The network for 'canonical wnt signaling pathway involved in negative regulation of apoptotic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

canonical wnt signaling pathway involved in negative regulation of apoptotic process

The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the negative regulation of apoptotic process.

NameDescriptionProbabilityFunc Analog Organism
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.946
TCF4transcription factor 40.873
BTRCbeta-transducin repeat containing0.855
FZD1frizzled homolog 1 (Drosophila)0.841
AXIN1axin 10.580
SKP1S-phase kinase-associated protein 10.579
LRP6low density lipoprotein receptor-related protein 60.549
GSK3Bglycogen synthase kinase 3 beta0.534
FGF18fibroblast growth factor 180.526
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.481
FBXW11F-box and WD repeat domain containing 110.465
CTNND1catenin (cadherin-associated protein), delta 10.374
CTNNBIP1catenin, beta interacting protein 10.347
CUL1cullin 10.321
GLIS2GLIS family zinc finger 20.270
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.252
PKP4plakophilin 40.196
FZD8frizzled homolog 8 (Drosophila)0.149
YAP1Yes-associated protein 10.145
WNT10Awingless-type MMTV integration site family, member 10A0.138
WIF1WNT inhibitory factor 10.126
CREBBPCREB binding protein0.118
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.105
IHHIndian hedgehog0.097
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.095
FOXC2forkhead box C2 (MFH-1, mesenchyme forkhead 1)0.089
SCRIBscribbled homolog (Drosophila)0.087
MAXMYC associated factor X0.083
FGF3fibroblast growth factor 30.082
FGF8fibroblast growth factor 8 (androgen-induced)0.079
PSEN1presenilin 10.072
SFRP1secreted frizzled-related protein 10.072
ZFP106zinc finger protein 106 homolog (mouse)0.071
ZFPM1zinc finger protein, multitype 10.069
CDH2cadherin 2, type 1, N-cadherin (neuronal)0.068
EP400E1A binding protein p4000.066
ENTPD2ectonucleoside triphosphate diphosphohydrolase 20.062
FGF4fibroblast growth factor 40.062
WNT1wingless-type MMTV integration site family, member 10.061
PARD3par-3 partitioning defective 3 homolog (C. elegans)0.059
LEF1lymphoid enhancer-binding factor 10.055
LBX1ladybird homeobox 10.054
CCT8chaperonin containing TCP1, subunit 8 (theta)0.054
ARandrogen receptor0.052
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.051
HES2hairy and enhancer of split 2 (Drosophila)0.046
RUNX3runt-related transcription factor 30.045
DSTdystonin0.044
EMDemerin0.044
CACNA1Gcalcium channel, voltage-dependent, T type, alpha 1G subunit0.043
FOXF2forkhead box F20.043
ST8SIA2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 20.042
IKIK cytokine, down-regulator of HLA II0.041
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.041
TNIKTRAF2 and NCK interacting kinase0.041
ZRANB1zinc finger, RAN-binding domain containing 10.041
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.041
NCOA2nuclear receptor coactivator 20.040
WNT6wingless-type MMTV integration site family, member 60.040
SHHsonic hedgehog0.039
FOXO1forkhead box O10.038
HIC1hypermethylated in cancer 10.038
SMAD7SMAD family member 70.038
FOXO3forkhead box O30.038
FBXW8F-box and WD repeat domain containing 80.038
AQP5aquaporin 50.037
CDH3cadherin 3, type 1, P-cadherin (placental)0.037
HOXC8homeobox C80.036
SMC1Astructural maintenance of chromosomes 1A0.035
CD6CD6 molecule0.034
FOXE1forkhead box E1 (thyroid transcription factor 2)0.033
FOXL1forkhead box L10.033
PKP1plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)0.033
FZD2frizzled homolog 2 (Drosophila)0.033
KIF5Bkinesin family member 5B0.033
HSPB1heat shock 27kDa protein 10.033
ZFYVE9zinc finger, FYVE domain containing 90.033
HSD17B14hydroxysteroid (17-beta) dehydrogenase 140.032
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.032
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.032
SDC2syndecan 20.032
DLX4distal-less homeobox 40.031
GRB7growth factor receptor-bound protein 70.031
CYP26A1cytochrome P450, family 26, subfamily A, polypeptide 10.030
FBXW7F-box and WD repeat domain containing 70.030
PELOpelota homolog (Drosophila)0.030
NKD2naked cuticle homolog 2 (Drosophila)0.030
SOX21SRY (sex determining region Y)-box 210.030
NPAS1neuronal PAS domain protein 10.029
DIO3deiodinase, iodothyronine, type III0.029
PAX7paired box 70.028
MMP11matrix metallopeptidase 11 (stromelysin 3)0.028
PLXDC1plexin domain containing 10.028
JPH3junctophilin 30.027
GDNFglial cell derived neurotrophic factor0.027
WNT3wingless-type MMTV integration site family, member 30.027
COL2A1collagen, type II, alpha 10.027
KNDC1kinase non-catalytic C-lobe domain (KIND) containing 10.027
CSF2colony stimulating factor 2 (granulocyte-macrophage)0.027
KAT2BK(lysine) acetyltransferase 2B0.026
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ctnnb1catenin (cadherin associated protein), beta 11.000
Trp53transformation related protein 531.000
Lef1lymphoid enhancer binding factor 10.970
Kitkit oncogene0.873
Ptenphosphatase and tensin homolog0.800
Smad3MAD homolog 3 (Drosophila)0.705
Cdkn1bcyclin-dependent kinase inhibitor 1B0.503
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.465
Gsk3bglycogen synthase kinase 3 beta0.421
Tcf7transcription factor 7, T-cell specific0.416
Pax3paired box gene 30.383
Fgfr2fibroblast growth factor receptor 20.371
Ccnd1cyclin D10.334
Leprleptin receptor0.330
BrafBraf transforming gene0.328
Kitlkit ligand0.271
Ptch1patched homolog 10.267
Pax6paired box gene 60.255
Stat3signal transducer and activator of transcription 30.250
Lystlysosomal trafficking regulator0.239
MaxMax protein0.237
Nf2neurofibromatosis 20.219
Nf1neurofibromatosis 10.216
Otx2orthodenticle homolog 2 (Drosophila)0.204
Axin1axin 10.195
Smad4MAD homolog 4 (Drosophila)0.187
Numbnumb gene homolog (Drosophila)0.187
Tgfb1transforming growth factor, beta 10.184
Bmpr1abone morphogenetic protein receptor, type 1A0.175
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.143
Itgb1integrin beta 1 (fibronectin receptor beta)0.143
Pbx1pre B-cell leukemia transcription factor 10.136
Esr1estrogen receptor 1 (alpha)0.129
Mdm2transformed mouse 3T3 cell double minute 20.124
Axin2axin20.120
Lrp6low density lipoprotein receptor-related protein 60.111
Trp73transformation related protein 730.108
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.106
Cdkn2acyclin-dependent kinase inhibitor 2A0.104
Htthuntingtin0.103
Bcl2B-cell leukemia/lymphoma 20.092
Dicer1Dicer1, Dcr-1 homolog (Drosophila)0.091
Otx1orthodenticle homolog 1 (Drosophila)0.091
Cd44CD44 antigen0.087
Hif1ahypoxia inducible factor 1, alpha subunit0.085
Meox2mesenchyme homeobox 20.084
Arandrogen receptor0.081
Rb1retinoblastoma 10.080
Trp63transformation related protein 630.078
Vhlvon Hippel-Lindau tumor suppressor0.077
Csf1colony stimulating factor 1 (macrophage)0.064
Psen1presenilin 10.063
Ptgs2prostaglandin-endoperoxide synthase 20.060
Runx1runt related transcription factor 10.059
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.058
Zeb1zinc finger E-box binding homeobox 10.058
Ahraryl-hydrocarbon receptor0.056
Ctnna1catenin (cadherin associated protein), alpha 10.054
Tead3TEA domain family member 30.052
Pla2g2aphospholipase A2, group IIA (platelets, synovial fluid)0.052
Stk11serine/threonine kinase 110.051
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.048
Smad2MAD homolog 2 (Drosophila)0.046
Tsc1tuberous sclerosis 10.043
Retret proto-oncogene0.042
Il6stinterleukin 6 signal transducer0.042
Tbx3T-box 30.041
Brca1breast cancer 10.040
Emx2empty spiracles homolog 2 (Drosophila)0.039
Cdk4cyclin-dependent kinase 40.038
Rararetinoic acid receptor, alpha0.035
Tyrtyrosinase0.035
Prkar1aprotein kinase, cAMP dependent regulatory, type I, alpha0.034
Sgpl1sphingosine phosphate lyase 10.033
E2f1E2F transcription factor 10.032
Sox11SRY-box containing gene 110.032
Zic2zinc finger protein of the cerebellum 20.032
Lyz2lysozyme 20.031
Cdkn2ccyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)0.031
Esr2estrogen receptor 2 (beta)0.030
Tax1bp3Tax1 (human T-cell leukemia virus type I) binding protein 30.030
Gli3GLI-Kruppel family member GLI30.030
Egr1early growth response 10.029
Adam17a disintegrin and metallopeptidase domain 170.029
S1pr2sphingosine-1-phosphate receptor 20.028
Col1a1collagen, type I, alpha 10.028
Thbs1thrombospondin 10.028
Ptpn11protein tyrosine phosphatase, non-receptor type 110.026
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.026
Vdrvitamin D receptor0.025
Sox9SRY-box containing gene 90.024
Foxp3forkhead box P30.024
Sox10SRY-box containing gene 100.024
Emx1empty spiracles homolog 1 (Drosophila)0.023
Tlr4toll-like receptor 40.022
Ctnnd1catenin (cadherin associated protein), delta 10.022
Sept1septin 10.022
Tyrp1tyrosinase-related protein 10.021
Foxa2forkhead box A20.021
Notch1Notch gene homolog 1 (Drosophila)0.021
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism