The network for 'positive regulation of actin nucleation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of actin nucleation

Any process that activates or increases the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament.

NameDescriptionProbabilityFunc Analog Organism
GAS7growth arrest-specific 71.000
ABL1c-abl oncogene 1, non-receptor tyrosine kinase1.000
ABI2abl-interactor 20.999
WASF1WAS protein family, member 10.989
WASF2WAS protein family, member 20.968
BAIAP2BAI1-associated protein 20.930
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.922
PFDN1prefoldin subunit 10.916
SOS1son of sevenless homolog 1 (Drosophila)0.850
WIPF1WAS/WASL interacting protein family, member 10.826
ADAM19ADAM metallopeptidase domain 190.786
SORBS3sorbin and SH3 domain containing 30.686
CYFIP1cytoplasmic FMR1 interacting protein 10.615
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.533
CYFIP2cytoplasmic FMR1 interacting protein 20.447
EPS8epidermal growth factor receptor pathway substrate 80.434
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.423
TPM4tropomyosin 40.272
ARPC1Bactin related protein 2/3 complex, subunit 1B, 41kDa0.254
PAK2p21 protein (Cdc42/Rac)-activated kinase 20.193
PICALMphosphatidylinositol binding clathrin assembly protein0.184
FMNL1formin-like 10.179
NCKAP1NCK-associated protein 10.146
CAP1CAP, adenylate cyclase-associated protein 1 (yeast)0.139
PFN1profilin 10.134
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.082
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.080
VAV1vav 1 guanine nucleotide exchange factor0.079
ARPC2actin related protein 2/3 complex, subunit 2, 34kDa0.078
CDC34cell division cycle 34 homolog (S. cerevisiae)0.074
TUBGCP4tubulin, gamma complex associated protein 40.074
ITSN1intersectin 1 (SH3 domain protein)0.063
ANXA2annexin A20.061
MCOLN1mucolipin 10.060
RAPGEF1Rap guanine nucleotide exchange factor (GEF) 10.047
DEF6differentially expressed in FDCP 6 homolog (mouse)0.047
CTTNcortactin0.046
ARPC5actin related protein 2/3 complex, subunit 5, 16kDa0.045
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.038
DLG5discs, large homolog 5 (Drosophila)0.038
COTL1coactosin-like 1 (Dictyostelium)0.035
PSTPIP1proline-serine-threonine phosphatase interacting protein 10.034
NCK1NCK adaptor protein 10.034
SPRR2Asmall proline-rich protein 2A0.031
DTNBP1dystrobrevin binding protein 10.031
PAK1p21 protein (Cdc42/Rac)-activated kinase 10.030
MAVSmitochondrial antiviral signaling protein0.029
KIAA0408KIAA04080.024
DNM2dynamin 20.024
ACTR2ARP2 actin-related protein 2 homolog (yeast)0.021
UBE2Zubiquitin-conjugating enzyme E2Z0.021
RIOK3RIO kinase 3 (yeast)0.017
GNGT2guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 20.017
NCKAP1LNCK-associated protein 1-like0.015
PIK3C2Bphosphoinositide-3-kinase, class 2, beta polypeptide0.014
ZDHHC24zinc finger, DHHC-type containing 240.014
FGRGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.014
RGS19regulator of G-protein signaling 190.013
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.012
UCP2uncoupling protein 2 (mitochondrial, proton carrier)0.012
PRKAA1protein kinase, AMP-activated, alpha 1 catalytic subunit0.012
GNB1guanine nucleotide binding protein (G protein), beta polypeptide 10.011
DAXXdeath-domain associated protein0.011
GRB2growth factor receptor-bound protein 20.011
RGS14regulator of G-protein signaling 140.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Sra-1specifically Rac1-associated protein 10.139
katanin-60katanin 600.031
HemHEM-protein0.027
RhoGAP93BCG3421 gene product from transcript CG3421-RA0.025
Vrp1Verprolin 10.024
RalaRas-related protein0.019
CG10413CG10413 gene product from transcript CG10413-RA0.016
Arp66BActin-related protein 66B0.015
bifbifocal0.013
Liprin-alphaCG11199 gene product from transcript CG11199-RB0.013
Eps-15Epidermal growth factor receptor pathway substrate clone 150.011
Cip4CG15015 gene product from transcript CG15015-RA0.011
mbcmyoblast city0.011
Letm1CG4589 gene product from transcript CG4589-RB0.010
Arp14DActin-related protein 14D0.010
MESR4Misexpression suppressor of ras 40.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Trim30dtripartite motif-containing 30D0.750
Pfn2profilin 20.626
Irf9interferon regulatory factor 90.473
9430031J16RikRIKEN cDNA 9430031J16 gene0.460
Stat1signal transducer and activator of transcription 10.455
Arpc4actin related protein 2/3 complex, subunit 40.348
Trim21tripartite motif-containing 210.290
Oasl22'-5' oligoadenylate synthetase-like 20.269
Parp14poly (ADP-ribose) polymerase family, member 140.234
Gbp3guanylate binding protein 30.204
Wipf1WAS/WASL interacting protein family, member 10.184
Uba7ubiquitin-like modifier activating enzyme 70.164
Sash3SAM and SH3 domain containing 30.150
Tuba1atubulin, alpha 1A0.145
Cttncortactin0.141
Dbnldrebrin-like0.132
Gbp7guanylate binding protein 70.131
Ifi203interferon activated gene 2030.122
Trim30atripartite motif-containing 30A0.118
Ddx60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.113
Maged1melanoma antigen, family D, 10.107
Stat6signal transducer and activator of transcription 60.104
Hif1ahypoxia inducible factor 1, alpha subunit0.100
Gnb2guanine nucleotide binding protein (G protein), beta 20.098
Sp100nuclear antigen Sp1000.091
Ptpn6protein tyrosine phosphatase, non-receptor type 60.083
Ddx58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.081
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.075
Shisa5shisa homolog 5 (Xenopus laevis)0.072
Gnai2guanine nucleotide binding protein (G protein), alpha inhibiting 20.070
Usp18ubiquitin specific peptidase 180.069
Fez1fasciculation and elongation protein zeta 1 (zygin I)0.065
Ms4a6bmembrane-spanning 4-domains, subfamily A, member 6B0.064
E4f1E4F transcription factor 10.063
Npas3neuronal PAS domain protein 30.063
Pcdh10protocadherin 100.062
Nbeaneurobeachin0.057
Oas1b2'-5' oligoadenylate synthetase 1B0.056
Epsti1epithelial stromal interaction 1 (breast)0.055
Tjp1tight junction protein 10.053
Cskc-src tyrosine kinase0.052
Plcg2phospholipase C, gamma 20.052
Adrbk1adrenergic receptor kinase, beta 10.052
Man2b1mannosidase 2, alpha B10.051
Arpc2actin related protein 2/3 complex, subunit 20.050
Oas32'-5' oligoadenylate synthetase 30.049
Ifi44interferon-induced protein 440.049
Adaradenosine deaminase, RNA-specific0.049
Parp10poly (ADP-ribose) polymerase family, member 100.048
Dhx58DEXH (Asp-Glu-X-His) box polypeptide 580.048
Fermt3fermitin family homolog 3 (Drosophila)0.047
Arhgef1Rho guanine nucleotide exchange factor (GEF) 10.047
0610031J06RikRIKEN cDNA 0610031J06 gene0.046
Rab4bRAB4B, member RAS oncogene family0.045
Rtp4receptor transporter protein 40.040
Samhd1SAM domain and HD domain, 10.039
Cdc42se1CDC42 small effector 10.038
Cotl1coactosin-like 1 (Dictyostelium)0.038
Kif3bkinesin family member 3B0.037
GmipGem-interacting protein0.036
ArhgdiaRho GDP dissociation inhibitor (GDI) alpha0.036
Lgals9lectin, galactose binding, soluble 90.035
Rps6ka4ribosomal protein S6 kinase, polypeptide 40.035
Pitpnm1phosphatidylinositol transfer protein, membrane-associated 10.035
Cd37CD37 antigen0.034
Tnfsf10tumor necrosis factor (ligand) superfamily, member 100.034
Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)0.034
Tap2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.034
Trim34atripartite motif-containing 34A0.034
Herc6hect domain and RLD 60.034
Hmha1histocompatibility (minor) HA-10.033
Cherpcalcium homeostasis endoplasmic reticulum protein0.033
Sfi1Sfi1 homolog, spindle assembly associated (yeast)0.033
Arhgap9Rho GTPase activating protein 90.032
Adcy7adenylate cyclase 70.032
Eid1EP300 interacting inhibitor of differentiation 10.032
Klraq1KLRAQ motif containing 10.032
Apbb1ipamyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein0.031
Slc4a1solute carrier family 4 (anion exchanger), member 10.031
Lxnlatexin0.031
Atp6v1aATPase, H+ transporting, lysosomal V1 subunit A0.031
Irgm1immunity-related GTPase family M member 10.031
D6Wsu116eDNA segment, Chr 6, Wayne State University 116, expressed0.031
BC006779cDNA sequence BC0067790.031
Rps6ka1ribosomal protein S6 kinase polypeptide 10.030
Vaspvasodilator-stimulated phosphoprotein0.030
H2-Q6histocompatibility 2, Q region locus 60.030
Samd9lsterile alpha motif domain containing 9-like0.030
H2-M3histocompatibility 2, M region locus 30.029
NmiN-myc (and STAT) interactor0.029
Kcnab2potassium voltage-gated channel, shaker-related subfamily, beta member 20.029
Trim12ctripartite motif-containing 12C0.029
Pcdh18protocadherin 180.028
Ctnna1catenin (cadherin associated protein), alpha 10.028
Ankfy1ankyrin repeat and FYVE domain containing 10.028
Ifih1interferon induced with helicase C domain 10.028
Gbp2guanylate binding protein 20.028
Trim5tripartite motif-containing 50.028
KelKell blood group0.027
Stxbp2syntaxin binding protein 20.027
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism