The network for 'negative regulation of locomotion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of locomotion

Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism.

NameDescriptionProbabilityFunc Analog Organism
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)1.000
FN1fibronectin 11.000
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.995
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.991
JAG1jagged 10.990
FGFR2fibroblast growth factor receptor 20.987
FLNAfilamin A, alpha0.987
RARAretinoic acid receptor, alpha0.968
TEKTEK tyrosine kinase, endothelial0.946
CD63CD63 molecule0.935
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.933
C1QAcomplement component 1, q subcomponent, A chain0.914
TGFB1transforming growth factor, beta 10.902
EGFRepidermal growth factor receptor0.900
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.884
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.875
IFITM2interferon induced transmembrane protein 2 (1-8D)0.873
TAL1T-cell acute lymphocytic leukemia 10.862
NCOA1nuclear receptor coactivator 10.858
PTPN1protein tyrosine phosphatase, non-receptor type 10.855
HOXB5homeobox B50.843
IFITM1interferon induced transmembrane protein 1 (9-27)0.832
CCR5chemokine (C-C motif) receptor 50.824
NOTCH3notch 30.822
FKBP1AFK506 binding protein 1A, 12kDa0.821
KRT15keratin 150.821
SP110SP110 nuclear body protein0.813
NOTCH1notch 10.782
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.771
COL6A1collagen, type VI, alpha 10.770
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.755
BMP2bone morphogenetic protein 20.754
HIPK2homeodomain interacting protein kinase 20.709
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.699
PLAUplasminogen activator, urokinase0.672
VCAM1vascular cell adhesion molecule 10.662
METmet proto-oncogene (hepatocyte growth factor receptor)0.655
SPTAN1spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)0.651
CCL4chemokine (C-C motif) ligand 40.640
TGFB3transforming growth factor, beta 30.622
THBS1thrombospondin 10.619
TIMP3TIMP metallopeptidase inhibitor 30.607
NCOR2nuclear receptor corepressor 20.584
SPTBN1spectrin, beta, non-erythrocytic 10.578
SMAD3SMAD family member 30.575
SLIT3slit homolog 3 (Drosophila)0.572
COL1A2collagen, type I, alpha 20.572
ITGA3integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)0.568
BMP1bone morphogenetic protein 10.560
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.549
SEMA4Asema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A0.546
IFITM3interferon induced transmembrane protein 3 (1-8U)0.544
RXRAretinoid X receptor, alpha0.523
C1QCcomplement component 1, q subcomponent, C chain0.518
IL1R1interleukin 1 receptor, type I0.514
ABI2abl-interactor 20.514
DPP4dipeptidyl-peptidase 40.511
HOXB6homeobox B60.502
GATA4GATA binding protein 40.498
FGF1fibroblast growth factor 1 (acidic)0.497
KRT6Bkeratin 6B0.497
IGF1insulin-like growth factor 1 (somatomedin C)0.492
ADRB1adrenergic, beta-1-, receptor0.468
PTGISprostaglandin I2 (prostacyclin) synthase0.465
COX17COX17 cytochrome c oxidase assembly homolog (S. cerevisiae)0.458
GHRgrowth hormone receptor0.457
SFRP1secreted frizzled-related protein 10.455
BCAR1breast cancer anti-estrogen resistance 10.454
KRT8keratin 80.453
CAV1caveolin 1, caveolae protein, 22kDa0.438
COL1A1collagen, type I, alpha 10.434
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.434
CTGFconnective tissue growth factor0.433
FBLN1fibulin 10.423
PDIA3protein disulfide isomerase family A, member 30.410
GNAI2guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 20.400
RND1Rho family GTPase 10.397
MMP14matrix metallopeptidase 14 (membrane-inserted)0.396
TFF1trefoil factor 10.394
ABCA1ATP-binding cassette, sub-family A (ABC1), member 10.391
PKP1plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)0.390
MAP3K3mitogen-activated protein kinase kinase kinase 30.389
TRIM21tripartite motif containing 210.387
BAIAP2BAI1-associated protein 20.384
ITGAVintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)0.381
TBX5T-box 50.370
BMPR1Bbone morphogenetic protein receptor, type IB0.366
APOC1apolipoprotein C-I0.364
MEF2Cmyocyte enhancer factor 2C0.364
CCND1cyclin D10.364
NAMPTnicotinamide phosphoribosyltransferase0.358
STRNstriatin, calmodulin binding protein0.354
IFI16interferon, gamma-inducible protein 160.352
PLATplasminogen activator, tissue0.345
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.335
TIMP1TIMP metallopeptidase inhibitor 10.334
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
ser-4Protein SER-40.670
egl-5Protein EGL-50.277
F52C12.4Protein F52C12.40.213
hlh-2Protein HLH-20.155
syg-1Protein SYG-10.136
egl-18Protein EGL-180.132
cam-1Protein CAM-10.117
unc-86Protein UNC-860.112
nhr-67Protein NHR-670.103
bli-1Protein BLI-10.101
sax-3Protein SAX-30.092
egl-13Protein EGL-130.090
unc-53Protein UNC-530.090
col-110Protein COL-1100.090
tbb-4Protein TBB-40.087
unc-42Protein UNC-420.083
smp-1Protein SMP-10.082
eat-4Protein EAT-40.073
ZC247.2Protein ZC247.20.067
goa-1Protein GOA-10.065
pqn-21Protein PQN-210.063
pdfr-1Protein PDFR-10.061
egl-36Protein EGL-360.060
ptr-14Protein PTR-140.060
CELE_E01G4.6Protein E01G4.60.060
F21C10.7Protein F21C10.70.058
ten-1Protein TEN-10.057
oct-2Protein OCT-20.056
R90.1Protein R90.10.052
unc-7Protein UNC-70.050
F14B8.6Protein F14B8.60.045
pry-1Protein PRY-10.044
sto-4Protein STO-40.044
ttr-24Protein TTR-240.043
vab-3Protein VAB-30.040
col-49Protein COL-490.039
K02A11.3Protein K02A11.30.039
daf-1Protein DAF-10.038
C11E4.6Protein C11E4.60.037
pqn-47Protein PQN-470.037
hlh-1Protein HLH-10.037
unc-37Protein UNC-370.035
csnk-1Protein CSNK-10.035
col-38Protein COL-380.034
egl-30Protein EGL-300.034
egl-46Protein EGL-460.034
sel-12Protein SEL-120.034
tag-163Protein TAG-1630.034
sax-7Protein SAX-70.034
ceh-18Protein CEH-180.033
pqn-53Protein PQN-530.033
ptp-3Protein PTP-30.033
spp-15Protein SPP-150.032
K01A12.3Protein K01A12.30.032
qua-1Protein QUA-10.031
unc-9Protein UNC-90.031
ser-3Protein SER-30.031
lin-12Protein LIN-120.031
ser-1Protein SER-10.030
ima-3Protein IMA-30.029
bar-1Protein BAR-10.029
CELE_M03D4.4Protein M03D4.40.029
ttyh-1Protein TTYH-10.029
col-56Protein COL-560.027
srr-3Protein SRR-30.027
vang-1Protein VANG-10.027
ceh-48Protein CEH-480.027
pat-3Protein PAT-30.027
unc-36Protein UNC-360.026
hum-6Protein HUM-60.026
mes-3Protein MES-30.026
cri-2Protein CRI-20.026
let-60Protein LET-600.025
unc-32Protein UNC-320.025
brp-1Protein BRP-10.025
kvs-4Protein KVS-40.025
pde-4Protein PDE-40.025
hmg-1.2Protein HMG-1.20.024
zfp-1Protein ZFP-10.024
mpk-1Protein MPK-10.024
ngp-1Protein NGP-10.024
sel-8Protein SEL-80.024
lin-29Protein LIN-290.024
unc-29Protein UNC-290.024
elt-6Protein ELT-60.024
mek-2Protein MEK-20.023
mab-23Protein MAB-230.023
ceh-22Protein CEH-220.023
daf-12Protein DAF-120.023
CELE_ZK829.7Protein ZK829.70.023
rsbp-1Protein RSBP-10.023
nhr-32Protein NHR-320.023
cwn-1Protein CWN-10.023
tsp-11Protein TSP-110.023
lin-17Protein LIN-170.023
ZK822.4Protein ZK822.40.022
col-138Protein COL-1380.022
sma-6Protein SMA-60.022
madf-2Protein MADF-20.021
lit-1Protein LIT-10.021
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
efnb2aephrin B2a0.769
cxcr4bchemokine (C-X-C motif), receptor 4b0.626
lmx1b.1LIM homeobox transcription factor 1, beta 10.381
kdrlkinase insert domain receptor like0.345
robo3roundabout homolog 30.219
itgb3bintegrin beta 3b0.198
sulf1sulfatase 10.172
ntn1anetrin 1a0.162
gli2aGLI-Kruppel family member GLI2a0.152
otpborthopedia homolog b0.139
epha4aeph receptor A4a0.138
prox1prospero-related homeobox gene 10.135
bocbrother of CDO0.127
ilkintegrin linked kinase0.110
cfl2lcofilin 2, like0.096
gli1GLI-Kruppel family member 10.089
robo1roundabout homolog 10.089
wnt3wingless-type MMTV integration site family, member 30.087
pdlim1PDZ and LIM domain 1 (elfin)0.086
irx2airoquois homeobox protein 2, a0.085
mibmind bomb0.084
tbx1T-box 10.083
shhasonic hedgehog a0.079
irx5airoquois homeobox protein 5a0.078
ubiad1UbiA prenyltransferase domain containing 10.076
fgf3fibroblast growth factor 30.075
tbx2bT-box 2b0.073
rorbRAR-related orphan receptor B0.071
cntn2contactin 20.071
sox2SRY-box containing gene 20.069
lhx2bLIM homeobox 2b0.064
mtpmicrosomal triglyceride transfer protein0.064
nf1aneurofibromin 1a0.063
ncam1bneural cell adhesion molecule 1b0.060
bmp2bbone morphogenetic protein 2b0.060
dtngdystrobrevin, gamma and dystrobrevin, gamma-like0.060
sox3SRY-box containing gene 30.059
fgfr2fibroblast growth factor receptor 20.059
wnt11rwingless-type MMTV integration site family, member 11, related0.058
fzd7bfrizzled homolog 7b0.058
robo2roundabout homolog 20.058
hcrthypocretin (orexin) neuropeptide precursor0.053
crhcorticotropin releasing hormone0.049
irx3airoquois homeobox protein 3a0.048
mbtps1membrane-bound transcription factor protease, site 10.048
srfserum response factor0.046
appaamyloid beta (A4) precursor protein a0.045
fgf8bfibroblast growth factor 8 b0.044
metmet proto-oncogene (hepatocyte growth factor receptor)0.043
spry4sprouty (Drosophila) homolog 40.043
foxd3forkhead box D30.042
ucn3lurocortin 3, like0.042
sox11aSRY-box containing gene 11a0.042
drd2adopamine receptor D2a0.041
esrrgaestrogen-related receptor gamma a0.041
ptmabprothymosin, alpha b0.041
prkciprotein kinase C, iota0.041
dab1adisabled homolog 1a (Drosophila)0.040
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.040
vegfcvascular endothelial growth factor c0.040
gnb1aguanine nucleotide binding protein (G protein), beta polypeptide 1a0.039
itgb1bintegrin, beta 1b0.039
neo1neogenin 10.039
wnt10awingless-type MMTV integration site family, member 10a0.036
fabp11afatty acid binding protein 11a0.036
axin2axin 2 (conductin, axil)0.035
plxna4plexin A40.034
axin1axin 10.034
notch3notch homolog 30.034
insm1ainsulinoma-associated 1a0.034
sulf2lsulfatase 2, like0.034
sh3gl1bSH3-domain GRB2-like 1b0.034
lfnglunatic fringe homolog0.033
tnfatumor necrosis factor a (TNF superfamily, member 2)0.033
kctd12.1potassium channel tetramerisation domain containing 12.10.033
tmem2transmembrane protein 20.033
slit2slit (Drosophila) homolog 20.032
rtn1areticulon 1a0.032
arhgef7bRho guanine nucleotide exchange factor (GEF) 7b0.032
slit1aslit homolog 1a (Drosophila)0.031
hspb6heat shock protein, alpha-crystallin-related, b60.030
pdx1pancreatic and duodenal homeobox 10.030
adipoqladiponectin, C1Q and collagen domain containing, like0.030
igf1rainsulin-like growth factor 1a receptor0.030
unc5bunc-5 homolog B (C. elegans)0.030
sox4aSRY-box containing gene 4a0.030
slit3slit (Drosophila) homolog 30.029
chatcholine acetyltransferase0.028
apcadenomatosis polyposis coli0.028
rxfp1relaxin/insulin-like family peptide receptor 10.028
nrp1aneuropilin 1a0.027
nsa2NSA2 ribosome biogenesis homolog (S. cerevisiae)0.027
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Ifitm3interferon induced transmembrane protein 30.033
Fgfr2fibroblast growth factor receptor 20.019
C1scomplement component 1, s subcomponent0.018
Adora2aadenosine A2a receptor0.017
Il4interleukin 40.016
Nlgn3neuroligin 30.016
Dag1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.015
Ifitm2interferon induced transmembrane protein 20.015
Acta2smooth muscle alpha-actin0.015
Mgpmatrix Gla protein0.015
Ptafrplatelet-activating factor receptor0.015
Kcnq2potassium voltage-gated channel, KQT-like subfamily, member 20.014
Cntn3contactin 3 (plasmacytoma associated)0.014
Sstr1somatostatin receptor 10.014
A3galt2alpha 1,3-galactosyltransferase 20.013
Cd4Cd4 molecule0.013
Gabrb3gamma-aminobutyric acid (GABA) A receptor, beta 30.013
Lims1LIM and senescent cell antigen-like domains 10.013
Itga6integrin, alpha 60.013
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.012
Hbe1hemoglobin, epsilon 10.012
Acap1ArfGAP with coiled-coil, ankyrin repeat and PH domains 10.012
Fgf2fibroblast growth factor 20.012
Rab3il1RAB3A interacting protein (rabin3)-like 10.012
Flt1FMS-related tyrosine kinase 10.012
Avpr2arginine vasopressin receptor 20.012
GraspGRP1 (general receptor for phosphoinositides 1)-associated scaffold protein0.012
Capn9calpain 90.012
Gja5gap junction protein, alpha 50.012
Sdc3syndecan 30.012
Galr3galanin receptor 30.012
Cd37CD37 molecule0.012
Syt11synaptotagmin XI0.012
Itpr2inositol 1,4,5-triphosphate receptor, type 20.012
Ece1endothelin converting enzyme 10.012
Trib1tribbles homolog 1 (Drosophila)0.011
Lnpepleucyl/cystinyl aminopeptidase0.011
Socs3suppressor of cytokine signaling 30.011
Cd38CD38 molecule0.011
Uoxurate oxidase0.011
Sox17SRY (sex determining region Y)-box 170.011
Slc6a7solute carrier family 6 (neurotransmitter transporter, L-proline), member 70.011
Grid1glutamate receptor, ionotropic, delta 10.011
Tp63tumor protein p630.011
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.011
Magi2membrane associated guanylate kinase, WW and PDZ domain containing 20.011
Shisa5shisa homolog 5 (Xenopus laevis)0.011
Gria1glutamate receptor, ionotropic, AMPA 10.011
Kcnt1potassium channel, subfamily T, member 10.011
Chrna7cholinergic receptor, nicotinic, alpha 70.011
Rasgrp1RAS guanyl releasing protein 1 (calcium and DAG-regulated)0.011
Masp2mannan-binding lectin serine peptidase 20.011
Cd14CD14 molecule0.011
Actbactin, beta0.010
Sept9septin 90.010
Slit3slit homolog 3 (Drosophila)0.010
Slc1a2solute carrier family 1 (glial high affinity glutamate transporter), member 20.010
Fgf14fibroblast growth factor 140.010
Cd5Cd5 molecule0.010
Rhocras homolog gene family, member C0.010
Gnb4guanine nucleotide binding protein (G protein), beta polypeptide 40.010
Epas1endothelial PAS domain protein 10.010
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.010
Ltbp4latent transforming growth factor beta binding protein 40.010
Impg2interphotoreceptor matrix proteoglycan 20.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism