coli0.992
Cdkn1bcyclin-dependent kinase inhibitor 1B0.990
Brca1breast cancer 10.964
Mdm4transformed mouse 3T3 cell double minute 40.958
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.954
Arid1bAT rich interactive domain 1B (SWI-like)0.932
Ren1renin 1 structural0.850
Cdkn2acyclin-dependent kinase inhibitor 2A0.841
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.831
Brca2breast cancer 20.829
Bcl2B-cell leukemia/lymphoma 20.823
Sirt1sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)0.817
Ptgs2prostaglandin-endoperoxide synthase 20.795
SkilSKI-like0.773
Vaspvasodilator-stimulated phosphoprotein0.753
E2f1E2F transcription factor 10.691
Hprthypoxanthine guanine phosphoribosyl transferase0.688
BaxBCL2-associated X protein0.679
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.672
Cyldcylindromatosis (turban tumor syndrome)0.618
Cdk4cyclin-dependent kinase 40.583
Msh2mutS homolog 2 (E. coli)0.561
BrafBraf transforming gene0.558
Kitkit oncogene0.554
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.526
Smad3MAD homolog 3 (Drosophila)0.489
Smad4MAD homolog 4 (Drosophila)0.478
H2-Aahistocompatibility 2, class II antigen A, alpha0.455
Trp73transformation related protein 730.455
Kdm2blysine (K)-specific demethylase 2B0.444
Vhlvon Hippel-Lindau tumor suppressor0.419
Cbx1chromobox homolog 1 (Drosophila HP1 beta)0.414
Cbx5chromobox homolog 5 (Drosophila HP1a)0.414
Leprleptin receptor0.407
Ccnd1cyclin D10.404
Agtr1aangiotensin II receptor, type 1a0.392
Rnf2ring finger protein 20.355
DaxxFas death domain-associated protein0.353
Ptch1patched homolog 10.345
Nos2nitric oxide synthase 2, inducible0.331
Dicer1Dicer1, Dcr-1 homolog (Drosophila)0.328
Ep300E1A binding protein p3000.325
Bcl2l1BCL2-like 10.318
Mybl2myeloblastosis oncogene-like 20.316
Tgfb1transforming growth factor, beta 10.316
Thbs1thrombospondin 10.315
Retret proto-oncogene0.314
Atmataxia telangiectasia mutated homolog (human)0.313
Abl1c-abl oncogene 1, non-receptor tyrosine kinase0.309
Nbnnibrin0.302
Edaectodysplasin-A0.298
Wt1Wilms tumor 1 homolog0.293
Itgb1integrin beta 1 (fibronectin receptor beta)0.261
Cd40CD40 antigen0.243
EdaraddEDAR (ectodysplasin-A receptor)-associated death domain0.243
Pmaip1phorbol-12-myristate-13-acetate-induced protein 10.233
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.223
Kitlkit ligand0.220
Gtse1G two S phase expressed protein 10.219
Rxraretinoid X receptor alpha0.206
Smc1astructural maintenance of chromosomes 1A0.205
Hdac1histone deacetylase 10.203
EvlEna-vasodilator stimulated phosphoprotein0.202
Cdkn2ccyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)0.201
En1engrailed 10.186
Enahenabled homolog (Drosophila)0.184
Cux1cut-like homeobox 10.168
Icam1intercellular adhesion molecule 10.160
Otx1orthodenticle homolog 1 (Drosophila)0.153
Zeb1zinc finger E-box binding homeobox 10.152
Dhx15DEAH (Asp-Glu-Ala-His) box polypeptide 150.148
Prrx1paired related homeobox 10.145
Arid4bAT rich interactive domain 4B (RBP1-like)0.137
Mycmyelocytomatosis oncogene0.134
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.133
RybpRING1 and YY1 binding protein0.126
Arandrogen receptor0.120
Prmt1protein arginine N-methyltransferase 10.117
Mndalmyeloid nuclear differentiation antigen like0.115
Smn1survival motor neuron 10.114
Dok1docking protein 10.113
Mecp2methyl CpG binding protein 20.109
Psmc5protease (prosome, macropain) 26S subunit, ATPase 50.109
RoraRAR-related orphan receptor alpha0.108
Mmp9matrix metallopeptidase 90.106
Stat3signal transducer and activator of transcription 30.104
S1pr2sphingosine-1-phosphate receptor 20.101
Tfdp2transcription factor Dp 20.100
Huwe1HECT, UBA and WWE domain containing 10.100
Ppardperoxisome proliferator activator receptor delta0.100
Col1a1collagen, type I, alpha 10.098
S1pr3sphingosine-1-phosphate receptor 30.097
Tgfbr2transforming growth factor, beta receptor II0.097
Cct6achaperonin containing Tcp1, subunit 6a (zeta)0.096
Ctnnb1catenin (cadherin associated protein), beta 10.095
Wdr5WD repeat domain 50.095
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism