The network for 'regulation of leukocyte proliferation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of leukocyte proliferation

Any process that modulates the frequency, rate or extent of leukocyte proliferation.

NameDescriptionProbabilityFunc Analog Organism
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.999
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.999
LCKlymphocyte-specific protein tyrosine kinase0.998
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.992
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.983
FGFR2fibroblast growth factor receptor 20.975
BIRC3baculoviral IAP repeat containing 30.973
CD80CD80 molecule0.963
SHC1SHC (Src homology 2 domain containing) transforming protein 10.963
SYKspleen tyrosine kinase0.960
EGFRepidermal growth factor receptor0.945
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.943
HLA-Gmajor histocompatibility complex, class I, G0.935
HLA-Bmajor histocompatibility complex, class I, B0.927
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.905
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.898
GRB2growth factor receptor-bound protein 20.889
PTPN6protein tyrosine phosphatase, non-receptor type 60.878
ICAM1intercellular adhesion molecule 10.871
HLA-DRB1major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 10.868
HLA-Amajor histocompatibility complex, class I, A0.861
HLA-Fmajor histocompatibility complex, class I, F0.860
CD86CD86 molecule0.847
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.847
TRAF1TNF receptor-associated factor 10.844
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.834
IL4Rinterleukin 4 receptor0.819
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.798
HLA-DMAmajor histocompatibility complex, class II, DM alpha0.794
BCL2B-cell CLL/lymphoma 20.791
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.788
PTPRCprotein tyrosine phosphatase, receptor type, C0.787
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.785
HLA-DQB1major histocompatibility complex, class II, DQ beta 10.767
SOCS3suppressor of cytokine signaling 30.743
HLA-Cmajor histocompatibility complex, class I, C0.705
TNFAIP3tumor necrosis factor, alpha-induced protein 30.705
CXCL9chemokine (C-X-C motif) ligand 90.705
IL1Binterleukin 1, beta0.695
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.686
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.679
LTAlymphotoxin alpha (TNF superfamily, member 1)0.669
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.660
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.652
RB1retinoblastoma 10.648
CD247CD247 molecule0.641
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.632
IL8interleukin 80.630
CXCL10chemokine (C-X-C motif) ligand 100.620
LATlinker for activation of T cells0.595
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.586
ZAP70zeta-chain (TCR) associated protein kinase 70kDa0.578
BCL2L1BCL2-like 10.578
CCR1chemokine (C-C motif) receptor 10.572
BTN3A2butyrophilin, subfamily 3, member A20.566
HLA-DPA1major histocompatibility complex, class II, DP alpha 10.563
INSRinsulin receptor0.557
ITGB2integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)0.555
HLA-DMBmajor histocompatibility complex, class II, DM beta0.554
IL10RAinterleukin 10 receptor, alpha0.545
HLA-Emajor histocompatibility complex, class I, E0.539
BTN3A1butyrophilin, subfamily 3, member A10.529
IL2RGinterleukin 2 receptor, gamma0.507
CCL2chemokine (C-C motif) ligand 20.485
CCR7chemokine (C-C motif) receptor 70.479
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.462
BTN3A3butyrophilin, subfamily 3, member A30.452
CASP9caspase 9, apoptosis-related cysteine peptidase0.450
CTLA4cytotoxic T-lymphocyte-associated protein 40.417
CD2CD2 molecule0.406
PTPN22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.403
CCR5chemokine (C-C motif) receptor 50.403
BCL2L11BCL2-like 11 (apoptosis facilitator)0.396
CD48CD48 molecule0.390
HCKhemopoietic cell kinase0.388
HDAC9histone deacetylase 90.387
TFF1trefoil factor 10.384
PTPN1protein tyrosine phosphatase, non-receptor type 10.380
FCER1GFc fragment of IgE, high affinity I, receptor for; gamma polypeptide0.369
CCL4chemokine (C-C motif) ligand 40.362
PLCG1phospholipase C, gamma 10.358
BCL2A1BCL2-related protein A10.354
BAXBCL2-associated X protein0.354
CBLBCas-Br-M (murine) ecotropic retroviral transforming sequence b0.352
TNFRSF9tumor necrosis factor receptor superfamily, member 90.347
TLR2toll-like receptor 20.344
CXCL2chemokine (C-X-C motif) ligand 20.343
LIFleukemia inhibitory factor (cholinergic differentiation factor)0.328
ABI1abl-interactor 10.326
PTK2PTK2 protein tyrosine kinase 20.323
HLA-DRB5major histocompatibility complex, class II, DR beta 50.312
CCL8chemokine (C-C motif) ligand 80.307
PAX3paired box 30.305
PSTPIP1proline-serine-threonine phosphatase interacting protein 10.303
CD163CD163 molecule0.297
TGIF1TGFB-induced factor homeobox 10.296
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.281
TANKTRAF family member-associated NFKB activator0.276
CD33CD33 molecule0.272
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Tnftumor necrosis factor0.999
Lyz2lysozyme 20.999
Cd19CD19 antigen0.993
Ighimmunoglobulin heavy chain complex0.993
Cd40CD40 antigen0.987
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.986
Myd88myeloid differentiation primary response gene 880.986
Ctnnb1catenin (cadherin associated protein), beta 10.979
Tlr4toll-like receptor 40.978
Ikzf1IKAROS family zinc finger 10.975
FasFas (TNF receptor superfamily member 6)0.974
Map3k14mitogen-activated protein kinase kinase kinase 140.967
Stat3signal transducer and activator of transcription 30.967
Ltalymphotoxin A0.952
Efnb2ephrin B20.938
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.936
Casp4caspase 4, apoptosis-related cysteine peptidase0.934
Tnfaip3tumor necrosis factor, alpha-induced protein 30.931
Foxp3forkhead box P30.930
Trp53transformation related protein 530.930
Ccl2chemokine (C-C motif) ligand 20.924
Icosinducible T-cell co-stimulator0.921
Ifnginterferon gamma0.917
Csf1colony stimulating factor 1 (macrophage)0.911
Ccr2chemokine (C-C motif) receptor 20.910
Itgb1integrin beta 1 (fibronectin receptor beta)0.907
Ptprcprotein tyrosine phosphatase, receptor type, C0.904
Fgfr2fibroblast growth factor receptor 20.904
Cd28CD28 antigen0.875
FynFyn proto-oncogene0.869
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.868
RybpRING1 and YY1 binding protein0.859
Tnfsf11tumor necrosis factor (ligand) superfamily, member 110.849
Ccr1chemokine (C-C motif) receptor 10.844
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.834
Nr3c1nuclear receptor subfamily 3, group C, member 10.818
Socs1suppressor of cytokine signaling 10.815
Ptenphosphatase and tensin homolog0.809
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.807
Ltblymphotoxin B0.794
Stat5asignal transducer and activator of transcription 5A0.781
FaslFas ligand (TNF superfamily, member 6)0.781
Drd2dopamine receptor D20.780
Cd22CD22 antigen0.777
Mmp9matrix metallopeptidase 90.767
Leprleptin receptor0.764
Birc3baculoviral IAP repeat-containing 30.753
Zeb1zinc finger E-box binding homeobox 10.751
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.735
Foxc1forkhead box C10.718
Ccr6chemokine (C-C motif) receptor 60.714
Cd86CD86 antigen0.712
Inpp5dinositol polyphosphate-5-phosphatase D0.708
Traf6TNF receptor-associated factor 60.708
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.700
Clec4nC-type lectin domain family 4, member n0.699
Cyldcylindromatosis (turban tumor syndrome)0.698
Rnf2ring finger protein 20.697
Il2rginterleukin 2 receptor, gamma chain0.696
Nckap1lNCK associated protein 1 like0.690
BtkBruton agammaglobulinemia tyrosine kinase0.683
Bcl3B-cell leukemia/lymphoma 30.664
Adam17a disintegrin and metallopeptidase domain 170.650
Batfbasic leucine zipper transcription factor, ATF-like0.648
Ncoa3nuclear receptor coactivator 30.648
Ccl4chemokine (C-C motif) ligand 40.643
Casp8caspase 80.635
Sykbspleen tyrosine kinase0.631
Prop1paired like homeodomain factor 10.628
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.621
Chrnb2cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)0.613
H2-Aahistocompatibility 2, class II antigen A, alpha0.605
Prdm1PR domain containing 1, with ZNF domain0.605
Il6interleukin 60.600
Prf1perforin 1 (pore forming protein)0.592
Rargretinoic acid receptor, gamma0.587
Stat5bsignal transducer and activator of transcription 5B0.576
Ntf3neurotrophin 30.565
Il1binterleukin 1 beta0.564
Irf8interferon regulatory factor 80.564
Ccl12chemokine (C-C motif) ligand 120.559
Rb1retinoblastoma 10.557
Prkcdprotein kinase C, delta0.549
Tgfb1transforming growth factor, beta 10.541
Latlinker for activation of T cells0.540
Casp1caspase 10.539
Csf2colony stimulating factor 2 (granulocyte-macrophage)0.537
Il10rainterleukin 10 receptor, alpha0.532
Nos1nitric oxide synthase 1, neuronal0.531
Inhbainhibin beta-A0.520
Esr1estrogen receptor 1 (alpha)0.517
Cd4CD4 antigen0.515
Ticam1toll-like receptor adaptor molecule 10.511
Il1rninterleukin 1 receptor antagonist0.508
Il4interleukin 40.506
Sh2d2aSH2 domain protein 2A0.506
Ptpn11protein tyrosine phosphatase, non-receptor type 110.503
Hrh1histamine receptor H10.503
WasWiskott-Aldrich syndrome homolog (human)0.499
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
RT1-DaRT1 class II, locus Da0.951
RT1-BaRT1 class II, locus Ba0.670
Cd37CD37 molecule0.383
RT1-Db1RT1 class II, locus Db10.289
RT1-BbRT1 class II, locus Bb0.263
Cd247Cd247 molecule0.244
Cd74Cd74 molecule, major histocompatibility complex, class II invariant chain0.194
RT1-DMbRT1 class II, locus DMb0.124
Nkg7natural killer cell group 7 sequence0.088
Cd2Cd2 molecule0.085
Vipvasoactive intestinal peptide0.076
Htr1b5-hydroxytryptamine (serotonin) receptor 1B0.076
Ciitaclass II, major histocompatibility complex, transactivator0.075
Napsanapsin A aspartic peptidase0.073
Il1binterleukin 1 beta0.071
Il10interleukin 100.069
Itgb7integrin, beta 70.067
Aif1allograft inflammatory factor 10.062
Il1rl1interleukin 1 receptor-like 10.062
Hckhemopoietic cell kinase0.061
Slfn2schlafen 20.056
Cfpcomplement factor properdin0.055
Fam108b1family with sequence similarity 108, member B10.048
Casp1caspase 10.048
Ptger4prostaglandin E receptor 4 (subtype EP4)0.046
Cd5Cd5 molecule0.046
Inpp5dinositol polyphosphate-5-phosphatase D0.045
Mmp10matrix metallopeptidase 100.043
Tas2r123taste receptor, type 2, member 1230.042
Metmet proto-oncogene0.041
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.041
RT1-DMaRT1 class II, locus DMa0.040
Bin2bridging integrator 20.038
Ptprcprotein tyrosine phosphatase, receptor type, C0.037
Reg3bregenerating islet-derived 3 beta0.036
Cd38CD38 molecule0.036
Serpinb1aserine (or cysteine) proteinase inhibitor, clade B, member 1a0.033
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.032
Gfi1growth factor independent 1 transcription repressor0.032
Sellselectin L0.032
F2rl2coagulation factor II (thrombin) receptor-like 20.030
Lef1lymphoid enhancer binding factor 10.030
Ppyr1pancreatic polypeptide receptor 10.030
Il1r1interleukin 1 receptor, type I0.030
Il18interleukin 180.029
Rassf5Ras association (RalGDS/AF-6) domain family member 50.029
Cd22CD22 molecule0.029
Scn11asodium channel, voltage-gated, type XI, alpha0.028
Cd44Cd44 molecule0.028
Csf1colony stimulating factor 1 (macrophage)0.027
Il4interleukin 40.027
Reg3gregenerating islet-derived 3 gamma0.027
Anxa2annexin A20.026
Prss2protease, serine, 20.026
Tgm1transglutaminase 1, K polypeptide0.026
Ptpn6protein tyrosine phosphatase, non-receptor type 60.026
Gpr114G protein-coupled receptor 1140.025
Nr5a2nuclear receptor subfamily 5, group A, member 20.025
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.025
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.025
Zbp1Z-DNA binding protein 10.025
Slc18a2solute carrier family 18 (vesicular monoamine), member 20.024
Grin2aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.024
Twist2twist homolog 2 (Drosophila)0.024
Aqp8aquaporin 80.023
Vom2r27vomeronasal 2 receptor, 270.023
Gadd45agrowth arrest and DNA-damage-inducible, alpha0.023
UST4rintegral membrane transport protein UST4r0.023
Il1rl2interleukin 1 receptor-like 20.023
Syt8synaptotagmin VIII0.023
C1qbcomplement component 1, q subcomponent, B chain0.022
Dcaf17DDB1 and CUL4 associated factor 170.022
Pmfbp1polyamine modulated factor 1 binding protein 10.022
Itgadintegrin, alpha D0.022
Socs3suppressor of cytokine signaling 30.022
Aldh6a1aldehyde dehydrogenase 6 family, member A10.022
Lcp2lymphocyte cytosolic protein 20.021
Serpinb7serpin peptidase inhibitor, clade B (ovalbumin), member 70.021
Mobkl2aMOB1, Mps One Binder kinase activator-like 2A (yeast)0.021
Ccl3chemokine (C-C motif) ligand 30.021
C3complement component 30.021
Zg16zymogen granule protein 160.021
Pthparathyroid hormone0.021
Fgbfibrinogen beta chain0.020
Arhgap4Rho GTPase activating protein 40.020
Il6interleukin 60.020
Ccr5chemokine (C-C motif) receptor 50.020
Tnfsf11tumor necrosis factor (ligand) superfamily, member 110.020
Adfpadipose differentiation related protein0.020
Laptm5lysosomal protein transmembrane 50.020
LOC100361571keratin associated protein 1-3-like0.020
Prr13proline rich 130.020
Impg2interphotoreceptor matrix proteoglycan 20.020
Slc34a1solute carrier family 34 (sodium phosphate), member 10.020
Gpr20G protein-coupled receptor 200.020
Cd53Cd53 molecule0.019
Calcacalcitonin-related polypeptide alpha0.019
Arhgap25Rho GTPase activating protein 250.019
Klrb1bkiller cell lectin-like receptor subfamily B member 1B0.019
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism