The network for 'positive regulation of leukocyte proliferation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of leukocyte proliferation

Any process that activates or increases the frequency, rate or extent of leukocyte proliferation.

NameDescriptionProbabilityFunc Analog Organism
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.998
LCKlymphocyte-specific protein tyrosine kinase0.993
GRB2growth factor receptor-bound protein 20.992
CD80CD80 molecule0.991
FGFR2fibroblast growth factor receptor 20.985
BCL2B-cell CLL/lymphoma 20.981
ICAM1intercellular adhesion molecule 10.979
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.973
IL1Binterleukin 1, beta0.963
TRAF1TNF receptor-associated factor 10.953
SYKspleen tyrosine kinase0.920
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.904
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.901
HLA-DRB1major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 10.890
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.873
SOCS3suppressor of cytokine signaling 30.869
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.847
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.842
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.811
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.797
BCL2L1BCL2-like 10.761
CCL4chemokine (C-C motif) ligand 40.748
TNFAIP3tumor necrosis factor, alpha-induced protein 30.734
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.712
CD86CD86 molecule0.712
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.710
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.705
IL2RGinterleukin 2 receptor, gamma0.689
BTN3A2butyrophilin, subfamily 3, member A20.683
CXCL9chemokine (C-X-C motif) ligand 90.668
BTN3A3butyrophilin, subfamily 3, member A30.663
IL2RBinterleukin 2 receptor, beta0.632
CCR5chemokine (C-C motif) receptor 50.620
IL8interleukin 80.589
PTPN1protein tyrosine phosphatase, non-receptor type 10.561
PTPRCprotein tyrosine phosphatase, receptor type, C0.555
BIDBH3 interacting domain death agonist0.554
IRAK1interleukin-1 receptor-associated kinase 10.551
PLCG1phospholipase C, gamma 10.544
BCL2L11BCL2-like 11 (apoptosis facilitator)0.538
CCR7chemokine (C-C motif) receptor 70.535
BTN3A1butyrophilin, subfamily 3, member A10.532
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.499
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.498
CD247CD247 molecule0.495
IL1R1interleukin 1 receptor, type I0.472
VAV1vav 1 guanine nucleotide exchange factor0.471
LATlinker for activation of T cells0.449
CTLA4cytotoxic T-lymphocyte-associated protein 40.447
JAK1Janus kinase 10.420
IL10interleukin 100.417
IFNGinterferon, gamma0.414
CCL20chemokine (C-C motif) ligand 200.411
CXCL10chemokine (C-X-C motif) ligand 100.402
BAXBCL2-associated X protein0.385
HLA-DMAmajor histocompatibility complex, class II, DM alpha0.377
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.375
CCL2chemokine (C-C motif) ligand 20.370
CXCL2chemokine (C-X-C motif) ligand 20.367
NCOA3nuclear receptor coactivator 30.366
HLA-DPA1major histocompatibility complex, class II, DP alpha 10.364
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.355
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.352
ITGALintegrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)0.352
IL6interleukin 6 (interferon, beta 2)0.350
CCL22chemokine (C-C motif) ligand 220.336
GRB7growth factor receptor-bound protein 70.334
IRF4interferon regulatory factor 40.330
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.309
TAL1T-cell acute lymphocytic leukemia 10.290
TNFRSF9tumor necrosis factor receptor superfamily, member 90.288
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.282
PTPN6protein tyrosine phosphatase, non-receptor type 60.281
BCL2A1BCL2-related protein A10.274
SH3BP2SH3-domain binding protein 20.271
STAT4signal transducer and activator of transcription 40.270
TLR2toll-like receptor 20.267
HDAC9histone deacetylase 90.261
CXCR6chemokine (C-X-C motif) receptor 60.251
FGF10fibroblast growth factor 100.239
IRAK2interleukin-1 receptor-associated kinase 20.232
FGFR1fibroblast growth factor receptor 10.227
NFKBIZnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta0.227
HLA-DPB1major histocompatibility complex, class II, DP beta 10.225
LIFleukemia inhibitory factor (cholinergic differentiation factor)0.218
BTN2A2butyrophilin, subfamily 2, member A20.215
CCR1chemokine (C-C motif) receptor 10.213
FGF1fibroblast growth factor 1 (acidic)0.212
SIGLEC7sialic acid binding Ig-like lectin 70.210
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.207
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.204
CCL5chemokine (C-C motif) ligand 50.200
GRAP2GRB2-related adaptor protein 20.196
IL7Rinterleukin 7 receptor0.193
INSRinsulin receptor0.190
MEFVMediterranean fever0.189
CCL8chemokine (C-C motif) ligand 80.189
IGF2insulin-like growth factor 2 (somatomedin A)0.186
TNFtumor necrosis factor0.184
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Lyz2lysozyme 21.000
Tnftumor necrosis factor0.997
Icosinducible T-cell co-stimulator0.987
Cd28CD28 antigen0.987
Tlr4toll-like receptor 40.980
Ltalymphotoxin A0.977
Ifnginterferon gamma0.974
Ikzf1IKAROS family zinc finger 10.970
Leprleptin receptor0.968
Cd40CD40 antigen0.966
Ighimmunoglobulin heavy chain complex0.965
Ccl2chemokine (C-C motif) ligand 20.945
Myd88myeloid differentiation primary response gene 880.938
Tgfb1transforming growth factor, beta 10.937
Ccr2chemokine (C-C motif) receptor 20.934
Tlr2toll-like receptor 20.934
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.925
Map3k14mitogen-activated protein kinase kinase kinase 140.924
Il10interleukin 100.886
Tnfaip3tumor necrosis factor, alpha-induced protein 30.875
Il4interleukin 40.870
Ltblymphotoxin B0.868
Nos3nitric oxide synthase 3, endothelial cell0.864
Pdcd1programmed cell death 10.856
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.840
RybpRING1 and YY1 binding protein0.834
Ccr7chemokine (C-C motif) receptor 70.830
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.828
Tnfsf14tumor necrosis factor (ligand) superfamily, member 140.827
Stat3signal transducer and activator of transcription 30.806
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.802
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.798
Socs1suppressor of cytokine signaling 10.794
Stat5bsignal transducer and activator of transcription 5B0.777
FasFas (TNF receptor superfamily member 6)0.767
Nos2nitric oxide synthase 2, inducible0.742
Irf4interferon regulatory factor 40.735
Gli2GLI-Kruppel family member GLI20.720
Batfbasic leucine zipper transcription factor, ATF-like0.711
Chrnb2cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)0.704
FaslFas ligand (TNF superfamily, member 6)0.694
Sh2d2aSH2 domain protein 2A0.685
Il2rbinterleukin 2 receptor, beta chain0.673
Rargretinoic acid receptor, gamma0.668
Tnfsf11tumor necrosis factor (ligand) superfamily, member 110.660
Ccr1chemokine (C-C motif) receptor 10.651
Ccl3chemokine (C-C motif) ligand 30.642
Ptenphosphatase and tensin homolog0.638
Cd6CD6 antigen0.630
Casp4caspase 4, apoptosis-related cysteine peptidase0.604
BtkBruton agammaglobulinemia tyrosine kinase0.596
Sfpi1SFFV proviral integration 10.592
Col1a1collagen, type I, alpha 10.583
Cxcl13chemokine (C-X-C motif) ligand 130.577
Itgb1integrin beta 1 (fibronectin receptor beta)0.574
Fgfr2fibroblast growth factor receptor 20.571
Pax2paired box gene 20.565
Cxcr5chemokine (C-X-C motif) receptor 50.553
Cd44CD44 antigen0.552
Sykbspleen tyrosine kinase0.551
Ppargperoxisome proliferator activated receptor gamma0.551
Vhlvon Hippel-Lindau tumor suppressor0.547
Efnb2ephrin B20.527
Cd80CD80 antigen0.521
Il1r1interleukin 1 receptor, type I0.516
Il2rginterleukin 2 receptor, gamma chain0.505
Clec4nC-type lectin domain family 4, member n0.502
Chrnb4cholinergic receptor, nicotinic, beta polypeptide 40.496
Lag3lymphocyte-activation gene 30.495
Cd4CD4 antigen0.493
Klrb1bkiller cell lectin-like receptor subfamily B member 1B0.491
Traf2TNF receptor-associated factor 20.473
Drd2dopamine receptor D20.469
Csf2colony stimulating factor 2 (granulocyte-macrophage)0.464
Mmp9matrix metallopeptidase 90.463
Ccl4chemokine (C-C motif) ligand 40.460
C3ar1complement component 3a receptor 10.458
Stat5asignal transducer and activator of transcription 5A0.445
Ccl7chemokine (C-C motif) ligand 70.434
Gli3GLI-Kruppel family member GLI30.432
Ccl12chemokine (C-C motif) ligand 120.430
Bcl2B-cell leukemia/lymphoma 20.417
Relreticuloendotheliosis oncogene0.415
Itgaxintegrin alpha X0.413
Gpr132G protein-coupled receptor 1320.410
FynFyn proto-oncogene0.389
Card11caspase recruitment domain family, member 110.371
Runx1runt related transcription factor 10.371
Pax8paired box gene 80.370
Foxn1forkhead box N10.361
Casp1caspase 10.357
Casp8caspase 80.355
Bcl3B-cell leukemia/lymphoma 30.349
Ephb2Eph receptor B20.347
Snai1snail homolog 1 (Drosophila)0.345
Tbx21T-box 210.341
Aireautoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)0.338
Irf8interferon regulatory factor 80.337
Nos1nitric oxide synthase 1, neuronal0.332
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
RT1-BaRT1 class II, locus Ba0.319
Ptprcprotein tyrosine phosphatase, receptor type, C0.178
Cd247Cd247 molecule0.158
Itgb7integrin, beta 70.147
Lcp1lymphocyte cytosolic protein 10.127
Cd37CD37 molecule0.126
Srd5a2steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)0.094
Casp1caspase 10.090
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.082
Il10interleukin 100.077
Ccr5chemokine (C-C motif) receptor 50.072
Slc18a2solute carrier family 18 (vesicular monoamine), member 20.069
Cd53Cd53 molecule0.069
Hckhemopoietic cell kinase0.067
Cd5Cd5 molecule0.058
Reg3bregenerating islet-derived 3 beta0.056
Prol1proline rich, lacrimal 10.053
P2rx2purinergic receptor P2X, ligand-gated ion channel, 20.052
Gzmkgranzyme K0.051
RT1-Db1RT1 class II, locus Db10.049
Cd2Cd2 molecule0.048
Ptger4prostaglandin E receptor 4 (subtype EP4)0.044
Zbp1Z-DNA binding protein 10.044
Scn11asodium channel, voltage-gated, type XI, alpha0.043
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.043
Prpg1proline-rich proteoglycan 10.042
Cfpcomplement factor properdin0.042
Il1rl1interleukin 1 receptor-like 10.039
Nkg7natural killer cell group 7 sequence0.038
Napsanapsin A aspartic peptidase0.035
Chatcholine acetyltransferase0.034
Olr1078olfactory receptor 10780.033
Gfra2GDNF family receptor alpha 20.033
Il1r1interleukin 1 receptor, type I0.031
Il7rinterleukin 7 receptor0.031
Egr3early growth response 30.030
Itgadintegrin, alpha D0.030
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.030
Hpgdshematopoietic prostaglandin D synthase0.030
Il1binterleukin 1 beta0.029
Ugt8UDP glycosyltransferase 80.029
Prl8a9prolactin family 8, subfamily a, member 90.029
Col10a1collagen, type X, alpha 10.028
Ptpn6protein tyrosine phosphatase, non-receptor type 60.028
Teddm1transmembrane epididymal protein 10.028
Apbb1ipamyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein0.028
Il4interleukin 40.026
Serpinb7serpin peptidase inhibitor, clade B (ovalbumin), member 70.025
Inpp5dinositol polyphosphate-5-phosphatase D0.025
Mmp10matrix metallopeptidase 100.024
Ly86lymphocyte antigen 860.024
Cxcl13chemokine (C-X-C motif) ligand 130.023
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.023
Myh3myosin, heavy chain 3, skeletal muscle, embryonic0.023
Csn1s1casein alpha s10.022
Tnfsf4tumor necrosis factor (ligand) superfamily, member 40.022
Tas2r123taste receptor, type 2, member 1230.022
Svs1seminal vesicle secretory protein 10.021
Prlhprolactin releasing hormone0.021
Il6interleukin 60.020
Il2rbinterleukin 2 receptor, beta0.020
Pspparotid secretory protein0.020
Serpinb2serpin peptidase inhibitor, clade B (ovalbumin), member 20.020
Igsf6immunoglobulin superfamily, member 60.020
Dnase1l3deoxyribonuclease 1-like 30.020
Arl5cADP-ribosylation factor-like 5C0.020
Lcp2lymphocyte cytosolic protein 20.019
Slc5a1solute carrier family 5 (sodium/glucose cotransporter), member 10.019
Ccl5chemokine (C-C motif) ligand 50.019
Syt8synaptotagmin VIII0.019
Myh1myosin, heavy polypeptide 1, skeletal muscle, adult0.019
Calcrcalcitonin receptor0.019
Olr1500olfactory receptor 15000.019
Tas2r126taste receptor, type 2, member 1260.019
Retret proto-oncogene0.019
Mmp3matrix metallopeptidase 30.019
Mobpmyelin-associated oligodendrocyte basic protein0.019
Btnl8butyrophilin-like 80.019
Trhthyrotropin releasing hormone0.019
Il6stinterleukin 6 signal transducer0.018
Gabarapl2GABA(A) receptor-associated protein like 20.018
Mca32mast cell antigen 320.018
Vipvasoactive intestinal peptide0.018
Bcl2a1dB-cell leukemia/lymphoma 2 related protein A1d0.018
Itpr2inositol 1,4,5-triphosphate receptor, type 20.018
Tnfrsf14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.018
Laptm5lysosomal protein transmembrane 50.017
Nat1N-acetyltransferase 10.017
Syngap1synaptic Ras GTPase activating protein 1 homolog (rat)0.017
Aldh6a1aldehyde dehydrogenase 6 family, member A10.017
Slfn2schlafen 20.017
Icosinducible T-cell co-stimulator0.017
Il18interleukin 180.017
Bin2bridging integrator 20.017
Il16interleukin 160.017
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism