The network for 'energy homeostasis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

energy homeostasis

Any process involved in the balance between food intake (energy input) and energy expenditure.

NameDescriptionProbabilityFunc Analog Organism
CEACAM1carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)1.000
CEACAM6carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)1.000
CEACAM7carcinoembryonic antigen-related cell adhesion molecule 70.997
PSG9pregnancy specific beta-1-glycoprotein 90.991
CEACAM5carcinoembryonic antigen-related cell adhesion molecule 50.986
PSG6pregnancy specific beta-1-glycoprotein 60.975
PSG4pregnancy specific beta-1-glycoprotein 40.885
PRKAB2protein kinase, AMP-activated, beta 2 non-catalytic subunit0.761
STRADASTE20-related kinase adaptor alpha0.709
PSG5pregnancy specific beta-1-glycoprotein 50.569
PSG3pregnancy specific beta-1-glycoprotein 30.554
PPARGperoxisome proliferator-activated receptor gamma0.379
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.375
ESRRGestrogen-related receptor gamma0.365
PSG1pregnancy specific beta-1-glycoprotein 10.353
BMPR1Bbone morphogenetic protein receptor, type IB0.318
CEACAM8carcinoembryonic antigen-related cell adhesion molecule 80.234
STRADBSTE20-related kinase adaptor beta0.233
PSG2pregnancy specific beta-1-glycoprotein 20.133
HNF4Ahepatocyte nuclear factor 4, alpha0.103
USP7ubiquitin specific peptidase 7 (herpes virus-associated)0.098
PRKAG2protein kinase, AMP-activated, gamma 2 non-catalytic subunit0.078
PSG7pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)0.075
ACACAacetyl-CoA carboxylase alpha0.059
PRKAA2protein kinase, AMP-activated, alpha 2 catalytic subunit0.046
KLHL24kelch-like 24 (Drosophila)0.044
TNIP2TNFAIP3 interacting protein 20.044
CLEC4MC-type lectin domain family 4, member M0.040
WFIKKN1WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 10.039
PHKBphosphorylase kinase, beta0.035
SHC1SHC (Src homology 2 domain containing) transforming protein 10.035
CARTPTCART prepropeptide0.030
S100PS100 calcium binding protein P0.028
TCN1transcobalamin I (vitamin B12 binding protein, R binder family)0.022
SYVN1synovial apoptosis inhibitor 1, synoviolin0.022
TMPRSS2transmembrane protease, serine 20.021
FNIP1folliculin interacting protein 10.020
TIE1tyrosine kinase with immunoglobulin-like and EGF-like domains 10.020
CLCA4chloride channel accessory 40.020
PRKAG1protein kinase, AMP-activated, gamma 1 non-catalytic subunit0.020
SNRKSNF related kinase0.019
BLMBloom syndrome, RecQ helicase-like0.019
NR0B2nuclear receptor subfamily 0, group B, member 20.018
MARK4MAP/microtubule affinity-regulating kinase 40.018
CYP19A1cytochrome P450, family 19, subfamily A, polypeptide 10.018
PROX1prospero homeobox 10.018
TBCKTBC1 domain containing kinase0.018
NR1I2nuclear receptor subfamily 1, group I, member 20.017
FGF5fibroblast growth factor 50.017
SCUBE3signal peptide, CUB domain, EGF-like 30.017
PRPH2peripherin 2 (retinal degeneration, slow)0.016
PAPPA2pappalysin 20.016
C5orf41chromosome 5 open reading frame 410.016
CYP4F3cytochrome P450, family 4, subfamily F, polypeptide 30.016
RNF2ring finger protein 20.016
CAB39calcium binding protein 390.015
NT5DC15'-nucleotidase domain containing 10.015
EPM2Aepilepsy, progressive myoclonus type 2A, Lafora disease (laforin)0.015
TMPRSS4transmembrane protease, serine 40.015
LCN2lipocalin 20.015
SLC35A3solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A30.014
C6orf203chromosome 6 open reading frame 2030.014
MAP3K8mitogen-activated protein kinase kinase kinase 80.014
PPM1Eprotein phosphatase, Mg2+/Mn2+ dependent, 1E0.014
ZMYND8zinc finger, MYND-type containing 80.014
NPC2Niemann-Pick disease, type C20.013
DUOX2dual oxidase 20.013
SLC6A14solute carrier family 6 (amino acid transporter), member 140.013
FXYD3FXYD domain containing ion transport regulator 30.013
THRBthyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)0.013
SLPIsecretory leukocyte peptidase inhibitor0.013
GFRA3GDNF family receptor alpha 30.013
GABRPgamma-aminobutyric acid (GABA) A receptor, pi0.012
TFF1trefoil factor 10.012
BAIAP2L1BAI1-associated protein 2-like 10.012
RAB3IL1RAB3A interacting protein (rabin3)-like 10.012
COL2A1collagen, type II, alpha 10.012
TGM3transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)0.012
SPIN1spindlin 10.012
WDR6WD repeat domain 60.012
SCRT1scratch homolog 1, zinc finger protein (Drosophila)0.012
BCORBCL6 corepressor0.012
CCDC111coiled-coil domain containing 1110.012
ARID1BAT rich interactive domain 1B (SWI1-like)0.012
TACSTD2tumor-associated calcium signal transducer 20.011
LACTB2lactamase, beta 20.011
SPINK5serine peptidase inhibitor, Kazal type 50.011
BMP2bone morphogenetic protein 20.011
CCDC6coiled-coil domain containing 60.011
PITX2paired-like homeodomain 20.011
GPRC5AG protein-coupled receptor, family C, group 5, member A0.011
LGALS13lectin, galactoside-binding, soluble, 130.011
PCGF2polycomb group ring finger 20.011
TRIM9tripartite motif containing 90.011
IMPDH1IMP (inosine 5'-monophosphate) dehydrogenase 10.011
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
mc2rmelanocortin 2 receptor0.906
mc1rmelanocortin 1 receptor0.890
mc3rmelanocortin 3 receptor0.882
mc5rbmelanocortin 5b receptor0.766
mc5ramelanocortin 5a receptor0.471
nr3c1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.353
igfbp6ainsulin-like growth factor binding protein 6a0.275
npy8arneuropeptide Y receptor Y8a0.258
gsdfgonadal somatic cell derived factor0.168
npy8brneuropeptide Y receptor Y8b0.141
fesfeline sarcoma oncogene0.132
ncam2neural cell adhesion molecule 20.126
ptprkprotein tyrosine phosphatase, receptor type, K0.109
LOC100003330melanocortin-2 receptor accessory protein 2-like0.085
mc4rmelanocortin 4 receptor0.083
cps1carbamoyl-phosphate synthase 1, mitochondrial0.082
mapk8bmitogen-activated protein kinase 8b0.068
dcst1DC-STAMP domain containing 10.059
ctbp2lC-terminal binding protein 2, like0.059
igfbp6binsulin-like growth factor binding protein 6b0.057
sh3gl1bSH3-domain GRB2-like 1b0.057
rc3rabconnectin 30.052
camk2n2calcium/calmodulin-dependent protein kinase II inhibitor 20.050
micall2amical-like 2a0.046
cyp11b2cytochrome P450, family 11, subfamily B, polypeptide 20.044
nfe2nuclear factor, erythroid-derived 20.041
or111-7odorant receptor, family D, subfamily 111, member 70.039
or115-10odorant receptor, family F, subfamily 115, member 100.036
spon2aspondin 2a, extracellular matrix protein0.036
slco1f1solute carrier organic anion transporter family, member 1F10.036
c1qtnf4C1q and tumor necrosis factor related protein 40.035
mical2bmicrotubule associated monoxygenase, calponin and LIM domain containing 2b0.033
otcornithine carbamoyltransferase0.030
chatcholine acetyltransferase0.027
snrk1SNF related kinase 10.026
smtnbsmoothelin b0.024
slc10a2solute carrier family 10 (sodium/bile acid cotransporter family), member 20.023
ddx46DEAD (Asp-Glu-Ala-Asp) box polypeptide 460.023
myd88myeloid differentiation primary response gene (88)0.022
scarb1scavenger receptor class B, member 10.021
calm2acalmodulin 2a (phosphorylase kinase, delta)0.021
grn1granulin 10.021
ppargc1alperoxisome proliferator-activated receptor gamma, coactivator 1 alpha like0.020
tfdp1btranscription factor Dp-1, b0.020
hsf2heat shock factor 20.020
lcklymphocyte-specific protein tyrosine kinase0.020
capslacalcyphosine-like a0.019
calrlcalreticulin like0.019
chrnb3bcholinergic receptor, nicotinic, beta polypeptide 3b0.018
stxbp6lsyntaxin binding protein 6 (amisyn), like0.018
paqr7bprogestin and adipoQ receptor family member VII, b0.017
opa1optic atrophy 1 (human)0.017
npy4rneuropeptide Y receptor Y40.017
or115-15odorant receptor, family F, subfamily 115, member 150.017
il22interleukin 220.017
drd2adopamine receptor D2a0.017
csnk1dbcasein kinase 1, delta b0.017
LOC553527hypothetical protein LOC5535270.016
itgb1b.1integrin, beta 1b.10.016
pdia5protein disulfide isomerase family A, member 50.016
gadd45bbgrowth arrest and DNA-damage-inducible, beta b0.016
sult1st4sulfotransferase family 1, cytosolic sulfotransferase 40.016
yod1YOD1 OTU deubiquinating enzyme 1 homolog (S. cerevisiae)0.016
nitr3cnovel immune-type receptor 3c0.015
rchy1ring finger and CHY zinc finger domain containing 10.015
slc16a1solute carrier family 16 (monocarboxylic acid transporters), member 10.015
agrpagouti related protein homolog0.015
arl4abADP-ribosylation factor-like 4ab0.015
ficdFIC domain containing0.015
elovl4aelongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4a0.015
LOC569648similar to CG14142-PA0.015
atxn7l3ataxin 7-like 30.014
aslargininosuccinate lyase0.014
srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.014
nr5a2nuclear receptor subfamily 5, group A, member 20.014
spock3sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 30.014
cyp2k22cytochrome P450, family 2, subfamily K, polypeptide 220.013
ift81intraflagellar transport 81 homolog0.013
or111-9odorant receptor, family D, subfamily 111, member 90.013
LOC563363cholesterol side-chain cleavage enzyme, mitochondrial-like0.013
nfatc4nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 40.013
hsd11b2hydroxysteroid 11-beta dehydrogenase 20.013
glra4bglycine receptor, alpha 4b0.012
slc43a3asolute carrier family 43, member 3a0.012
nr1d2anuclear receptor subfamily 1, group D, member 2a0.012
itgb1b.2integrin, beta 1b.20.012
tgfbr2transforming growth factor, beta receptor II0.012
abca1aATP-binding cassette, sub-family A (ABC1), member 1A0.012
sst6somatostatin 60.012
plxnb2aplexin b2a0.011
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Rargretinoic acid receptor, gamma0.890
Rarbretinoic acid receptor, beta0.867
Bmp7bone morphogenetic protein 70.600
Rararetinoic acid receptor, alpha0.504
Ece1endothelin converting enzyme 10.484
Bmp4bone morphogenetic protein 40.460
Ednraendothelin receptor type A0.424
Cdkn2dcyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)0.393
Hoxa3homeobox A30.341
Col11a2collagen, type XI, alpha 20.289
Thrathyroid hormone receptor alpha0.284
BmperBMP-binding endothelial regulator0.250
DbpD site albumin promoter binding protein0.159
Gdf5growth differentiation factor 50.151
Smosmoothened homolog (Drosophila)0.141
Acvr1activin A receptor, type 10.125
Tefthyrotroph embryonic factor0.123
Rxraretinoid X receptor alpha0.118
Msx2homeobox, msh-like 20.116
Gdf6growth differentiation factor 60.111
Cdkn1bcyclin-dependent kinase inhibitor 1B0.090
Thrbthyroid hormone receptor beta0.088
Ednrbendothelin receptor type B0.085
Msx1homeobox, msh-like 10.085
Sox9SRY-box containing gene 90.084
Prrx1paired related homeobox 10.084
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.078
Eya1eyes absent 1 homolog (Drosophila)0.074
Pax8paired box gene 80.071
Hand2heart and neural crest derivatives expressed transcript 20.068
Lhx1LIM homeobox protein 10.065
Foxc1forkhead box C10.056
Nr1d1nuclear receptor subfamily 1, group D, member 10.052
Tgfb2transforming growth factor, beta 20.052
Bmp5bone morphogenetic protein 50.051
Pbx1pre B-cell leukemia transcription factor 10.051
Prrx2paired related homeobox 20.050
Lrp6low density lipoprotein receptor-related protein 60.046
Plac1placental specific protein 10.046
Fgfr1fibroblast growth factor receptor 10.042
Tgfbr2transforming growth factor, beta receptor II0.041
Sertad2SERTA domain containing 20.041
Hand1heart and neural crest derivatives expressed transcript 10.039
LOC100503041PDZ domain-containing protein 7-like0.037
Prkab1protein kinase, AMP-activated, beta 1 non-catalytic subunit0.036
Slc26a4solute carrier family 26, member 40.036
Tgfbr3transforming growth factor, beta receptor III0.035
Hoxb3homeobox B30.035
Pax2paired box gene 20.032
Rspo2R-spondin 2 homolog (Xenopus laevis)0.032
Klf16Kruppel-like factor 160.031
Prkag1protein kinase, AMP-activated, gamma 1 non-catalytic subunit0.030
Foxo1forkhead box O10.030
Gli2GLI-Kruppel family member GLI20.029
Foxc2forkhead box C20.027
Ptch1patched homolog 10.027
Fosl2fos-like antigen 20.026
Smad6MAD homolog 6 (Drosophila)0.026
Bmp2bone morphogenetic protein 20.025
Leprleptin receptor0.025
Smad3MAD homolog 3 (Drosophila)0.025
Adcy9adenylate cyclase 90.024
Cdoncell adhesion molecule-related/down-regulated by oncogenes0.024
Gdf1growth differentiation factor 10.023
Foxo3forkhead box O30.023
Mark4MAP/microtubule affinity-regulating kinase 40.022
Klf9Kruppel-like factor 90.021
Ceacam10carcinoembryonic antigen-related cell adhesion molecule 100.021
Gdf3growth differentiation factor 30.021
Per3period homolog 3 (Drosophila)0.021
Fgfr2fibroblast growth factor receptor 20.021
Igll1immunoglobulin lambda-like polypeptide 10.020
Tdgf1teratocarcinoma-derived growth factor 10.020
Crxos1Crx opposite strand transcript 10.019
Nr1d2nuclear receptor subfamily 1, group D, member 20.019
Dio3deiodinase, iodothyronine type III0.018
Mplmyeloproliferative leukemia virus oncogene0.018
Arl10ADP-ribosylation factor-like 100.018
Sox4SRY-box containing gene 40.018
Isg20l2interferon stimulated exonuclease gene 20-like 20.018
Prop1paired like homeodomain factor 10.017
Zfp42zinc finger protein 420.017
Cilp2cartilage intermediate layer protein 20.016
Dag1dystroglycan 10.016
Mybl2myeloblastosis oncogene-like 20.016
Duox2dual oxidase 20.016
Gdf7growth differentiation factor 70.016
St6galnac1ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 10.016
Oaz3ornithine decarboxylase antizyme 30.015
Itga8integrin alpha 80.015
Esrraestrogen related receptor, alpha0.015
Abp1amiloride binding protein 1 (amine oxidase, copper-containing)0.015
Fmn1formin 10.015
Gpc3glypican 30.015
Clip2CAP-GLY domain containing linker protein 20.015
Ptenphosphatase and tensin homolog0.014
Dppa5adevelopmental pluripotency associated 5A0.014
Gas1growth arrest specific 10.014
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
LOC100366119Mpv17 transgene, kidney disease mutant-like (predicted)-like0.018
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism